| 491. | Josh Willingham | 2B | FLA | 21 | 2/17/1979 | 6-1 | 200 | R-R | MLB | 2004-2008 | University of North Alabama | 9 |
| 492. | Paul Maholm | P | MIN | 18 | 6/25/1982 | 6-2 | 215 | L-L | MLB | 2005-2008 | Germantown High School (Germantown,TN) | 5 |
| 494. | Billy Keppinger | LF | KC | 21 | 12/15/1978 | 6-0 | 195 | L-L | AA | | Cumberland University (Tenn.) | 12 |
| 495. | Derrick Depriest | P | MTL | 23 | 11/21/1976 | 6-8 | 230 | R-R | AA | | University of North Carolina | 110 |
| 496. | Adam Bonner | OF | TB | 19 | 3/11/1981 | 6-5 | 206 | L-R | A+ | | Jefferson State Community College | 11 |
| 498. | Matthew Birkett | CF | DET | 18 | 1/13/1982 | 5-11 | 160 | R-R | Rookie | | West Torrance High School (Torrance,CA) | 15 |
| 499. | Jarrett Roenicke | RF | SD | 20 | 1/15/1980 | 6-2 | 195 | L-L | A- | | Yuba (Calif.) Community College | 19 |
| 500. | Mike Napoli | C | ANA | 18 | 10/31/1981 | 6-1 | 205 | R-R | MLB | 2006-2008 | Flanagan High School (Pembroke Pines,FL) | 1 |
| 501. | Daryl Clark | IF | MIL | 20 | 9/25/1979 | 6-2 | 205 | L-R | AA | | University of North Carolina | 111 |
| 503. | Kaulana Kuhaulua | IF | STL | 20 | 1/30/1980 | 6-0 | 166 | R-R | AA | | Los Angeles Community College | 80 |
| 504. | Joel Crump | P | BAL | 18 | 8/20/1981 | 6-2 | 210 | R-R | Rookie | | Yuma High School (Yuma,AZ) | 6 |
| 505. | Travis Chapman | IF | PHI | 22 | 6/5/1978 | 6-2 | 185 | R-R | MLB | 2003-2003 | Mississippi State University | 108 |
| 507. | Jason Olson | P | LA | 22 | 6/12/1978 | 6-2 | 180 | R-R | AAA | | Armstrong Atlantic State University | 11 |
| 508. | Josh McMillan | P | TOR | 21 | 7/8/1978 | 6-0 | 175 | L-L | A | | Riverside Community College | 65 |
| 512. | Chris Elmore | P | BOS | 23 | 4/28/1977 | 6-1 | 195 | L-L | AAA | | University of North Carolina | 112 |
| 518. | Ryan Gill | P | NYY | 23 | 2/1/1977 | 6-3 | 200 | R-R | A- | | University of Louisiana-Lafayette | 60 |
| 519. | Doug Slaten | P | ARI | 20 | 2/4/1980 | 6-5 | 190 | L-L | MLB | 2006-2008 | Los Angeles Pierce College | 77 |
| 520. | Trey Hodges | P | ATL | 22 | 6/29/1978 | 6-3 | 187 | R-R | MLB | 2002-2003 | Louisiana State University | 118 |