| Chris Stewart | C | 36.192 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | Traded from Braves to Diamondbacks for cash |
| Joshua Fields | RP | 33.011 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Activated from DL |
| Drew Smyly | SP | 29.078 | Chicago Cubs | South Bend (A) | Assigned to South Bend (A) for rehab |
| Colten Brewer | RP | 25.305 | San Diego Padres | El Paso (AAA) | Assigned to El Paso (AAA) |
| Eric Lauer | P | 23.088 | San Diego Padres | San Diego Padres (MLB) | Activated from DL |
| Cory Mazzoni | P | 28.315 | Chicago Cubs | Iowa (AAA) | Designated for Assignment |
| Rio Ruiz | 3B | 24.100 | Atlanta Braves | Gwinnett (AAA) | Assigned to Gwinnett (AAA) |
| Mike Montgomery | SP | 29.060 | Chicago Cubs | Chicago Cubs (MLB) | Activated from DL |
| Bobby Wilson | C | 35.144 | Chicago Cubs | Chicago Cubs (MLB) | Traded from Twins to Cubs for Chris Gimenez |
| Chris Gimenez | C | 35.246 | Minnesota Twins | Minnesota Twins (MLB) | Traded from Cubs to Twins for Bobby Wilson |
| J.B. Wendelken | P | 25.159 | Oakland Athletics | Oakland Athletics (MLB) | Recalled from Nashville (AAA) |
| Nick Martini | CF | 28.064 | Oakland Athletics | Nashville (AAA) | Assigned to Nashville (AAA) |
| Frankie Montas | SP | 25.162 | Oakland Athletics | Oakland Athletics (MLB) | Recalled from Nashville (AAA) |
| Ivan Herrera | C | 18.090 | St. Louis Cardinals | Springfield (AA) | Assigned to Springfield (AA) |
| Angel Reyes | P | 20.317 | Detroit Tigers | Connecticut (A-) | Assigned to Connecticut (A-) |
| Chavez Fernander | P | 21.054 | Detroit Tigers | Connecticut (A-) | Assigned to Connecticut (A-) |
| Jack O'Loughlin | P | 18.169 | Detroit Tigers | Gulf Coast Tigers (East) (Rk) | Assigned to Gulf Coast Tigers (East) (Rk) |
| Griffin Roberts | P | 22.078 | St. Louis Cardinals | Palm Beach (A+) | Assigned to Palm Beach (A+) |
| Xavier Javier | P | 20.202 | Detroit Tigers | Connecticut (A-) | Assigned to Connecticut (A-) |
| Thaddeus Ward | P | 21.226 | Boston Red Sox | Gulf Coast Red Sox (Rk) | Assigned to Gulf Coast Red Sox (Rk) |
| Hector Martinez | 2B | 21.302 | Detroit Tigers | Connecticut (A-) | Assigned to Connecticut (A-) |
| Josh Shaw | 2B-3B | 21.273 | St. Louis Cardinals | Palm Beach (A+) | Assigned to Palm Beach (A+) |
| Matt Pita | RF | 21.131 | New York Yankees | Tampa (A+) | Assigned to Tampa (A+) |
| Kingston Liniak | CF | 18.293 | Detroit Tigers | Connecticut (A-) | Assigned to Connecticut (A-) |
| Ezequiel De La Cruz | P | 19.221 | Arizona Diamondbacks | Missoula (Rk) | Assigned to Missoula (Rk) |
| Jake Lee | P | 23.061 | Los Angeles Angels | Arizona Angels (Rk) | Assigned to Arizona Angels (Rk) |
| Oliver Rosario | P | 19.076 | Arizona Diamondbacks | Missoula (Rk) | Assigned to Missoula (Rk) |
| Rymer Liriano | RF | 27.071 | Milwaukee Brewers | Colorado Springs (AAA) | Assigned to Colorado Springs (AAA) |
| Jorge Barrosa | OF | 17.194 | Arizona Diamondbacks | Missoula (Rk) | Assigned to Missoula (Rk) |
| Douglas Lanza | C | 20.169 | Arizona Diamondbacks | Missoula (Rk) | Assigned to Missoula (Rk) |
| Rigo Fernandez | P | 20.276 | Chicago White Sox | Great Falls (Rk) | Assigned to Great Falls (Rk) |
| Jorge Benitez | P | 19.090 | Seattle Mariners | Everett (A-) | Assigned to Everett (A-) |
| Luis Alvarado | OF | 21.237 | Los Angeles Angels | Arizona Angels (Rk) | Assigned to Arizona Angels (Rk) |
| Tyler Smith | P | 22.284 | Los Angeles Angels | Arizona Angels (Rk) | Assigned to Arizona Angels (Rk) |
| Danny Hultzen | P | 28.275 | Chicago Cubs | Iowa (AAA) | Assigned to Iowa (AAA) |
| Billy Wilson | OF | 22.094 | Cleveland Indians | Mahoning Valley (A-) | Assigned to Mahoning Valley (A-) |
| Jonathan Engelmann | OF | 21.346 | Cleveland Indians | Mahoning Valley (A-) | Assigned to Mahoning Valley (A-) |
| Michel Gelabert | P | 21.235 | Arizona Diamondbacks | Missoula (Rk) | Assigned to Missoula (Rk) |
| Liu Fuenmayor | P | 19.209 | Arizona Diamondbacks | Missoula (Rk) | Assigned to Missoula (Rk) |
| Kyle Tyler | P | 21.246 | Los Angeles Angels | Arizona Angels (Rk) | Assigned to Arizona Angels (Rk) |
| Carlos Machorro | P | 21.344 | Cincinnati Reds | Billings (Rk) | Assigned to Billings (Rk) |
| Jonathan Willems | 3B | 19.296 | Cincinnati Reds | Billings (Rk) | Assigned to Billings (Rk) |
| Reagan Biechler | P | 23.294 | Colorado Rockies | Grand Junction (Rk) | Assigned to Grand Junction (Rk) |
| Miguel Hernandez | SS | 19.139 | Cincinnati Reds | Billings (Rk) | Assigned to Billings (Rk) |
| Mike Spooner | OF | 21.194 | Cincinnati Reds | Dayton (A) | Assigned to Dayton (A) |
| Reniel Ozuna | OF | 20.032 | Cincinnati Reds | Billings (Rk) | Assigned to Billings (Rk) |
| Austin Gardner | P | 23.271 | New York Yankees | Staten Island (A-) | Assigned to Staten Island (A-) |
| Ryan Peurifoy | OF | 23.157 | Pittsburgh Pirates | Bristol (Rk) | Assigned to Bristol (Rk) |
| Nate Scantlin | CF | 19.194 | Cincinnati Reds | Dayton (A) | Assigned to Dayton (A) |
| Daniel Bies | P | 22.143 | New York Yankees | Staten Island (A-) | Assigned to Staten Island (A-) |
| Alexander Vizcaino | P | 21.100 | New York Yankees | Charleston (sc) (A) | Assigned to Charleston (sc) (A) |
| Michael Berglund | C | 21.043 | Tampa Bay Rays | Hudson Valley (A-) | Assigned to Hudson Valley (A-) |
| Jesus Ortiz | P | 21.026 | Tampa Bay Rays | Bowling Green (A) | Assigned to Bowling Green (A) |
| Jhoan Quijada | P | 23.246 | Chicago White Sox | Charlotte (AAA) | Assigned to Charlotte (AAA) |
| Chris Sharpe | OF | 22.085 | Pittsburgh Pirates | West Virginia (A) | Activated from disabled list |
| Raul Wallace | OF | 23.011 | Cincinnati Reds | Dayton (A) | DL-7 Injured |
| Lorenzo Cedrola | OF | 20.230 | Cincinnati Reds | Dayton (A) | DL-7 Injured |
| Adam Scott | P | 22.325 | Cleveland Indians | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Donny Sands | 3B | 22.106 | New York Yankees | Tampa (A+) | Activated from disabled list |
| Brendan McKay | P | 22.256 | Tampa Bay Rays | Charlotte (A+) | DL-7 Injured |
| Justin Topa | P | 27.176 | Texas Rangers | Down East (A+) | Assigned to Down East (A+) |
| Nick Pasquale | P | 27.307 | Cleveland Indians | Akron (AA) | Assigned to Akron (AA) |
| Matt Peacock | P | 24.184 | Arizona Diamondbacks | Visalia (A+) | DL-7 Injured |
| Jake Winston | P-IF | 24.351 | Arizona Diamondbacks | Visalia (A+) | Activated from disabled list |
| Steven Linkous | IF | 23.336 | Colorado Rockies | Lancaster (A+) | Activated from disabled list |
| Julian Leon | C | 22.219 | Los Angeles Angels | Inland Empire (A+) | Activated from disabled list |
| Vince Fernandez | OF | 23.036 | Colorado Rockies | Lancaster (A+) | Placed on temporarily inactive list |
| Jose Vinicio | SS | 25.051 | Arizona Diamondbacks | Reno (AAA) | Assigned to Reno (AAA) |
| Luis Barrera | OF | 22.289 | Oakland Athletics | Midland (AA) | Activated from disabled list |
| Marshall Kasowski | P | 23.173 | Los Angeles Dodgers | Tulsa (AA) | DL-7 Injured |
| James Naile | P | 25.203 | Oakland Athletics | Nashville (AAA) | Assigned to Nashville (AAA) |
| Nathan Bannister | P | 24.256 | Seattle Mariners | Tacoma (AAA) | Assigned to Tacoma (AAA) |
| Jordan Gore | SS | 24.027 | Minnesota Twins | Chattanooga (AA) | DL-7 Injured |
| Jordan Yamamoto | P | 22.111 | Miami Marlins | Jacksonville (AA) | Activated from disabled list |
| Forrest Snow | P | 29.243 | Tampa Bay Rays | Durham (AAA) | Assigned to Durham (AAA) |
| Thomas Jankins | P | 23.059 | Milwaukee Brewers | Colorado Springs (AAA) | Assigned to Colorado Springs (AAA) |
| John Polonius | SS-2B | 27.229 | San Francisco Giants | Sacramento (AAA) | Assigned to Sacramento (AAA) |
| Josh DeGraaf | P | 25.214 | Toronto Blue Jays | New Hampshire (AA) | Activated from disabled list |
| Kurt Spomer | P | 29.051 | Detroit Tigers | Erie (AA) | Activated from disabled list |
| Jordan Romano | P | 25.131 | Toronto Blue Jays | New Hampshire (AA) | DL-7 Injured |
| Adonis Rosa | P | 23.286 | New York Yankees | Trenton (AA) | Assigned to Trenton (AA) |
| Ryan Bollinger | P | 27.207 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| Jordan Johnson | P | 24.349 | San Francisco Giants | Richmond (AA) | Assigned to Richmond (AA) |
| Erik Davis | P | 31.326 | Milwaukee Brewers | Colorado Springs (AAA) | Activated from disabled list |
| Kevin McGowan | P | 26.317 | New York Mets | Las Vegas (AAA) | Reinstated to active roster |
| Dylan Unsworth | P | 25.341 | Los Angeles Angels | Salt Lake (AAA) | Reinstated to active roster |
| Anthony Bass | P | 30.303 | Chicago Cubs | Iowa (AAA) | Placed on temporarily inactive list |
| Casey Coleman | P | 31.058 | Chicago Cubs | Iowa (AAA) | Activated from disabled list |
| Chris Stewart | C | 36.192 | Arizona Diamondbacks | Reno (AAA) | Assigned to Reno (AAA) |
| Kristopher Negron | SS | 32.210 | Seattle Mariners | Tacoma (AAA) | Traded from Diamondbacks to Mariners for cash |
| Asher Wojciechowski | P | 29.252 | Chicago White Sox | Charlotte (AAA) | DL-7 Injured |
| Todd Hankins | 3B-OF | 27.285 | Cleveland Indians | Columbus (AAA) | Activated from disabled list |
| Chris Gimenez | C-OF | 35.246 | Minnesota Twins | Rochester (AAA) | Assigned to Rochester (AAA) |
| Ryan Dull | RP | 28.332 | Oakland Athletics | Nashville (AAA) | Assigned to Nashville (AAA) |
| Albert Pujols | DH | 38.227 | Los Angeles Angels | Los Angeles Angels (MLB) | DL-10 Left knee surgery |
| Justin Upton | LF | 31.005 | Los Angeles Angels | Los Angeles Angels (MLB) | Activated from DL |
| Jose Briceno | C | 25.345 | Los Angeles Angels | Los Angeles Angels (MLB) | Recalled from Salt Lake (AAA) |
| Dawel Lugo | 2B | 23.260 | Detroit Tigers | Detroit Tigers (MLB) | Recalled from Toledo (AAA) |
| Jose Iglesias | SS | 28.237 | Detroit Tigers | Detroit Tigers (MLB) | DL-10 Lower abdominal strain |
| Cody Anderson | RP | 27.350 | Cleveland Indians | Mahoning Valley (A-) | Assigned to Mahoning Valley (A-) for rehab |
| Ariel Hernandez | P | 26.181 | Milwaukee Brewers | Colorado Springs (AAA) | Designated for Assignment |
| Aaron Brooks | P | 28.125 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Contract purchased from minors |
| Jacob Barnes | RP | 28.138 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Recalled from Colorado Springs (AAA) |
| Taylor Williams | P | 27.040 | Milwaukee Brewers | Colorado Springs (AAA) | Assigned to Colorado Springs (AAA) |
| Freddy Peralta | P | 22.087 | Milwaukee Brewers | Colorado Springs (AAA) | Assigned to Colorado Springs (AAA) |
| Joey Votto | 1B | 34.355 | Cincinnati Reds | Cincinnati Reds (MLB) | Activated from DL |
| Austin Brice | RP | 26.072 | Cincinnati Reds | Cincinnati Reds (MLB) | Recalled from Louisville (AAA) |
| Preston Tucker | RF-LF | 28.055 | Cincinnati Reds | Louisville (AAA) | Assigned to Louisville (AAA) |
| Robert Stephenson | RP | 25.187 | Cincinnati Reds | Cincinnati Reds (MLB) | DL-10 Right shoulder tendinitis |
| Clint Frazier | OF | 23.358 | New York Yankees | Tampa (A+) | Assigned to Tampa (A+) for rehab |
| Alec Mills | RP | 26.274 | Chicago Cubs | Iowa (AAA) | Assigned to Iowa (AAA) |
| Jacob Rhame | P | 25.167 | New York Mets | Las Vegas (AAA) | Assigned to Las Vegas (AAA) |
| James Norwood | P | 24.249 | Chicago Cubs | Iowa (AAA) | Assigned to Iowa (AAA) |
| Yimi Garcia | RP | 28.012 | Los Angeles Dodgers | Rancho Cucamonga (A+) | Assigned to Rancho Cucamonga (A+) |
| Austin Hale | C | 22.309 | - | | Announced retirement |
| Kristopher Negron | SS | 32.210 | Seattle Mariners | Tacoma (AAA) | Assigned to Tacoma (AAA) |
| Mac James | C | 25.089 | Tampa Bay Rays | Durham (AAA) | Activated from disabled list |
