| Giovanny Gallegos | P | 26.322 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| Matt Chapman | 3B | 25.064 | Oakland Athletics | Stockton (A+) | Assigned to Stockton (A+) for rehab |
| Yuli Gurriel | 1B | 34.022 | Houston Astros | Houston Astros (MLB) | Reinstated to active roster |
| Cionel Perez | p | 22.071 | Houston Astros | Corpus Christi (AA) | Assigned to Corpus Christi (AA) |
| Orlando Arcia | SS | 23.331 | Milwaukee Brewers | Colorado Springs (AAA) | Assigned to Colorado Springs (AAA) |
| Aaron Wilkerson | P | 29.037 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Recalled from Colorado Springs (AAA) |
| Vincent Velasquez | SP | 26.024 | Philadelphia Phillies | Philadelphia Phillies (MLB) | DL-10 Right forearm contusion |
| Pat Neshek | RP | 37.300 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Activated from DL |
| Jake Thompson | SP | 24.151 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Recalled from Lehigh Valley (AAA) |
| Zac Curtis | RP | 25.362 | Philadelphia Phillies | Lehigh Valley (AAA) | Assigned to Lehigh Valley (AAA) |
| Dillon Maples | P | 26.053 | Chicago Cubs | Chicago Cubs (MLB) | Recalled from Iowa (AAA) |
| Brian Duensing | RP | 35.129 | Chicago Cubs | Chicago Cubs (MLB) | DL-10 Left shoulder fatigue |
| David Hale | P | 30.278 | New York Yankees | New York Yankees (MLB) | Contract purchased from minors |
| Luke Gregerson | RP | 34.048 | St. Louis Cardinals | Memphis (AAA) | Assigned to Memphis (AAA) for rehab |
| Marc Rzepczynski | P | 32.327 | Cleveland Indians | Cleveland Indians (MLB) | Contract purchased from minors |
| Corban Joseph | 2B | 29.246 | Baltimore Orioles | Bowie (AA) | Outrighted to minors |
| Jimmie Sherfy | P | 26.187 | Arizona Diamondbacks | Reno (AAA) | Assigned to Reno (AAA) |
| Silvino Bracho | RP | 25.349 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | Recalled from Reno (AAA) |
| Carlos Asuaje | 2B | 26.242 | San Diego Padres | San Diego Padres (MLB) | Recalled from El Paso (AAA) |
| Matt Szczur | LF | 28.346 | San Diego Padres | San Diego Padres (MLB) | Designated for Assignment |
| Allen Cordoba | LF | 22.208 | San Diego Padres | Lake Elsinore (A+) | Activated from DL and assigned to Lake Elsinore (A+) |
| Shawn Morimando | P | 25.223 | | | Released by Indians |
| Francisco Cervelli | C | 32.117 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Transferred to 10-day DL |
| Adam Plutko | P | 26.272 | Cleveland Indians | Columbus (AAA) | Assigned to Columbus (AAA) |
| Brady Puckett | P | 22.336 | Miami Marlins | Gulf Coast Marlins (Rk) | Assigned to Gulf Coast Marlins (Rk) |
| Omar Fernandez | P | 19.072 | San Diego Padres | Arizona Padres 2 (Rk) | Assigned to Arizona Padres 2 (Rk) |
| Rafael Mejia | 3B | 20.201 | Chicago Cubs | Arizona Cubs (Rk) | Assigned to Arizona Cubs (Rk) |
| Ruben Reyes | OF | 22.274 | Chicago Cubs | Arizona Cubs (Rk) | Assigned to Arizona Cubs (Rk) |
| Matt Esparza | P | 23.313 | Cleveland Indians | Arizona Indians (Rk) | Assigned to Arizona Indians (Rk) |
| Tyler Alamo | C | 23.060 | AZL Cubs 2 | Arizona Cubs 2 (Rk) | Assigned to Arizona Cubs 2 (Rk) |
| Sandro Cabrera | P | 23.009 | San Francisco Giants | San Jose (A+) | Assigned to San Jose (A+) |
| Otto Lopez | SS | 19.273 | Toronto Blue Jays | Vancouver (A-) | Assigned to Vancouver (A-) |
| Ramsey Romano | SS | 23.052 | - | | Released by Cubs |
| Carter Capps | P | 27.328 | San Diego Padres | Lake Elsinore (A+) | Assigned to Lake Elsinore (A+) |
| Korey Anderson | P | 23.293 | San Diego Padres | Tri-City (A-) | Assigned to Tri-City (A-) |
| Raffi Vizcaino | P | 22.212 | San Francisco Giants | Salem-Keizer (A-) | Assigned to Salem-Keizer (A-) |
| Kevin Martir | C | 24.140 | Philadelphia Phillies | Williamsport (A-) | Assigned to Williamsport (A-) |
| Taylor Ahearn | OF | 23.218 | Boston Red Sox | Lowell (A-) | Assigned to Lowell (A-) |
| Brian Mims | 2B | 22.109 | Philadelphia Phillies | Williamsport (A-) | Assigned to Williamsport (A-) |
| Tre' Gantt | OF | 22.052 | Cleveland Indians | Columbus (AAA) | Assigned to Columbus (AAA) |
| Jesus Alastre | OF | 21.218 | Philadelphia Phillies | Lakewood (A) | DL-7 Injured |
| Quincy Nieporte | 1B-C | 23.337 | Philadelphia Phillies | Lakewood (A) | DL-7 Injured |
| Cal Mitchell | OF | 19.115 | Pittsburgh Pirates | West Virginia (A) | Activated from disabled list |
| Miguel Flames | C | 20.290 | New York Yankees | Charleston (sc) (A) | Activated from disabled list |
| Walter Rasquin | 1B | 22.102 | New York Mets | Columbia (A) | DL-7 Injured |
| Zach Davis | OF | 24.002 | Chicago Cubs | South Bend (A) | Assigned to South Bend (A) |
| Roberto Caro | OF | 24.279 | Chicago Cubs | Myrtle Beach (A+) | Assigned to Myrtle Beach (A+) |
| Garrett Hope | C | 24.186 | Los Angeles Dodgers | Great Lakes (A) | DL-7 Injured |
| Sam Tewes | P | 23.145 | St. Louis Cardinals | Springfield (AA) | Assigned to Springfield (AA) |
| Zech Lemond | P | 25.265 | Miami Marlins | Jupiter (A+) | DL-7 Injured |
| Connor Myers | OF | 24.148 | Chicago Cubs | Tennessee (AA) | Assigned to Tennessee (AA) |
| Ronel Blanco | P | 24.304 | Houston Astros | Corpus Christi (AA) | Assigned to Corpus Christi (AA) |
| Hunter Smith | P | 24.105 | Boston Red Sox | Salem (A+) | Activated from disabled list |
| Daniel Gonzalez | C | 22.208 | Chicago White Sox | Winston-Salem (A+) | Activated from disabled list |
| Matt Custred | P | 24.296 | Los Angeles Angels | Inland Empire (A+) | Assigned to Inland Empire (A+) |
| Rowan Wick | P | 25.234 | San Diego Padres | El Paso (AAA) | Assigned to El Paso (AAA) |
| Michael Johnson | P | 27.179 | Los Angeles Dodgers | Tulsa (AA) | Assigned to Tulsa (AA) |
| Layne Somsen | P | 29.026 | Los Angeles Dodgers | Oklahoma City (AAA) | Assigned to Oklahoma City (AAA) |
| Daniel Spingola | OF | 25.057 | - | | Released by Cubs |
| Trey Martin | OF | 25.202 | Chicago Cubs | Iowa (AAA) | Assigned to Iowa (AAA) |
| Kolton Mahoney | P | 26.042 | Miami Marlins | Jacksonville (AA) | Assigned to Jacksonville (AA) |
| Michael Barash | C | 23.262 | Los Angeles Angels | Mobile (AA) | Assigned to Mobile (AA) |
| Mason McCullough | P | 25.175 | Arizona Diamondbacks | Jackson (AA) | DL-7 Injured |
| Kevin Medrano | 2B-3B | 28.041 | Arizona Diamondbacks | Reno (AAA) | Assigned to Reno (AAA) |
| Brian Ellington | P | 27.331 | Arizona Diamondbacks | Jackson (AA) | Assigned to Jackson (AA) |
| Jake Johansen | P | 27.159 | Chicago White Sox | Birmingham (AA) | Activated from disabled list |
| Samil De Los Santos | P | 24.174 | Los Angeles Angels | Mobile (AA) | Activated from disabled list |
| Erick Castillo | C | 25.126 | Chicago Cubs | Tennessee (AA) | Activated from disabled list |
| Evan Marzilli | OF | 27.110 | Arizona Diamondbacks | Jackson (AA) | Assigned to Jackson (AA) |
| Brody Koerner | P | 24.257 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| Dorssys Paulino | SS | 23.222 | Cleveland Indians | Columbus (AAA) | Assigned to Columbus (AAA) |
| Trevor Kelley | P | 24.254 | Boston Red Sox | Pawtucket (AAA) | Assigned to Pawtucket (AAA) |
| Josh Smith | P | 28.263 | Boston Red Sox | Portland (AA) | Assigned to Portland (AA) |
| Jaycob Brugman | OF | 26.165 | Baltimore Orioles | Bowie (AA) | DL-7 Injured |
| Andrew Ely | IF | 25.159 | New York Mets | Binghamton (AA) | Activated from disabled list |
| Corban Joseph | 2B | 29.246 | Baltimore Orioles | Bowie (AA) | |
| Nick Sergakis | 3B | 25.086 | New York Mets | Binghamton (AA) | DL-7 Injured |
| Ali Solis | C | 30.276 | Chicago Cubs | Iowa (AAA) | DL-7 Injured |
| Wilfredo Tovar | SS | 26.325 | St. Louis Cardinals | Memphis (AAA) | Placed on temporarily inactive list |
| Chris Coghlan | LF-CF | 33.013 | Chicago Cubs | Iowa (AAA) | Activated from disabled list |
| Alex Burg | OF | 30.327 | Los Angeles Dodgers | Oklahoma City (AAA) | Activated from disabled list |
| Matt Tracy | P | 29.217 | Toronto Blue Jays | Buffalo (AAA) | Assigned to Buffalo (AAA) |
| Rogelio Armenteros | P | 24.001 | Houston Astros | Fresno (AAA) | Placed on temporarily inactive list |
| Jordyn Adams | OF | 18.257 | Los Angeles Angels | Arizona Angels (Rk) | Signed out of draft (North Carolina HS) |
| C.J. Alexander | 3b | 21.349 | Atlanta Braves | Danville (Rk) | Assigned to Danville (Rk) |
| Alex King | SS | 22.272 | Arizona Diamondbacks | Missoula (Rk) | Assigned to Missoula (Rk) |
| Zack Jones | C | 23.362 | Arizona Diamondbacks | Hillsboro (A-) | Assigned to Hillsboro (A-) |
| Douglas Lanza | C | 20.109 | Arizona Diamondbacks | Missoula (Rk) | Assigned to Missoula (Rk) |
| A.J. Graffanino | SS | 20.350 | Atlanta Braves | Danville (Rk) | Assigned to Danville (Rk) |
| Alec Rennard | P | 23.056 | Pittsburgh Pirates | Bristol (Rk) | Assigned to Bristol (Rk) |
| Mike Brettell | P | 20.353 | St. Louis Cardinals | Johnson City (Rk) | Assigned to Johnson City (Rk) |
| Allen Montgomery | P | 21.320 | Pittsburgh Pirates | Bristol (Rk) | Assigned to Bristol (Rk) |
| Kyle Datres | 3B | 21.177 | Colorado Rockies | Boise (A-) | Assigned to Boise (A-) |
| Grant Little | LF | 20.358 | San Diego Padres | Tri-City (A-) | Assigned to Tri-City (A-) |
| Andy McGuire | SS | 23.211 | Toronto Blue Jays | Vancouver (A-) | Assigned to Vancouver (A-) |
| Devin Mann | IF | 21.140 | Los Angeles Dodgers | Great Lakes (A) | Reinstated to active roster |
| Luis Robert | OF | 20.332 | Chicago White Sox | Winston-Salem (A+) | DL-7 Injured |
| Jose Quezada | P | 22.298 | San Diego Padres | Arizona Padres (Rk) | Assigned to Arizona Padres (Rk) |
| Blake Townsend | P | 17.087 | Seattle Mariners | Arizona Mariners (Rk) | Assigned to Arizona Mariners (Rk) |
| Damon Casetta-Stubbs | P | 18.345 | Seattle Mariners | Arizona Mariners (Rk) | Assigned to Arizona Mariners (Rk) |
| Luis Ubiera | OF | 21.287 | Chicago Cubs | Arizona Cubs (Rk) | Assigned to Arizona Cubs (Rk) |
| Holden Laws | P | 18.206 | Seattle Mariners | Arizona Mariners (Rk) | Assigned to Arizona Mariners (Rk) |
