| Ervin Santana | SP | 35.195 | Minnesota Twins | Minnesota Twins (MLB) | Activated from DL |
| Taylor Motter | SS | 28.309 | Minnesota Twins | Minnesota Twins (MLB) | Designated for Assignment |
| Giovanny Gallegos | P | 26.345 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| Andrew Miller | RP | 33.064 | Cleveland Indians | Akron (AA) | Assigned to Akron (AA) for rehab |
| Chris Rusin | RP | 31.275 | Colorado Rockies | Colorado Rockies (MLB) | DL-10 Left plantar fascitis |
| Harrison Musgrave | P | 26.143 | Colorado Rockies | Colorado Rockies (MLB) | Activated from DL |
| Yoenis Cespedes | LF | 32.287 | New York Mets | New York Mets (MLB) | DL-10 Twin heel calcifications |
| Paulo Orlando | RF | 32.265 | Kansas City Royals | Omaha (AAA) | Assigned to Omaha (AAA) |
| Enny Romero | RP | 27.181 | Kansas City Royals | Omaha (AAA) | Outrighted to minors |
| Yasiel Puig | RF | 27.229 | Los Angeles Dodgers | Oklahoma City (AAA) | Assigned to Oklahoma City (AAA) for rehab |
| Matt Albers | RP | 35.185 | Milwaukee Brewers | Colorado Springs (AAA) | Assigned to Colorado Springs (AAA) for rehab |
| Jeff McNeil | 2B | 26.107 | New York Mets | New York Mets (MLB) | Contract purchased from minors |
| Phillip Evans | SS | 25.317 | New York Mets | New York Mets (MLB) | Contract purchased from minors |
| Ty Kelly | LF | 30.004 | New York Mets | New York Mets (MLB) | Designated for Assignment |
| Zack Britton | RP | 30.215 | New York Yankees | New York Yankees (MLB) | Traded from Orioles to Yankees for Dillon Tate, Cody Carroll and Josh Rogers |
| Cody Carroll | P | 25.282 | Baltimore Orioles | Norfolk (AAA) | Traded from Yankees with Dillon Tate and Josh Rogers to Orioles for Zach Britton |
| Dillon Tate | P | 24.084 | Baltimore Orioles | Bowie (AA) | Traded from Yankees with Cody Carroll and Josh Rogers to Orioles for Zach Britton |
| Josh Rogers | P | 24.014 | Baltimore Orioles | Norfolk (AAA) | Traded from Yankees with Dillon Tate and Cody Carroll to Orioles for Zach Britton |
| Brandon Woodruff | P | 25.164 | Milwaukee Brewers | Colorado Springs (AAA) | Assigned to Colorado Springs (AAA) |
| Nate Orf | C | 28.173 | Milwaukee Brewers | Colorado Springs (AAA) | Assigned to Colorado Springs (AAA) |
| Eric Thames | 1B | 31.256 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Activated from DL |
| Junior Guerra | RP | 33.189 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Activated from DL |
| Gary Sanchez | C | 25.234 | New York Yankees | New York Yankees (MLB) | DL-10 Right groin strain |
| Kyle Higashioka | C | 28.095 | New York Yankees | New York Yankees (MLB) | Recalled from Scranton/Wilkes-Barre (AAA) |
| Drew Anderson | RP | 24.124 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Recalled from Lehigh Valley (AAA) |
| Yacksel Rios | P | 25.027 | Philadelphia Phillies | Lehigh Valley (AAA) | Assigned to Lehigh Valley (AAA) |
| Jesse Hahn | SP | 28.359 | Kansas City Royals | Northwest Arkansas (AA) | Assigned to Northwest Arkansas (AA) for rehab |
| Blaine Boyer | RP | 37.013 | Kansas City Royals | Northwest Arkansas (AA) | Assigned to Northwest Arkansas (AA) for rehab |
| Delino Deshields | LF | 25.342 | Texas Rangers | Round Rock (AAA) | Assigned to Round Rock (AAA) |
| Brandon Mann | P | 34.069 | Texas Rangers | Texas Rangers (MLB) | Recalled from Round Rock (AAA) |
| Eddie Butler | RP | 27.133 | Chicago Cubs | Chicago Cubs (MLB) | Activated from DL |
| Luke Farrell | p | 27.047 | Chicago Cubs | Iowa (AAA) | Assigned to Iowa (AAA) |
| Drew Pomeranz | SP | 29.244 | Boston Red Sox | Boston Red Sox (MLB) | Activated from DL |
| Tzu-Wei Lin | SS | 24.159 | Boston Red Sox | Pawtucket (AAA) | Assigned to Pawtucket (AAA) |
| Ryan Borucki | SP | 24.115 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Recalled from Buffalo (AAA) |
| Tim Mayza | P | 26.191 | Toronto Blue Jays | Buffalo (AAA) | Assigned to Buffalo (AAA) |
| Marco Estrada | SP | 35.019 | Toronto Blue Jays | Buffalo (AAA) | Assigned to Buffalo (AAA) for rehab |
| Frankie Montas | SP | 25.125 | Oakland Athletics | Oakland Athletics (MLB) | Recalled from Nashville (AAA) |
| Franklin Barreto | 2B | 22.148 | Oakland Athletics | Nashville (AAA) | Assigned to Nashville (AAA) |
| Clay Buchholz | SP | 33.344 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | Activated from DL |
| Matt Koch | SP | 27.264 | Arizona Diamondbacks | Reno (AAA) | Assigned to Reno (AAA) |
| Andrew Miller | RP | 33.064 | Cleveland Indians | Akron (AA) | Transferred to 60-day DL |
| Shane Bieber | SP | 23.054 | Cleveland Indians | Cleveland Indians (MLB) | Recalled from Columbus (AAA) |
| Johnny Field | OF | 26.155 | Cleveland Indians | Columbus (AAA) | Claimed off waivers from Rays by Indians and assigned to Columbus (AAA) |
| Yandy Diaz | 3B | 26.351 | Cleveland Indians | Columbus (AAA) | Assigned to Columbus (AAA) |
| Jackson Stephens | P | 24.074 | Cincinnati Reds | Cincinnati Reds (MLB) | DL-10 Torn lateral mensiscus in right knee |
| Homer Bailey | SP | 32.082 | Cincinnati Reds | Cincinnati Reds (MLB) | Activated from DL |
| Daniel Poncedeleon | P | 26.190 | St. Louis Cardinals | Memphis (AAA) | Assigned to Memphis (AAA) |
| Austin Gomber | RP | 24.243 | St. Louis Cardinals | St. Louis Cardinals (MLB) | Recalled from Memphis (AAA) |
| Dan Barnes | RP | 28.276 | Toronto Blue Jays | Gulf Coast Blue Jays (Rk) | Assigned to GCL Blue Jays (Rk) for rehab |
| Magneuris Sierra | OF | 22.108 | Miami Marlins | Miami Marlins (MLB) | Recalled from New Orleans (AAA) |
| Garrett Cooper | IF | 27.211 | Miami Marlins | Miami Marlins (MLB) | DL-10 Right wrist sprain |
| Casey Crosby | P | 29.310 | Minnesota Twins | Gulf Coast Twins (Rk) | Assigned to Gulf Coast Twins (Rk) |
| Jagger Rusconi | OF | 22.006 | Boston Red Sox | Gulf Coast Red Sox (Rk) | Assigned to Gulf Coast Red Sox (Rk) |
| Logan Taylor | P | 26.224 | New York Mets | Gulf Coast Mets (Rk) | Assigned to Gulf Coast Mets (Rk) |
| Chevis Hoover | P | 24.279 | Miami Marlins | Gulf Coast Marlins (Rk) | Assigned to Gulf Coast Marlins (Rk) |
| Christian Cavaness | OF | 24.130 | Minnesota Twins | Gulf Coast Twins (Rk) | Assigned to Gulf Coast Twins (Rk) |
| Clarke Schmidt | P | 22.155 | New York Yankees | Gulf Coast Yankees (Rk) | Assigned to Gulf Coast Yankees (Rk) |
| Connor Jones | P | 23.249 | New York Yankees | Gulf Coast Yankees (Rk) | Assigned to Gulf Coast Yankees (Rk) |
| Brett Lilek | P | 24.348 | Miami Marlins | Gulf Coast Marlins (Rk) | Assigned to Gulf Coast Marlins (Rk) |
| Taylor Braley | IF-P | 22.193 | Miami Marlins | Gulf Coast Marlins (Rk) | Assigned to Gulf Coast Marlins (Rk) |
| Chaz Hebert | P | 25.323 | New York Yankees | Gulf Coast Yankees (Rk) | Assigned to Gulf Coast Yankees (Rk) |
| Wes Helsabeck | P | 26.017 | Los Angeles Dodgers | Arizona Dodgers (Rk) | Assigned to Arizona Dodgers (Rk) |
| Bo Tucker | P | 23.062 | Los Angeles Angels | Arizona Angels (Rk) | Assigned to Arizona Angels (Rk) |
| Brett Eibner | OF | 29.234 | Texas Rangers | Arizona Rangers (Rk) | Assigned to Arizona Rangers (Rk) |
| Daniel Barrios | 1B | 23.097 | New York Yankees | Staten Island (A-) | Assigned to Staten Island (A-) |
| David Metzgar | IF-OF | 23.226 | Seattle Mariners | Pulaski (Rk) | Assigned to Pulaski (Rk) |
| Mason McCullough | P | 25.198 | Arizona Diamondbacks | Hillsboro (A-) | Assigned to Hillsboro (A-) |
| Jake Winston | P-IF | 24.314 | Arizona Diamondbacks | Visalia (A+) | Assigned to Visalia (A+) |
| Aldemar Burgos | OF | 21.182 | San Diego Padres | Fort Wayne (A) | Assigned to Fort Wayne (A) |
| Austin Pettibone | P | 25.317 | Texas Rangers | Spokane (A-) | Assigned to Spokane (A-) |
| Gian Paul Gonzalez | C | 22.195 | Cleveland Indians | Mahoning Valley (A-) | Assigned to Mahoning Valley (A-) |
| Erich Weiss | 3B | 26.317 | Pittsburgh Pirates | West Virginia (A-) | Assigned to West Virginia (A-) |
| Huascar Ynoa | P | 20.057 | Atlanta Braves | Florida (A+) | Assigned to Florida (A+) |
| Eduardo Navas | C | 22.110 | New York Yankees | Charleston (sc) (A) | Placed on temporarily inactive list |
| Sebastian Rivero | C | 19.250 | Kansas City Royals | Lexington (A) | DL-7 Injured |
| Kellin Deglan | C | 26.082 | New York Yankees | Charleston (sc) (A) | Assigned to Charleston (sc) (A) |
| Troy Bacon | P | 21.301 | Atlanta Braves | Rome (A) | Assigned to Rome (A) |
| Tyler Keele | P | 24.341 | Arizona Diamondbacks | Kane County (A) | Assigned to Kane County (A) |
| Tirso Ornelas | OF | 18.135 | San Diego Padres | Fort Wayne (A) | DL-7 Injured |
| Peter Solomon | P | 21.342 | Houston Astros | Buies Creek (A+) | Assigned to Buies Creek (A+) |
| Bryan Dobzanski | P | 22.328 | St. Louis Cardinals | Palm Beach (A+) | Assigned to Palm Beach (A+) |
| Ben Rodriguez | C-1B | 23.257 | Minnesota Twins | Fort Myers (A+) | Assigned to Fort Myers (A+) |
| Angel Perdomo | P | 24.078 | Toronto Blue Jays | Dunedin (A+) | Activated from disabled list |
| Lewin Diaz | 1B | 21.247 | Minnesota Twins | Fort Myers (A+) | DL-7 Injured |
| Ryan Lidge | C | 23.270 | New York Yankees | Trenton (AA) | Assigned to Trenton (AA) |
| Daniel Sweet | OF | 23.208 | Cincinnati Reds | Pensacola (AA) | Assigned to Pensacola (AA) |
| Jacob Condra-Bogan | P | 23.328 | Washington Nationals | Potomac (A+) | Assigned to Potomac (A+) |
| Matthew Derosier | P | 24.011 | - | | Released by Nationals |
| Zach McKinstry | SS | 23.086 | Los Angeles Dodgers | Tulsa (AA) | Assigned to Tulsa (AA) |
| Nick Yarnall | OF | 23.280 | Los Angeles Dodgers | Rancho Cucamonga (A+) | Activated from disabled list |
| Tyler Marincov | OF | 26.278 | Oakland Athletics | Midland (AA) | DL-7 Injured |
| Andrew Sopko | P | 23.351 | Los Angeles Dodgers | Tulsa (AA) | DL-7 Injured |
| Madison Younginer | P | 27.263 | Los Angeles Dodgers | Tulsa (AA) | Assigned to Tulsa (AA) |
| Logan Bawcom | P | 29.264 | Los Angeles Dodgers | Oklahoma City (AAA) | Assigned to Oklahoma City (AAA) |
| Matt Tomshaw | P | 29.219 | Chicago White Sox | Birmingham (AA) | Assigned to Birmingham (AA) |
| Peter O'Brien | C | 28.009 | Miami Marlins | New Orleans (AAA) | Assigned to New Orleans (AAA) |
| Dorssys Paulino | SS | 23.245 | Cleveland Indians | Akron (AA) | Assigned to Akron (AA) |
| Daniel Johnson | OF | 23.013 | Washington Nationals | Harrisburg (AA) | Activated from disabled list |
| Tyler Mapes | P | 27.006 | Washington Nationals | Harrisburg (AA) | DL-7 Injured |
| Connor Marabell | OF-IF | 24.118 | Cleveland Indians | Columbus (AAA) | Assigned to Columbus (AAA) |
| Francisco Diaz | C | 28.125 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| Dillon Tate | P | 24.084 | Baltimore Orioles | Bowie (AA) | Activated from disabled list and Assigned to Bowie (AA) |
| Jaycob Brugman | OF | 26.188 | Baltimore Orioles | Bowie (AA) | Assigned to Bowie (AA) |
| Ranfi Casimiro | P | 26.008 | Philadelphia Phillies | Reading (AA) | Assigned to Reading (AA) |
| Osmer Morales | P | 25.267 | Los Angeles Angels | Salt Lake (AAA) | DL-7 Injured |
| Alex Burg | OF | 30.350 | Los Angeles Dodgers | Oklahoma City (AAA) | Activated from disabled list |
| Erick Matta | C | 24.106 | Texas Rangers | Round Rock (AAA) | Activated from disabled list |
| Buddy Baumann | P | 30.228 | New York Mets | Las Vegas (AAA) | Activated from disabled list |
| Shawn O'Malley | SS | 30.209 | Colorado Rockies | Albuquerque (AAA) | Reinstated to active roster |
| Richie Shaffer | 3B | 27.131 | Milwaukee Brewers | Colorado Springs (AAA) | Assigned to Colorado Springs (AAA) |
| Matt McBride | C | 33.062 | Philadelphia Phillies | Lehigh Valley (AAA) | DL-7 Injured |
| Danny Ortiz | OF | 28.200 | Philadelphia Phillies | Lehigh Valley (AAA) | DL-7 Injured |
| Nick Tepesch | P | 29.285 | Toronto Blue Jays | Buffalo (AAA) | Activated from disabled list |
| Cody Carroll | P | 25.282 | Baltimore Orioles | Norfolk (AAA) | Assigned to Norfolk (AAA) |
| Roberto Osuna | P | 23.167 | Toronto Blue Jays | Buffalo (AAA) | Assigned to Buffalo (AAA) |
| Brandon Cumpton | P | 29.250 | Toronto Blue Jays | Buffalo (AAA) | Placed on temporarily inactive list |
| Manuel Guzman | 2B | 23.164 | - | | Released by Angels |
| Jesus Balaguer | P | 24.346 | - | | Released by Astros |
| Chesny Young | IF | 25.291 | Chicago Cubs | Iowa (AAA) | DL-7 Injured |
| Stephen McGee | C | 27.167 | - | | Released by Padres |
| Ryan Hanigan | C | 37.342 | - | | Released by Giants |
| Ryan Jeffers | C | 21.051 | Minnesota Twins | Cedar Rapids (A) | Assigned to Cedar Rapids (A) |
| Austin Piscotty | OF | 22.099 | - | | Announced retirement |
| William Hancock | C | 21.266 | Kansas City Royals | Lexington (A) | Assigned to Lexington (A) |
| Gabriel Mora | C | 18.053 | New York Yankees | Tampa (A+) | Assigned to Tampa (A+) |
| Anderson Nunez | P | 20.144 | Toronto Blue Jays | Gulf Coast Blue Jays (Rk) | Assigned to Gulf Coast Blue Jays (Rk) |
| Carlos Sierra | P | 23.279 | Houston Astros | Gulf Coast Astros (Rk) | Assigned to Gulf Coast Astros (Rk) |
| Boog Powell | OF | 25.191 | Oakland Athletics | Nashville (AAA) | Assigned to Nashville (AAA) |
| Alexi Ogando | P | 34.293 | Cleveland Indians | Columbus (AAA) | Placed on restricted list |
