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| 2004 | Topps | Regular Issue | 115 | Minnesota Twins | Johan Santana profile |
| 2005 | Bowman | Heritage | 150 | Minnesota Twins | Johan Santana profile |
| 2005 | Fleer | Tradition | 1 | No team | AL ERA Leaders Johan Santana, Curt Schilling, Jake Westbrook |
| 2005 | Fleer | Tradition | 3 | No team | AL Win Leaders Bartolo Colon, Johan Santana, Curt Schilling |
| 2005 | Fleer | Tradition | 5 | No team | AL Strikeout Leaders Pedro Martinez, Johan Santana, Curt Schilling |
| 2005 | Fleer | Tradition | 124 | Minnesota Twins | Johan Santana profile |
| 2005 | Fleer | Tradition | 338 | Minnesota Twins | Johan Santana AL Cy Young profile |
| 2005 | Topps | Regular Issue | 341 | No team | AL ERA Leaders Johan Santana, Curt Schilling, Jake Westbrook |
| 2005 | Topps | Regular Issue | 713 | Minnesota Twins | Johan Santana AL Cy Young Award winner profile |
| 2006 | Topps | Heritage | 367 | Minnesota Twins | Johan Santana profile |
| 2007 | Topps | Regular Issue | 80 | Minnesota Twins | Johan Santana profile |
| 2007 | Topps | Regular Issue | 321 | Minnesota Twins | Johan Santana AL Cy Young profile |
| 2008 | Bowman | Regular Issue | 60 | New York Mets | Johan Santana profile |
| 2008 | Topps | Regular Issue | 115 | Minnesota Twins | Johan Santana profile |
| 2008 | Topps | Regular Issue | 287 | Minnesota Twins | Classic Combos Joe Mauer, Justin Morneau, Johan Santana |
| 2008 | Topps | Regular Issue | 322 | Tampa Bay Rays | AL Strikeout Leaders Erik Bedard, Scott Kazmir, Johan Santana |
| 2009 | Topps | Heritage | 29 | New York Mets | Johan Santana profile |
| 2009 | Topps | Regular Issue | 206 | New York Mets | NL ERA Leaders Tim Lincecum, Jake Peavy, Johan Santana |
| 2009 | Topps | Regular Issue | 259 | No team | NL Strikeout Leaders Dan Haren, Tim Lincecum, Johan Santana |
| 2009 | Topps | Regular Issue | 310 | New York Mets | Johan Santana profile |
| 2010 | Topps | Regular Issue | 573 | New York Mets | Johan Santana profile |
| 2010 | Upper Deck | Regular Issue | 333 | New York Mets | Johan Santana profile |
| 2010 | Upper Deck | Regular Issue | 588 | New York Mets | Team Checklists Jose Reyes, Johan Santana |
| 2011 | Bowman | Regular Issue | 36 | New York Mets | Johan Santana profile |
| 2011 | Topps | Regular Issue | 56 | New York Mets | Johan Santana profile |
| 2012 | Topps | Heritage | 93 | New York Mets | Johan Santana profile |
