| Jason Adam | P | 25.360 | San Diego Padres | San Antonio (AA) | Assigned to San Antonio (AA) |
| Marty Anderson | p | 24.197 | New York Mets | Columbia (A) | Assigned to Columbia (A) |
| Shaun Anderson | p | 22.273 | San Francisco Giants | San Jose (A+) | Assigned to San Jose (A+) |
| Greifer Andrade | ss | 20.183 | Seattle Mariners | Everett (A-) | Activated from disabled list |
| Joan Baez | P | 22.215 | Washington Nationals | Potomac (A+) | Assigned to Potomac (A+) |
| Eduard Bazardo | p | 21.332 | Boston Red Sox | Gulf Coast Red Sox (Rk) | Assigned to Gulf Coast Red Sox (Rk) |
| Omar Bencomo | p | 28.169 | Miami Marlins | New Orleans (AAA) | Assigned to New Orleans (AAA) |
| Anfernee Benitez | | 22.005 | Arizona Diamondbacks | Kane County (A) | Assigned to Kane County (A) |
| T.J. Bennett | if | 25.007 | San Francisco Giants | Richmond (AA) | Assigned to Richmond (AA) |
| Vic Black | RP | 29.067 | San Francisco Giants | Salem-Keizer (A-) | Assigned to Salem-Keizer (A-) |
| Tyler Bortnick | 2B | 30.026 | Milwaukee Brewers | Colorado Springs (AAA) | Assigned to Colorado Springs (AAA) |
| Casey Brown | P | 24.093 | Philadelphia Phillies | Williamsport (A-) | Assigned to Williamsport (A-) |
| Miguel Burgos | P | 22.043 | Toronto Blue Jays | Bluefield (Rk) | Assigned to Bluefield (Rk) |
| Mauricio Cabrera | RP | 23.310 | Atlanta Braves | Gulf Coast Braves (Rk) | Activated from disabled list |
| Luis Castro | 3B | 21.314 | Colorado Rockies | Boise (A-) | Activated from disabled list |
| Henry Centeno | P | 22.339 | Minnesota Twins | Gulf Coast Twins (Rk) | Activated from disabled list |
| Ricardo Cespedes | of | 19.339 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Juan Corniel | p | 21.209 | Houston Astros | Greeneville (Rk) | Assigned to Greeneville (Rk) |
| Zac Correll | P | 21.183 | Cincinnati Reds | Dayton (A) | Assigned to Dayton (A) |
| Jose De Leon | SP | 24.356 | Tampa Bay Rays | Gulf Coast Rays (Rk) | Assigned to Gulf Coast Rays (Rk) |
| Abel De Los Santos | RP | 24.250 | Los Angeles Angels | Mobile (AA) | Assigned to Mobile (AA) |
| Sam Dexter | ss | 23.144 | Chicago White Sox | Winston-Salem (A+) | Activated from disabled list |
| Ryan Dobson | if | 22.088 | Arizona Diamondbacks | Hillsboro (A-) | Assigned to Hillsboro (A-) |
| Pedro Echemendia | p | 26.045 | St. Louis Cardinals | Springfield (AA) | Assigned to Springfield (AA) |
| Carlos Estevez | RP | 24.213 | Colorado Rockies | Albuquerque (AAA) | Assigned to Albuquerque (AAA) |
| Mike Estevez | p | 24.305 | Toronto Blue Jays | Gulf Coast Blue Jays (Rk) | Assigned to Gulf Coast Blue Jays (Rk) |
| Luke Farrell | p | 26.052 | Los Angeles Dodgers | Oklahoma City (AAA) | Traded from Royals to Dodgers for cash considerations |
| Matt Gage | P | 24.168 | San Francisco Giants | Salem-Keizer (A-) | Assigned to Salem-Keizer (A-) |
| Leury Garcia | CF | 26.133 | Chicago White Sox | Charlotte (AAA) | Assigned to Charlotte (AAA) for rehab |
| Jordan George | 1b | 25.013 | Pittsburgh Pirates | Altoona (AA) | Assigned to Altoona (AA) |
| Cam Gibson | of | 23.167 | Detroit Tigers | Lakeland (A+) | Activated from disabled list |
| Merandy Gonzalez | p | 21.294 | Miami Marlins | Jupiter (A+) | Assigned to Jupiter (A+) |
| Casey Grayson | IF | 25.340 | St. Louis Cardinals | Gulf Coast Cardinals (Rk) | Activated from disabled list |
| Alex Guenette | c | 22.047 | Milwaukee Brewers | Helena (Rk) | Assigned to Helena (Rk) |
| Chris Hatcher | RP | 32.198 | Los Angeles Dodgers | Arizona Dodgers (Rk) | Assigned to Arizona Dodgers (Rk) for rehab |
| Yonardo Herdenez | p | 21.313 | Toronto Blue Jays | Lansing (A) | Assigned to Lansing (A) |
| Alex Hermeling | p | 24.129 | Los Angeles Dodgers | Rancho Cucamonga (A+) | Activated from disabled list |
| Ivan Hernandez | P | 26.001 | Los Angeles Angels | Mobile (AA) | Assigned to Mobile (AA) |
| Taylor Hill | RP | 28.139 | Washington Nationals | Harrisburg (AA) | Assigned to Harrisburg (AA) |
| Trenton Hill | p | 23.141 | Miami Marlins | Greensboro (A) | Assigned to Greensboro (A) |
| Wei-Chieh Huang | p | 23.306 | Arizona Diamondbacks | Visalia (A+) | Assigned to Visalia (A+) |
| Dakota Hudson | p | 22.317 | St. Louis Cardinals | Memphis (AAA) | Assigned to Memphis (AAA) |
| Dedgar Jimenez | P | 21.145 | Boston Red Sox | Portland (AA) | Assigned to Portland (AA) |
| Luis Jimenez | p | 22.208 | Cleveland Indians | Lake County (A) | Activated from disabled list |
| Shawn Kelley | CL | 33.094 | Washington Nationals | Syracuse (AAA) | Assigned to Syracuse (AAA) for rehab |
| Casey Kelly | SP | 27.298 | San Francisco Giants | Sacramento (AAA) | Signed to Minor League Contract |
| Adam Kolarek | P | 28.196 | Tampa Bay Rays | Durham (AAA) | Assigned to Durham (AAA) |
| Sam Lewis | P | 25.294 | Arizona Diamondbacks | Visalia (A+) | Assigned to Visalia (A+) |
| Ronaldo Marrero | p | 21.173 | Houston Astros | Tri City (A-) | Assigned to Tri City (A-) |
| Jose Martinez | P | 23.106 | Arizona Diamondbacks | Hillsboro (A-) | Assigned to Hillsboro (A-) |
| James Naile | p | 24.171 | Oakland Athletics | Stockton (A+) | Assigned to Stockton (A+) |
| Mitchell Osnowitz | P | 26.027 | Boston Red Sox | Lowell (A-) | Assigned to Lowell (A-) |
| David Owen | p | 23.281 | San Francisco Giants | Salem-Keizer (A-) | Assigned to Salem-Keizer (A-) |
| Angel Padron | p | 19.316 | Boston Red Sox | Gulf Coast Red Sox (Rk) | Assigned to Gulf Coast Red Sox (Rk) |
| Matt Pare | 1B | 26.254 | San Francisco Giants | Sacramento (AAA) | Activated from disabled list |
| Delvin Perez | if | 18.247 | St. Louis Cardinals | Johnson City (Rk) | Assigned to Johnson City (Rk) |
| Ivan Pineyro | P | 25.304 | Arizona Diamondbacks | Reno (AAA) | Assigned to Reno (AAA) |
| Anthony Recker | C | 33.335 | Minnesota Twins | Rochester (AAA) | Assigned to Rochester (AAA) |
| Nate Reed | P | 29.241 | San Francisco Giants | Sacramento (AAA) | Assigned to Sacramento (AAA) |
| Eddy Reynoso | c | 22.356 | Boston Red Sox | Gulf Coast Red Sox (Rk) | Assigned to Gulf Coast Red Sox (Rk) |
| Junior Rincon | P | 25.235 | Atlanta Braves | Gwinnett (AAA) | Assigned to Gwinnett (AAA) |
| Reid Russell | of | 21.342 | Houston Astros | Greeneville (Rk) | Assigned to Greeneville (Rk) |
| Chris Smith | 2b | 28.345 | Toronto Blue Jays | Buffalo (AAA) | Assigned to Buffalo (AAA) |
| Taylor Sparks | 3B | 24.117 | Cincinnati Reds | Dayton (A) | Assigned to Dayton (A) |
| Carlos Suniaga | p | 20.064 | Minnesota Twins | Gulf Coast Twins (Rk) | Assigned to Gulf Coast Twins (Rk) |
| Ricky Surum | ss | 22.234 | New York Yankees | Tampa (A+) | Assigned to Tampa (A+) |
| Darnell Sweeney | SS | 26.178 | Cincinnati Reds | Louisville (AAA) | Activated from disabled list |
| Placido Torres | p | 24.073 | New York Mets | Gulf Coast Mets (Rk) | Activated from disabled list |
| Steve Villines | p | 22.014 | New York Mets | Brooklyn (A-) | Assigned to Brooklyn (A-) |
| Colin Walsh | 3B | 27.306 | Houston Astros | Corpus Christi (AA) | Signed to Minor League Contract |
| Tyler Wells | p | 22.337 | Minnesota Twins | Gulf Coast Twins (Rk) | Activated from disabled list |
| Brandon Woodruff | P | 24.169 | Milwaukee Brewers | Colorado Springs (AAA) | Assigned to Colorado Springs (AAA) |
| Guillermo Zuniga | p | 18.292 | Atlanta Braves | Gulf Coast Braves (Rk) | Activated from disabled list |
| Stephen Drew | 3B-SS | 34.135 | Washington Nationals | Washington Nationals (MLB) | DL-10 Abdominal strain |
| Adrian Gonzalez | 1B | 35.082 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Transferred to 60-day DL |
| Wily Peralta | SP | 28.082 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Designated for Assignment |
| Kirk Nieuwenhuis | CF-LF | 29.357 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Contract purchased from minors |
| Robbie Ray | SP | 25.302 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | DL-7 Concussion |
| Silvino Bracho | RP | 25.012 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | Recalled from Reno (AAA) |
| Diego Moreno | RP | 30.008 | Cleveland Indians | Cleveland Indians (MLB) | Claimed off waivers from Rays by Indians |
| Boone Logan | RP | 32.350 | Cleveland Indians | Cleveland Indians (MLB) | Transferred to 60-day DL |
| Pedro Beato | RP | 30.275 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Contract purchased from minors |
| James Adduci | RF | 32.075 | Detroit Tigers | Detroit Tigers (MLB) | Recalled from Toledo (AAA) |
| Alex Presley | RF-LF | 32.004 | Detroit Tigers | Detroit Tigers (MLB) | DL-10 Strained right side |
| Jordan Lyles | RP | 26.283 | Colorado Rockies | Colorado Rockies (MLB) | Designated for Assignment |
| Raimel Tapia | CF | 23.175 | Colorado Rockies | Colorado Rockies (MLB) | Recalled from Albuquerque (AAA) |
| Greg Holland | CL | 31.251 | Colorado Rockies | Colorado Rockies (MLB) | Reinstated from paternity leave list |
| Daniel Bard | RP | 32.034 | New York Mets | St. Lucie (A+) | DL-7 Injured |
| Dean Kiekhefer | RP | 28.052 | Seattle Mariners | Tacoma (AAA) | DL-7 Injured |
| Eddie Gamboa | RP | 32.220 | Los Angeles Dodgers | Tulsa (AA) | Placed on temporary inactive list |
| Edubray Ramos | RP | 24.222 | Philadelphia Phillies | Lehigh Valley (AAA) | DL-7 Injured |
| Ian Parmley | OF-P | 27.222 | Toronto Blue Jays | Buffalo (AAA) | DL-7 Injured |
| Jacob May | CF | 25.188 | Chicago White Sox | Charlotte (AAA) | Placed on temporary inactive list |
| Kyle Kendrick | SP | 32.337 | Boston Red Sox | Pawtucket (AAA) | DL-7 Injured |
| Miguel Almonte | RP | 24.116 | Kansas City Royals | Omaha (AAA) | DL-7 Right rotator cuff injury |
| Paul Clemens | SP | 29.166 | | | Released by Twins |
| Tyler Ladendorf | 2B | 29.144 | Chicago White Sox | Charlotte (AAA) | DL-7 Injured |
| Brett Ash | P | 26.063 | Seattle Mariners | Arkansas (AA) | DL-7 Injured |
| Caleb Ramsey | LF | 28.295 | | | Released by Nationals |
| Jantzen Witte | IF | 27.206 | Boston Red Sox | Pawtucket (AAA) | DL-7 Injured |
| Jose Rosario | P | 26.334 | Chicago Cubs | Tennessee (AA) | DL-7 Injured |
| Tyler Knigge | P | 28.275 | Seattle Mariners | Arkansas (AA) | DL-7 Injured |
| Chace Numata | C | 24.349 | Philadelphia Phillies | Reading (AA) | DL-7 Injured |
| Emilio Guerrero | SS | 24.342 | Toronto Blue Jays | New Hampshire (AA) | DL-7 Injured |
| Luis Jean | SS | 22.346 | Colorado Rockies | Hartford (AA) | DL-7 Injured |
| Luis Valenzuela | SS | 23.338 | Atlanta Braves | Mississippi (AA) | DL-7 Injured |
| Mitchell Walding | SS | 24.322 | Philadelphia Phillies | Reading (AA) | DL-7 Injured |
| Thomas Robson | P | 24.032 | Toronto Blue Jays | New Hampshire (AA) | DL-7 Injured |
| Austin Sexton | p | 23.012 | St. Louis Cardinals | Peoria (A) | DL-7 Injured |
| Brian Gonzalez | P | 21.278 | Baltimore Orioles | Frederick (A+) | DL-7 Injured |
| Cody Ramer | ss | 23.247 | | | Announced retirement |
| Colin Bray | OF-P | 24.041 | Arizona Diamondbacks | Visalia (A+) | DL-7 Injured |
| Dustin Frailey | of | 23.160 | Detroit Tigers | Lakeland (A+) | DL-7 Injured |
| Franderlyn Romero | P | 24.158 | Baltimore Orioles | Frederick (A+) | DL-7 Injured |
| Grant Heyman | OF | 23.264 | Arizona Diamondbacks | Visalia (A+) | DL-7 Injured |
| Junior Fernandez | p | 20.149 | St. Louis Cardinals | Palm Beach (A+) | DL-7 Injured |
| Justin Donatella | p | 22.316 | Arizona Diamondbacks | Visalia (A+) | DL-7 Injured |
| Ben Johnson | of | 23.086 | Colorado Rockies | Asheville (A) | Placed on temporary inactive list |
| Blake Taylor | P | 21.347 | New York Mets | Columbia (A) | DL-7 Injured |
| C.J. Chatham | ss | 22.219 | Boston Red Sox | Greenville (A) | DL-7 Injured |
| Dash Winningham | 1B | 21.292 | New York Mets | Columbia (A) | DL-7 Injured |
| Patrick Murphy | P | 22.049 | Toronto Blue Jays | Gulf Coast Blue Jays (Rk) | DL-7 Injured |
| Connor MacDonald | 1b | 21.153 | | | Released by Astros |
| Edgar Martinez | p | 20.016 | Miami Marlins | Dominican Marlins (Rk) | Assigned to DSL Marlins (Rk) |
| Raymond Lopez | of | 18.237 | Kansas City Royals | Arizona Royals (Rk) | DL-60 Injured |
| Luis Ysla | P | 25.093 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Traded from Red Sox to Dodgers for cash |
| Jimmy Kerrigan | of | 23.135 | Minnesota Twins | Cedar Rapids (A) | Signed as undrafted free agent (Virginia Commonwealth) |
| Geral Silva | p | 22.273 | Miami Marlins | Miami Marlins (MLB) | Assignment Unknown |
| Michael Fairchild | p | 22.312 | Seattle Mariners | Arizona Mariners (Rk) | Signed as undrafted free agent (Azusa Pacific) |
