| Yoeli Lopez | OF | 21.337 | - | | Released by Gulf Coast Braves |
| Spencer Howard | P | 22.340 | Philadelphia Phillies | Gulf Coast Phillies (Rk) | Assigned to Gulf Coast Phillies (Rk) |
| Liarvis Breto | P | 26.084 | Detroit Tigers | West Michigan (A) | Assigned to West Michigan (A) |
| Connor Hollis | IF | 24.227 | Tampa Bay Rays | Gulf Coast Rays (Rk) | Assigned to Gulf Coast Rays (Rk) |
| Ignacio Radney | P | 17.272 | New York Yankees | Gulf Coast Yankees (Rk) | Assigned to Gulf Coast Yankees (Rk) |
| Eric Wagaman | 1B | 21.323 | New York Yankees | Gulf Coast Yankees (Rk) | Assigned to Gulf Coast Yankees (Rk) |
| Caleb Dirks | P | 26.024 | Atlanta Braves | Gulf Coast Braves (Rk) | Assigned to Gulf Coast Braves (Rk) |
| Corbin Clouse | P | 24.007 | Atlanta Braves | Gulf Coast Braves (Rk) | Assigned to Gulf Coast Braves (Rk) |
| Deurys Marte | P | 20.008 | New York Yankees | Gulf Coast Yankees (Rk) | Assigned to Gulf Coast Yankees (Rk) |
| Ronaldo Urdaneta | SS | 20.227 | Houston Astros | Tri City (A-) | Assigned to Tri City (A-) |
| Christian Mejias | P | 20.045 | Houston Astros | Gulf Coast Astros (Rk) | Assigned to Gulf Coast Astros (Rk) |
| Alexander Palma | OF | 23.259 | New York Yankees | Gulf Coast Yankees (Rk) | Assigned to Gulf Coast Yankees (Rk) |
| Hai-Cheng Gong | P | 20.187 | Pittsburgh Pirates | Gulf Coast Pirates (Rk) | Assigned to Gulf Coast Pirates (Rk) |
| Albertus Barber | P | 23.136 | Philadelphia Phillies | Williamsport (A-) | Assigned to Williamsport (A-) |
| Hsin-Chih Lin | P | 20.107 | Philadelphia Phillies | Clearwater (A+) | Assigned to Clearwater (A+) |
| Josh Simpson | P | 21.318 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Trevor Kehe | OF | 22.088 | Baltimore Orioles | Delmarva (A) | Assigned to Delmarva (A) |
| Domingo Gonzalez | P | 19.280 | Pittsburgh Pirates | Gulf Coast Pirates (Rk) | Assigned to Gulf Coast Pirates (Rk) |
| Justin Montgomery | P | 22.296 | Tampa Bay Rays | Gulf Coast Rays (Rk) | Assigned to Gulf Coast Rays (Rk) |
| Jose Martinez | 3B | 20.156 | New York Yankees | Gulf Coast Yankees (Rk) | Assigned to Gulf Coast Yankees (Rk) |
| Carlos Caminero | P | 21.289 | Atlanta Braves | Gulf Coast Braves (Rk) | Assigned to Gulf Coast Braves (Rk) |
| Jeremiah Burks | SS | 22.176 | Detroit Tigers | Gulf Coast Tigers (East) (Rk) | Assigned to Gulf Coast Tigers (East) (Rk) |
| Yandy Vega | P | 20.213 | Pittsburgh Pirates | Gulf Coast Pirates (Rk) | Assigned to Gulf Coast Pirates (Rk) |
| Jack Bowins | P | 17.184 | Boston Red Sox | Gulf Coast Red Sox (Rk) | Reinstated to active roster |
| Corey Ray | CF | 24.284 | Milwaukee Brewers | Arizona Brewers (Rk) | Assigned to Arizona Brewers (Rk) |
| Jose Quezada | OF | 20.342 | Los Angeles Angels | Orem (Rk) | Assigned to Orem (Rk) |
| Edwuin Bencomo | P | 20.080 | San Diego Padres | Arizona Padres (Rk) | Assigned to Arizona Padres (Rk) |
| Nicholas Vizcaino | 1B | 22.106 | - | | Released by Danville |
| Andres Santiago | P | 29.250 | Atlanta Braves | Mississippi (AA) | Assigned to Mississippi (AA) |
| Shael Mendoza | 2B | 22.261 | Colorado Rockies | Asheville (A) | Assigned to Asheville (A) |
| Igor Baez | C | 24.027 | - | | Released by Batavia |
| Abdallah Aris | P | 22.268 | - | | Released by Williamsport |
| Charlie Ruegger | P | 21.354 | New York Yankees | Charleston (sc) (A) | Assigned to Charleston (sc) (A) |
| Nick Matera | C | 22.308 | Philadelphia Phillies | Lakewood (A) | Assigned to Lakewood (A) |
| Michael Gomez | P | 22.322 | Philadelphia Phillies | Lakewood (A) | Assigned to Lakewood (A) |
| Blake Bennett | P | 23.118 | Philadelphia Phillies | Williamsport (A-) | Assigned to Williamsport (A-) |
| Hector Martinez | 2B | 22.244 | Detroit Tigers | Connecticut (A-) | Assigned to Connecticut (A-) |
| Jeff Lindgren | P | 22.289 | Miami Marlins | Jupiter (A+) | Assigned to Jupiter (A+) |
| Tyler Carr | P | 23.063 | Philadelphia Phillies | Williamsport (A-) | Assigned to Williamsport (A-) |
| Alec Kisena | P | 23.265 | New York Mets | Brooklyn (A-) | Assigned to Brooklyn (A-) |
| Gustavo Armas | P | 23.170 | Philadelphia Phillies | Clearwater (A+) | Assigned to Clearwater (A+) |
| Cole Gordon | 1B-P | 23.275 | New York Mets | Columbia (A) | Assigned to Columbia (A) |
| Hansel Paulino | P | 23.182 | Houston Astros | Quad Cities (A) | Assigned to Quad Cities (A) |
| Luis Cedeno | P | 24.354 | Philadelphia Phillies | Reading (AA) | Assigned to Reading (AA) |
| Briam Campusano | P | 23.099 | New York Mets | Columbia (A) | Assigned to Columbia (A) |
| Eduardo Navas | C | 23.089 | New York Yankees | Charleston (sc) (A) | Assigned to Charleston (sc) (A) |
| Leonardo Molina | OF | 21.355 | New York Yankees | Tampa (A+) | Assigned to Tampa (A+) |
| Chandler Avant | 2B | 23.358 | New York Mets | Binghamton (AA) | Assigned to Binghamton (AA) |
| Jake Simon | P | 22.163 | New York Mets | Columbia (A) | Assigned to Columbia (A) |
| Thomas Szapucki | P | 23.021 | New York Mets | St. Lucie (A+) | Assigned to St. Lucie (A+) |
| LJ Hatch | IF-P | 25.046 | Colorado Rockies | Lancaster (A+) | Assigned to Lancaster (A+) |
| Walter Rasquin | 1B | 23.104 | New York Mets | Columbia (A) | Activated from disabled list |
| Christian Tripp | P | 22.112 | New York Mets | Columbia (A) | DL-7 Injured |
| Abrahan Gutierrez | C | 19.246 | Philadelphia Phillies | Lakewood (A) | DL-7 Injured |
| Alvaro Seijas | P | 20.266 | St. Louis Cardinals | Palm Beach (A+) | Assigned to Palm Beach (A+) |
| Joey Gonzalez | P-IF | 22.174 | Houston Astros | Fayetteville (A+) | Assigned to Fayetteville (A+) |
| Layne Henderson | P | 23.025 | Houston Astros | Corpus Christi (AA) | Assigned to Corpus Christi (AA) |
| Efrain Contreras | P | 19.183 | San Diego Padres | Fort Wayne (A) | Reinstated to active roster |
| Alex Holderbach | C | 22.189 | Houston Astros | Quad Cities (A) | Activated from disabled list |
| Isiah Gilliam | OF | 22.345 | New York Yankees | Trenton (AA) | Assigned to Trenton (AA) |
| David Metzgar | IF-OF | 24.205 | New York Yankees | Tampa (A+) | Assigned to Tampa (A+) |
| Turner Larkins | P | 23.240 | Toronto Blue Jays | New Hampshire (AA) | Assigned to New Hampshire (AA) |
| Ronnie Williams | P | 23.179 | St. Louis Cardinals | Springfield (AA) | Assigned to Springfield (AA) |
| Jake Fishman | P | 24.145 | Toronto Blue Jays | Dunedin (A+) | Assigned to Dunedin (A+) |
| Alexander Vargas | P | 21.344 | Chicago Cubs | Tennessee (AA) | Assigned to Tennessee (AA) |
| Erling Moreno | P | 22.171 | Chicago Cubs | Myrtle Beach (A+) | Activated from disabled list |
| Jose Queliz | C | 26.330 | Arizona Diamondbacks | Reno (AAA) | Assigned to Reno (AAA) |
| Rodolfo Martinez | P | 25.090 | San Francisco Giants | San Jose (A+) | Assigned to San Jose (A+) |
| Scott Boches | P | 24.259 | Seattle Mariners | Tacoma (AAA) | Assigned to Tacoma (AAA) |
| Sandro Fabian | OF | 21.119 | San Francisco Giants | San Jose (A+) | Activated from disabled list |
| Rafael Montero | P | 28.259 | Texas Rangers | Frisco (AA) | Assigned to Frisco (AA) |
| Justin Ferrell | P | 25.073 | Houston Astros | Round Rock (AAA) | Assigned to Round Rock (AAA) |
| Matt Bush | P | 33.145 | Texas Rangers | Frisco (AA) | DL-7 Injured |
| Connor Grey | P | 25.058 | Arizona Diamondbacks | Reno (AAA) | Assigned to Reno (AAA) |
| Thomas Burrows | P-1B | 24.292 | Atlanta Braves | Gwinnett (AAA) | Assigned to Gwinnett (AAA) |
| Jakob Hernandez | P | 23.045 | Philadelphia Phillies | Lehigh Valley (AAA) | Assigned to Lehigh Valley (AAA) |
| Zack Zehner | OF | 26.329 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| Mandy Alvarez | IF | 24.354 | New York Yankees | Trenton (AA) | Assigned to Trenton (AA) |
| Ryan Lidge | C | 24.249 | New York Yankees | Trenton (AA) | Assigned to Trenton (AA) |
| Gavin Cecchini | SS | 25.193 | New York Mets | Syracuse (AAA) | Assigned to Syracuse (AAA) |
| Spenser Watkins | P | 26.310 | Detroit Tigers | Toledo (AAA) | Assigned to Toledo (AAA) |
| Andres Sotillo | C | 25.187 | Toronto Blue Jays | New Hampshire (AA) | Activated from disabled list |
| Nate Pearson | P | 22.317 | Toronto Blue Jays | New Hampshire (AA) | Activated from disabled list |
| Kevin Smith | IF | 22.364 | Toronto Blue Jays | New Hampshire (AA) | DL-7 Injured |
| Tom Layne | P | 34.243 | - | | Released by Memphis |
| Drew Smyly | P | 30.020 | Milwaukee Brewers | San Antonio (AAA) | Signed to Minor League Contract |
| Matt Reistetter | C | 27.059 | Washington Nationals | Fresno (AAA) | Activated from disabled list |
| Blake Allemand | IF | 27.002 | Milwaukee Brewers | San Antonio (AAA) | Activated from disabled list |
| Abraham Almonte | OF | 30.012 | Arizona Diamondbacks | Reno (AAA) | DL-7 Injured |
| Kyle Mcgrath | P | 26.337 | San Diego Padres | El Paso (AAA) | DL-7 Injured |
| Raudy Read | C | 25.247 | Washington Nationals | Fresno (AAA) | Placed on temporarily inactive list |
| Dilson Herrera | 2B | 25.122 | - | | Released by Mets |
| Carlos Gomez | CF | 33.211 | - | | Elected Free Agency |
| Jenrry Mejia | P | 29.265 | Boston Red Sox | Pawtucket (AAA) | DL-7 Injured |
| Rafael De Paula | P | 28.101 | Atlanta Braves | Gwinnett (AAA) | DL-7 Injured |
| Jonathan Aro | P | 28.266 | Atlanta Braves | Gwinnett (AAA) | Activated from disabled list |
| Jake Brentz | P | 24.292 | Pittsburgh Pirates | Indianapolis (AAA) | Placed on temporarily inactive list |
| Tyler Alexander | P | 24.354 | Detroit Tigers | Detroit Tigers (MLB) | Contract purchased from minors |
| Brian Marconi | P | 22.055 | Philadelphia Phillies | Williamsport (A-) | Assigned to Williamsport (A-) |
| Reed Harrington | P | 20.329 | Boston Red Sox | Gulf Coast Red Sox (Rk) | Assigned to Gulf Coast Red Sox (Rk) |
| Jake Prizina | P | 22.160 | Baltimore Orioles | Gulf Coast Orioles (Rk) | Assigned to Gulf Coast Orioles (Rk) |
| Graeme Stinson | P | 21.331 | Tampa Bay Rays | Gulf Coast Rays (Rk) | Assigned to Gulf Coast Rays (Rk) |
| Christian Johnson | OF | 18.029 | Tampa Bay Rays | Gulf Coast Rays (Rk) | Assigned to Gulf Coast Rays (Rk) |
| Herbert Iser | C | 21.201 | Philadelphia Phillies | Williamsport (A-) | Assigned to Williamsport (A-) |
| Brock Love | P | 22.261 | Miami Marlins | Gulf Coast Marlins (Rk) | Assigned to Gulf Coast Marlins (Rk) |
| Kenedy Corona | OF | 19.104 | New York Mets | Gulf Coast Mets (Rk) | Assigned to Gulf Coast Mets (Rk) |
| Nick Bennett | P | 21.305 | Milwaukee Brewers | Rocky Mountain (Rk) | Assigned to Rocky Mountain (Rk) |
| Drew Parrish | P | 21.207 | Kansas City Royals | Burlington (Rk) | Assigned to Burlington (Rk) |
| Dustin Skelton | C | 21.337 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Logan Ondrusek | P | 34.140 | Washington Nationals | Fresno (AAA) | Activated from disabled list |
| Dilson Herrera | 2B | 25.122 | - | | Released by Syracuse |
| Josh Jung | 3B | 21.141 | Texas Rangers | Arizona Rangers (Rk) | Signed out of draft (Texas Tech) |
