| Derek Fisher | LF | 24.350 | Houston Astros | Houston Astros (MLB) | Recalled from Fresno (AAA) |
| Jose Miguel Fernandez | 2b | 30.101 | Los Angeles Angels | Los Angeles Angels (MLB) | Recalled from Salt Lake (AAA) |
| Franklin Barreto | 2B | 22.161 | Oakland Athletics | Nashville (AAA) | Assigned to Nashville (AAA) |
| Tyler O'Neill | c | 23.045 | St. Louis Cardinals | St. Louis Cardinals (MLB) | DL-10 DL-10 Inflammation of the groin area |
| Sandy Alcantara | SP | 22.334 | Miami Marlins | New Orleans (AAA) | Activated from DL and assigned to New Orleans (AAA) |
| Kevin Kaczmarski | OF | 26.219 | New York Mets | Las Vegas (AAA) | Outrighted to minors |
| Adeiny Hechavarria | SS | 29.113 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Traded from Rays to Pirates for Matt Seelinger |
| Matt Seelinger | P | 23.109 | Tampa Bay Rays | Bowling Green (A) | Traded from Pirates to Rays for Adeiny Hechevarria |
| Brett Cecil | RP | 32.035 | St. Louis Cardinals | Memphis (AAA) | Assigned to Memphis (AAA) for rehab |
| Jeremy Bleich | RP | 31.049 | Oakland Athletics | Nashville (AAA) | Designated for Assignment |
| Mike Fiers | SP | 33.052 | Oakland Athletics | Oakland Athletics (MLB) | Traded from Tigers to Athletics for future considerations |
| Hunter Strickland | RP | 29.316 | San Francisco Giants | San Jose (A+) | Assigned to San Jose (A+) for rehab |
| Adolis Garcia | of | 25.157 | St. Louis Cardinals | St. Louis Cardinals (MLB) | Contract purchased from minors |
| Rafael Devers | 3B | 21.286 | Boston Red Sox | Lowell (A-) | Assigned to Lowell (A-) for rehab |
| Ryan Lamarre | CF | 29.258 | Chicago White Sox | Chicago White Sox (MLB) | Recalled from Charlotte (AAA) |
| Dustin Garneau | C | 30.359 | Chicago White Sox | Charlotte (AAA) | Assigned to Charlotte (AAA) |
| Kevan Smith | C | 30.039 | Chicago White Sox | Chicago White Sox (MLB) | Reinstated to active roster |
| Leury Garcia | CF | 27.141 | Chicago White Sox | Chicago White Sox (MLB) | DL-10 Left hamstring strain |
| Robbie Grossman | DH-RF | 28.324 | Minnesota Twins | Minnesota Twins (MLB) | DL-10 Right hamstring strain |
| Johnny Field | OF | 26.168 | Minnesota Twins | Minnesota Twins (MLB) | Recalled from Rochester (AAA) |
| Dylan Stowell | P | 23.205 | Minnesota Twins | Gulf Coast Twins (Rk) | Assigned to Gulf Coast Twins (Rk) |
| Matt McGarry | 2B | 22.135 | New York Yankees | Gulf Coast Yankees (Rk) | Assigned to Gulf Coast Yankees (Rk) |
| Doug Domnarski | P | 24.029 | Detroit Tigers | Gulf Coast Tigers (East) (Rk) | Assigned to Gulf Coast Tigers (East) (Rk) |
| Luis Arcaya | C | 19.161 | Miami Marlins | Gulf Coast Marlins (Rk) | Assigned to Gulf Coast Marlins (Rk) |
| Nick Duron | P | 22.189 | Boston Red Sox | Gulf Coast Red Sox (Rk) | Assigned to Gulf Coast Red Sox (Rk) |
| Layne Henderson | P | 22.059 | Houston Astros | Tri City (A-) | Assigned to Tri City (A-) |
| Ryan Haug | C | 23.220 | Pittsburgh Pirates | Gulf Coast Pirates (Rk) | Assigned to Gulf Coast Pirates (Rk) |
| Desmond Lindsay | OF | 21.203 | New York Mets | Gulf Coast Mets (Rk) | Assigned to Gulf Coast Mets (Rk) |
| Andrew Karp | P | 22.311 | Washington Nationals | Gulf Coast Nationals (Rk) | Assigned to Gulf Coast Nationals (Rk) |
| Doug Norman | P | 22.291 | Cincinnati Reds | Arizona Reds (Rk) | Assigned to Arizona Reds (Rk) |
| Kevin Merrell | SS | 22.236 | Oakland Athletics | Arizona Athletics (Rk) | Assigned to Arizona Athletics (Rk) |
| Alex Bostic | P | 23.265 | San Francisco Giants | Arizona Giants Orange (Rk) | Assigned to Arizona Giants Orange (Rk) |
| Daniel De La Fuente | P | 21.019 | Houston Astros | Greeneville (Rk) | Assigned to Greeneville (Rk) |
| Eric Sogard | 2B | 32.076 | Milwaukee Brewers | Colorado Springs (AAA) | Assigned to Colorado Springs (AAA) |
| Eduardo Salazar | P | 20.093 | Houston Astros | Greeneville (Rk) | Assigned to Greeneville (Rk) |
| Santis Sanchez | C | 19.350 | Oakland Athletics | Arizona Athletics (Rk) | Assigned to Arizona Athletics (Rk) |
| Mitch Spires | SS | 22.148 | Los Angeles Angels | Mobile (AA) | Assigned to Mobile (AA) |
| Jordan Qsar | CF | 22.248 | Tampa Bay Rays | Hudson Valley (A-) | Assigned to Hudson Valley (A-) |
| Michael Helman | IF | 22.075 | Minnesota Twins | Cedar Rapids (A) | Assigned to Cedar Rapids (A) |
| David Metzgar | IF-OF | 23.239 | New York Yankees | Charleston (sc) (A) | Assigned to Charleston (sc) (A) |
| Eric Hanhold | P | 24.278 | New York Mets | Brooklyn (A-) | Assigned to Brooklyn (A-) |
| Bubba Hollins | 3B | 22.244 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Jake Stone | OF | 23.187 | Tampa Bay Rays | Bowling Green (A) | Assigned to Bowling Green (A) |
| Nolan Martinez | P | 20.037 | New York Yankees | Charleston (sc) (A) | Assigned to Charleston (sc) (A) |
| Justin Bridgman | 2B | 23.047 | Tampa Bay Rays | Bowling Green (A) | Assigned to Bowling Green (A) |
| Jose Devers | SS | 18.243 | Miami Marlins | Jupiter (A+) | Assigned to Jupiter (A+) |
| Ricky Surum | IF | 23.242 | New York Yankees | Trenton (AA) | Assigned to Trenton (AA) |
| Alexander Vargas | P | 21.013 | New York Yankees | Charleston (sc) (A) | Assigned to Charleston (sc) (A) |
| Deivi Garcia | P | 19.079 | New York Yankees | Tampa (A+) | Assigned to Tampa (A+) |
| Luis Pintor | SS | 23.061 | Miami Marlins | Greensboro (A) | Assigned to Greensboro (A) |
| Domingo Robles | P | 20.099 | Pittsburgh Pirates | Bradenton (A+) | Assigned to Bradenton (A+) |
| Tom De Blok | P | 22.090 | Detroit Tigers | West Michigan (A) | DL-7 Injured |
| Luis Jimenez | P | 23.216 | Cleveland Indians | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Jose Miranda | SS | 20.038 | Minnesota Twins | Fort Myers (A+) | Assigned to Fort Myers (A+) |
| Phoenix Sanders | P | 23.062 | Tampa Bay Rays | Charlotte (A+) | Assigned to Charlotte (A+) |
| Matt Seelinger | P | 23.109 | Tampa Bay Rays | Bowling Green (A) | Assigned to Bowling Green (A) |
| Chad Spanberger | C | 22.279 | Toronto Blue Jays | Dunedin (A+) | Assigned to Dunedin (A+) |
| Vidal Brujan | 2B | 20.178 | Tampa Bay Rays | Charlotte (A+) | Assigned to Charlotte (A+) |
| Edwin Uceta | P | 20.209 | Los Angeles Dodgers | Rancho Cucamonga (A+) | Assigned to Rancho Cucamonga (A+) |
| Brandon Lopez | SS | 24.331 | - | | Released by Twins |
| James Marvel | P | 24.323 | Pittsburgh Pirates | Altoona (AA) | Assigned to Altoona (AA) |
| Connor Johnstone | P | 23.306 | Atlanta Braves | Florida (A+) | Assigned to Florida (A+) |
| Kyle Muller | P | 20.303 | Atlanta Braves | Mississippi (AA) | Assigned to Mississippi (AA) |
| Anthony Marzi | P | 25.252 | Minnesota Twins | Fort Myers (A+) | Assigned to Fort Myers (A+) |
| David Jacob | 1B | 23.048 | - | | Announced retirement |
| Austin Hamilton | P | 24.360 | Los Angeles Dodgers | Rancho Cucamonga (A+) | DL-7 Injured |
| Ralph Garza | P | 24.122 | Houston Astros | Fresno (AAA) | Assigned to Fresno (AAA) |
| Jon Olczak | P | 24.265 | Milwaukee Brewers | Biloxi (AA) | Activated from disabled list |
| Nate Griep | P | 24.299 | Milwaukee Brewers | Biloxi (AA) | DL-7 Injured |
| Jorge Alcala | P | 23.009 | Minnesota Twins | Chattanooga (AA) | Activated from disabled list |
| Sherman Johnson | 3B | 28.022 | Los Angeles Angels | Salt Lake (AAA) | Assigned to Salt Lake (AAA) |
| Kyle Holder | SS | 24.073 | New York Yankees | Trenton (AA) | DL-7 Injured |
| Shane Opitz | SS | 26.209 | Milwaukee Brewers | Colorado Springs (AAA) | DL-7 Injured |
| Scott McGough | P | 28.279 | Colorado Rockies | Albuquerque (AAA) | Placed on temporarily inactive list |
| Parker Morin | C | 27.035 | Kansas City Royals | Omaha (AAA) | Reinstated to active roster |
| Matt Purke | P | 28.020 | New York Mets | Las Vegas (AAA) | DL-7 Injured |
| Nelson Gonzalez | P | 28.172 | Colorado Rockies | Albuquerque (AAA) | Reinstated to active roster |
| Tommy Joseph | C | 27.021 | Texas Rangers | Round Rock (AAA) | Activated from disabled list |
| Cody Decker | 1B | 31.201 | Arizona Diamondbacks | Reno (AAA) | DL-7 Injured |
| Osmer Morales | P | 25.280 | Los Angeles Angels | Salt Lake (AAA) | Activated from disabled list |
| Robinson Cano | 2B | 35.288 | Seattle Mariners | Tacoma (AAA) | Assigned to Tacoma (AAA) |
| Myles Jaye | P | 26.222 | Cleveland Indians | Columbus (AAA) | DL-7 Injured |
| Stephen Fife | P | 31.306 | Cleveland Indians | Columbus (AAA) | Reinstated to active roster |
| Michael Pineda | SP | 29.200 | Minnesota Twins | Gulf Coast Twins (Rk) | Assigned to GCL Twins (Rk) for rehab |
| Joe Ross | SP | 25.077 | Washington Nationals | Gulf Coast Nationals (Rk) | Assigned to GCL Nationals (rk) for rehab |
| Deck McGuire | P | 29.044 | Los Angeles Angels | Salt Lake (AAA) | Assigned to Salt Lake (AAA) |
| Garrett Brown | CF | 24.143 | - | | Released by Pirates |
| Aaron Cox | P | 24.001 | - | | Announced retirement |
| Charlie Madden | C | 22.340 | Boston Red Sox | Portland (AA) | Activated from disabled list |
| Jackson Williams | C | 32.084 | Pittsburgh Pirates | Indianapolis (AAA) | DL-7 Injured |
| Michael Burrows | P | 18.272 | Pittsburgh Pirates | Gulf Coast Pirates (Rk) | Assigned to Gulf Coast Pirates (Rk) |
| George Springer | CF-RF | 28.321 | Houston Astros | Houston Astros (MLB) | DL-10 Sprained left thumb |
