| Telmito Agustin | of | 19.326 | Washington Nationals | Hagerstown (A) | Assigned to Hagerstown (A) |
| Arismendy Alcantara | SS | 24.307 | Oakland Athletics | Stockton (A+) | Assigned to Stockton (A+) |
| Matt Anderson | P | 24.287 | Seattle Mariners | Jackson (AA) | Activated from disabled list |
| Shawn Armstrong | RP | 25.354 | Cleveland Indians | Lake County (A) | Assigned to Lake County (A) |
| Pedro Baez | RP | 28.173 | Los Angeles Dodgers | Tulsa (AA) | Assigned to Tulsa (AA) |
| Franklin Barreto | SS | 20.186 | Oakland Athletics | Nashville (AAA) | Assigned to Nashville (AAA) |
| Will Barring | of | 23.129 | New York Mets | Columbia (A) | Assigned to Columbia (A) |
| Alex Bostic | p | 21.290 | San Francisco Giants | San Jose (A+) | Assigned to San Jose (A+) |
| Steven Brault | SP | 24.124 | Pittsburgh Pirates | Bristol (Rk) | Assigned to Bristol (Rk) |
| Tyler Britton | p | 22.178 | Houston Astros | Tri City (A-) | Assigned to Tri City (A-) |
| Andrew Brodbeck | 2b | 23.221 | St. Louis Cardinals | Palm Beach (A+) | Activated from disabled list |
| Stephen Bruno | SS | 25.287 | Chicago Cubs | Tennessee (AA) | Reinstated to active roster |
| Vicente Campos | P | 24.035 | Arizona Diamondbacks | Reno (AAA) | Assigned to Reno (AAA) |
| Jacy Cave | of | 21.222 | Arizona Diamondbacks | Kane County (A) | Assigned to Kane County (A) |
| Ryan Chaffee | P | 28.105 | Miami Marlins | New Orleans (AAA) | Assigned to New Orleans (AAA) |
| Christian Colon | 2B-3B | 27.109 | Kansas City Royals | Omaha (AAA) | Assigned to Omaha (AAA) |
| Tommy Coyle | 2B-SS | 25.311 | Tampa Bay Rays | Montgomery (AA) | Activated from disabled list |
| Colton Davis | p | 22.238 | Minnesota Twins | Elizabethton (Rk) | Activated from disabled list |
| Miguel Del Castillo | C | 24.322 | San Diego Padres | El Paso (AAA) | Assigned to El Paso (AAA) |
| Sidney Duprey Conde | p | 19.289 | San Francisco Giants | Salem-Keizer (A-) | Assigned to Salem-Keizer (A-) |
| Geno Encina | p | 22.055 | Toronto Blue Jays | Lansing (A) | Assigned to Lansing (A) |
| Billy Fleming | 2B | 23.345 | New York Yankees | Staten Island (A-) | Assigned to Staten Island (A-) |
| Giovanny Gallegos | P | 25.017 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| Austin Gomber | P | 22.281 | St. Louis Cardinals | Springfield (AA) | Activated from disabled list |
| Alex Gunn | p | 24.358 | Arizona Diamondbacks | Kane County (A) | Assigned to Kane County (A) |
| Jacob Heyward | of | 21.030 | San Francisco Giants | Salem-Keizer (A-) | Assigned to Salem-Keizer (A-) |
| Nick Highberger | p | 22.300 | Oakland Athletics | Stockton (A+) | Assigned to Stockton (A+) |
| Jon Kennedy | p | 20.346 | Atlanta Braves | Carolina (A+) | Assigned to Carolina (A+) |
| Brandon Macias | SS-3B | 27.325 | Milwaukee Brewers | Colorado Springs (AAA) | Activated from disabled list |
| Mark Malave | | 21.238 | Chicago Cubs | South Bend (A) | Assigned to South Bend (A) |
| Evan Marshall | RP | 26.135 | Arizona Diamondbacks | Reno (AAA) | Activated from disabled list |
| Jonathan Martinez | P | 22.065 | Chicago Cubs | Tennessee (AA) | Assigned to Tennessee (AA) |
| Brian Moran | P | 27.335 | Atlanta Braves | Gwinnett (AAA) | Activated from disabled list |
| Zach Morris | p | 23.178 | Philadelphia Phillies | Lakewood (A) | Activated from disabled list |
| James Naile | p | 23.204 | Oakland Athletics | Midland (AA) | Assigned to Midland (AA) |
| Rey Navarro | 2B-3B | 26.252 | Los Angeles Angels | Orem (Rk) | Activated from disabled list |
| Ryan Newell | P | 25.074 | Miami Marlins | Greensboro (A) | Assigned to Greensboro (A) |
| Justin O'Conner | C | 24.153 | Tampa Bay Rays | Montgomery (AA) | Activated from disabled list |
| Edgar Olmos | RP | 26.141 | Baltimore Orioles | Norfolk (AAA) | Reinstated to active roster |
| Logan Ondrusek | RP | 31.199 | Baltimore Orioles | Bowie (AA) | Assigned to Bowie (AA) |
| Brad Peacock | RP | 28.211 | Houston Astros | Fresno (AAA) | Assigned to Fresno (AAA) |
| Jose Pena | P | 25.162 | New York Yankees | Charleston (sc) (A) | Assigned to Charleston (sc) (A) |
| Tyson Perez | P | 26.247 | Houston Astros | Gulf Coast Astros (Rk) | Activated from disabled list |
| Tyrone Perry | 1b | 20.312 | Milwaukee Brewers | Arizona Brewers (Rk) | Assigned to Arizona Brewers (Rk) |
| Cal Quantrill | p | 21.202 | San Diego Padres | Fort Wayne (A) | Assigned to Fort Wayne (A) |
| Cody Ramer | ss | 22.280 | Los Angeles Angels | Orem (Rk) | Assigned to Orem (Rk) |
| Alfredo Reyes | SS | 22.331 | Pittsburgh Pirates | West Virginia (A) | Activated from disabled list |
| Gregori Rivero | C | 20.096 | Philadelphia Phillies | Clearwater (A+) | Assigned to Clearwater (A+) |
| Niuman Romero | SS | 31.219 | New York Mets | Las Vegas (AAA) | Activated from disabled list |
| Wilson Santos | P | 24.316 | San Francisco Giants | San Jose (A+) | Assigned to San Jose (A+) |
| Max Schrock | ss | 21.323 | Oakland Athletics | Midland (AA) | Assigned to Midland (AA) |
| Steve Selsky | RF-LF | 27.042 | Cincinnati Reds | Louisville (AAA) | Assigned to Louisville (AAA) |
| Cody Stashak | p | 22.088 | Minnesota Twins | Fort Myers (A+) | Activated from disabled list |
| Drew Steckenrider | OF-P | 25.233 | Miami Marlins | New Orleans (AAA) | Activated from disabled list |
| Jameson Taillon | SP | 24.287 | Pittsburgh Pirates | Bristol (Rk) | Assigned to Bristol (Rk) |
| Duane Underwood | P | 22.042 | Chicago Cubs | Myrtle Beach (A+) | Assigned to Myrtle Beach (A+) |
| Cesar Valdez | P | 31.167 | Houston Astros | Fresno (AAA) | Reinstated to active roster |
| Emilio Vargas | p | 20.019 | Arizona Diamondbacks | Visalia (A+) | Assigned to Visalia (A+) |
| Mike Wallace | p | 22.102 | Pittsburgh Pirates | West Virginia (A-) | Assigned to West Virginia (A-) |
| Austin Wynns | C | 25.264 | Baltimore Orioles | Norfolk (AAA) | Assigned to Norfolk (AAA) |
| Eric Young | lf | 31.098 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Traded from Brewers to Yankees for cash considerations |
| Shawn Zarraga | C | 27.222 | Los Angeles Dodgers | Oklahoma City (AAA) | Assigned to Oklahoma City (AAA) |
| Michael Bourn | RF | 33.247 | Baltimore Orioles | Baltimore Orioles (MLB) | Traded from Diamondbacks to Orioles for Jason Heinrich |
| Jason Heinrich | 1b | 20.085 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | Traded from Orioles to Diamondbacks for Michael Bourn |
| Joey Rickard | RF-LF | 25.102 | Baltimore Orioles | Baltimore Orioles (MLB) | Transferred to 60-day DL |
| Justin Ruggiano | cf | 34.141 | New York Mets | New York Mets (MLB) | Transferred to 60-day DL |
| Fernando Salas | CL | 31.093 | New York Mets | New York Mets (MLB) | Traded from Angels to Mets for Erik Manoah |
| Erik Manoah | P | 20.253 | Los Angeles Angels | Los Angeles Angels (MLB) | Traded from Mets to Angels for Fernando Salas |
| Nevin Ashley | C | 32.017 | Texas Rangers | Round Rock (AAA) | Traded from Mets to Rangers for future considerations |
| Christian Bergman | RP | 28.119 | Colorado Rockies | Colorado Rockies (MLB) | Recalled from Albuquerque (AAA) |
| Luis Avilan | RP | 27.043 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Recalled from Oklahoma City (AAA) |
| Darwin Barney | 2B-3B | 30.296 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Placed on bereavement list |
| Ryan Goins | 3B-2B | 28.200 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Recalled from Buffalo (AAA) |
| Aaron Sanchez | SP | 24.061 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Recalled from Dunedin (A+) |
| Drew Stubbs | RF | 31.331 | Baltimore Orioles | Baltimore Orioles (MLB) | Claimed off waivers from Rangers by Orioles |
| Ben Gamel | RF | 24.106 | Seattle Mariners | Seattle Mariners (MLB) | Traded from Yankees to Mariners for Juan De Paula and Jio Orozco |
| Juan De Paula | p | 18.343 | New York Yankees | New York Yankees (MLB) | Traded from Mariners with Jio Orozco to Yankees for Ben Gamel |
| Jio Orozco | p | 19.016 | New York Yankees | New York Yankees (MLB) | Traded from Mariners with Juan De Paula to Yankees for Ben Gamel |
| Chien-Ming Wang | RP | 36.153 | Kansas City Royals | Kansas City Royals (MLB) | DL-15 Right biceps tendinitis |
| Brooks Pounders | RP | 25.339 | Kansas City Royals | Kansas City Royals (MLB) | Recalled from Omaha (AAA) |
| Scott Alexander | RP | 27.052 | Kansas City Royals | Kansas City Royals (MLB) | Recalled from Omaha (AAA) |
| Jake Esch | SP | 26.157 | Miami Marlins | Miami Marlins (MLB) | Recalled from New Orleans (AAA) |
| David Phelps | SP | 29.326 | Miami Marlins | Miami Marlins (MLB) | DL-15 Left oblique strain |
| Yan Gomes | C | 29.043 | Cleveland Indians | Cleveland Indians (MLB) | Transferred to 60-day DL |
| Tommy La Stella | 3B | 27.212 | Chicago Cubs | Chicago Cubs (MLB) | Recalled from Iowa (AAA) |
| Ashur Tolliver | P | 28.220 | Baltimore Orioles | Norfolk (AAA) | Designated for Assignment |
| Tyson Ross | SP | 29.131 | San Diego Padres | San Diego Padres (MLB) | Transferred to 60-day DL |
| Perci Garner | RP | 27.261 | Cleveland Indians | Cleveland Indians (MLB) | Contract purchased from minors |
| Kyle Lobstein | RP | 27.019 | Baltimore Orioles | Baltimore Orioles (MLB) | Traded from Pirates to Orioles for Zach Phillips |
| Kyle Lobstein | RP | 27.019 | Baltimore Orioles | Baltimore Orioles (MLB) | Designated for Assignment |
| Zach Phillips | P | 29.344 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Traded from Orioles to Pirates for Kyle Lobstein |
| Hector Sanchez | C | 26.287 | San Diego Padres | San Diego Padres (MLB) | Contract purchased from minors |
| Christian Bethancourt | C-RF | 24.364 | San Diego Padres | San Diego Padres (MLB) | DL-15 Left intercostal strain |
| Mark Reynolds | 1B | 33.028 | Colorado Rockies | Colorado Rockies (MLB) | Activated from DL |
| Daniel Descalso | SS-2B | 29.316 | Colorado Rockies | Colorado Rockies (MLB) | Placed on paternity leave |
| Coco Crisp | LF | 36.304 | Cleveland Indians | Cleveland Indians (MLB) | Traded from Athletics to Indians for Colt Hynes |
| Colt Hynes | RP | 31.064 | Oakland Athletics | Oakland Athletics (MLB) | Traded from Indians to Athletics for Coco Crisp |
| Joey Wendle | 2B | 26.127 | Oakland Athletics | Oakland Athletics (MLB) | Recalled from Nashville (AAA) |
| Shelby Miller | SP | 25.325 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | Recalled from Reno (AAA) |
| Jarrett Grube | P | 34.299 | Seattle Mariners | Tacoma (AAA) | Outrighted to minors |
| Alexi Casilla | 2b | 32.042 | Toronto Blue Jays | Buffalo (AAA) | DL-7 Injured |
| Chris Reed | P | 26.103 | Miami Marlins | New Orleans (AAA) | Placed on restricted list |
| Clint Frazier | OF | 21.359 | New York Yankees | Scranton/Wilkes-Barre (AAA) | DL-7 Injured |
| David Peterson | P | 26.239 | Atlanta Braves | Mississippi (AA) | DL-7 Injured |
| Dovydas Neverauskas | P | 23.229 | Pittsburgh Pirates | Indianapolis (AAA) | Suspended for remaining of season due too off-field incident |
| Gift Ngoepe | SS-2B | 26.225 | Pittsburgh Pirates | Indianapolis (AAA) | Suspended for remaining of season due too off-field incident |
| Kevin Medrano | IF | 26.102 | Arizona Diamondbacks | Reno (AAA) | DL-7 Injured |
| Mike Hauschild | P | 26.221 | Houston Astros | Fresno (AAA) | Placed on temporary inactive list |
| Trevor Oaks | P | 23.158 | Los Angeles Dodgers | Oklahoma City (AAA) | DL-7 Injured |
| Victor Mateo | P | 27.035 | Atlanta Braves | Mississippi (AA) | DL-7 Injured |
| El'Hajj Muhammad | P | 25.055 | Cincinnati Reds | Pensacola (AA) | Placed on temporary inactive list |
| Joseph Odom | C | 24.235 | Atlanta Braves | Mississippi (AA) | DL-7 Injured |
| Kohl Stewart | P | 21.328 | Minnesota Twins | Chattanooga (AA) | DL-7 Injured |
| Ryan Walker | IF | 24.158 | Minnesota Twins | Chattanooga (AA) | DL-7 Injured |
| Elio Castillo | 1B | 22.183 | Texas Rangers | High Desert (A+) | Placed on temporary inactive list |
| LJ Brewster | p | 22.121 | Miami Marlins | Greensboro (A) | DL-7 Injured |
