| Darwin Alvarado | of | 18.246 | Detroit Tigers | Gulf Coast Tigers (East) (Rk) | Assigned to Gulf Coast Tigers (East) (Rk) |
| Christian Arroyo | 3B | 22.045 | San Francisco Giants | Sacramento (AAA) | Activated from disabled list |
| Anthony Bass | RP | 29.256 | Texas Rangers | Arizona Rangers (Rk) | Activated from disabled list |
| Joel Bender | P | 25.346 | Cincinnati Reds | Pensacola (AA) | Assigned to Pensacola (AA) |
| Jake Bivens | if | 22.050 | Detroit Tigers | Gulf Coast Tigers (East) (Rk) | Assigned to Gulf Coast Tigers (East) (Rk) |
| Matt Blandino | p | 21.350 | Cincinnati Reds | Dayton (A) | Assigned to Dayton (A) |
| Ronny Brito | ss | 18.114 | Los Angeles Dodgers | Ogden (Rk) | Assigned to Ogden (Rk) |
| Trevor Brown | C | 25.242 | San Francisco Giants | Sacramento (AAA) | Activated from disabled list |
| Ty Buttrey | P | 24.105 | Boston Red Sox | Portland (AA) | Assigned to Portland (AA) |
| Derek Campbell | IF | 26.016 | Philadelphia Phillies | Clearwater (A+) | Activated from disabled list |
| Roberto Caro | of | 23.292 | Chicago Cubs | Myrtle Beach (A+) | Assigned to Myrtle Beach (A+) |
| Tom Colletti | p | 22.022 | | Arizona Padres 2 (Rk) | Assigned to Myrtle Beach (A+) |
| Gene Cone | of | 22.296 | New York Mets | Columbia (A) | Activated from disabled list |
| Shane Cooper | ss | 22.207 | Detroit Tigers | Gulf Coast Tigers (East) (Rk) | Assigned to Gulf Coast Tigers (East) (Rk) |
| Chris Cotton | P | 26.235 | Los Angeles Dodgers | Tulsa (AA) | Activated from disabled list |
| Weston Davis | P | 21.008 | Washington Nationals | Hagerstown (A) | Assigned to Hagerstown (A) |
| Rafael Devers | 3B | 20.263 | Boston Red Sox | Pawtucket (AAA) | Reinstated to active roster |
| Cody Dube | p | 22.266 | Baltimore Orioles | Delmarva (A) | Assigned to Delmarva (A) |
| Jon Duplantier | p | 23.003 | Arizona Diamondbacks | Visalia (A+) | Reinstated to active roster |
| Montana Durapau | P | 25.109 | Pittsburgh Pirates | Indianapolis (AAA) | Assigned to Indianapolis (AAA) |
| Tyler Fallwell | p | 21.249 | Kansas City Royals | Lexington (A) | Assigned to Lexington (A) |
| Collin Ferguson | 1b | 24.155 | Colorado Rockies | Lancaster (A+) | Activated from disabled list |
| Drew Finley | p | 21.004 | New York Yankees | Charleston (sc) (A) | Assigned to Charleston (sc) (A) |
| Rene Garcia | C | 27.115 | Milwaukee Brewers | Biloxi (AA) | Assigned to Biloxi (AA) |
| Willy Garcia | LF | 24.313 | Chicago White Sox | Charlotte (AAA) | Assigned to Charlotte (AAA) |
| Craig Gentry | LF-RF | 33.228 | Baltimore Orioles | Norfolk (AAA) | Assigned to Norfolk (AAA) |
| Francisco German | p | 20.200 | Detroit Tigers | Gulf Coast Tigers (East) (Rk) | Assigned to Gulf Coast Tigers (East) (Rk) |
| Yoel Gonzalez | C | 20.347 | Pittsburgh Pirates | West Virginia (A) | Assigned to West Virginia (A) |
| Grayson Greiner | C | 24.276 | Detroit Tigers | Erie (AA) | Activated from disabled list |
| Kory Groves | p | 24.315 | Baltimore Orioles | Aberdeen (A-) | Assigned to Aberdeen (A-) |
| Jake Hager | SS | 24.132 | Tampa Bay Rays | Durham (AAA) | Activated from disabled list |
| Tim Hill | P | 27.154 | Kansas City Royals | Northwest Arkansas (AA) | Assigned to Northwest Arkansas (AA) |
| Garrett Hope | c | 23.199 | Los Angeles Dodgers | Ogden (Rk) | Assigned to Ogden (Rk) |
| Micah Johnson | LF | 26.208 | Atlanta Braves | Gwinnett (AAA) | Assigned to Gwinnett (AAA) |
| Ryan Karstetter | 3b | 20.165 | Detroit Tigers | Gulf Coast Tigers (East) (Rk) | Assigned to Gulf Coast Tigers (East) (Rk) |
| Michael Kopech | P | 21.075 | Chicago White Sox | Birmingham (AA) | Reinstated to active roster |
| Braulio Lara | P | 28.206 | Washington Nationals | Harrisburg (AA) | Activated from disabled list |
| Jonathan Loaisiga | p | 22.254 | New York Yankees | Charleston (sc) (A) | Assigned to Charleston (sc) (A) |
| Zach Logue | p | 21.082 | Toronto Blue Jays | Vancouver (A-) | Assigned to Vancouver (A-) |
| Vimael Machin | ss | 23.292 | Chicago Cubs | Myrtle Beach (A+) | Assigned to Myrtle Beach (A+) |
| Luis Madero | p | 20.090 | Arizona Diamondbacks | Hillsboro (A-) | Assigned to Hillsboro (A-) |
| Joey Martarano | 3B | 22.351 | Chicago Cubs | South Bend (A) | Assigned to South Bend (A) |
| Starling Marte | CF | 28.278 | Pittsburgh Pirates | Indianapolis (AAA) | Assigned to Indianapolis (AAA) for rehab |
| Welfrin Mateo | 2b | 21.310 | New York Yankees | Staten Island (A-) | Activated from disabled list |
| Andrew McKirahan | RP | 27.156 | Cincinnati Reds | Billings (Rk) | Assigned to Billings (Rk) |
| Alex Mejia | IF | 26.177 | St. Louis Cardinals | Memphis (AAA) | Assigned to Memphis (AAA) |
| Francisco Mejia | C | 21.261 | Cleveland Indians | Akron (AA) | Reinstated to active roster |
| Jose Morales | P | 22.152 | Washington Nationals | Hagerstown (A) | Assigned to Hagerstown (A) |
| Mike Morin | RP | 26.072 | Los Angeles Angels | Salt Lake (AAA) | Assigned to Salt Lake (AAA) |
| Jimmy Murphy | p | 22.273 | Baltimore Orioles | Aberdeen (A-) | Assigned to Aberdeen (A-) |
| Tucker Nathans | IF | 28.250 | Baltimore Orioles | Bowie (AA) | Assigned to Bowie (AA) |
| Gabriel Noriega | SS-2B | 26.304 | Milwaukee Brewers | Colorado Springs (AAA) | Assigned to Colorado Springs (AAA) |
| Chris O'Brien | C | 27.355 | Baltimore Orioles | Bowie (AA) | Assigned to Bowie (AA) |
| Joe Pistorese | p | 24.272 | Seattle Mariners | Modesto (A+) | Assigned to Modesto (A+) |
| Will Reed | p | 21.254 | Pittsburgh Pirates | Gulf Coast Pirates (Rk) | Assigned to Gulf Coast Pirates (Rk) |
| Rob Refsnyder | LF | 26.110 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| Jesus Reyes | p | 24.143 | Cincinnati Reds | Pensacola (AA) | Assigned to Pensacola (AA) |
| Trevor Richards | p | 24.060 | Miami Marlins | Jacksonville (AA) | Assigned to Jacksonville (AA) |
| Michael Rivera | p | 20.025 | Seattle Mariners | Arizona Mariners (Rk) | Assigned to Arizona Mariners (Rk) |
| Thomas Robson | P | 24.017 | Toronto Blue Jays | Dunedin (A+) | Activated from disabled list |
| Jerry Sands | LF | 29.290 | San Francisco Giants | Richmond (AA) | Activated from disabled list |
| Danny Santana | RF-LF | 26.249 | Atlanta Braves | Gwinnett (AAA) | Assigned to Gwinnett (AAA) for rehab |
| Daniel Schlereth | P | 31.066 | Miami Marlins | New Orleans (AAA) | Assigned to New Orleans (AAA) |
| Ryan Schlosser | p | 21.165 | Atlanta Braves | Rome (A) | Assigned to Rome (A) |
| Jaime Schultz | P | 26.024 | Tampa Bay Rays | Durham (AAA) | Assigned to Durham (AAA) |
| Pedro Severino | C | 23.359 | Washington Nationals | Syracuse (AAA) | Activated from DL |
| Chance Sisco | C | 22.140 | Baltimore Orioles | Norfolk (AAA) | Reinstated to active roster |
| Keith Skinner | c | 23.091 | New York Yankees | Staten Island (A-) | Assigned to Staten Island (A-) |
| Joe Smith | RP | 33.114 | Toronto Blue Jays | Buffalo (AAA) | Assigned to Buffalo (AAA) for rehab |
| Sammy Solis | RP | 28.338 | Washington Nationals | Syracuse (AAA) | Assigned to Syracuse (AAA) |
| Juan Soto | of | 18.262 | Washington Nationals | Hagerstown (A) | Activated from disabled list |
| Dylan Stock | p | 20.358 | Detroit Tigers | Gulf Coast Tigers (East) (Rk) | Assigned to Gulf Coast Tigers (East) (Rk) |
| Albert Suarez | SP | 27.279 | San Francisco Giants | Sacramento (AAA) | Assigned to Sacramento (AAA) |
| Kevin Taylor | 2B | 26.001 | New York Mets | Binghamton (AA) | Activated from disabled list |
| Michael Velasquez | P | 24.136 | Tampa Bay Rays | Princeton (Rk) | Assigned to Princeton (Rk) |
| Jonny Venters | RP | 32.116 | Tampa Bay Rays | Charlotte (A+) | Assigned to Charlotte (A+) |
| Javier Villarroel | p | 19.256 | Detroit Tigers | Gulf Coast Tigers (East) (Rk) | Assigned to Gulf Coast Tigers (East) (Rk) |
| Brandon White | p | 22.205 | Atlanta Braves | Florida (A+) | Assigned to Florida (A+) |
| Mac Williamson | OF | 26.364 | San Francisco Giants | Sacramento (AAA) | Assigned to Sacramento (AAA) |
| Wes Wilson | C | 27.330 | New York Yankees | Tampa (A+) | Assigned to Tampa (A+) |
| Shawn Zarraga | C | 28.174 | Los Angeles Dodgers | Tulsa (AA) | Assigned to Tulsa (AA) |
| Johnny Cueto | SP | 31.149 | San Francisco Giants | San Francisco Giants (MLB) | DL-10 Blister issues, right hand |
| Madison Bumgarner | SP | 27.347 | San Francisco Giants | San Francisco Giants (MLB) | Activated from DL |
| Magneuris Sierra | OF | 21.098 | St. Louis Cardinals | St. Louis Cardinals (MLB) | Recalled from Springfield (AA) |
| Stephen Piscotty | RF | 26.181 | St. Louis Cardinals | St. Louis Cardinals (MLB) | DL-10 Right groin strain |
| Joe Mauer | 1B | 34.086 | Minnesota Twins | Minnesota Twins (MLB) | Activated from DL |
| Byron Buxton | CF | 23.208 | Minnesota Twins | Minnesota Twins (MLB) | DL-10 Left groin strain |
| Joe Kelly | RP | 29.035 | Boston Red Sox | Boston Red Sox (MLB) | DL-10 Strained left hamstring |
| Brandon Workman | RP | 28.335 | Boston Red Sox | Boston Red Sox (MLB) | Recalled from Pawtucket (AAA) |
| Will Harris | RP | 32.320 | Houston Astros | Houston Astros (MLB) | DL-10 Right shoulder inflammation |
| Reymin Guduan | P | 25.120 | Houston Astros | Houston Astros (MLB) | Recalled from Fresno (AAA) |
| Starlin Castro | 2B | 27.112 | New York Yankees | New York Yankees (MLB) | Activated from DL |
| Jeanmar Gomez | RP | 28.285 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Signed to Minor League Contract |
| Chris Rearick | P | 29.222 | Los Angeles Dodgers | Tulsa (AA) | DL-7 Injured |
| Layne Somsen | P | 28.039 | Los Angeles Dodgers | Tulsa (AA) | DL-7 Injured |
| Nick Tepesch | SP | 28.275 | Minnesota Twins | Gulf Coast Twins (Rk) | DL-7 Injured |
| Juan Ciriaco | 2B | 27.008 | Colorado Rockies | Albuquerque (AAA) | DL-7 Injured |
| Stephen Johnson | P | 26.143 | San Francisco Giants | Richmond (AA) | DL-7 Injured |
| Ashley Graeter | IF | 27.284 | Colorado Rockies | Hartford (AA) | DL-7 Injured |
| David Holman | P | 27.044 | Colorado Rockies | Hartford (AA) | DL-7 Injured |
| Dustin Houle | C | 23.247 | Milwaukee Brewers | Biloxi (AA) | DL-7 Injured |
| Stetson Allie | 3B | 26.123 | Los Angeles Dodgers | Tulsa (AA) | DL-7 Injured |
| Cam Gibson | of | 23.152 | Detroit Tigers | Lakeland (A+) | DL-7 Injured |
| Charlie Meyer | c | 24.185 | Milwaukee Brewers | Carolina (A+) | DL-7 Injured |
| Greyfer Eregua | P | 23.272 | Los Angeles Angels | Inland Empire (A+) | DL-7 Injured |
| Jose Pujols | RF-OF | 21.289 | Philadelphia Phillies | Clearwater (A+) | DL-7 Injured |
| Andrew Potter | P | 23.155 | | | Released by Pirates |
| Dany Hernandez | p | 26.035 | Pittsburgh Pirates | Bristol (Rk) | Assigned to Bristol (Rk) |
| Mike Blazek | RP | 28.120 | Milwaukee Brewers | Colorado Springs (AAA) | Assigned to Colorado Springs (AAA) |
