| Justin Upton | LF-CF | 28.325 | Detroit Tigers | Detroit Tigers (MLB) | Placed on bereavement list |
| Josh Rutledge | 3B-2B | 27.085 | Boston Red Sox | Boston Red Sox (MLB) | Transferred to 60-day DL |
| Drew Pomeranz | SP | 27.235 | Boston Red Sox | Boston Red Sox (MLB) | Traded from Padres to Red Sox for Anderson Espinoza |
| Anderson Espinoza | p | 18.128 | San Diego Padres | San Diego Padres (MLB) | Traded from Red Sox to Padres for Drew Pomeranz |
| Erik Gonzalez | 3B | 24.319 | Cleveland Indians | Cleveland Indians (MLB) | Recalled from Columbus (AAA) |
| William Cuevas | P | 25.274 | Boston Red Sox | Boston Red Sox (MLB) | Recalled from Pawtucket (AAA) |
| Junichi Tazawa | RP | 30.039 | Boston Red Sox | Boston Red Sox (MLB) | DL-15 Right shoulder impingement |
| Luke Maile | C | 25.159 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Recalled from Durham (AAA) |
| Corey Knebel | RP | 24.232 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Recalled from Colorado Springs (AAA) |
| Kevin Jepsen | RP | 31.354 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Signed to 1-year contract for 2016-2016 ($0m) |
| Edward Mujica | RP | 32.066 | | | Released by Phillies |
| George Kottaras | c | 33.060 | | | Released by Giants |
| Joe Panik | 2B | 25.258 | San Francisco Giants | San Francisco Giants (MLB) | Transferred to 15-day DL |
| Scott Carroll | RP | 31.294 | Chicago White Sox | Charlotte (AAA) | Outrighted to minors |
| Melvin Upton | LF | 31.328 | San Diego Padres | San Diego Padres (MLB) | Placed on bereavement list |
| Spencer Adams | P | 20.093 | Chicago White Sox | Winston-Salem (A+) | Activated from disabled list |
| Jose Almonte | OF | 19.309 | Texas Rangers | Arizona Rangers (Rk) | Activated from disabled list |
| Carlos Alonso | 2B | 28.151 | Philadelphia Phillies | Reading (AA) | Assigned to Reading (AA) |
| Bryan Anderson | C | 29.211 | Oakland Athletics | Nashville (AAA) | Assigned to Nashville (AAA) |
| Tim Arakawa | 2b | 23.088 | Los Angeles Angels | Arkansas (AA) | Assigned to Arkansas (AA) |
| Carlos Belonis | OF | 21.330 | Milwaukee Brewers | Wisconsin (A) | Activated from disabled list |
| Andy Beltre | P | 23.009 | Miami Marlins | Jupiter (A+) | Assigned to Jupiter (A+) |
| Omar Bencomo | p | 27.155 | Minnesota Twins | Chattanooga (AA) | Activated from disabled list |
| Mike Blazek | RP | 27.121 | Milwaukee Brewers | Colorado Springs (AAA) | Assigned to Colorado Springs (AAA) |
| Colten Brewer | P | 23.259 | Pittsburgh Pirates | Bradenton (A+) | Reinstated to active roster |
| Billy Burns | CF | 26.319 | Oakland Athletics | Nashville (AAA) | Assigned to Nashville (AAA) |
| Adam Cimber | P | 25.334 | San Diego Padres | El Paso (AAA) | Assigned to El Paso (AAA) |
| Jason Coats | RF | 26.141 | Chicago White Sox | Charlotte (AAA) | Assigned to Charlotte (AAA) |
| Jarred Cosart | SP | 26.051 | Miami Marlins | New Orleans (AAA) | Activated from disabled list |
| Keith Couch | P | 26.252 | Boston Red Sox | Pawtucket (AAA) | Assigned to Pawtucket (AAA) |
| William Cuicas | SS | 21.164 | Philadelphia Phillies | Lakewood (A) | Assigned to Lakewood (A) |
| Dayan Diaz | P | 27.155 | Cincinnati Reds | Louisville (AAA) | Reinstated to active roster |
| Thomas Dorminy | P | 24.044 | San Diego Padres | Lake Elsinore (A+) | Assigned to Lake Elsinore (A+) |
| Nick Duron | p | 20.167 | Boston Red Sox | Gulf Coast Red Sox (Rk) | Assigned to Gulf Coast Red Sox (Rk) |
| Anderson Espinoza | p | 18.128 | San Diego Padres | Fort Wayne (A) | Assigned to Fort Wayne (A) |
| Tyler Ferguson | p | 22.283 | Texas Rangers | Spokane (A-) | Assigned to Spokane (A-) |
| Junior Flores | p | 21.275 | Milwaukee Brewers | Wisconsin (A) | Assigned to Wisconsin (A) |
| Seth Frankoff | P | 27.322 | Los Angeles Dodgers | Oklahoma City (AAA) | Assigned to Oklahoma City (AAA) |
| Preston Gainey | P | 25.152 | Milwaukee Brewers | Brevard County (A+) | Assigned to Brevard County (A+) |
| Omar Garcia | CF | 22.348 | Milwaukee Brewers | Biloxi (AA) | Assigned to Biloxi (AA) |
| Casey Gillaspie | 1B | 23.171 | Tampa Bay Rays | Durham (AAA) | Assigned to Durham (AAA) |
| Miguel Gomez | c | 23.210 | San Francisco Giants | San Jose (A+) | Assigned to San Jose (A+) |
| Raywilly Gomez | C | 26.171 | New York Mets | Binghamton (AA) | Activated from disabled list |
| Cody Gunter | 3B | 22.088 | Washington Nationals | Hagerstown (A) | Assigned to Hagerstown (A) |
| Kelvin Gutierrez | SS | 21.321 | Washington Nationals | Hagerstown (A) | Assigned to Hagerstown (A) |
| Roberto Hernandez | RP | 35.319 | Atlanta Braves | Gwinnett (AAA) | Signed to Minor League Contract |
| Neil Holland | P | 27.335 | Washington Nationals | Gulf Coast Nationals (Rk) | Assigned to Gulf Coast Nationals (Rk) |
| T.J. House | P | 26.289 | Cleveland Indians | Columbus (AAA) | Assigned to Columbus (AAA) |
| Jake Johansen | P | 25.173 | Washington Nationals | Hagerstown (A) | Assigned to Hagerstown (A) |
| Munenori Kawasaki | 3B | 35.042 | Chicago Cubs | Iowa (AAA) | Assigned to Iowa (AAA) |
| Josh Kimborowicz | P | 24.120 | Los Angeles Dodgers | Ogden (Rk) | Assigned to Ogden (Rk) |
| Mark Laird | of | 23.108 | Philadelphia Phillies | Williamsport (A-) | Assigned to Williamsport (A-) |
| Taylor Lindsey | 2B | 24.226 | San Diego Padres | El Paso (AAA) | Assigned to El Paso (AAA) |
| Nolan Long | p | 22.177 | Los Angeles Dodgers | Ogden (Rk) | Assigned to Ogden (Rk) |
| David Lough | LF-RF | 30.176 | Philadelphia Phillies | Lehigh Valley (AAA) | Activated from disabled list |
| Jake Lowery | C | 25.359 | Washington Nationals | Potomac (A+) | Activated from disabled list |
| Parker Markel | P | 25.303 | Tampa Bay Rays | Hudson Valley (A-) | Assigned to Hudson Valley (A-) |
| Bladimir Matos | p | 22.176 | Atlanta Braves | Danville (Rk) | Assigned to Danville (Rk) |
| Jeffeson Medina | p | 22.045 | Seattle Mariners | Everett (A-) | Assigned to Everett (A-) |
| Yonathan Mendoza | 3b | 22.155 | Cleveland Indians | Mahoning Valley (A-) | Assigned to Mahoning Valley (A-) |
| Ryan Metzler | IF | 23.117 | Toronto Blue Jays | Lansing (A) | Activated from disabled list |
| Shelby Miller | SP | 25.278 | Arizona Diamondbacks | Reno (AAA) | Assigned to Reno (AAA) |
| Sam Moll | P | 24.194 | Colorado Rockies | Albuquerque (AAA) | Assigned to Albuquerque (AAA) |
| Jose Monegro | P | 26.299 | Texas Rangers | High Desert (A+) | Assigned to High Desert (A+) |
| Hector Olivera | 2b | 31.101 | Atlanta Braves | Gulf Coast Braves (Rk) | Assigned to GCL Braves (Rk) for rehab |
| Angel Perdomo | P | 22.069 | Toronto Blue Jays | Lansing (A) | Reinstated to active roster |
| John Polonius | SS | 25.183 | San Francisco Giants | Augusta (A) | Assigned to Augusta (A) |
| Josh Prevost | P | 24.182 | New York Mets | Gulf Coast Mets (Rk) | Activated from disabled list |
| Benino Pruneda | P | 27.341 | Kansas City Royals | Omaha (AAA) | Assigned to Omaha (AAA) |
| Hunter Renfroe | RF | 24.169 | San Diego Padres | El Paso (AAA) | Reinstated to active roster |
| Jairo Rodriguez | C | 27.325 | Minnesota Twins | Chattanooga (AA) | Activated from disabled list |
| Sharlon Schoop | 1B-2B | 29.091 | Baltimore Orioles | Bowie (AA) | Activated from disabled list |
| Myles Smith | P | 24.114 | Arizona Diamondbacks | Visalia (A+) | Assigned to Visalia (A+) |
| Jack Snodgrass | P | 28.218 | Texas Rangers | Round Rock (AAA) | Assigned to Round Rock (AAA) |
| Glenn Sparkman | P | 24.065 | Kansas City Royals | Northwest Arkansas (AA) | Assigned to Northwest Arkansas (AA) |
| Eric Stamets | IF | 24.294 | Cleveland Indians | Columbus (AAA) | Assigned to Columbus (AAA) |
| Tyler Sturdevant | P | 30.207 | Tampa Bay Rays | Durham (AAA) | Assigned to Durham (AAA) |
| Tomas Telis | C | 25.027 | Miami Marlins | New Orleans (AAA) | Assigned to New Orleans (AAA) |
| Sam Tuivailala | RP | 23.269 | St. Louis Cardinals | Memphis (AAA) | Assigned to Memphis (AAA) |
| Chase Vallot | C | 19.328 | Kansas City Royals | Arizona Royals (Rk) | Assigned to Arizona Royals (Rk) |
| Connor Walsh | P | 23.270 | Chicago White Sox | Winston-Salem (A+) | Activated from disabled list |
| Garrett Weber | SS-2B | 27.108 | Miami Marlins | Jacksonville (AA) | Assigned to Jacksonville (AA) |
| Mitchell White | p | 21.199 | Los Angeles Dodgers | Great Lakes (A) | Assigned to Great Lakes (A) |
| David Whitehead | P | 24.085 | Pittsburgh Pirates | Bristol (Rk) | Assigned to Bristol (Rk) |
| Cody Winiarski | P | 26.322 | Chicago White Sox | Birmingham (AA) | Activated from disabled list |
| Alex Winkelman | p | 22.157 | Houston Astros | Lancaster (A+) | Assigned to Lancaster (A+) |
| Angel Nesbitt | P | 25.223 | Detroit Tigers | Erie (AA) | DL-7 Injured |
| Brandon Allen | IF | 30.153 | Cincinnati Reds | Louisville (AAA) | DL-7 Injured |
| Chris Narveson | RP | 34.207 | Miami Marlins | New Orleans (AAA) | DL-7 Injured |
| Dylan Axelrod | RP | 30.350 | Miami Marlins | New Orleans (AAA) | DL-7 Injured |
| J.R. Graham | RP | 26.182 | New York Yankees | Trenton (AA) | DL-7 Injured |
| James Jones | RF | 27.294 | Texas Rangers | Round Rock (AAA) | Placed on temporary inactive list |
| Wesley Wright | RP | 31.168 | | | Released by Red Sox |
| Ben Klimesh | P | 26.062 | Cincinnati Reds | Pensacola (AA) | DL-7 Injured |
| Blayne Weller | P | 26.166 | Los Angeles Angels | Salt Lake (AAA) | DL-7 Injured |
| Nik Turley | P | 26.307 | | | Released by Red Sox |
| Ramon Torres | SS-2B | 23.174 | Kansas City Royals | Omaha (AAA) | DL-7 Injured |
| Aaron Brown | RF | 24.025 | Philadelphia Phillies | Reading (AA) | DL-7 Injured |
| Calten Daal | SS | 22.348 | Cincinnati Reds | Pensacola (AA) | DL-7 Injured |
| Juan Martinez | P | 24.000 | Cincinnati Reds | Daytona (A+) | DL-7 Injured |
| Matt Milroy | P | 25.283 | Texas Rangers | High Desert (A+) | DL-7 Injured |
| Matt Sergey | p | 26.351 | Oakland Athletics | Stockton (A+) | DL-7 Injured |
| Scott Williams | P | 22.240 | Texas Rangers | High Desert (A+) | DL-7 Injured |
| Chuck Weaver | p | 25.192 | Miami Marlins | Greensboro (A) | DL-7 Injured |
| Francis Guerrero | C | 21.241 | | | Released by Reds |
| Austin Shields | p | 18.234 | Pittsburgh Pirates | Gulf Coast Pirates (Rk) | Signed out of draft (Ontario HS) |
| C.J. Chatham | ss | 21.205 | Boston Red Sox | Gulf Coast Red Sox (Rk) | Signed out of draft (Florida Atlantic) |
| Easton McGee | p | 18.201 | Tampa Bay Rays | Gulf Coast Rays (Rk) | Signed out of draft (Kentucky HS) |
| Boomer Synek | c | 23.036 | Pittsburgh Pirates | Gulf Coast Pirates (Rk) | Signed as undrafted free agent (Evansville) |
| Oswaldo Cabrera | ss | 17.136 | New York Yankees | Gulf Coast Yankees (Rk) | Assigned to GCL Yankees East (Rk) |
| Michael Brantley | LF | 29.061 | Cleveland Indians | Akron (AA) | Assigned to Akron (AA) for rehab |
| Tyler Peyton | p | 22.106 | Chicago Cubs | Chicago Cubs (MLB) | Signed out of draft (Iowa) |
| Stephen Ridings | p | 20.331 | Chicago Cubs | Chicago Cubs (MLB) | Signed out of draft (Haverford) |
