| 1 | 25 | June-Reg | Scott Heard | C | 18 | 6-2 | 190 | L | R | A+ | | Rancho Bernardo (San Diego,CA) | $1,475,000 |
| 1 | 35** | June-Reg | Tyrell Godwin | CF | 20 | 6-0 | 200 | L | R | MLB | 2005-2005 | University of North Carolina | |
| 1 | 39 | June-Reg | Chad Hawkins | P | 21 | 6-7 | 205 | R | R | A+ | | Baylor University | $625,000 |
| 2 | 56 | June-Reg | Jason Bourgeois | IF | 18 | 5-9 | 170 | B | R | MLB | 2008-2009 | Forest Brook (Houston,TX) | $621,000 |
| 2 | 64 | June-Reg | Randy Truselo | P | 19 | 6-3 | 190 | R | R | A | | Delcastle (Wilmington,DE) | $600,000 |
| 3 | 94 | June-Reg | Chris Russ | P | 20 | 6-3 | 0 | L | L | A+ | | Towson University | $407,500 |
| 4 | 124 | June-Reg | Laynce Nix | OF | 19 | 6-0 | 190 | L | L | MLB | 2003-2009 | Midland (Midland,TX) | $250,000 |
| 5 | 154 | June-Reg | Greg Runser | P | 21 | 6-1 | 200 | R | R | AA | | University of Houston | $170,000 |
| 6 | 184 | June-Reg | Matt Meisenheimer | P | 18 | 6-3 | 180 | R | R | A | | Greenville (Greenville,TX) | $160,000 |
| 7 | 214** | June-Reg | Virgil Vasquez | P | 18 | 6-3 | 205 | R | R | MLB | 2007-2009 | Santa Barbara (Santa Barbara,CA) | $0 |
| 8 | 244 | June-Reg | Nick Masset | P | 18 | 6-4 | 190 | R | R | MLB | 2006-2009 | Pinellas Park (Pinellas Park,FL) | $175,000 |
| 9 | 274 | June-Reg | Edwin Encarnacion | IF | 17 | 6-1 | 175 | R | R | MLB | 2005-2009 | Manuela Toro (Caguas,PR) | $55,000 |
| 10 | 304 | June-Reg | Billy Montgomery | OF | 20 | 6-0 | 190 | B | R | Rookie | | San Diego State University | $45,000 |
| 11 | 334** | June-Reg | Mike Moat | P | 18 | 6-1 | 190 | R | R | A+ | | Niwot (Longmont,CO) | |
| 12 | 364 | June-Reg | Branden Pack | 1B | 21 | 6-3 | 215 | B | R | A+ | | University of South Carolina | |
| 13 | 394 | June-Reg | Chris Wailand | P | | | | | | College | | State College of Florida, Manatee-Sarasota | |
| 14 | 424** | June-Reg | Myron Leslie | 3B | 18 | 6-3 | 210 | B | R | AA | | | |
| 15 | 454** | June-Reg | Scott Nicholson | P | 20 | 6-0 | 170 | L | L | A- | | Oregon State University | |
| 16 | 484 | June-Reg | Anthony Mongeluzzo | OF | 21 | 6-1 | 210 | R | R | A | | Florida Atlantic University | |
| 17 | 514** | June-Reg | Andrew Myette | P | | | 0 | | | - | | Guildford Park (Surrey,BC) | |
| 18 | 544 | June-Reg | Keith Stamler | P | 20 | 6-2 | 177 | R | R | AAA | | St. John's University | |
| 19 | 574 | June-Reg | A.J. Murray | P | 18 | 6-3 | 200 | B | L | MLB | 2007-2008 | Uintah (Vernal,UT) | |
| 20 | 604 | June-Reg | Tyler Martin | IF | 22 | 6-2 | 185 | B | R | AA | | Mississippi State University | |
| 21 | 634 | June-Reg | Marion Gleason | P | | | 0 | | | - | | Bountiful (Bountiful,UT) | |
| 22 | 664 | June-Reg | Caleb Crosby | | 20 | 6-5 | 225 | R | R | College | | Chipola College | |
| 23 | 694 | June-Reg | Bobb Evans | | 19 | 5-11 | 185 | L | L | A | | Pepperdine University | |
| 24 | 724 | June-Reg | Timothy Riley | 2B-OF | | | 0 | | | - | | James Madison University | |
| 25 | 754 | June-Reg | Frank Sansonetti | CF | | | 0 | L | L | Ind | | College of Staten Island | |
| 26 | 784 | June-Reg | Jason Gray | | 22 | 6-1 | 210 | L | R | Rookie | | Rice University | |
| 27 | 814** | June-Reg | Sean Thompson | P | 19 | 6-2 | 195 | L | L | A+ | | El Camino College | |
| 28 | 844 | June-Reg | Ryan Heath | P | | | 0 | | | - | | Midvale (Mesa,IN) | |
| 29 | 874 | June-Reg | Justin Quaempts | | | 6-3 | 223 | R | R | Ind | | Linn-Benton Community College | |
| 30 | 904 | June-Reg | Nick Devenney | P | 19 | 6-3 | 240 | R | R | A | | Delgado Community College | |
| 31 | 934 | June-Reg | Joe Lane | P | | | 0 | | | - | | Osbourn (Manassas,VA) | |
| 32 | 964 | June-Reg | Casey Berry | P | 19 | 6-1 | 180 | R | R | Rookie | | Cowley College | |
| 33 | 994 | June-Reg | Michael Vargo | P | | | 0 | | | - | | Fountain Hills (Fountain Hills,AZ) | |
| 34 | 1024** | June-Reg | Garrett Bauer | | 18 | 6-0 | 163 | R | L | A- | | Lafayette (Ballwin,MO) | |
| 35 | 1054 | June-Reg | Worth Scott | | | | | | | Ind | | Hendersonville (Hendersonville,TN) | |
| 36 | 1084 | June-Reg | Daniel Ellison | P | | | 0 | | | - | | Houston (Houston,MS) | |
| 37 | 1114** | June-Reg | Chris Pillsbury | P | 18 | 6-3 | 190 | R | R | A | | Arlington Country Day School (Jacksonville,FL) | |
| 38 | 1144 | June-Reg | Dustin Smith | C | 19 | 6-2 | 210 | R | R | AA | | Cowley College | |
| 39 | 1174 | June-Reg | Michael Steller | P | | | 0 | | | Ind | | George Mason University | |
| 40 | 1203 | June-Reg | Brian Pecor | P | | | 0 | | | - | | Overton (Memphis,TN) | |
| 41 | 1232 | June-Reg | Benjamin Ashworth | P | | | 0 | | | - | | St. Petersburg College | |
| 42 | 1261** | June-Reg | Juan Serrato | P | 18 | 6-2 | 175 | R | R | A+ | | Norte Vista (Riverside,CA) | |
| 43 | 1289** | June-Reg | Erik Thompson | P | 18 | 5-11 | 180 | R | R | AAA | | Pine Forest (Pensacola,FL) | |
| 44 | 1316 | June-Reg | Julian Davis | 1B | | | 0 | | | - | | | |
| 45 | 1342 | June-Reg | James Radford | P | | | 0 | | | - | | Bartow (Bartow,FL) | |
| 46 | 1366 | June-Reg | Matt Kline | OF | | | 0 | | | - | | Arroyo Grande (Arroyo Grande,CA) | |
| 47 | 1388 | June-Reg | Jason Guy | OF | 18 | 5-10 | 170 | L | L | Rookie | | Charlotte (Punta Gorda,FL) | |
| 48 | 1408 | June-Reg | Ryan Lupul | | 20 | 6-0 | 185 | L | L | Ind | | North Idaho College | |
| 49 | 1428** | June-Reg | Shane Reedy | P | 18 | 6-2 | 200 | R | R | Rookie | | Kearns (Kearns,UT) | |
| 50 | 1448 | June-Reg | Ruben Feliciano | P | 20 | 6-2 | 175 | R | R | A | | Kingsborough (Brooklyn,NY) | |
