| Jorge Lopez | SP | 25.166 | Milwaukee Brewers | Colorado Springs (AAA) | Assigned to Colorado Springs (AAA) |
| Orlando Arcia | SS | 23.356 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Recalled from Colorado Springs (AAA) |
| Brandon Belt | 1B | 30.097 | San Francisco Giants | San Francisco Giants (MLB) | DL-10 Hyperextended Right Knee |
| Kelby Tomlinson | SS | 28.040 | San Francisco Giants | Sacramento (AAA) | Assigned to Sacramento (AAA) |
| Chris Stratton | P | 27.338 | San Francisco Giants | San Francisco Giants (MLB) | Recalled from Sacramento (AAA) |
| Evan Longoria | 3B | 32.292 | San Francisco Giants | San Francisco Giants (MLB) | Activated from DL |
| Ty Kelly | LF | 30.006 | New York Mets | Las Vegas (AAA) | Outrighted to minors |
| Daniel Castro | 2B | 25.254 | Colorado Rockies | Albuquerque (AAA) | Outrighted to minors |
| Dayan Diaz | P | 29.166 | Los Angeles Angels | Inland Empire (A+) | Assigned to Inland Empire (A+) |
| Matt Reynolds | 3B | 27.235 | Washington Nationals | Washington Nationals (MLB) | Recalled from Syracuse (AAA) |
| Anthony Rendon | 3B | 28.050 | Washington Nationals | Washington Nationals (MLB) | Placed on paternity leave list |
| Michael Perez | C | 25.353 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Contract purchased from minors |
| Shane Robinson | RF-CF | 33.269 | New York Yankees | New York Yankees (MLB) | Contract purchased from minors |
| Luis Cessa | SP | 26.092 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| Ranger Suarez | p | 22.335 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Recalled from Reading (AA) |
| Drew Anderson | RP | 24.126 | Philadelphia Phillies | Lehigh Valley (AAA) | Assigned to Lehigh Valley (AAA) |
| Ryan Carpenter | SP | 27.338 | Detroit Tigers | Toledo (AAA) | Activated from DL and assigned to Toledo (AAA) |
| Oliver Drake | RP | 31.194 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Claimed off waivers from Angels by Blue Jays |
| J.A. Happ | SP | 35.280 | New York Yankees | New York Yankees (MLB) | Traded from Blue Jays to Yankees for Billy McKinney and Brandon Drury |
| Billy McKinney | CF | 23.337 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Traded from Yankees with Brandon Drury to Blue Jays for J.A. Happ |
| Brandon Drury | 3B | 25.339 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Traded from Yankees with Billy McKinney to Blue Jays for J.A. Happ |
| Joe Panik | 2B | 27.269 | San Francisco Giants | Sacramento (AAA) | Assigned to Sacramento (AAA) for rehab |
| Francisco Cervelli | C | 32.142 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Activated from DL |
| Jacob Stallings | C | 28.216 | Pittsburgh Pirates | Indianapolis (AAA) | Assigned to Indianapolis (AAA) |
| Brandon Workman | RP | 29.347 | Boston Red Sox | Pawtucket (AAA) | Assigned to Pawtucket (AAA) |
| Jesse Winker | OF | 24.343 | Cincinnati Reds | Cincinnati Reds (MLB) | DL-10 Right shoulder subluxation |
| Alex Blandino | SS | 25.262 | Cincinnati Reds | Cincinnati Reds (MLB) | Transferred to 60-day DL |
| Mason Williams | CF | 26.340 | Cincinnati Reds | Cincinnati Reds (MLB) | Contract purchased from minors |
| Brent Suter | RP | 28.331 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Transferred to 60-day DL |
| Joakim Soria | RP | 34.069 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Traded from White Sox to Brewers for Kodi Medeiros and Wilber Perez |
| Kodi Medeiros | P | 22.062 | Chicago White Sox | Birmingham (AA) | Traded from Brewers with Wilber Perez to White Sox for Joakim Soria |
| Tim Federowicz | C | 30.356 | Houston Astros | Houston Astros (MLB) | Designated for Assignment |
| Francisco Arcia | C | 28.315 | Los Angeles Angels | Los Angeles Angels (MLB) | Contract purchased from minors |
| Martin Maldonado | C | 31.344 | Houston Astros | Houston Astros (MLB) | Traded from Angels to Astros for Patrick Sandoval |
| Patrick Sandoval | P | 21.281 | Los Angeles Angels | Inland Empire (A+) | Traded from Astros to Angels for Martin Maldonado |
| Jordan Desguin | p | 24.269 | Seattle Mariners | Seattle Mariners (MLB) | Signed to Minor League Contract |
| Seung-Hwan Oh | CL | 36.011 | Colorado Rockies | Colorado Rockies (MLB) | Traded from Blue Jays to Rockies for Chad Spangenberger and Forrest Wall |
| Forrest Wall | 2B | 22.249 | Toronto Blue Jays | New Hampshire (AA) | Traded from Rockies with Chad Spanberger to Blue Jays for Seunghwan Oh |
| Chad Spanberger | C | 22.268 | Toronto Blue Jays | Lansing (A) | Traded from Rockies with Forrest Wall to Rockies for Seunghwan Oh |
| Kris Bryant | 3B | 26.204 | Chicago Cubs | Chicago Cubs (MLB) | DL-10 Left shoulder inflammation |
| David Bote | 3B | 25.110 | Chicago Cubs | Chicago Cubs (MLB) | Recalled from Iowa (AAA) |
| Jose Marmolejos | 1B | 25.205 | Washington Nationals | Syracuse (AAA) | Designated for Assignment |
| Tommy Milone | SP | 31.160 | Washington Nationals | Washington Nationals (MLB) | Contract purchased from minors |
| Trevor Bettencourt | P | 24.005 | Philadelphia Phillies | Gulf Coast Phillies (Rk) | Assigned to Gulf Coast Phillies (Rk) |
| Luis Mojica | P | 20.158 | Miami Marlins | Gulf Coast Marlins (Rk) | Assigned to Gulf Coast Marlins (Rk) |
| Victor Tademo | 3B | 19.017 | Minnesota Twins | Fort Myers (A+) | Assigned to Fort Myers (A+) |
| Bailey Falter | P | 21.093 | Philadelphia Phillies | Gulf Coast Phillies (Rk) | Assigned to Gulf Coast Phillies (Rk) |
| Tyler Kolek | P | 22.224 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Mauricio Cabrera | P | 24.307 | Chicago White Sox | Arizona White Sox (Rk) | Assigned to Arizona White Sox (Rk) |
| Joey Marciano | P | 23.196 | San Francisco Giants | San Jose (A+) | Assigned to San Jose (A+) |
| Zach Willeman | P | 22.121 | Los Angeles Dodgers | Arizona Dodgers (Rk) | Assigned to Arizona Dodgers (Rk) |
| Vijay Miller | P | 20.260 | San Diego Padres | Arizona Padres 2 (Rk) | Assigned to Arizona Padres 2 (Rk) |
| Adrian Rodriguez | P | 21.352 | Cincinnati Reds | Billings (Rk) | Assigned to Billings (Rk) |
| Mac Sceroler | P | 23.108 | Cincinnati Reds | Dayton (A) | Assigned to Dayton (A) |
| Austin Rubick | P | 20.349 | Milwaukee Brewers | Wisconsin (A) | Assigned to Wisconsin (A) |
| Domenic Mazza | P | 23.362 | San Francisco Giants | Salem-Keizer (A-) | Assigned to Salem-Keizer (A-) |
| Hunter Williams | P | 22.170 | Colorado Rockies | Asheville (A) | Assigned to Asheville (A) |
| Chris Corbett | C | 24.019 | San Francisco Giants | San Jose (A+) | Assigned to San Jose (A+) |
| Jake Romanski | C | 27.216 | Boston Red Sox | Lowell (A-) | Assigned to Lowell (A-) |
| Felix Viloria | P | 21.236 | Detroit Tigers | Connecticut (A-) | Assigned to Connecticut (A-) |
| Oswaldo Castillo | P | 21.342 | Detroit Tigers | Connecticut (A-) | Assigned to Connecticut (A-) |
| Cam Warner | IF | 24.144 | Detroit Tigers | Connecticut (A-) | Assigned to Connecticut (A-) |
| Daniel Alvarez | P | 22.028 | New York Yankees | Charleston (sc) (A) | Assigned to Charleston (sc) (A) |
| Kyle Zurak | P | 23.240 | New York Yankees | Tampa (A+) | Assigned to Tampa (A+) |
| Deon Stafford | C | 22.131 | Pittsburgh Pirates | West Virginia (A) | DL-7 Injured |
| Rafelin Lorenzo | C | 21.192 | Pittsburgh Pirates | West Virginia (A) | Activated from disabled list |
| Will Gaddis | P | 22.136 | Colorado Rockies | Asheville (A) | DL-7 Injured |
| Cameron Ming | P | 22.085 | Baltimore Orioles | Delmarva (A) | Assigned to Delmarva (A) |
| Robert Tyler | P | 23.038 | Colorado Rockies | Lancaster (A+) | Assigned to Lancaster (A+) |
| Todd Isaacs | OF | 22.065 | Cleveland Indians | Lake County (A) | DL-7 Injured |
| Austen Wade | OF | 22.160 | Cleveland Indians | Lake County (A) | Activated from disabled list |
| Alexis Olmeda | C | 24.112 | Los Angeles Angels | Salt Lake (AAA) | Assigned to Salt Lake (AAA) |
| Chad Spanberger | C | 22.268 | Toronto Blue Jays | Lansing (A) | Assigned to Lansing (A) |
| Joe Cronin | P-IF | 24.072 | Minnesota Twins | Fort Myers (A+) | DL-7 Injured |
| Matt Wivinis | P | 25.002 | New York Yankees | Trenton (AA) | Assigned to Trenton (AA) |
| Harrison Cooney | P | 26.123 | Boston Red Sox | Portland (AA) | Assigned to Portland (AA) |
| D.J. Wilson | OF | 21.291 | Chicago Cubs | Myrtle Beach (A+) | Activated from disabled list |
| Roberto Caro | OF | 24.304 | Chicago Cubs | Myrtle Beach (A+) | DL-7 Injured |
| Francisco Jimenez | P | 23.295 | Baltimore Orioles | Frederick (A+) | Assigned to Frederick (A+) |
| Elvis Araujo | P | 27.011 | - | | Released by Orioles |
| Jordan Zimmerman | IF | 23.247 | Los Angeles Angels | Inland Empire (A+) | DL-7 Injured |
| Tanner Murphy | C | 23.149 | San Francisco Giants | San Jose (A+) | DL-7 Injured |
| Simon Mathews | P | 22.306 | Los Angeles Angels | Salt Lake (AAA) | Assigned to Salt Lake (AAA) |
| Patrick Sandoval | P | 21.281 | Los Angeles Angels | Inland Empire (A+) | Assigned to Inland Empire (A+) |
| Jordan Desguin | P | 24.269 | Seattle Mariners | Modesto (A+) | Assigned to Modesto (A+) |
| Logan Bawcom | P | 29.266 | Los Angeles Dodgers | Tulsa (AA) | Assigned to Tulsa (AA) |
| Madison Younginer | P | 27.265 | - | | Released by Dodgers |
| Marcus Littlewood | C | 26.130 | Arizona Diamondbacks | Jackson (AA) | Activated from disabled list |
| Tyler Pike | P | 24.181 | Atlanta Braves | Mississippi (AA) | Activated from disabled list |
| Connor Johnstone | P | 23.295 | Atlanta Braves | Mississippi (AA) | DL-7 Injured |
| Alberto Rosario | C | 31.197 | Arizona Diamondbacks | Reno (AAA) | Assigned to Reno (AAA) |
| Kodi Medeiros | P | 22.062 | Chicago White Sox | Birmingham (AA) | Assigned to Birmingham (AA) |
| Juan Kelly | 1B | 24.010 | Toronto Blue Jays | New Hampshire (AA) | DL-7 Injured |
| Scotty Burcham | IF | 25.039 | Colorado Rockies | Hartford (AA) | Activated from disabled list |
| Chad De La Guerra | IF | 25.244 | Boston Red Sox | Portland (AA) | Activated from disabled list |
| CJ Hinojosa | SS | 24.011 | San Francisco Giants | Richmond (AA) | Placed on temporarily inactive list |
| Caleb Frare | P | 25.018 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| Matt Kent | P | 25.316 | Boston Red Sox | Pawtucket (AAA) | Assigned to Pawtucket (AAA) |
| Kyle Mcgowin | P | 26.242 | Washington Nationals | Syracuse (AAA) | Assigned to Syracuse (AAA) |
| Trevor Kelley | P | 24.279 | Boston Red Sox | Pawtucket (AAA) | Assigned to Pawtucket (AAA) |
| Forrest Wall | 2B | 22.249 | Toronto Blue Jays | New Hampshire (AA) | Assigned to New Hampshire (AA) |
| Kevin Lenik | P | 26.360 | Kansas City Royals | Omaha (AAA) | DL-7 Injured |
| Ben Revere | CF | 30.084 | - | | Released by Angels |
| Nellie Rodriguez | 1B | 24.044 | Cleveland Indians | Columbus (AAA) | DL-7 Injured |
| Kyle Funkhouser | P | 24.132 | Detroit Tigers | Toledo (AAA) | DL-7 Injured |
| Josh Smith | P | 30.354 | Boston Red Sox | Pawtucket (AAA) | Placed on temporarily inactive list |
| Billy Fleming | 2B | 25.309 | New York Yankees | Scranton/Wilkes-Barre (AAA) | DL-7 Injured |
| Gunnar Heidt | IF | 25.317 | Toronto Blue Jays | Buffalo (AAA) | Placed on temporarily inactive list |
| Matt Reistetter | C | 26.082 | Washington Nationals | Syracuse (AAA) | Activated from disabled list |
| Simon Mathews | P | 22.306 | Los Angeles Angels | Burlington (A) | Assigned to Burlington (A) |
| Jonathan India | SS | 21.223 | Cincinnati Reds | Billings (Rk) | Assigned to Billings (Rk) |
| Brady Schanuel | P | 21.155 | Milwaukee Brewers | Arizona Brewers (Rk) | Assigned to Arizona Brewers (Rk) |
| Logan Gillaspie | P | 21.100 | Milwaukee Brewers | Helena (Rk) | Assigned to Helena (Rk) |
| Franklin Hernandez | P | 22.271 | Milwaukee Brewers | Helena (Rk) | Assigned to Helena (Rk) |
| Luke Sherley | SS | 22.080 | Detroit Tigers | West Michigan (A) | Assigned to West Michigan (A) |
| Ethan DeCaster | P | 23.272 | Detroit Tigers | West Michigan (A) | Assigned to West Michigan (A) |
| Tarik Skubal | P | 21.248 | Detroit Tigers | West Michigan (A) | Assigned to West Michigan (A) |
| Liarvis Breto | P | 25.107 | Detroit Tigers | Lakeland (A+) | Assigned to Lakeland (A+) |
| J.T. Salter | P | 22.046 | Seattle Mariners | Arizona Mariners (Rk) | Assigned to Arizona Mariners (Rk) |
| Casey Mize | P | 21.086 | Detroit Tigers | Gulf Coast Tigers West (Rk) | Assigned to GCL Tigers West (Rk) |
| Jake Mayer | P | 23.030 | Seattle Mariners | Arizona Mariners (Rk) | Assigned to Arizona Mariners (Rk) |
