| Brandon Guyer | LF-RF | 32.117 | Cleveland Indians | Akron (AA) | Assigned to Akron (AA) for rehab |
| Lonnie Chisenhall | RF | 29.233 | Cleveland Indians | Akron (AA) | Assigned to Akron (AA) for rehab |
| David Phelps | RP | 31.228 | Seattle Mariners | Seattle Mariners (MLB) | Transferred to 60-day DL |
| Alex Colome | RP | 29.145 | Seattle Mariners | Seattle Mariners (MLB) | Traded from Rays with Denard Span to Mariners for Andrew Moore and Tommy Romero |
| Denard Span | CF | 34.088 | Seattle Mariners | Seattle Mariners (MLB) | Traded from Rays with Alex Colome to Mariners for Andrew Moore and Tommy Romero |
| Andrew Moore | p | 23.357 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Traded from Mariners with Tommy Romero to Rays for Alex Colome and Denard Span |
| Tommy Romero | p | 20.321 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Traded from Mariners with Andrew Moore to Rays for Alex Colome and Denard Span |
| Carlos Torres | P | 35.215 | Washington Nationals | Washington Nationals (MLB) | Outrighted to minors |
| Jett Bandy | C | 28.060 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Designated for Assignment |
| Joey Wendle | 2B | 28.029 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Reinstated to active roster |
| Willy Adames | SS | 22.266 | Tampa Bay Rays | Durham (AAA) | Assigned to Durham (AAA) |
| Mikie Mahtook | LF | 28.176 | Detroit Tigers | Toledo (AAA) | Assigned to Toledo (AAA) |
| Jeimer Candelario | 3B | 24.182 | Detroit Tigers | Detroit Tigers (MLB) | Activated from DL |
| Alexi Ogando | P | 34.233 | Cleveland Indians | Columbus (AAA) | Outrighted to minors |
| Luiz Gohara | P | 21.298 | Atlanta Braves | Atlanta Braves (MLB) | Placed on bereavement list |
| Matt Wisler | SP | 25.255 | Atlanta Braves | Atlanta Braves (MLB) | Recalled from Gwinnett (AAA) |
| Justin Miller | P | 30.347 | Washington Nationals | Washington Nationals (MLB) | Contract purchased from minors |
| George Kontos | RP | 32.347 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Designated for Assignment |
| Joe Musgrove | SP | 25.172 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Activated from DL |
| Tom Kahnle | RP | 28.291 | New York Yankees | New York Yankees (MLB) | Activated from DL |
| Dalton Pompey | CF | 25.165 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Recalled from Buffalo (AAA) |
| Jorge Lopez | SP | 25.104 | Milwaukee Brewers | Colorado Springs (AAA) | Assigned to Colorado Springs (AAA) |
| Orlando Arcia | SS | 23.294 | Milwaukee Brewers | Colorado Springs (AAA) | Assigned to Colorado Springs (AAA) |
| Eric Sogard | 2B | 32.003 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Recalled from Colorado Springs (AAA) |
| Adrian Houser | RP | 25.112 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Recalled from Biloxi (AA) |
| Mac Williamson | OF | 27.314 | San Francisco Giants | San Francisco Giants (MLB) | Activated from DL |
| Erik Kratz | C | 37.344 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Traded from Yankees to Brewers for future considerations |
| Luis Cedeno | P | 23.315 | - | | Released by Yankees |
| Jeffry Parra | C | 20.121 | San Francisco Giants | Augusta (A) | DL-7 Injured |
| Alan Crowley | C | 22.082 | Atlanta Braves | Rome (A) | Activated from disabled list |
| Kole Enright | 3B | 20.124 | Texas Rangers | Hickory (A) | DL-7 Injured |
| Daniel Ramos | P | 23.080 | New York Yankees | Charleston (sc) (A) | Activated from disabled list |
| Noah Bremer | P | 22.012 | Texas Rangers | Hickory (A) | Activated from disabled list |
| Kyle McPherson | IF | 22.106 | San Francisco Giants | Augusta (A) | Assigned to Augusta (A) |
| Tyler Brown | 2B | 23.127 | San Francisco Giants | Richmond (AA) | Assigned to Richmond (AA) |
| Carlos Martinez | C | 23.023 | Atlanta Braves | Mississippi (AA) | Assigned to Mississippi (AA) |
| Kyle Holder | SS | 24.000 | New York Yankees | Charleston (sc) (A) | Assigned to Charleston (sc) (A) |
| Luis Carrasco | P | 23.256 | Philadelphia Phillies | Williamsport (A-) | Assigned to Williamsport (A-) |
| Andrew Brown | P | 20.213 | Philadelphia Phillies | Lakewood (A) | Assigned to Lakewood (A) |
| Dalton Blaser | OF | 24.114 | - | | Released by Yankees |
| Jacob Taylor | P | 22.325 | - | | Announced retirement |
| Jose Azocar | OF | 22.014 | Detroit Tigers | West Michigan (A) | Assigned to West Michigan (A) |
| Gabe Friese | P | 23.020 | Milwaukee Brewers | Wisconsin (A) | Placed on temporarily inactive list |
| Tyler Day | P | 24.123 | Tampa Bay Rays | Bowling Green (A) | Activated from disabled list |
| Austin Hamilton | P | 24.287 | Los Angeles Dodgers | Great Lakes (A) | Activated from disabled list |
| Brent Diaz | C | 22.064 | Milwaukee Brewers | Wisconsin (A) | Assigned to Wisconsin (A) |
| Luke Burch | OF | 24.037 | Detroit Tigers | Lakeland (A+) | Assigned to Lakeland (A+) |
| Zach Logue | P | 22.032 | Toronto Blue Jays | Dunedin (A+) | Assigned to Dunedin (A+) |
| Matthew Gunter | P | 23.107 | Toronto Blue Jays | Lansing (A) | Assigned to Lansing (A) |
| Orlando Razo | P | 23.107 | Seattle Mariners | Clinton (A) | Assigned to Clinton (A) |
| Tommy Romero | P | 20.321 | Tampa Bay Rays | Bowling Green (A) | Assigned to Bowling Green (A) |
| Logan Lombana | P | 23.312 | Minnesota Twins | Fort Myers (A+) | Activated from disabled list |
| Zack Mozingo | P | 24.029 | Tampa Bay Rays | Charlotte (A+) | Assigned to Charlotte (A+) |
| Paco Rodriguez | P | 27.039 | Minnesota Twins | Chattanooga (AA) | Assigned to Chattanooga (AA) |
| Alberto Tirado | P | 23.166 | Philadelphia Phillies | Clearwater (A+) | Assigned to Clearwater (A+) |
| Kevin Kaczmarski | OF | 26.146 | New York Mets | Las Vegas (AAA) | Assigned to Las Vegas (AAA) |
| Matt Frawley | P | 22.291 | New York Yankees | Tampa (A+) | Assigned to Tampa (A+) |
| Nick Fanti | P | 21.146 | Philadelphia Phillies | Williamsport (A-) | Assigned to Williamsport (A-) |
| Deivy Mendez | P | 22.211 | - | | Released by Rays |
| Kevonte Mitchell | 3B | 22.287 | Chicago Cubs | Myrtle Beach (A+) | DL-7 Injured |
| Tyler Pearson | C | 26.040 | Chicago Cubs | Myrtle Beach (A+) | Assigned to Myrtle Beach (A+) |
| Jason Alexander | P | 25.085 | Los Angeles Angels | Inland Empire (A+) | Activated from disabled list |
| Gio Brusa | OF | 24.303 | San Francisco Giants | San Jose (A+) | DL-7 Injured |
| Dylan Manwaring | 3B | 23.240 | San Francisco Giants | San Jose (A+) | Assigned to San Jose (A+) |
| Joe Gatto | P | 22.346 | Los Angeles Angels | Mobile (AA) | Assigned to Mobile (AA) |
| Yusniel Diaz | OF | 21.230 | Los Angeles Dodgers | Tulsa (AA) | Activated from disabled list |
| Justin De Fratus | P | 30.217 | Los Angeles Dodgers | Tulsa (AA) | Assigned to Tulsa (AA) |
| Isan Diaz | SS | 21.363 | Miami Marlins | Jacksonville (AA) | Activated from disabled list |
| Kohl Stewart | P | 23.230 | Minnesota Twins | Chattanooga (AA) | Placed on temporarily inactive list |
| Casey Crosby | P | 29.250 | Minnesota Twins | Chattanooga (AA) | DL-7 Injured |
| Nathan Bates | P | 24.085 | Los Angeles Angels | Mobile (AA) | Placed on restricted list |
| Jose Vinicio | SS | 24.319 | Arizona Diamondbacks | Jackson (AA) | Activated from disabled list |
| Jose Queliz | C | 25.291 | Arizona Diamondbacks | Reno (AAA) | Assigned to Reno (AAA) |
| Sal Giardina | C | 26.025 | Atlanta Braves | Gwinnett (AAA) | Assigned to Gwinnett (AAA) |
| Sean Miller | SS | 23.227 | Minnesota Twins | Chattanooga (AA) | Assigned to Chattanooga (AA) |
| Ryan Clark | 1B-P | 24.167 | Los Angeles Angels | Salt Lake (AAA) | Assigned to Salt Lake (AAA) |
| Zach Lee | P | 26.255 | Tampa Bay Rays | Durham (AAA) | Assigned to Durham (AAA) |
| Zach Coppola | OF | 24.016 | Philadelphia Phillies | Reading (AA) | DL-7 Injured |
| Kyle Martin | 1B | 25.193 | Philadelphia Phillies | Reading (AA) | Activated from disabled list |
| Jacob Waguespack | P | 24.201 | Philadelphia Phillies | Lehigh Valley (AAA) | Assigned to Lehigh Valley (AAA) |
| Tyler Viza | P | 23.216 | Philadelphia Phillies | Lehigh Valley (AAA) | Assigned to Lehigh Valley (AAA) |
| Joey Denato | P-OF | 26.069 | Philadelphia Phillies | Reading (AA) | Assigned to Reading (AA) |
| Billy Fleming | 2B | 25.247 | New York Yankees | Trenton (AA) | Assigned to Trenton (AA) |
| Austin Coley | P | 25.315 | Pittsburgh Pirates | Altoona (AA) | Assigned to Altoona (AA) |
| J.T. Brubaker | P | 24.189 | Pittsburgh Pirates | Indianapolis (AAA) | Assigned to Indianapolis (AAA) |
| Nelson Molina | SS-2B | 23.025 | Colorado Rockies | Hartford (AA) | Signed to Minor League Contract |
| Ivan Pineyro | P | 26.239 | Los Angeles Angels | Salt Lake (AAA) | Reinstated to active roster |
| Colton Plaia | C | 27.242 | New York Mets | Las Vegas (AAA) | DL-7 Injured |
| David Holman | P | 27.359 | Colorado Rockies | Albuquerque (AAA) | DL-7 Injured |
| Ali Solis | C | 30.239 | Chicago Cubs | Iowa (AAA) | Activated from disabled list |
| Aaron Laffey | P | 33.040 | New York Mets | Las Vegas (AAA) | Signed to Minor League Contract |
| Jordan Jankowski | P | 29.008 | - | | Released by Angels |
| Colton Turner | P | 27.128 | Chicago White Sox | Charlotte (AAA) | Activated from disabled list |
| Wilkin Castillo | C | 33.358 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| Adam Lind | 1B-DH | 34.313 | - | | Released by Yankees |
| Brock Stassi | 1B | 28.291 | - | | Released by Twins |
| Jacob Taylor | P | 22.325 | - | | Announced retirement |
| Wilmer Font | RP | 28.001 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Traded from Athletics to Rays for Peter Bayer |
| Peter Bayer | P | 24.080 | Oakland Athletics | Oakland Athletics (MLB) | Traded from Rays to Athletics for Wilmer Font |
| Santiago Casilla | RP | 35.079 | Oakland Athletics | Oakland Athletics (MLB) | DL-10 Right shoulder strain |
| Jacob Taylor | P | 22.325 | - | | Announced retirement |
| Jacob Taylor | P | 22.325 | - | | Announced retirement |
| Jacob Taylor | P | 22.325 | - | | Announced retirement |
| Dustin Pedroia | 2B | 34.282 | Boston Red Sox | Boston Red Sox (MLB) | Activated from DL |
