| Jose Rondon | SS | 22.149 | San Diego Padres | San Diego Padres (MLB) | Recalled from San Antonio (AA) |
| Logan Ondrusek | RP | 31.167 | Baltimore Orioles | Baltimore Orioles (MLB) | Signed to 1-year contract for 2016-2016 ($0m) |
| Chaz Roe | RP | 29.294 | Baltimore Orioles | Baltimore Orioles (MLB) | Designated for Assignment |
| Steven Brault | SP | 24.092 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Recalled from Indianapolis (AAA) |
| Zach McAllister | SP | 28.235 | Cleveland Indians | Cleveland Indians (MLB) | Activated from DL |
| Jeff Manship | RP | 31.195 | Cleveland Indians | Cleveland Indians (MLB) | DL-15 Right wrist tendinitis |
| Kyle Lohse | RP | 37.299 | | | Refused minor league assignment, declared free agent |
| Jose Lobaton | C | 31.282 | Washington Nationals | Washington Nationals (MLB) | DL-15 Left elbow tendinitis |
| Pedro Severino | C | 23.010 | Washington Nationals | Washington Nationals (MLB) | Recalled from Syracuse (AAA) |
| Logan Morrison | 1B | 28.340 | Tampa Bay Rays | Tampa Bay Rays (MLB) | DL-15 Strained right forearm |
| Oswaldo Arcia | RF | 25.082 | Tampa Bay Rays | Tampa Bay Rays (MLB) | DL-15 Strained right elbow |
| Brad Boxberger | RP | 28.064 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Activated from DL |
| Nick Franklin | 2b | 25.150 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Recalled from Durham (AAA) |
| Cole Figueroa | 3B | 29.030 | Miami Marlins | New Orleans (AAA) | Designated for Assignment |
| Lorenzo Cain | CF | 30.108 | Kansas City Royals | Kansas City Royals (MLB) | Activated from DL |
| Cole Gillespie | RF | 32.040 | Miami Marlins | Miami Marlins (MLB) | Designated for Assignment |
| Tyler White | 1B-DH | 25.274 | Houston Astros | Houston Astros (MLB) | Recalled from Fresno (AAA) |
| Luis Valbuena | 3B | 30.242 | Houston Astros | Houston Astros (MLB) | DL-15 Strained right hamstring |
| Cesar Ramos | RP | 32.038 | Detroit Tigers | Detroit Tigers (MLB) | Signed to Minor League Contract |
| Ryan Weber | P | 25.352 | Atlanta Braves | Atlanta Braves (MLB) | Recalled from Gwinnett (AAA) |
| David Peralta | LF | 28.351 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | Activated from DL |
| Andrew Cashner | SP | 29.322 | Miami Marlins | Miami Marlins (MLB) | Traded from Padres with Colin Rea and Tayron Guerrero to Marlins for Jarred Cosart,Josh Naylor,Luis Castillo and Carter Capps |
| Colin Rea | SP | 26.029 | Miami Marlins | Miami Marlins (MLB) | Traded from Padres with Andrew Cashner and Tayron Guerrero to Marlins for Jarred Cosart,Josh Naylor,Luis Castillo and Carter Capps |
| Jarred Cosart | SP | 26.066 | San Diego Padres | San Diego Padres (MLB) | Traded from Marlins with Josh Naylor,Luis Castillo and Carter Capps to Padres for Andrew Cashner,Colin Rea and Tayron Guerrero |
| Carter Capps | RP | 25.357 | San Diego Padres | San Diego Padres (MLB) | Traded from Marlins with Jarred Cosart,Luis Castillo and Josh Naylor to Padres for Andrew Cashner,Colin Rea and Tayron Guerrero |
| Chris Coghlan | LF | 31.042 | Chicago Cubs | Chicago Cubs (MLB) | Activated from DL |
| Guillermo Heredia | of | 25.180 | Seattle Mariners | Seattle Mariners (MLB) | Recalled from Tacoma (AAA) |
| Sandy Alcantara | p | 20.327 | St. Louis Cardinals | Palm Beach (A+) | Assigned to Palm Beach (A+) |
| Travis Ballew | P | 25.090 | Miami Marlins | Jacksonville (AA) | Assigned to Jacksonville (AA) |
| David Berg | p | 23.124 | Chicago Cubs | Tennessee (AA) | Activated from disabled list |
| Julio Borbon | LF-CF | 30.160 | Baltimore Orioles | Bowie (AA) | Outrighted to minors |
| Greg Brody | IF | 24.282 | San Francisco Giants | Arizona Giants (Rk) | Assigned to Arizona Giants (Rk) |
| Ryan Castellanos | p | 22.106 | Detroit Tigers | West Michigan (A) | Assigned to West Michigan (A) |
| C.J. Chatham | ss | 21.220 | Boston Red Sox | Lowell (A-) | Assigned to Lowell (A-) |
| P.J. Conlon | p | 22.261 | New York Mets | St. Lucie (A+) | Activated from disabled list |
| Nick Conner | p | 23.075 | Washington Nationals | Gulf Coast Nationals (Rk) | Assigned to Gulf Coast Nationals (Rk) |
| Josh Conway | OF | 25.109 | Chicago Cubs | Arizona Cubs (Rk) | Assigned to Arizona Cubs (Rk) |
| Keith Couch | P | 26.267 | Boston Red Sox | Portland (AA) | Assigned to Portland (AA) |
| Derian Cruz | ss | 17.300 | Atlanta Braves | Danville (Rk) | Assigned to Danville (Rk) |
| Zac Curtis | RP | 24.026 | Arizona Diamondbacks | Reno (AAA) | Assigned to Reno (AAA) |
| Grant DeBruin | 3B | 26.032 | Washington Nationals | Hagerstown (A) | Reinstated to active roster |
| Thomas Dorminy | P | 24.059 | San Diego Padres | Tri-City (A-) | Assigned to Tri-City (A-) |
| Tanner English | OF | 23.141 | Minnesota Twins | Gulf Coast Twins (Rk) | Activated from disabled list |
| Junior Flores | p | 21.290 | Milwaukee Brewers | Arizona Brewers (Rk) | Assigned to Arizona Brewers (Rk) |
| Jairo Garcia | p | 21.186 | New York Yankees | Gulf Coast Yankees (Rk) | Assigned to Gulf Coast Yankees (Rk) |
| Mitch Ghelfi | c | 23.309 | Milwaukee Brewers | Brevard County (A+) | Assigned to Brevard County (A+) |
| Chris Godinez | 2b | 23.101 | New York Yankees | Staten Island (A-) | Assigned to Staten Island (A-) |
| Marvin Gorgas | P | 20.193 | Seattle Mariners | Tacoma (AAA) | Assigned to Tacoma (AAA) |
| Hunter Harvey | P | 21.233 | Baltimore Orioles | Aberdeen (A-) | Assigned to Aberdeen (A-) |
| Keith Hessler | RP | 27.137 | San Diego Padres | El Paso (AAA) | Assigned to El Paso (AAA) |
| Brian Holmes | P | 25.181 | Houston Astros | Gulf Coast Astros (Rk) | Assigned to Gulf Coast Astros (Rk) |
| Jason Hursh | P | 24.302 | Atlanta Braves | Gwinnett (AAA) | Assigned to Gwinnett (AAA) |
| Myles Jaye | P | 24.215 | Detroit Tigers | Toledo (AAA) | Assigned to Toledo (AAA) |
| Brian Jeroloman | C | 31.081 | Washington Nationals | Syracuse (AAA) | Reinstated to active roster |
| Jason Jester | P | 25.087 | San Diego Padres | El Paso (AAA) | Assigned to El Paso (AAA) |
| Don Kelly | 3b-lf | 36.166 | Miami Marlins | New Orleans (AAA) | Outrighted to minors |
| Keenan Kish | p | 24.252 | Cincinnati Reds | Dayton (A) | Assigned to Dayton (A) |
| Jeremy Kivel | P | 22.287 | Cincinnati Reds | Daytona (A+) | Activated from disabled list |
| Ricky Knapp | P | 24.071 | New York Mets | Las Vegas (AAA) | Assigned to Las Vegas (AAA) |
| Mark Laird | of | 23.123 | Philadelphia Phillies | Williamsport (A-) | Assigned to Williamsport (A-) |
| Mat Latos | SP | 28.234 | Washington Nationals | Gulf Coast Nationals (Rk) | Assigned to Gulf Coast Nationals (Rk) |
| Jesus Lopez | SS | 19.298 | Oakland Athletics | Beloit (A) | Assigned to Beloit (A) |
| Greg Maisto | P | 21.255 | Tampa Bay Rays | Gulf Coast Rays (Rk) | Assigned to Gulf Coast Rays (Rk) |
| Chad Martin | p | 22.209 | New York Yankees | Staten Island (A-) | Assigned to Staten Island (A-) |
| Jhonny Mateo | p | 21.345 | Detroit Tigers | Gulf Coast Tigers (East) (Rk) | Assigned to Gulf Coast Tigers (Rk) |
| Angel Mejia | P | 21.170 | San Diego Padres | Lake Elsinore (A+) | Assigned to Lake Elsinore (A+) |
| Tomas Morales | C | 25.000 | Pittsburgh Pirates | Bradenton (A+) | Assigned to Bradenton (A+) |
| Melvin Morel | p | 22.228 | Detroit Tigers | Gulf Coast Tigers (East) (Rk) | Assigned to Gulf Coast Tigers (Rk) |
| Jairo Munoz | P | 24.353 | Philadelphia Phillies | Gulf Coast Phillies (Rk) | Activated from disabled list |
| Franklin Navarro | C | 21.286 | Detroit Tigers | Connecticut (A-) | Assigned to Connecticut (A-) |
| Cristian Pache | of | 17.253 | Atlanta Braves | Danville (Rk) | Assigned to Danville (Rk) |
| Olbis Parra | p | 21.302 | San Francisco Giants | Salem-Keizer (A-) | Assigned to Salem-Keizer (A-) |
| Dorssys Paulino | SS | 21.251 | Cleveland Indians | Arizona Indians (Rk) | Assigned to Arizona Indians (Rk) |
| Matt Pirro | p | 23.097 | Washington Nationals | Auburn (A-) | Assigned to Auburn (A-) |
| John Polonius | SS | 25.198 | San Francisco Giants | Augusta (A) | Assigned to Augusta (A) |
| Zach Remillard | 3b | 22.159 | Chicago White Sox | Kannapolis (A) | Assigned to Kannapolis (A) |
| Cory Riordan | P | 30.066 | Detroit Tigers | Erie (AA) | Assigned to Erie (AA) |
| Jesus Rodriguez | p | 18.164 | Detroit Tigers | Gulf Coast Tigers (East) (Rk) | Assigned to Gulf Coast Tigers (Rk) |
| Elier Sanchez | p | 29.299 | San Diego Padres | San Antonio (AA) | Assigned to San Antonio (AA) |
| Juan Santos | P | 20.335 | Houston Astros | Quad Cities (A) | Assigned to Quad Cities (A) |
| Malcolm Seibert | 2b | 22.255 | Tampa Bay Rays | Charlotte (A+) | Assigned to Charlotte (A+) |
| Hector Silvestre | P | 23.228 | Washington Nationals | Potomac (A+) | Assigned to Potomac (A+) |
| Drew Steckenrider | OF-P | 25.201 | Miami Marlins | New Orleans (AAA) | Assigned to New Orleans (AAA) |
| Matt Tomshaw | P | 27.225 | Miami Marlins | New Orleans (AAA) | Assigned to New Orleans (AAA) |
| Jose Urena | RP | 24.322 | Miami Marlins | New Orleans (AAA) | Assigned to New Orleans (AAA) |
| Javier Villarroel | p | 18.272 | Detroit Tigers | Gulf Coast Tigers (East) (Rk) | Assigned to Gulf Coast Tigers (Rk) |
| John Werner | p | 24.209 | Texas Rangers | Hickory (A) | Activated from disabled list |
| Jonah Wesely | P | 21.234 | Los Angeles Angels | Burlington (A) | Assigned to Burlington (A) |
| Taylor Widener | p | 21.279 | New York Yankees | Charleston (sc) (A) | Assigned to Charleston (sc) (A) |
| Bryce Zak | p | 24.272 | Tampa Bay Rays | Princeton (Rk) | Assigned to Princeton (Rk) |
| Alexi Casilla | 2b | 32.010 | Toronto Blue Jays | Buffalo (AAA) | DL-7 Injured |
| Colt Hynes | RP | 31.032 | Toronto Blue Jays | Buffalo (AAA) | DL-7 Injured |
| Logan Darnell | P | 27.178 | Minnesota Twins | Rochester (AAA) | DL-7 Injured |
| Miguel Gonzalez | C | 25.239 | Detroit Tigers | Toledo (AAA) | DL-7 Injured |
| Moises Sierra | rf | 27.309 | Miami Marlins | Jacksonville (AA) | DL-7 Injured |
| D.J. Hicks | 1b | 26.119 | Minnesota Twins | Chattanooga (AA) | DL-7 Injured |
| Ramon Laureano | OF | 22.015 | Houston Astros | Corpus Christi (AA) | Suspended 3 games for his role in a brawl |
| Victor Payano | P | 23.286 | Texas Rangers | Frisco (AA) | Placed on temporary inactive list |
| Aaron Attaway | IF | 24.146 | Toronto Blue Jays | Dunedin (A+) | DL-7 Injured |
| Blake Butler | 2b | 22.274 | Cincinnati Reds | Daytona (A+) | DL-7 Injured |
| Joseph Daris | OF | 24.252 | | | Released by Braves |
| Starlyn Suriel | P | 22.255 | Toronto Blue Jays | Dunedin (A+) | DL-7 Injured |
| Alexis Maldonado | SS | 25.048 | Toronto Blue Jays | Lansing (A) | DL-7 Injured |
| Carl Wise | 3b | 22.066 | Toronto Blue Jays | Lansing (A) | DL-7 Injured |
| Jose Almonte | OF | 19.324 | Texas Rangers | Hickory (A) | DL-7 Injured |
| Lucas Herbert | c | 19.244 | Atlanta Braves | Rome (A) | DL-7 Injured |
| Scott Frazier | P | 24.240 | | | Released by Cubs |
| Erick Gonzalez | c | 19.331 | Chicago Cubs | Dominican Cubs (Rk) | Assigned to DSL Cubs (Rk) |
| Jorge Andrade | 2b | 21.235 | Minnesota Twins | Gulf Coast Twins (Rk) | DL-7 Injured |
| Kolton Kendrick | 1b | 19.354 | Minnesota Twins | Gulf Coast Twins (Rk) | DL-7 Injured |
| Luis Perez | p | 19.114 | | | Released by Braves |
| Luis Rosario | p | 21.231 | New York Yankees | Gulf Coast Yankees (Rk) | DL-60 Injured |
| Bernardo Heras | c | 20.270 | Houston Astros | Gulf Coast Astros (Rk) | Assigned to GCL Astros (Rk) |
| Felipe Tejada | p | 18.153 | Houston Astros | Gulf Coast Astros (Rk) | Assigned to GCL Astros (Rk) |
| Gilberto Celestino | cf | 17.167 | Houston Astros | Gulf Coast Astros (Rk) | Assigned to GCL Astros (Rk) |
| Jack Kruger | c | 21.277 | Los Angeles Angels | Arizona Angels (Rk) | Signed out of draft (Mississippi State) |
| Justin Garza | p | 22.132 | Cleveland Indians | Arizona Indians (Rk) | Assigned to AZL Indians (Rk) |
