| 381. | Michael Paustian | P | TEX | 20 | 3/20/1981 | 6-4 | 210 | R-R | Rookie | | Freed-Hardeman University (Tenn.) | 12 |
| 382. | Ty Kirkman | P | MTL | 18 | 12/21/1982 | 6-3 | 180 | L-L | A- | | Mount Carmel High School (Chicago,IL) | 5 |
| 385. | Cedric Watkins | OF | KC | 18 | 5/25/1983 | 5-11 | 210 | R-R | Rookie | | Bassett High School (Bassett,VA) | 2 |
| 387. | Landon Stockman | P | DET | 21 | 8/28/1979 | 6-2 | 190 | R-R | A+ | | Kennesaw State University | 14 |
| 388. | Travis Hinton | OF | MIL | 20 | 11/21/1980 | 6-1 | 210 | L-L | A+ | | Chandler-Gilbert Community College | 2 |
| 389. | Tony Arthur | P | ANA | 22 | 12/16/1978 | 6-1 | 215 | L-L | A | | Arkansas State University | 27 |
| 391. | Brendan Fuller | P | TOR | 20 | 9/13/1980 | 6-1 | 205 | R-R | A | | University of South Florida | 71 |
| 392. | Lance Davis | P | FLA | 19 | 11/19/1981 | 6-2 | 190 | R-R | A- | | George County High School (Lucedale,MS) | 2 |
| 394. | Kip Bouknight | P | COL | 22 | 11/16/1978 | 6-0 | 190 | R-R | AAA | | University of South Carolina | 93 |
| 395. | Adam Wheeler | P | NYY | 18 | 4/26/1983 | 6-6 | 180 | R-R | A | | Campbell High School (Smyrna,GA) | 4 |
| 396. | Tanner Brock | P | CIN | 22 | 12/21/1978 | 6-3 | 190 | R-R | Rookie | | Mississippi State University | 114 |
| 397. | Matt Knox | IF | CLE | 21 | 12/29/1979 | 6-4 | 215 | R-R | A+ | | Millersville University of Pennsylvania | 4 |
| 398. | Brandon Warriax | SS | ARI | 22 | 6/23/1979 | 6-0 | 165 | R-R | AA | | California State University, Fullerton | 187 |
| 400. | Matt Kauffman | P | LA | 22 | 10/8/1978 | 6-3 | 190 | L-L | Rookie | | San Jose State University | 68 |
| 401. | Chris Mabeus | P | OAK | 22 | 2/11/1979 | 6-3 | 210 | R-R | MLB | 2006-2006 | Lewis-Clark State College | 76 |
| 405. | Bryon Jeffcoat | IF | ATL | 22 | 5/14/1979 | 6-1 | 190 | R-R | AA | | University of South Carolina | 94 |
| 406. | Juan Serrato | P | SF | 19 | 11/4/1981 | 6-2 | 175 | R-R | A+ | | Riverside Community College | 71 |