| 198. | Sergio Mitre | P | CHC | 20 | 2/16/1981 | 6-4 | 210 | R-R | MLB | 2003-2007 | San Diego Community College | 32 |
| 199. | Timothy King | P | TB | 17 | 8/22/1983 | 6-3 | 200 | L-L | A | | Deer Park High School (Deer Park,TX) | 9 |
| 202. | Chad Bentz | P | MTL | 21 | 5/5/1980 | 6-2 | 210 | R-L | MLB | 2004-2005 | Long Beach State University | 110 |
| 204. | Mike McCuistion | C | PIT | 19 | 5/14/1982 | 6-2 | 190 | L-R | A+ | | Yucaipa High School (Yucaipa,CA) | 7 |
| 205. | Chris Tierney | P | KC | 17 | 9/1/1983 | 6-6 | 225 | L-L | A+ | | Rockport High School (Rockport,IL) | 1 |
| 207. | Tom Farmer | P | DET | 21 | 7/27/1979 | 6-2 | 195 | R-R | AAA | | University of Miami (Florida) | 167 |
| 209. | Rich Hill | P | ANA | 21 | 3/11/1980 | 6-4 | 180 | L-L | MLB | 2005-2008 | University of Texas-San Antonio | 11 |
| 217. | Josh Noviskey | C | CLE | 18 | 3/15/1983 | 6-4 | 210 | B-R | A | | Newton High School (Newton,NJ) | 2 |
| 219. | John Axford | P | SEA | 18 | 4/1/1983 | 6-5 | 185 | R-R | AAA | | Assumption College High School (ON) | |
| 220. | David Cuen | P | LA | 17 | 8/4/1983 | 6-4 | 180 | L-L | A | | Cibola High School (Yuma,AZ) | 3 |
| 225. | Roberto Nieves | P | ATL | 18 | 12/25/1982 | 6-2 | 170 | B-R | A | | De Gracis High School (Vega Alta,PR) | |