| Casey McGehee | 3B | 33.298 | Detroit Tigers | Detroit Tigers (MLB) | Contract purchased from minors |
| Kyle Ryan | SP | 24.316 | Detroit Tigers | Detroit Tigers (MLB) | Recalled from Toledo (AAA) |
| Jordan Zimmermann | SP | 30.075 | Detroit Tigers | Detroit Tigers (MLB) | DL-15 Strained right lat |
| Nick Castellanos | 3B | 24.155 | Detroit Tigers | Detroit Tigers (MLB) | DL-15 Fractured left hand |
| Jose Valdez | RP | 26.158 | Los Angeles Angels | Los Angeles Angels (MLB) | Recalled from Salt Lake (AAA) |
| Tim Lincecum | SP | 32.052 | Los Angeles Angels | Los Angeles Angels (MLB) | Designated for Assignment |
| Matt Thornton | RP | 39.325 | San Diego Padres | San Diego Padres (MLB) | Designated for Assignment |
| Andrew Bailey | RP | 32.067 | | | Released by Phillies |
| Brett Oberholtzer | SP | 27.036 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Designated for Assignment |
| Jake Thompson | SP | 22.187 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Contract purchased from minors |
| Taijuan Walker | SP | 23.358 | Seattle Mariners | Seattle Mariners (MLB) | Activated from DL |
| Clayton Richard | SP | 32.329 | San Diego Padres | San Diego Padres (MLB) | Signed to 1-year contract for 2016-2016 ($0m) |
| Curtis Partch | RP | 29.174 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Contract purchased from minors |
| Roberto Hernandez | RP | 35.341 | Atlanta Braves | Atlanta Braves (MLB) | Contract purchased from minors |
| Desmond Jennings | LF | 29.280 | Tampa Bay Rays | Tampa Bay Rays (MLB) | DL-15 Left knee contusion |
| Mikie Mahtook | CF | 26.249 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Activated from DL |
| Ryan Zimmerman | 1B | 31.312 | Washington Nationals | Washington Nationals (MLB) | DL-15 Left wrist contusion |
| Brian Goodwin | OF | 25.277 | Washington Nationals | Washington Nationals (MLB) | Recalled from Syracuse (AAA) |
| Bud Norris | RP | 31.157 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | DL-15 Mild back strain |
| Ross Stripling | P | 26.256 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Recalled from Oklahoma City (AAA) |
| Pat Venditte | RP | 31.037 | Seattle Mariners | Tacoma (AAA) | Traded from Blue Jays to Mariners for PTBNL |
| Donn Roach | SP | 26.235 | Seattle Mariners | Tacoma (AAA) | Designated for Assignment |
| Hunter Cervenka | RP | 26.215 | Miami Marlins | Miami Marlins (MLB) | Traded from Braves to Marlins for Anfernee Seymour and Michael Mader |
| Michael Mader | P | 22.169 | Atlanta Braves | Atlanta Braves (MLB) | Traded from Marlins with Anfernee Seymour to Braves for Hunter Cervenka |
| Anfernee Seymour | SS | 21.043 | Atlanta Braves | Atlanta Braves (MLB) | Traded from Marlins with Michael Mader to Braves for Hunter Cervenka |
| Arquimedes Caminero | RP | 29.051 | Seattle Mariners | Seattle Mariners (MLB) | Traded from Pirates to Mariners for future considerations |
| Patrick Schuster | P | 25.280 | Oakland Athletics | Oakland Athletics (MLB) | Recalled from Nashville (AAA) |
| Blake Parker | RP | 31.048 | Seattle Mariners | Seattle Mariners (MLB) | Designated for Assignment |
| Doug Fister | SP | 32.184 | Houston Astros | Houston Astros (MLB) | Reinstated from paternity leave |
| T.J. House | P | 26.311 | Cleveland Indians | Cleveland Indians (MLB) | Recalled from Columbus (AAA) |
| Chasen Shreve | RP | 26.025 | New York Yankees | New York Yankees (MLB) | Recalled from Scranton/Wilkes-Barre (AAA) |
| Nate Schierholtz | rf | 32.173 | | | Suspended 80 games for violation of MLB drug policy for PED |
| Scott Alexander | RP | 27.027 | Kansas City Royals | Arizona Royals (Rk) | Assigned to Arizona Royals (Rk) |
| Eliezer Alvarez | 2B-3B | 21.295 | St. Louis Cardinals | Peoria (A) | Activated from disabled list |
| Will Anderson | P | 23.345 | St. Louis Cardinals | Gulf Coast Cardinals (Rk) | Assigned to Gulf Coast Cardinals (Rk) |
| John Barbato | RP | 24.026 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| Agapito Barrios | p | 22.249 | Houston Astros | Quad Cities (A) | Assigned to Quad Cities (A) |
| Carson Blair | C | 26.292 | Texas Rangers | Frisco (AA) | Assigned to Frisco (AA) |
| Jake Brentz | P | 21.326 | Seattle Mariners | Clinton (A) | Assigned to Clinton (A) |
| Lucas Brown | p | 22.268 | Baltimore Orioles | Gulf Coast Orioles (Rk) | Assigned to Gulf Coast Orioles (Rk) |
| Stephen Bruno | SS | 25.262 | Chicago Cubs | Eugene (A-) | Assigned to Eugene (A-) |
| Henry Centeno | P | 21.347 | Tampa Bay Rays | Charlotte (A+) | Assigned to Charlotte (A+) |
| Nick Collins | c | 22.115 | Oakland Athletics | Beloit (A) | Assigned to Beloit (A) |
| Cortland Cox | P | 21.276 | Cleveland Indians | Akron (AA) | Assigned to Akron (AA) |
| Jason Creasy | P | 24.085 | Pittsburgh Pirates | West Virginia (A-) | Activated from disabled list |
| Matt Crownover | p | 23.154 | Washington Nationals | Potomac (A+) | Reinstated to active roster |
| Frederick Cuevas | of | 18.283 | New York Yankees | Gulf Coast Yankees (Rk) | Assigned to Gulf Coast Yankees (Rk) |
| Jacob Dahlstrand | P | 24.133 | Boston Red Sox | Portland (AA) | Activated from disabled list |
| Matt Dean | 3B | 23.227 | Toronto Blue Jays | New Hampshire (AA) | Assigned to New Hampshire (AA) |
| Samuel Deduno | SP | 33.035 | Baltimore Orioles | Norfolk (AAA) | Assigned to Norfolk (AAA) |
| Casey Delgado | p | 26.052 | New York Mets | St. Lucie (A+) | Activated from disabled list |
| Jordan Desguin | p | 22.280 | Milwaukee Brewers | Wisconsin (A) | Assigned to Wisconsin (A) |
| Raynel Espinal | p | 22.304 | New York Yankees | Pulaski (Rk) | Assigned to Pulaski (Rk) |
| Jon Fitzsimmons | P | 24.251 | Cleveland Indians | Lake County (A) | Assigned to Lake County (A) |
| Bladimil Franco | OF | 22.281 | St. Louis Cardinals | State College (A-) | Assigned to State College (A-) |
| J.J. Franco | SS | 24.186 | Chicago White Sox | Great Falls (Rk) | Assigned to Great Falls (Rk) |
| Aramis Garcia | C | 23.206 | San Francisco Giants | Arizona Giants (Rk) | Assigned to Arizona Giants (Rk) |
| Jairo Garcia | p | 21.193 | New York Yankees | Gulf Coast Yankees (Rk) | Assigned to Gulf Coast Yankees (Rk) |
| Gabby Guerrero | P | 22.238 | Arizona Diamondbacks | Mobile (AA) | Assigned to Mobile (AA) |
| Joe Harvey | P | 24.210 | New York Yankees | Gulf Coast Yankees (Rk) | Assigned to Gulf Coast Yankees (Rk) |
| Shawn Haviland | P | 30.269 | Cleveland Indians | Columbus (AAA) | Signed to Minor League Contract |
| Elieser Hernandez | P | 21.095 | Houston Astros | Lancaster (A+) | Assigned to Lancaster (A+) |
| Jared James | of | 22.165 | Atlanta Braves | Rome (A) | Assigned to Rome (A) |
| Connor Jones | p | 21.300 | St. Louis Cardinals | State College (A-) | Assigned to State College (A-) |
| Brian Keller | p | 22.046 | New York Yankees | Pulaski (Rk) | Assigned to Pulaski (Rk) |
| Nick Kingham | P | 24.272 | Pittsburgh Pirates | Gulf Coast Pirates (Rk) | Assigned to Gulf Coast Pirates (Rk) |
| Ryan Krill | 1b | 23.142 | New York Yankees | Gulf Coast Yankees (Rk) | Assigned to Gulf Coast Yankees (Rk) |
| Trey Lambert | P | 25.062 | Miami Marlins | Greensboro (A) | Assigned to Greensboro (A) |
| Trevor Lane | p | 22.102 | New York Yankees | Gulf Coast Yankees (Rk) | Assigned to Gulf Coast Yankees (Rk) |
| Kai-Wei Lin | p | 20.140 | Arizona Diamondbacks | Missoula (Rk) | Assigned to Missoula (Rk) |
| Logan Lombana | p | 22.020 | Minnesota Twins | Cedar Rapids (A) | Reinstated to active roster |
| Grayson Long | p | 22.071 | Los Angeles Angels | Arizona Angels (Rk) | Assigned to Arizona Angels (Rk) |
| Braxton Lorenzini | p | 21.123 | San Diego Padres | Tri-City (A-) | Assigned to Tri-City (A-) |
| Casey McGehee | 3B | 33.298 | Detroit Tigers | Toledo (AAA) | Assigned to Toledo (AAA) |
| Zeke McGranahan | P | 25.215 | Baltimore Orioles | Delmarva (A) | Activated from disabled list |
| Shawn Morimando | P | 23.259 | Cleveland Indians | Columbus (AAA) | Assigned to Columbus (AAA) |
| Jose Nin | p | 21.047 | Philadelphia Phillies | Clearwater (A+) | Assigned to Clearwater (A+) |
| Paddy O'Brien | p | 22.303 | New York Yankees | Gulf Coast Yankees (Rk) | Assigned to Gulf Coast Yankees (Rk) |
| Brian Olson | c | 23.197 | Minnesota Twins | Gulf Coast Twins (Rk) | Assigned to Gulf Coast Twins (Rk) |
| Luis Ortiz | P | 20.319 | Milwaukee Brewers | Biloxi (AA) | Assigned to Biloxi (AA) |
| Dillon Overton | P | 24.355 | Oakland Athletics | Nashville (AAA) | Assigned to Nashville (AAA) |
| Brad Peacock | SP | 28.186 | Houston Astros | Fresno (AAA) | Assigned to Fresno (AAA) |
| Shawn Pleffner | RF | 26.354 | Washington Nationals | Harrisburg (AA) | Activated from disabled list |
| Jose Polonia | 3b | 20.239 | New York Yankees | Gulf Coast Yankees (Rk) | Assigned to Gulf Coast Yankees (Rk) |
| Victor Robles | of | 19.079 | Washington Nationals | Gulf Coast Nationals (Rk) | Activated from disabled list |
| Elier Sanchez | p | 29.306 | San Diego Padres | Lake Elsinore (A+) | Assigned to Lake Elsinore (A+) |
| Donny Sands | 3b | 20.082 | New York Yankees | Pulaski (Rk) | Assigned to Pulaski (Rk) |
| Wilson Santos | P | 24.291 | San Francisco Giants | Arizona Giants (Rk) | Assigned to Arizona Giants (Rk) |
| Jesse Scholtens | p | 22.122 | San Diego Padres | Tri-City (A-) | Assigned to Tri-City (A-) |
| Wilson Soriano | OF | 24.219 | Colorado Rockies | Hartford (AA) | Reinstated to active roster |
| Neftali Soto | 1b | 27.159 | Washington Nationals | Syracuse (AAA) | Assigned to Syracuse (AAA) |
| Ryan Stephens | OF | 24.031 | Colorado Rockies | Modesto (A+) | Assigned to Modesto (A+) |
| Tyler Stephenson | c | 19.355 | Cincinnati Reds | Dayton (A) | Activated from disabled list |
| James Teague | p | 21.342 | Baltimore Orioles | Aberdeen (A-) | Assigned to Aberdeen (A-) |
| Kodie Tidwell | ss | 22.003 | San Diego Padres | Lake Elsinore (A+) | Assigned to Lake Elsinore (A+) |
| Matt Trowbridge | P | 23.135 | Baltimore Orioles | Gulf Coast Orioles (Rk) | Activated from disabled list |
| Chuck Vazquez | c | 22.316 | New York Yankees | Gulf Coast Yankees (Rk) | Assigned to Gulf Coast Yankees (Rk) |
| Carlos Vidal | of | 20.251 | New York Yankees | Staten Island (A-) | Assigned to Staten Island (A-) |
| Jason Vosler | IF | 22.334 | Chicago Cubs | Tennessee (AA) | Activated from disabled list |
| Brandon Wagner | 3b | 20.348 | New York Yankees | Pulaski (Rk) | Assigned to Pulaski (Rk) |
| T.J. Weir | IF-P | 24.326 | San Diego Padres | San Antonio (AA) | Assigned to San Antonio (AA) |
| Matt Whitehouse | P | 25.115 | Cleveland Indians | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Patrick Wisdom | IF | 24.345 | St. Louis Cardinals | Gulf Coast Cardinals (Rk) | Activated from disabled list |
| Hunter Wood | P | 22.359 | Tampa Bay Rays | Montgomery (AA) | Assigned to Montgomery (AA) |
| Bobby Korecky | P | 36.325 | Toronto Blue Jays | Buffalo (AAA) | DL-7 Injured |
| Marc Krauss | 1B | 28.306 | New York Mets | Las Vegas (AAA) | DL-7 Injured |
| Ryan Lollis | LF | 29.233 | San Francisco Giants | Sacramento (AAA) | DL-7 Injured |
| Auston Bousfield | OF | 23.032 | San Diego Padres | El Paso (AAA) | DL-7 Injured |
| Brady Shoemaker | LF | 29.088 | | | Released by White Sox |
| John Werner | p | 24.216 | Texas Rangers | Hickory (A) | DL-7 Injured |
| Jorge Marban | P | 27.244 | | | Released by Red Sox |
| Angel Villalona | IF | 25.358 | San Francisco Giants | Richmond (AA) | DL-7 Injured |
| Luis Mendez | 2B-SS | 23.217 | Texas Rangers | Frisco (AA) | DL-7 Injured |
| Ryan Cordell | OF | 24.128 | Texas Rangers | Frisco (AA) | DL-7 Injured |
| Adenson Verastegui | p | 23.168 | | | Released by Tigers |
| Bralin Jackson | OF | 22.247 | Tampa Bay Rays | Charlotte (A+) | DL-7 Injured |
| Daniel Bravo | SS | 21.171 | San Diego Padres | Lake Elsinore (A+) | Suspended |
| Edmundo Sosa | SS | 20.153 | St. Louis Cardinals | Palm Beach (A+) | DL-7 Injured |
| Jason Hoppe | P | 24.054 | Los Angeles Angels | Inland Empire (A+) | Placed on temporary inactive list |
| Jose Fernandez | SS | 23.078 | | | Released by Braves |
| Rogelio Armenteros | p | 22.037 | Houston Astros | Lancaster (A+) | Placed on temporary inactive list |
| Wirkin Estevez | P | 24.144 | Washington Nationals | Potomac (A+) | DL-7 Injured |
| Austin Smith | p | 20.028 | San Diego Padres | Fort Wayne (A) | DL-7 Injured |
| Dalton Geekie | p | 21.307 | Atlanta Braves | Rome (A) | DL-7 Injured |
| Joe Pistorese | p | 23.295 | Seattle Mariners | Clinton (A) | Placed on temporary inactive list |
| Kevin Franklin | 3B | 21.255 | Cincinnati Reds | Dayton (A) | DL-7 Injured |
| Leudys Baez | of | 20.041 | Atlanta Braves | Rome (A) | DL-7 Injured |
| Matt Jones | OF | 22.150 | Los Angeles Dodgers | Great Lakes (A) | DL-7 Injured |
| Matt Railey | OF | 21.143 | | | Released by Diamondbacks |
| Victor Gonzalez | P | 20.264 | Los Angeles Dodgers | Great Lakes (A) | DL-7 Injured |
| Wigberto Nevarez | C | 24.324 | Atlanta Braves | Rome (A) | DL-7 Injured |
| Brandon Marsh | of | 18.231 | Los Angeles Angels | Arizona Angels (Rk) | DL-60 Injured |
| Brandon Bonilla | p | 22.289 | Baltimore Orioles | Gulf Coast Orioles (Rk) | Signed out of draft (Hawaii Pacific) |
| T.J. Friedl | of | 20.358 | Cincinnati Reds | Billings (Rk) | Signed as undrafted free agent (Nevada) |
| Juan Torres | p | 21.073 | Arizona Diamondbacks | Arizona Diamondbacks (Rk) | Assigned to AZL Diamondbacks (Rk) |
