| Dean Aldridge | P | 23.033 | Detroit Tigers | Connecticut (A-) | Assigned to Connecticut (A-) |
| Greg Allen | OF | 24.169 | Cleveland Indians | Columbus (AAA) | Assigned to Columbus (AAA) |
| Will Allen | C | 25.159 | Detroit Tigers | Erie (AA) | Assigned to Erie (AA) |
| Aaron Altherr | RF | 26.229 | Philadelphia Phillies | Reading (AA) | Assigned to Reading (AA) for rehab |
| Jeff Ames | P | 26.212 | Tampa Bay Rays | Durham (AAA) | Assigned to Durham (AAA) |
| Tyler Anderson | RP | 27.244 | Colorado Rockies | Albuquerque (AAA) | Assigned to Albuquerque (AAA) for rehab |
| Mark Appel | P | 26.047 | Philadelphia Phillies | Gulf Coast Phillies (Rk) | Activated from disabled list |
| Tyler Badamo | P | 25.023 | Arizona Diamondbacks | Jackson (AA) | Assigned to Jackson (AA) |
| Jett Bandy | C | 27.158 | Milwaukee Brewers | Wisconsin (A) | Assigned to Wisconsin (A) for rehab |
| Wendolyn Bautista | p | 24.157 | Cincinnati Reds | Louisville (AAA) | Assigned to Louisville (AAA) |
| Chris Betts | c | 20.174 | Tampa Bay Rays | Hudson Valley (A-) | Assigned to Hudson Valley (A-) |
| Boomer Biegalski | p | 23.049 | Oakland Athletics | Stockton (A+) | Activated from disabled list |
| Emilio Bonifacio | RF | 32.130 | Arizona Diamondbacks | Reno (AAA) | Assigned to Reno (AAA) |
| Mike Broadway | RP | 30.154 | Tampa Bay Rays | Montgomery (AA) | Assigned to Montgomery (AA) |
| Trenton Brooks | of | 22.059 | Cleveland Indians | Lake County (A) | Activated from disabled list |
| Carlos Canelon | c | 22.260 | Houston Astros | Corpus Christi (AA) | Assigned to Corpus Christi (AA) |
| Juan Ciriaco | SS-LF | 34.016 | San Francisco Giants | Sacramento (AAA) | Activated from disabled list |
| Kevin Cornelius | SS | 25.003 | Chicago Cubs | Tennessee (AA) | Activated from disabled list |
| Carlos Correa | SS | 22.343 | Houston Astros | Corpus Christi (AA) | Assigned to Corpus Christi (AA) for rehab |
| Cale Coshow | P | 25.046 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| Joe Cronin | if | 23.108 | Minnesota Twins | Fort Myers (A+) | Assigned to Fort Myers (A+) |
| Juan De La Cruz | C | 24.026 | Cleveland Indians | Akron (AA) | Activated from disabled list |
| Eduardo de Oleo | C | 24.218 | Houston Astros | Fresno (AAA) | Assigned to Fresno (AAA) |
| Eduardo Del Rosario | P | 22.104 | Minnesota Twins | Fort Myers (A+) | Assigned to Fort Myers (A+) |
| Francisco Diaz | C | 27.163 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| Randy Dobnak | p | 22.226 | Minnesota Twins | Cedar Rapids (A) | Assigned to Cedar Rapids (A) |
| Luke Dykstra | 2B | 21.298 | St. Louis Cardinals | Palm Beach (A+) | Activated from disabled list |
| Ryan Erickson | p | 24.004 | Chicago White Sox | Great Falls (Rk) | Assigned to Great Falls (Rk) |
| Elys Escobar | c | 20.344 | Detroit Tigers | Lakeland (A+) | Assigned to Lakeland (A+) |
| Calvin Faucher | p | 21.344 | Minnesota Twins | Elizabethton (Rk) | Activated from disabled list |
| Adonis Garcia | 3B | 32.141 | Atlanta Braves | Gulf Coast Braves (Rk) | Assigned to Gulf Coast Braves (Rk) for rehab |
| Grayson Greiner | C | 24.324 | Detroit Tigers | Toledo (AAA) | Assigned to Toledo (AAA) |
| Kelvin Gutierrez | SS | 23.003 | Washington Nationals | Potomac (A+) | Assigned to Potomac (A+) |
| Eric Haase | C | 24.256 | Cleveland Indians | Columbus (AAA) | Assigned to Columbus (AAA) |
| Will Headean | p | 23.324 | San Diego Padres | Lake Elsinore (A+) | Assigned to Lake Elsinore (A+) |
| Odubel Herrera | CF | 25.246 | Philadelphia Phillies | Reading (AA) | Assigned to Reading (AA) for rehab |
| Cameron Hill | P | 23.099 | Cleveland Indians | Columbus (AAA) | Assigned to Columbus (AAA) |
| Chase Hodson | p | 25.052 | New York Yankees | Charleston (sc) (A) | Assigned to Charleston (sc) (A) |
| Carter Hope | P | 22.207 | Kansas City Royals | Arizona Royals (Rk) | Assigned to Arizona Royals (Rk) |
| Jason Hursh | P | 25.334 | Atlanta Braves | Gwinnett (AAA) | Assigned to Gwinnett (AAA) |
| Connor Jones | p | 22.325 | St. Louis Cardinals | Springfield (AA) | Assigned to Springfield (AA) |
| A.J. Kennedy | c | 23.220 | San Diego Padres | Fort Wayne (A) | Activated from disabled list |
| Jeff Kinley | p | 25.198 | Miami Marlins | Jacksonville (AA) | Assigned to Jacksonville (AA) |
| Michael Kohn | RP | 31.066 | Minnesota Twins | Rochester (AAA) | Assigned to Rochester (AAA) |
| Erik Kratz | C | 37.077 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Traded from Indians to Yankees for cash considerations |
| Joey Krehbiel | P | 24.254 | Arizona Diamondbacks | Reno (AAA) | Assigned to Reno (AAA) |
| Jared Lakind | 1B | 25.175 | Miami Marlins | Jupiter (A+) | Assigned to Jupiter (A+) |
| Jacob Lee | IF-P | 27.310 | Cleveland Indians | Akron (AA) | Activated from disabled list |
| Ryan Lillie | p | 21.122 | Miami Marlins | Greensboro (A) | Assigned to Greensboro (A) |
| Mitch Longo | of | 22.231 | Cleveland Indians | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Diomar Lopez | p | 20.259 | San Diego Padres | Arizona Padres 2 (Rk) | Assigned to Arizona Padres 2 (Rk) |
| Chris Mathewson | p | 21.097 | Los Angeles Dodgers | Rancho Cucamonga (A+) | Assigned to Rancho Cucamonga (A+) |
| Domenic Mazza | p | 23.033 | San Francisco Giants | San Jose (A+) | Assigned to San Jose (A+) |
| Francisco Mejia | C | 21.309 | Cleveland Indians | Columbus (AAA) | Assigned to Columbus (AAA) |
| Mike Meyers | SS | 23.246 | Boston Red Sox | Portland (AA) | Assigned to Portland (AA) |
| Amaurys Minier | 3B | 21.214 | Minnesota Twins | Cedar Rapids (A) | Activated from disabled list |
| Nelson Molina | SS | 22.123 | Minnesota Twins | Chattanooga (AA) | Assigned to Chattanooga (AA) |
| Jordan Montgomery | P | 24.247 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| Colin Moran | 3B | 24.334 | Houston Astros | Quad Cities (A) | Assigned to Quad Cities (A) for rehab |
| Victor Moscote | c | 23.113 | New York Mets | St. Lucie (A+) | Assigned to St. Lucie (A+) |
| Aaron Myers | p | 23.363 | Baltimore Orioles | Delmarva (A) | Activated from disabled list |
| Carlos Narvaez | c | 18.278 | New York Yankees | Tampa (A+) | Assigned to Tampa (A+) |
| Angel Nesbitt | P | 26.270 | Detroit Tigers | Erie (AA) | Assigned to Erie (AA) |
| Miguel Nunez | P | 24.308 | Philadelphia Phillies | Gulf Coast Phillies (Rk) | Activated from disabled list |
| Shawn O'Malley | RF-3B | 29.247 | Seattle Mariners | Tacoma (AAA) | Activated from disabled list |
| Hunter Owen | of | 23.343 | Pittsburgh Pirates | West Virginia (A-) | Assigned to West Virginia (A-) |
| Connor Owings | of | 23.112 | Arizona Diamondbacks | Kane County (A) | Assigned to Kane County (A) |
| Joel Payamps | P | 23.146 | Arizona Diamondbacks | Reno (AAA) | Assigned to Reno (AAA) |
| Robbie Perkins | C | 23.094 | Colorado Rockies | Albuquerque (AAA) | Assigned to Albuquerque (AAA) |
| Anderson Polanco | p | 24.359 | Cleveland Indians | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Jose Queliz | C | 25.024 | Arizona Diamondbacks | Jackson (AA) | Activated from disabled list |
| Jonathan Rodriguez | 1B | 28.010 | Minnesota Twins | Rochester (AAA) | Assigned to Rochester (AAA) |
| Chaz Roe | RP | 30.326 | Tampa Bay Rays | Durham (AAA) | Assigned to Durham (AAA) |
| Daniel Salters | c | 24.207 | Cleveland Indians | Akron (AA) | Assigned to Akron (AA) |
| Anibal Sanchez | RP | 33.186 | Detroit Tigers | West Michigan (A) | Assigned to West Michigan (A) for rehab |
| Wynston Sawyer | C | 25.291 | Los Angeles Dodgers | Arizona Dodgers (Rk) | Assigned to Arizona Dodgers (Rk) |
| Gary Schwartz | of | 21.222 | Atlanta Braves | Florida (A+) | Assigned to Florida (A+) |
| Carlos Sepulveda | 2b | 21.004 | Chicago Cubs | Arizona Cubs (Rk) | Assigned to Arizona Cubs (Rk) |
| Justus Sheffield | P | 21.110 | New York Yankees | Trenton (AA) | Assigned to Trenton (AA) |
| Gresuan Silverio | c | 18.238 | Detroit Tigers | Connecticut (A-) | Assigned to Connecticut (A-) |
| Caleb Smith | P | 26.034 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| David Sosebee | p | 24.006 | New York Yankees | Trenton (AA) | Assigned to Trenton (AA) |
| William Soto | P | 21.200 | Los Angeles Dodgers | Great Lakes (A) | Assigned to Great Lakes (A) |
| Matt Tracy | P | 28.278 | Minnesota Twins | Chattanooga (AA) | Activated from disabled list |
| Carlos Vidal | of | 21.276 | New York Yankees | Charleston (sc) (A) | Activated from disabled list |
| Paul Voelker | P | 25.012 | Detroit Tigers | Toledo (AAA) | Assigned to Toledo (AAA) |
| Ryan Walker | IF | 25.158 | Minnesota Twins | Rochester (AAA) | Assigned to Rochester (AAA) |
| Jordan Weems | C | 24.297 | Boston Red Sox | Gulf Coast Red Sox (Rk) | Activated from disabled list |
| Wes Wilson | C | 28.013 | New York Yankees | Trenton (AA) | Assigned to Trenton (AA) |
| Jack Wynkoop | p | 23.302 | Colorado Rockies | Hartford (AA) | Reinstated to active roster |
| Andrew Bailey | RP | 33.092 | Los Angeles Angels | Los Angeles Angels (MLB) | Transferred to 60-day DL |
| Brandon Phillips | 2B | 36.064 | Los Angeles Angels | Los Angeles Angels (MLB) | Traded from Braves to Angels for Tony Sanchez |
| Tony Sanchez | c | 29.103 | Atlanta Braves | Atlanta Braves (MLB) | Traded from Angels to Braves for Brandon Phillips |
| Leonys Martin | CF | 29.178 | Chicago Cubs | Chicago Cubs (MLB) | Traded from Mariners to Cubs for future considerations |
| Justin Verlander | SP | 34.192 | Houston Astros | Houston Astros (MLB) | Traded from Tigers to Astros for Franklin Perez, Daz Cameron and Jake Rogers |
| Franklin Perez | p | 19.268 | Detroit Tigers | Detroit Tigers (MLB) | Traded from Astros with Daz Cameron and Jake Rogers to Tigers for Justin Verlander |
| Jake Rogers | c | 22.135 | Detroit Tigers | Detroit Tigers (MLB) | Traded from Astros with Daz Cameron and Franklin Perez to Tigers for Justin Verlander |
| Daz Cameron | of | 20.228 | Detroit Tigers | Detroit Tigers (MLB) | Traded from Astros with Franklin Perez and Jake Rogers to Tigers for Justin Verlander |
| Anthony Bass | RP | 29.304 | Texas Rangers | Round Rock (AAA) | Designated for Assignment |
| Miguel Gonzalez | SP | 33.096 | Texas Rangers | Texas Rangers (MLB) | Traded from White Sox to Rangers for TiQuan Forbes |
| Ti'Quan Forbes | SS | 21.005 | Chicago White Sox | Chicago White Sox (MLB) | Traded from Rangers to White Sox for Miguel Gonzalez |
| Kevin Siegrist | RP | 28.042 | St. Louis Cardinals | St. Louis Cardinals (MLB) | Activated from DL and designated for assignment |
| John Gant | RP | 25.025 | St. Louis Cardinals | St. Louis Cardinals (MLB) | Recalled from Memphis (AAA) |
| Brock Stassi | 1B | 28.024 | Philadelphia Phillies | Lehigh Valley (AAA) | Designated for Assignment |
| Juan Nicasio | RP | 31.000 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Claimed off waivers from Pirates by Phillies |
| Dayan Diaz | P | 28.202 | Houston Astros | Fresno (AAA) | Designated for Assignment |
| Cameron Maybin | LF | 30.149 | Houston Astros | Houston Astros (MLB) | Claimed off waivers from Angels by Astros |
| Justin Upton | LF | 30.006 | Los Angeles Angels | Los Angeles Angels (MLB) | Traded from Tigers to Angels for Grayson Long and PTBNL |
| Grayson Long | p | 23.096 | Detroit Tigers | Detroit Tigers (MLB) | Traded from Angels with PTBNL to Tigers for Justin Upton |
| Giovanny Gallegos | P | 26.017 | New York Yankees | New York Yankees (MLB) | Recalled from Scranton/Wilkes-Barre (AAA) |
| Juan Centeno | C | 27.288 | Houston Astros | Houston Astros (MLB) | Recalled from Fresno (AAA) |
| Evan Gattis | DH-C | 31.013 | Houston Astros | Houston Astros (MLB) | DL-10 Right wrist soreness |
| Tucker Barnhart | C | 26.236 | Cincinnati Reds | Cincinnati Reds (MLB) | Placed on paternity leave list |
| Jerad Eickhoff | SP | 27.060 | Philadelphia Phillies | Philadelphia Phillies (MLB) | DL-10 Nerve irritation in right hand |
| Conor Gillaspie | 3B | 30.044 | San Francisco Giants | Sacramento (AAA) | DL-7 Injured |
| Eric Jokisch | P | 28.033 | Arizona Diamondbacks | Reno (AAA) | Placed on temporary inactive list |
| Kyle Higashioka | C | 27.133 | New York Yankees | Scranton/Wilkes-Barre (AAA) | DL-7 Injured |
| Mike Kickham | RP | 28.262 | Miami Marlins | New Orleans (AAA) | Placed on temporary inactive list |
| Angel Ventura | P | 24.146 | Milwaukee Brewers | Colorado Springs (AAA) | DL-7 Injured |
| Jack Mayfield | IF-P | 26.335 | Houston Astros | Fresno (AAA) | DL-7 Injured |
| Jesse Jenner | c | 24.044 | St. Louis Cardinals | Memphis (AAA) | DL-7 Injured |
| Kevin Comer | P | 25.030 | Houston Astros | Fresno (AAA) | DL-7 Injured |
| Rosell Herrera | SS | 24.319 | Colorado Rockies | Albuquerque (AAA) | Placed on temporary inactive list |
| Dace Kime | P | 25.178 | Cleveland Indians | Akron (AA) | DL-7 Injured |
| Jon Keller | P | 25.023 | Baltimore Orioles | Frederick (A+) | DL-7 Injured |
| Anthony Dimino | c | 24.026 | New York Mets | St. Lucie (A+) | DL-7 Injured |
| Tyler Beardsley | p | 23.106 | Minnesota Twins | Cedar Rapids (A) | DL-7 Injured |
| Casey Scoggins | of | 23.170 | | | Released by Twins |
