| 1 | 29 | June-Reg | Derick Grigsby | P | 20 | 6-0 | 190 | R | R | - | | Northeast Texas Community College | |
| 2 | 70 | June-Reg | Mitch Talbot | P | 18 | 6-2 | 175 | R | R | MLB | 2008-2008 | Canyon View (Cedar City,UT) | $550,000 |
| 3 | 101 | June-Reg | Rory Shortell | P | 21 | 6-3 | 205 | R | R | A+ | | San Diego State University | |
| 4 | 131 | June-Reg | Mark McLemore | P | 21 | 6-2 | 210 | L | L | MLB | 2007-2007 | Oregon State University | |
| 5 | 161** | June-Reg | Pat Misch | P | 20 | 6-2 | 170 | R | L | MLB | 2006-2009 | Western Michigan University | $0 |
| 6 | 191 | June-Reg | J.P. Duran | P | 22 | 5-10 | 190 | R | R | A- | | St. Mary's University | |
| 7 | 221 | June-Reg | Scott Robinson | 1B-OF | 18 | 6-1 | 185 | L | L | A+ | | Rancho Bernardo (San Diego,CA) | |
| 8 | 251 | June-Reg | Bill Westhoff | P | 22 | 6-0 | 195 | R | R | A+ | | University of Dallas | |
| 9 | 281 | June-Reg | Andy Topham | IF | 21 | 6-2 | 200 | R | R | A- | | Stanford University | |
| 10 | 311** | June-Reg | Brad Chedister | P | | | | | | Rookie | | Panola College | |
| 11 | 341 | June-Reg | Jason Reuss | OF | 22 | 6-6 | 215 | R | R | A- | | University of Nevada | |
| 12 | 371 | June-Reg | Chance Douglass | P | 18 | 6-1 | 190 | R | R | AAA | | Canyon Randall (Amarillo,TX) | |
| 13 | 401 | June-Reg | Nick Covarrubias | OF | 22 | 6-2 | 205 | R | R | A- | | Long Beach State University | |
| 14 | 431 | June-Reg | William Boening | P | 17 | 6-5 | 210 | R | R | - | | Yoakum (Yoakum,TX) | |
| 15 | 461 | June-Reg | Jeff Mackor | C | 22 | 6-1 | 215 | R | R | AA | | Boston College | |
| 16 | 491 | June-Reg | Jared Gothreaux | P | 22 | 6-0 | 205 | R | R | AAA | | McNeese State University | |
| 17 | 521 | June-Reg | Daniel Freeman | P | 19 | 6-2 | 210 | R | R | A+ | | Texarkana College | |
| 18 | 551 | June-Reg | Brent Long | P | 22 | 6-3 | 180 | R | R | Rookie | | Brevard Community College | |
| 19 | 581 | June-Reg | Aaron Heitzman | P | 22 | 6-0 | 185 | L | L | A+ | | Minnesota State University-Mankato | |
| 20 | 611 | June-Reg | Justin Glover | OF | | | 0 | | | - | | Grant (Portland,OR) | |
| 21 | 641 | June-Reg | Ivan Naccarata | H | 20 | 6-0 | 190 | L | R | A+ | | Chipola College | |
| 22 | 671 | June-Reg | Sam Fischer | P | 19 | 6-0 | 180 | R | R | A | | University of Dayton | |
| 23 | 701 | June-Reg | Jesse Harrington | IF | 22 | 6-0 | 170 | R | R | A- | | Concordia University | |
| 24 | 731** | June-Reg | Nick Tisone | P | 18 | 6-1 | 185 | R | R | A+ | | Mandeville (Mandeville,LA) | |
| 25 | 761** | June-Reg | Ethien Santana | OF | 18 | 5-11 | 153 | L | L | A+ | | Colegio Bautista (San Juan,PR) | |
| 26 | 791 | June-Reg | Randy McGarvey | C | 23 | 6-3 | 200 | L | R | A- | | Coastal Carolina University | |
| 27 | 821** | June-Reg | Shawn Burris | P | 18 | 5-11 | 180 | L | L | - | | Poteet (Mesquite,TX) | $0 |
| 28 | 851 | June-Reg | Kevin Davidson | C | 21 | 5-9 | 200 | R | R | AAA | | Rollins College | |
| 29 | 881 | June-Reg | Sean Kramer | P | 21 | 6-3 | 220 | R | R | A- | | Hill College | |
| 30 | 911** | June-Reg | Ladd Hall | P | 20 | 6-3 | 205 | R | R | College | | Eastern Arizona College | |
| 31 | 941 | June-Reg | Andy Salmela | IF | 22 | 6-3 | 210 | R | R | A- | | Augustana College | |
| 32 | 971 | June-Reg | Tyson Olson | LF | | | 0 | | | - | | Dixie State College of Utah | |
| 33 | 1001 | June-Reg | Pat Peavey | 3B-SS | 22 | 6-1 | 205 | R | R | AA | - | Santa Clara University | |
| 34 | 1031 | June-Reg | Michael Lorsbach | OF | 22 | 6-6 | 220 | L | R | Rookie | | Rice University | |
| 35 | 1061 | June-Reg | Shawn Williams | CF | 18 | 6-2 | 190 | B | R | A+ | | Clearwater Central Catholic (Clearwater,FL) | |
| 36 | 1091 | June-Reg | Adam Seuss | OF | 21 | 6-0 | 195 | L | R | A+ | | University of California | |
| 37 | 1121 | June-Reg | Dustin Hawkins | OF | 22 | 6-0 | 185 | L | L | A | | Wichita State University | |
| 38 | 1151 | June-Reg | Ryan Larson | 3B | 22 | 6-3 | 210 | R | R | A- | | University of California-San Diego | |
| 39 | 1181** | June-Reg | Nick Stavinoha | RF | 20 | 6-2 | 225 | R | R | MLB | 2008-2009 | San Jacinto College | $0 |
| 40 | 1211 | June-Reg | Adam Yesalusky | P | | | 0 | | | - | | Minersville (Minersville,PA) | |
| 41 | 1241** | June-Reg | Scott Feldman | P | 19 | 6-4 | 210 | R | R | MLB | 2005-2009 | College of San Mateo | |
| 42 | 1271 | June-Reg | Chase Medford | P | 18 | 6-0 | 180 | L | L | - | | Richland (Fort Worth,TX) | |
| 43 | 1300** | June-Reg | Freddy Thon | | 18 | 6-2 | 215 | L | L | AA | | Baldwin School (Guaynabo,PR) | |
| 44 | 1328 | June-Reg | William Mac-Holmes | P | 17 | 6-1 | 180 | R | R | - | | Burke (Omaha,NE) | |
| 45 | 1355 | June-Reg | Ryan McKeller | P | 18 | 6-5 | 210 | R | R | AAA | | McLennan Community College | |
| 46 | 1381 | June-Reg | Eric Brock | P | 18 | | 0 | | | - | | Santa Margarita Catholic (Rancho Santa Margarita,CA) | |
| 47 | 1407 | June-Reg | Raymar Diaz | OF | 18 | 6-7 | 190 | R | R | A+ | | Laredo Community College | |
| 48 | 1433 | June-Reg | Kyle Thompson | P | | | 0 | | | - | | Palomar College | |