| Pablo Sandoval | 3B | 31.353 | San Francisco Giants | San Francisco Giants (MLB) | DL-10 Right hamstring strain |
| Kelby Tomlinson | SS | 28.044 | San Francisco Giants | San Francisco Giants (MLB) | Recalled from Sacramento (AAA) |
| Joe Panik | 2B | 27.273 | San Francisco Giants | San Francisco Giants (MLB) | Activated from DL |
| Matt Den Dekker | CF-OF | 30.355 | New York Mets | Las Vegas (AAA) | Outrighted to minors |
| Gordon Beckham | SS | 31.317 | Seattle Mariners | Tacoma (AAA) | Designated for Assignment |
| Adam Warren | RP | 30.340 | Seattle Mariners | Seattle Mariners (MLB) | Traded from Yankees to Mariners for future considerations |
| Tim Federowicz | C | 30.360 | | | Refused minor league assignment, declared free agent |
| Warwick Saupold | P | 28.195 | Detroit Tigers | Toledo (AAA) | Outrighted to minors |
| Sam Freeman | RP | 31.036 | Atlanta Braves | Atlanta Braves (MLB) | DL-10 Left shoulder inflammation |
| Julio Urias | SP | 21.352 | Los Angeles Dodgers | Arizona Dodgers (Rk) | Assigned to AZL Dodgers (Rk) for rehab |
| Roberto Osuna | P | 23.173 | Houston Astros | Houston Astros (MLB) | Traded from Blue Jays to Astros for Ken Giles, David Paulino and Hector Perez |
| Joey Harris | C | 24.167 | Washington Nationals | Gulf Coast Nationals (Rk) | Assigned to Gulf Coast Nationals (Rk) |
| Clarke Schmidt | P | 22.161 | New York Yankees | Staten Island (A-) | Assigned to Staten Island (A-) |
| Hobie Harris | P | 25.037 | New York Yankees | Gulf Coast Yankees (Rk) | Assigned to Gulf Coast Yankees (Rk) |
| Sam Coonrod | P | 25.311 | San Francisco Giants | Arizona Giants (Rk) | Assigned to Arizona Giants (Rk) |
| Kyle Lloyd | P | 27.287 | San Diego Padres | Arizona Padres (Rk) | Assigned to Arizona Padres (Rk) |
| Jordan Cowan | 2B-SS | 23.108 | Seattle Mariners | Arizona Mariners (Rk) | Assigned to Arizona Mariners (Rk) |
| Jeff Moberg | IF | 24.012 | Colorado Rockies | Asheville (A) | Assigned to Asheville (A) |
| Moises Ceja | P | 22.348 | Colorado Rockies | Asheville (A) | Assigned to Asheville (A) |
| Daniel Camarena | P | 25.263 | San Francisco Giants | Sacramento (AAA) | Assigned to Sacramento (AAA) |
| Terence Connelly | IF | 24.145 | Arizona Diamondbacks | Kane County (A) | Assigned to Kane County (A) |
| Hansel Paulino | P | 22.209 | Houston Astros | Quad Cities (A) | Assigned to Quad Cities (A) |
| Brandon Bonilla | P | 24.282 | Baltimore Orioles | Delmarva (A) | Assigned to Delmarva (A) |
| Iolana Akau | C | 22.334 | - | | Released by A's |
| Alex Katz | P | 23.291 | Baltimore Orioles | Frederick (A+) | Assigned to Frederick (A+) |
| Bret Boswell | IF | 23.299 | Colorado Rockies | Lancaster (A+) | Assigned to Lancaster (A+) |
| Jeter Downs | SS | 20.003 | Cincinnati Reds | Dayton (A) | DL-7 Injured |
| Billy Cooke | OF-IF | 22.308 | Seattle Mariners | Clinton (A) | Activated from disabled list |
| Miguel Mercedes | 3B | 22.322 | Oakland Athletics | Beloit (A) | Activated from disabled list |
| Luis Aquino | P | 25.030 | Chicago Cubs | South Bend (A) | DL-7 Injured |
| Jesus Lopez | SS | 21.298 | Oakland Athletics | Beloit (A) | DL-7 Injured |
| Ryan Lawlor | P | 24.203 | Chicago Cubs | South Bend (A) | Activated from disabled list |
| Luis Silverio | OF | 23.033 | Arizona Diamondbacks | Visalia (A+) | Assigned to Visalia (A+) |
| Alexis Olmeda | C | 24.116 | Los Angeles Angels | Burlington (A) | Assigned to Burlington (A) |
| J.B. Bukauskas | P | 21.292 | Houston Astros | Buies Creek (A+) | Assigned to Buies Creek (A+) |
| Simon Mathews | P | 22.310 | Los Angeles Angels | Inland Empire (A+) | Assigned to Inland Empire (A+) |
| Jose Martinez | SS | 21.349 | St. Louis Cardinals | Springfield (AA) | Assigned to Springfield (AA) |
| Franklin Perez | P | 20.236 | Detroit Tigers | Lakeland (A+) | DL-7 Injured |
| Ronnie Dawson | OF | 23.072 | Houston Astros | Corpus Christi (AA) | Assigned to Corpus Christi (AA) |
| Stephen Smith | OF-P | 23.269 | Arizona Diamondbacks | Visalia (A+) | DL-7 Injured |
| Jo Adell | OF | 19.113 | Los Angeles Angels | Mobile (AA) | Assigned to Mobile (AA) |
| Nolan Long | P | 24.192 | Los Angeles Dodgers | Tulsa (AA) | Assigned to Tulsa (AA) |
| Edwin Diaz | SS | 22.340 | Oakland Athletics | Midland (AA) | Assigned to Midland (AA) |
| Ronel Blanco | P | 24.333 | Houston Astros | Corpus Christi (AA) | Activated from disabled list |
| J.P. Sportman | IF | 26.186 | Oakland Athletics | Nashville (AAA) | Assigned to Nashville (AAA) |
| Stetson Allie | 1B | 27.139 | Los Angeles Dodgers | Oklahoma City (AAA) | Assigned to Oklahoma City (AAA) |
| Jon Olczak | P | 24.258 | Milwaukee Brewers | Biloxi (AA) | DL-7 Injured |
| Connor Johnstone | P | 23.299 | Atlanta Braves | Mississippi (AA) | Activated from disabled list |
| Kyle Wright | P-IF | 22.302 | Atlanta Braves | Gwinnett (AAA) | Assigned to Gwinnett (AAA) |
| Jeff Ames | P | 27.180 | Milwaukee Brewers | Biloxi (AA) | Assigned to Biloxi (AA) |
| Ryne Harper | P | 29.125 | Minnesota Twins | Rochester (AAA) | Assigned to Rochester (AAA) |
| Brett Austin | C | 25.248 | Chicago White Sox | Birmingham (AA) | Assigned to Birmingham (AA) |
| Matthew Grimes | P | 26.330 | Baltimore Orioles | Bowie (AA) | Assigned to Bowie (AA) |
| Khayyan Norfork | 3B-2B | 29.192 | Washington Nationals | Harrisburg (AA) | DL-7 Injured |
| Brady Lail | P | 24.355 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| Jordan Weems | C | 25.265 | Boston Red Sox | Portland (AA) | Assigned to Portland (AA) |
| Drew Ward | 3B | 23.247 | Washington Nationals | Harrisburg (AA) | Assigned to Harrisburg (AA) |
| James Reeves | P | 25.053 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| Lucas Long | P | 25.296 | Baltimore Orioles | Norfolk (AAA) | Assigned to Norfolk (AAA) |
| Mason Melotakis | P | 27.032 | Colorado Rockies | Albuquerque (AAA) | DL-7 Injured |
| Luis Pena | P | 22.341 | Los Angeles Angels | Salt Lake (AAA) | Reinstated to active roster |
| Marc Rzepczynski | P | 32.356 | Seattle Mariners | Tacoma (AAA) | Assigned to Tacoma (AAA) |
| Mike Hauschild | P | 28.189 | - | | Released by Astros |
| Jacob Wilson | 2B | 28.001 | Washington Nationals | Syracuse (AAA) | Activated from disabled list |
| Brody Koerner | P | 24.286 | New York Yankees | Scranton/Wilkes-Barre (AAA) | DL-7 Injured |
| Edwin Espinal | 1B | 24.188 | Detroit Tigers | Toledo (AAA) | DL-7 Injured |
| Josh Smith | P | 30.358 | Boston Red Sox | Pawtucket (AAA) | Reinstated to active roster |
| Caleb Frare | P | 25.022 | Chicago White Sox | Charlotte (AAA) | Assigned to Charlotte (AAA) |
| Ken Giles | RP | 27.313 | Toronto Blue Jays | Buffalo (AAA) | Traded from Astros with Hector Perez and David Paulino to Blue Jays for Roberto Osuna |
| David Paulino | P | 24.174 | Toronto Blue Jays | Buffalo (AAA) | Traded from Astros with Hector Perez and Ken Giles to Blue Jays for Roberto Osuna |
| Hector Perez | P | 22.054 | Toronto Blue Jays | New Hampshire (AA) | Traded from Astros with Ken Giles and David Paulino to Blue Jays for Roberto Osuna |
| Addison Reed | CL | 29.215 | Minnesota Twins | Minnesota Twins (MLB) | Activated from DL |
| Zach Duke | RP | 35.102 | Seattle Mariners | Seattle Mariners (MLB) | Traded from Twins to Mariners for Chase De Jong and Ryan Costello |
| Chase De Jong | P | 24.213 | Minnesota Twins | Minnesota Twins (MLB) | Traded from Mariners with Ryan Costello to Twins for Zach Duke |
| Ryan Costello | 3b | 22.047 | Minnesota Twins | Gulf Coast Twins (Rk) | Traded from Mariners with Chase De Jong to Twins for Zach Duke |
| Dan Vogelbach | 1B | 25.225 | Seattle Mariners | Tacoma (AAA) | Assigned to Tacoma (AAA) |
| Kyle Seager | 3B | 30.270 | Seattle Mariners | Seattle Mariners (MLB) | Placed on paternity leave list |
| James Paxton | SP | 29.266 | Seattle Mariners | Seattle Mariners (MLB) | Activated from DL |
| Zach Vincej | SS | 27.090 | Seattle Mariners | Seattle Mariners (MLB) | Contract purchased from minors |
| Andrew Miller | RP | 33.070 | Cleveland Indians | Columbus (AAA) | Assigned to Columbus (AAA) for rehab |
| Ryan Dull | RP | 28.301 | Oakland Athletics | Oakland Athletics (MLB) | Recalled from Nashville (AAA) |
| Frankie Montas | SP | 25.131 | Oakland Athletics | Nashville (AAA) | Assigned to Nashville (AAA) |
| Greg Allen | CF | 25.137 | Cleveland Indians | Cleveland Indians (MLB) | Recalled from Columbus (AAA) |
| Adam Plutko | P | 26.301 | Cleveland Indians | Columbus (AAA) | Assigned to Columbus (AAA) |
| Carlos Martinez | SP | 26.313 | St. Louis Cardinals | St. Louis Cardinals (MLB) | Activated from DL |
| Luke Gregerson | RP | 34.077 | St. Louis Cardinals | St. Louis Cardinals (MLB) | DL-10 Right shoulder impingement |
| Tyler Webb | P | 28.010 | St. Louis Cardinals | Memphis (AAA) | Assigned to Memphis (AAA) |
| Lance Lynn | SP | 31.079 | New York Yankees | New York Yankees (MLB) | Traded from Twins to Yankees for Luis Rijo and Tyler Austin |
| Luis Rijo | P | 19.327 | Minnesota Twins | Minnesota Twins (MLB) | Traded from Yankees with Tyler Austin to Twins for Lance Lynn |
| Tyler Austin | 1B | 26.328 | Minnesota Twins | Rochester (AAA) | Traded from Yankees with Luis Rijo to Twins for Lance Lynn |
| Oliver Drake | RP | 31.198 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Designated for Assignment |
| J.P. Crawford | SS | 23.200 | Philadelphia Phillies | Gulf Coast Phillies (Rk) | Assigned to GCL Phillies East (Rk) for rehab |
| Dylan Floro | P | 27.215 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Recalled from Oklahoma City (AAA) |
| Ross Stripling | RP | 28.249 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | DL-10 Right first toe inflammation |
| Nathan Rodriguez | C | 22.304 | Milwaukee Brewers | Carolina (A+) | Placed on temporarily inactive list |
| Jose Flores | P | 29.056 | - | | Released by Giants |
| Ryan Bollinger | P | 27.176 | New York Yankees | New York Yankees (MLB) | Contract purchased from minors |
| Trevor May | RP | 28.310 | Minnesota Twins | Minnesota Twins (MLB) | Recalled from Rochester (AAA) |
| Jonathan India | SS | 21.227 | Cincinnati Reds | Dayton (A) | Assigned to Dayton (A) |
| Cristofer Ogando | P | 24.280 | Arizona Diamondbacks | Missoula (Rk) | Assigned to Missoula (Rk) |
| Gerald Ogando | P | 18.002 | Arizona Diamondbacks | Missoula (Rk) | Assigned to Missoula (Rk) |
| Jose Butto | P | 20.133 | New York Mets | Brooklyn (A-) | Assigned to Brooklyn (A-) |
| Mitch Stallings | P | 23.030 | Atlanta Braves | Danville (Rk) | Assigned to Danville (Rk) |
| Tyler Webb | SS | 22.106 | Minnesota Twins | Gulf Coast Twins (Rk) | Assigned to Gulf Coast Twins (Rk) |
| J.J. Schwarz | C | 22.124 | Oakland Athletics | Vermont (A-) | Assigned to Vermont (A-) |
| Bramdon Perez | OF | 18.234 | Boston Red Sox | Gulf Coast Red Sox (Rk) | Assigned to Gulf Coast Red Sox (Rk) |
| Reid Schaller | P | 21.119 | Washington Nationals | Auburn (A-) | Assigned to Auburn (A-) |
| Lane Milligan | C | 23.130 | Boston Red Sox | Lowell (A-) | Assigned to Lowell (A-) |
| Eddie Jimenez | P | 22.356 | Boston Red Sox | Greenville (A) | Assigned to Greenville (A) |
| Devin Sweet | P | 22.??? | Seattle Mariners | Arizona Mariners (Rk) | Assigned to Arizona Mariners (Rk) |
| Seth Beer | OF-1B | 21.315 | Houston Astros | Buies Creek (A+) | Assigned to Buies Creek (A+) |
| Matt McGarry | 2B | 22.128 | New York Yankees | Gulf Coast Yankees (Rk) | Assigned to Gulf Coast Yankees (Rk) |
| Grant Anderson | P | 21.039 | Seattle Mariners | Arizona Mariners (Rk) | Assigned to Arizona Mariners (Rk) |
| Marc Rzepczynski | P | 32.356 | Seattle Mariners | Tacoma (AAA) | |
| Troy Scribner | P | 27.028 | Arizona Diamondbacks | Arizona Diamondbacks (Rk) | Assigned to Arizona Diamondbacks (Rk) |
| Francis Ventura | P | 25.078 | - | | Released by Rangers |
| Joey O'Brien | P | 20.244 | Seattle Mariners | Arizona Mariners (Rk) | |
| Yordi Rosario | P | 19.181 | Chicago White Sox | Arizona White Sox (Rk) | Assigned to Arizona White Sox (Rk) |
| Luis Cossio | DH | 21.230 | - | | Released by Diamondbacks |
