| Ryan Dull | RP | 29.176 | Oakland Athletics | Las Vegas (AAA) | Assigned to Las Vegas (AAA) |
| Chris Bassitt | RP | 30.033 | Oakland Athletics | Oakland Athletics (MLB) | DL-10 Right lower leg contusion |
| Matt Olson | 1B | 24.363 | Oakland Athletics | Oakland Athletics (MLB) | DL-10 Right hand surgery |
| Drew Verhagen | RP | 28.156 | Detroit Tigers | Detroit Tigers (MLB) | DL-10 Right shoulder injury |
| Gregory Soto | p | 24.044 | Detroit Tigers | Detroit Tigers (MLB) | Suspended 20 games for Conduct Detrimental or Prejudicial to Baseball |
| Peter Bourjos | CF | 31.362 | Los Angeles Angels | Los Angeles Angels (MLB) | Contract purchased from minors |
| Chasen Shreve | RP | 28.258 | St. Louis Cardinals | St. Louis Cardinals (MLB) | Outrighted to minors |
| Socrates Brito | RF | 26.202 | San Diego Padres | San Diego Padres (MLB) | Claimed off waivers from Diamondbacks by Giants |
| Koda Glover | RP | 25.348 | Washington Nationals | Washington Nationals (MLB) | DL-10 Right forearm strain |
| Jake Noll | OF | 25.019 | Washington Nationals | Washington Nationals (MLB) | Contract purchased from minors |
| Howie Kendrick | 2B | 35.259 | Washington Nationals | Washington Nationals (MLB) | DL-10 Left hamstring strain |
| Michael Taylor | CF | 28.001 | Washington Nationals | Washington Nationals (MLB) | DL-10 Left knee and hip strain |
| Riley Ferrell | P | 25.160 | Miami Marlins | Miami Marlins (MLB) | DL-10 Right biceps tendinitis |
| Ronald Torreyes | SS | 26.206 | Minnesota Twins | Rochester (AAA) | Assigned to Rochester (AAA) |
| Addison Reed | CL | 30.090 | Minnesota Twins | Minnesota Twins (MLB) | DL-10 Left thumb sprain |
| Steve Pearce | LF | 35.349 | Boston Red Sox | Boston Red Sox (MLB) | DL-10 Left calf |
| Dustin Pedroia | 2B | 35.223 | Boston Red Sox | Boston Red Sox (MLB) | DL-10 Left knee rehab |
| Marco Hernandez | SS-2B | 26.202 | Boston Red Sox | Boston Red Sox (MLB) | DL-10 Left shoulder |
| Ryne Harper | P | 30.000 | Minnesota Twins | Minnesota Twins (MLB) | Contract purchased from minors |
| Matt Duffy | 3B | 28.071 | Tampa Bay Rays | Tampa Bay Rays (MLB) | DL-10 Back and hamstring |
| Travis Jankowski | LF | 27.286 | San Diego Padres | San Diego Padres (MLB) | DL-60 Fractured left wrist |
| Matt Magill | RP | 29.137 | Minnesota Twins | Minnesota Twins (MLB) | DL-10 Right shoulder tendinitis |
| Gabriel Moya | P | 24.077 | Minnesota Twins | Minnesota Twins (MLB) | DL-10 Left shoulder tendinitis |
| Miguel Sano | 3B-DH | 25.320 | Minnesota Twins | Minnesota Twins (MLB) | DL-10 Right heel laceration |
| Jharel Cotton | SP | 27.068 | Oakland Athletics | Oakland Athletics (MLB) | Transferred to 60-day DL |
| Kendrys Morales | DH | 35.281 | Oakland Athletics | Oakland Athletics (MLB) | Traded from Blue Jays to Athletics for Jesus Lopez and future considerations |
| Jesus Lopez | SS | 22.173 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Traded from Athletics with future considerations to Blue Jays for Kendrys Morales |
| Jordan Patterson | OF | 27.044 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Traded from Reds to Blue Jays |
| Jesus Castillo | P | 23.213 | Los Angeles Angels | Mobile (AA) | Designated for Assignment |
| Adam Rosales | SS | 35.312 | Minnesota Twins | Minnesota Twins (MLB) | Signed to Minor League Contract |
| Adrian Rondon | SS | 20.263 | Los Angeles Angels | Los Angeles Angels (MLB) | Traded from Rays to Angels for cash |
| Sam Freeman | RP | 31.277 | | | Released by Braves |
| Sam Freeman | RP | 31.277 | Los Angeles Angels | Los Angeles Angels (MLB) | Signed to Minor League Contract |
| Peter Alonso | IF | 24.110 | New York Mets | New York Mets (MLB) | Contract purchased from minors |
| John Lantigua | OF | 21.213 | - | | Released by Gulf Coast Pirates |
| Gabriel Gonzalez | P | 20.165 | - | | Released by Gulf Coast Yankees East |
| Jose Jimenez | P | 22.110 | - | | Released by Gulf Coast Nationals |
| Jesus Graterol | SS | 21.350 | - | | Released by Gulf Coast Yankees East |
| Emison Soto | OF | 22.360 | - | | Released by Gulf Coast Pirates |
| Jairo Garcia | P | 24.061 | - | | Released by Gulf Coast Yankees East |
| Bringnel Mendez | P | 25.055 | - | | Released by Gulf Coast Yankees East |
| Steven Kraft | OF | 22.263 | - | | Released by Gulf Coast Pirates |
| Nestor Oronel | P | 22.104 | - | | Released by Gulf Coast Yankees East |
| Jeremy Pena | SS | 21.186 | Houston Astros | Quad Cities (A) | Assigned to Quad Cities (A) |
| Sergio Suarez | P | 23.308 | - | | Released by Arizona Rangers |
| Marcus Mack | CF | 20.238 | - | | Released by Arizona Rangers |
| Beder Gutierrez | OF | 22.073 | - | | Released by Arizona Rangers |
| Miguel Gamboa | 3B | 21.156 | - | | Released by Arizona Mariners |
| Edwin Quezada | P | 22.125 | - | | Released by Arizona Mariners |
| Michael Suarez | P | 24.006 | - | | Released by Arizona Mariners |
| Rainie Aguilar | C | 22.266 | - | | Released by Arizona Padres |
| Luis Pasen | P | 24.072 | - | | Released by Ogden |
| Evy Ruibal | P | 23.180 | - | | Released by Ogden |
| Clark Beeker | P | 26.125 | - | | Released by Elizabethton |
| Andy Cosgrove | C | 22.239 | - | | Released by Elizabethton |
| Heath Renz | P | 23.223 | - | | Released by Princeton |
| Griffin Garabito | SS | 21.237 | - | | Released by Pulaski |
| Feliberto Bonilla | P | 20.340 | - | | Released by Everett |
| Troy Dixon | CF | 22.030 | - | | Released by Spokane |
| Kyle Keith | P | 24.127 | - | | Released by Spokane |
| Andrew Lantrip | P | 23.321 | - | | Released by Mahoning Valley |
| Logan Mattix | CF | 22.315 | - | | Released by Tri City |
| Alec Maley | P | 23.225 | - | | Released by Auburn |
| Jake Cousins | P | 24.256 | - | | Released by Auburn |
| Luis Encarnacion | 3B | 21.230 | - | | Released by Tri City |
| Andy Diaz | OF | 23.127 | - | | Released by Staten Island |
| B.J. Myers | P | 22.333 | - | | Released by Hudson Valley |
| Colin Morse | P | 22.315 | - | | Released by Auburn |
| Devin Conn | IF-OF | 21.358 | Houston Astros | Quad Cities (A) | Assigned to Quad Cities (A) |
| Brett Conine | P | 22.162 | Houston Astros | Quad Cities (A) | Assigned to Quad Cities (A) |
| Brett Daniels | P | 23.031 | Houston Astros | Quad Cities (A) | Assigned to Quad Cities (A) |
| Shawn Dubin | P | 23.203 | Houston Astros | Quad Cities (A) | Assigned to Quad Cities (A) |
| Ross Adolph | OF | 22.100 | Houston Astros | Quad Cities (A) | Assigned to Quad Cities (A) |
| Enmanuel Valdez | DH | 20.089 | Houston Astros | Quad Cities (A) | Assigned to Quad Cities (A) |
| Andy Pineda | OF | 22.136 | Houston Astros | Quad Cities (A) | Assigned to Quad Cities (A) |
| Oscar Campos | C | 22.109 | Houston Astros | Quad Cities (A) | Assigned to Quad Cities (A) |
| Alex Holderbach | C | 22.091 | Houston Astros | Quad Cities (A) | Assigned to Quad Cities (A) |
| Nivaldo Rodriguez | P | 21.345 | Houston Astros | Quad Cities (A) | Assigned to Quad Cities (A) |
| Mark Moclair | P | 22.014 | Houston Astros | Quad Cities (A) | Assigned to Quad Cities (A) |
| Austin Hansen | P | 22.214 | Houston Astros | Quad Cities (A) | Assigned to Quad Cities (A) |
| RJ Freure | P | 21.264 | Houston Astros | Quad Cities (A) | Assigned to Quad Cities (A) |
| Manny Olloque | 3B | 22.320 | - | | Released by Lexington |
| Jared Johnson | P | 23.208 | - | | Released by Hagerstown |
| Kameron Esthay | 1B-P | 24.112 | - | | Released by Hagerstown |
| Dylan Prohoroff | P | 24.118 | - | | Released by Greensboro |
| Andres Torres | P | 23.148 | - | | Released by West Virginia |
| Ryan Dorow | SS | 23.219 | Texas Rangers | Hickory (A) | Assigned to Hickory (A) |
| Miguel Angel Sierra | SS | 21.115 | Houston Astros | Buies Creek (A+) | Assigned to Buies Creek (A+) |
| Alfredo Angarita | 2B | 22.131 | Houston Astros | Buies Creek (A+) | Assigned to Buies Creek (A+) |
| Mike Papierski | C | 23.030 | Houston Astros | Buies Creek (A+) | Assigned to Buies Creek (A+) |
| Edgardo Sandoval | P | 22.261 | Houston Astros | Buies Creek (A+) | Assigned to Buies Creek (A+) |
| Chandler Taylor | OF-IF | 23.049 | Houston Astros | Buies Creek (A+) | Assigned to Buies Creek (A+) |
| Scott Manea | C | 23.097 | Houston Astros | Buies Creek (A+) | Assigned to Buies Creek (A+) |
| Jesus Lopez | SS | 22.173 | Toronto Blue Jays | Lansing (A) | Assigned to Lansing (A) |
| JP France | P | 23.358 | Houston Astros | Buies Creek (A+) | Assigned to Buies Creek (A+) |
| Parker Mushinski | P-1B | 23.126 | Houston Astros | Buies Creek (A+) | Assigned to Buies Creek (A+) |
| Leovanny Rodriguez | P | 22.287 | Houston Astros | Buies Creek (A+) | Assigned to Buies Creek (A+) |
| Cesar Rosado | P | 22.278 | Houston Astros | Buies Creek (A+) | Assigned to Buies Creek (A+) |
| Chad Donato | P | 23.298 | Houston Astros | Buies Creek (A+) | Assigned to Buies Creek (A+) |
| Jairo Solis | P | 19.096 | Houston Astros | Quad Cities (A) | DL-7 Injured |
| Ruben Castro | C | 22.260 | Houston Astros | Quad Cities (A) | DL-7 Injured |
| Alex McKenna | OF | 21.202 | Houston Astros | Quad Cities (A) | DL-7 Injured |
| Zack Mozingo | P | 24.335 | - | | Released by Charlotte |
| Mike Wallace | P | 24.310 | - | | Released by Bradenton |
| Jordan Jess | P | 26.057 | - | | Released by Bradenton |
| Deivy Mendez | P | 23.152 | - | | Released by Bradenton |
| Devin Davis | 1B | 22.041 | - | | Released by Charlotte |
| Blaine Prescott | 2B | 23.243 | - | | Released by Down East |
| Luke Lanphere | P | 23.179 | - | | Released by Down East |
| Tyler Ivey | P | 22.319 | Houston Astros | Corpus Christi (AA) | Assigned to Corpus Christi (AA) |
| Colin McKee | P | 24.279 | Houston Astros | Corpus Christi (AA) | Assigned to Corpus Christi (AA) |
| J.J. Matijevic | SS | 23.134 | Houston Astros | Corpus Christi (AA) | Assigned to Corpus Christi (AA) |
| Jose Hernandez | P | 23.331 | Houston Astros | Corpus Christi (AA) | Assigned to Corpus Christi (AA) |
| Osvaldo Duarte | SS | 23.069 | Houston Astros | Corpus Christi (AA) | Assigned to Corpus Christi (AA) |
| Chuckie Robinson | C | 24.103 | Houston Astros | Corpus Christi (AA) | Assigned to Corpus Christi (AA) |
| Gabriel Valdez | P | 23.154 | Houston Astros | Corpus Christi (AA) | Assigned to Corpus Christi (AA) |
| Brendon Davis | SS | 21.242 | Texas Rangers | Frisco (AA) | Assigned to Frisco (AA) |
| Josh Altmann | SS | 24.264 | Texas Rangers | Frisco (AA) | Assigned to Frisco (AA) |
| Charles Leblanc | SS | 22.297 | Texas Rangers | Frisco (AA) | Assigned to Frisco (AA) |
| Andretty Cordero | DH-3B | 21.328 | Texas Rangers | Frisco (AA) | Assigned to Frisco (AA) |
| Emerson Martinez | P | 24.075 | Texas Rangers | Frisco (AA) | Assigned to Frisco (AA) |
| Jake Lemoine | P | 25.119 | Texas Rangers | Frisco (AA) | Assigned to Frisco (AA) |
| Yoel Espinal | P | 26.140 | Texas Rangers | Frisco (AA) | Assigned to Frisco (AA) |
| Jairo Beras | OF | 23.093 | Texas Rangers | Frisco (AA) | Assigned to Frisco (AA) |
| Blake Bass | IF | 25.297 | Texas Rangers | Frisco (AA) | Assigned to Frisco (AA) |
| Yoel Espinal | P | 26.140 | Texas Rangers | Down East (A+) | Assigned to Down East (A+) |
| Alex Kowalczyk | C | 25.161 | Texas Rangers | Down East (A+) | Assigned to Down East (A+) |
| Grant Sides | P | 29.278 | - | | Released by Lake Elsinore |
| Colby Blueberg | P | 25.320 | - | | Released by Lake Elsinore |
| Ben Sheckler | P | 23.320 | - | | Released by Lake Elsinore |
| John Brontsema | 3B | 24.104 | - | | Released by NW Arkansas |
| Joshua Morgan | SS | 23.132 | Texas Rangers | Frisco (AA) | Assigned to Frisco (AA) |
| Preston Beck | OF | 28.152 | Texas Rangers | Frisco (AA) | Assigned to Frisco (AA) |
| Wesley Benjamin | P | 25.244 | Oakland Athletics | Nashville (AAA) | Assigned to Nashville (AAA) |
| Franklin Rollin | 2B | 23.214 | Texas Rangers | Frisco (AA) | Assigned to Frisco (AA) |
| Ledarious Clark | OF | 25.090 | Texas Rangers | Frisco (AA) | Assigned to Frisco (AA) |
| James Jones | OF | 30.184 | Texas Rangers | Frisco (AA) | Assigned to Frisco (AA) |
| Pedro Payano | P | 24.181 | Texas Rangers | Frisco (AA) | Assigned to Frisco (AA) |
| Charles Moorman | C | 25.077 | Texas Rangers | Frisco (AA) | Assigned to Frisco (AA) |
| Justin Ferrell | P | 24.340 | Houston Astros | Corpus Christi (AA) | Assigned to Corpus Christi (AA) |
| Ryan Hartman | P | 24.340 | Texas Rangers | Round Rock (AAA) | Assigned to Round Rock (AAA) |
| Forrest Whitley | P | 21.193 | Texas Rangers | Round Rock (AAA) | Assigned to Round Rock (AAA) |
| Corbin Martin | P | 23.090 | Texas Rangers | Round Rock (AAA) | Assigned to Round Rock (AAA) |
| Spencer Jones | P | 24.186 | - | | Released by Montgomery |
| Seth Varner | P | 27.060 | - | | Released by Chattanooga |
| Matthew Grimes | P | 27.205 | - | | Released by Bowie |
| Eric Stout | P | 26.000 | - | | Released by El Paso |
| Nick Schulz | OF | 27.329 | - | | Released by El Paso |
| Ryan Bollinger | P | 28.051 | - | | Released by El Paso |
| Rigo Beltran | P | 24.207 | - | | Released by Tacoma |
| Drew Ferguson | OF | 26.236 | Texas Rangers | Round Rock (AAA) | Assigned to Round Rock (AAA) |
| Eric Karch | P | 27.164 | - | | Released by Rochester |
| Daniel Sweet | OF | 24.089 | - | | Released by Louisville |
| Chris Paul | IF | 26.166 | - | | Released by Rochester |
| Stuart Turner | C | 27.091 | - | | Released by Louisville |
| Dario Alvarez | P | 30.069 | - | | Released by Rochester |
| Jon Kemmer | OF | 28.130 | - | | Released by Rochester |
| Kevin Comer | P | 26.238 | - | | Released by Rochester |
| Alex Perez | P-IF | 26.154 | - | | Released by Rochester |
| Joel Polanco | C | 33.181 | - | | Released by Norfolk |
| Pat Dean | P | 29.306 | - | | Released by Rochester |
| Brandon Guyer | OF | 33.058 | Chicago White Sox | Charlotte (AAA) | Assigned to Charlotte (AAA) |
| Rene Rivera | C | 35.240 | Washington Nationals | Syracuse (AAA) | Assigned to Syracuse (AAA) |
| Jacob Nix | P | 23.078 | San Diego Padres | San Diego Padres (MLB) | DL-10 Elbow strain |
| Bobby Wahl | P | 27.006 | Milwaukee Brewers | Milwaukee Brewers (MLB) | DL-10 Torn ACL in right knee |
| Corey Knebel | RP | 27.122 | Milwaukee Brewers | Milwaukee Brewers (MLB) | DL-10 Right elbow |
