| Derek Holland | SP | 29.257 | Texas Rangers | Texas Rangers (MLB) | DL-15 Left shoulder inflammation |
| Luke Jackson | RP | 24.304 | Texas Rangers | Texas Rangers (MLB) | Recalled from Round Rock (AAA) |
| Antoan Richardson | CF | 32.259 | | | Released by Dodgers |
| Kyle Lobstein | RP | 26.315 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Recalled from Indianapolis (AAA) |
| Alfredo Simon | SP | 35.046 | Cincinnati Reds | Cincinnati Reds (MLB) | DL-15 Right shoulder strain |
| Michael Lorenzen | RP | 24.171 | Cincinnati Reds | Cincinnati Reds (MLB) | Activated from DL |
| Ashur Tolliver | P | 28.151 | Baltimore Orioles | Baltimore Orioles (MLB) | Recalled from Norfolk (AAA) |
| Brian Duensing | RP | 33.121 | Baltimore Orioles | Baltimore Orioles (MLB) | DL-15 Left elbow surgery |
| Chin-Hui Tsao | RP | 35.021 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Transferred to 60-day DL |
| Dan Runzler | RP | 31.085 | | | Released by Twins |
| Logan Verrett | RP | 26.004 | New York Mets | New York Mets (MLB) | Recalled from Las Vegas (AAA) |
| Wade LeBlanc | RP | 31.320 | Seattle Mariners | Tacoma (AAA) | Traded from Blue Jays to Mariners for future considerations |
| Charlie Furbush | RP | 30.073 | Seattle Mariners | Seattle Mariners (MLB) | Transferred to 60-day DL |
| Tom Wilhelmsen | RP | 32.190 | Seattle Mariners | Seattle Mariners (MLB) | Signed to 1-year contract for 2016-2016 ($0m) |
| Jordan Pacheco | 1B | 30.144 | Cincinnati Reds | Cincinnati Reds (MLB) | Activated from DL and outrighted to minors |
| Jordan Pacheco | 1B | 30.144 | | | Refused minor league assignment, declared free agent |
| Edrick Agosto | p | 19.207 | Tampa Bay Rays | Princeton (Rk) | Assigned to Princeton (Rk) |
| Sergio Alcantara | SS | 19.348 | Arizona Diamondbacks | Arizona Diamondbacks (Rk) | Assigned to Arizona Diamondbacks (Rk) |
| Kolby Allard | p | 18.314 | Atlanta Braves | Danville (Rk) | Assigned to Danville (Rk) |
| Blake Allemand | ss | 23.357 | Milwaukee Brewers | Brevard County (A+) | Assigned to Brevard County (A+) |
| Adrian Almeida | P | 21.118 | New York Mets | Kingsport (Rk) | Assigned to Kingsport (Rk) |
| Bryan Anderson | C | 29.189 | Oakland Athletics | Nashville (AAA) | Activated from disabled list |
| Carl Anderson | OF-P | 23.295 | Pittsburgh Pirates | Bradenton (A+) | Assigned to Bradenton (A+) |
| Josh Anderson | 3b | 23.231 | Arizona Diamondbacks | Missoula (Rk) | Assigned to Missoula (Rk) |
| Greifer Andrade | ss | 19.147 | Seattle Mariners | Arizona Mariners (Rk) | Assigned to Arizona Mariners (Rk) |
| Ivan Andueza | p | 21.136 | Oakland Athletics | Vermont (A-) | Assigned to Vermont (A-) |
| Jonathan Arauz | ss | 17.324 | Houston Astros | Greeneville (Rk) | Assigned to Greeneville (Rk) |
| Elias Arias | of | 21.358 | Atlanta Braves | Danville (Rk) | Assigned to Danville (Rk) |
| Estarlin Arias | p | 22.032 | St. Louis Cardinals | Johnson City (Rk) | Assigned to Johnson City (Rk) |
| Gabino Avalos | p | 21.312 | Atlanta Braves | Danville (Rk) | Assigned to Danville (Rk) |
| Cecilio Aybar | ss | 22.212 | New York Mets | Kingsport (Rk) | Assigned to Kingsport (Rk) |
| Anthony Banda | P | 22.317 | Arizona Diamondbacks | Reno (AAA) | Assigned to Reno (AAA) |
| Luis Bandes | of | 20.039 | St. Louis Cardinals | Johnson City (Rk) | Assigned to Johnson City (Rk) |
| Daniel Bard | RP | 30.363 | St. Louis Cardinals | Johnson City (Rk) | Assigned to Johnson City (Rk) |
| Scott Barnes | RP | 28.292 | Chicago Cubs | Iowa (AAA) | Activated from disabled list |
| Hunter Barnett | p | 21.314 | Toronto Blue Jays | Bluefield (Rk) | Assigned to Bluefield (Rk) |
| Will Barring | of | 23.060 | New York Mets | Kingsport (Rk) | Assigned to Kingsport (Rk) |
| Alexis Bastardo | OF | 22.117 | Pittsburgh Pirates | Bristol (Rk) | Assigned to Bristol (Rk) |
| Derek Beasley | P | 24.142 | Oakland Athletics | Vermont (A-) | Assigned to Vermont (A-) |
| Jalen Beeks | P | 22.348 | Boston Red Sox | Portland (AA) | Assigned to Portland (AA) |
| Kirby Bellow | p | 24.222 | Arizona Diamondbacks | Hillsboro (A-) | Assigned to Hillsboro (A-) |
| T.J. Bennett | if | 23.336 | San Francisco Giants | Sacramento (AAA) | Assigned to Sacramento (AAA) |
| Marc Berube | p | 23.131 | Oakland Athletics | Vermont (A-) | Assigned to Vermont (A-) |
| Palmer Betts | P | 22.071 | Arizona Diamondbacks | Arizona Diamondbacks (Rk) | Assigned to Arizona Diamondbacks (Rk) |
| Alex Bisacca | p | 23.000 | New York Yankees | Pulaski (Rk) | Assigned to Pulaski (Rk) |
| Nick Blackburn | p | 21.348 | Arizona Diamondbacks | Hillsboro (A-) | Assigned to Hillsboro (A-) |
| Felipe Blanco | SS | 22.196 | San Diego Padres | San Antonio (AA) | Assigned to San Antonio (AA) |
| Skye Bolt | of | 22.159 | Oakland Athletics | Beloit (A) | Activated from disabled list |
| Lisalverto Bonilla | P | 26.005 | Los Angeles Dodgers | Tulsa (AA) | Assigned to Tulsa (AA) |
| Austin Bossart | c | 22.354 | Philadelphia Phillies | Clearwater (A+) | Assigned to Clearwater (A+) |
| David Bote | SS | 23.077 | Chicago Cubs | Myrtle Beach (A+) | Assigned to Myrtle Beach (A+) |
| Gabriel Bracamonte | c | 21.039 | Houston Astros | Greeneville (Rk) | Assigned to Greeneville (Rk) |
| Sandy Brito | p | 19.339 | Tampa Bay Rays | Princeton (Rk) | Assigned to Princeton (Rk) |
| Andrew Brodbeck | 2b | 23.152 | St. Louis Cardinals | Johnson City (Rk) | Activated from disabled list |
| Max Brown | of | 23.054 | Arizona Diamondbacks | Hillsboro (A-) | Assigned to Hillsboro (A-) |
| J.T. Brubaker | p | 22.218 | Pittsburgh Pirates | Bradenton (A+) | Assigned to Bradenton (A+) |
| Earl Burl | of | 22.225 | Toronto Blue Jays | Bluefield (Rk) | Assigned to Bluefield (Rk) |
| Blake Butera | if | 23.320 | Tampa Bay Rays | Princeton (Rk) | Assigned to Princeton (Rk) |
| Edgar Cabral | c | 20.285 | Philadelphia Phillies | Lakewood (A) | Assigned to Lakewood (A) |
| Ricardo Castro | p | 20.163 | Houston Astros | Greeneville (Rk) | Assigned to Greeneville (Rk) |
| Ruben Castro | C | 19.348 | Houston Astros | Greeneville (Rk) | Assigned to Greeneville (Rk) |
| Christian Cavaness | of | 22.099 | Minnesota Twins | Elizabethton (Rk) | Assigned to Elizabethton (Rk) |
| Erlin Cerda | 3b | 22.049 | Cleveland Indians | Lake County (A) | Assigned to Lake County (A) |
| Ricardo Cespedes | of | 18.303 | New York Mets | Kingsport (Rk) | Assigned to Kingsport (Rk) |
| Yonny Chirinos | P | 22.179 | Tampa Bay Rays | Montgomery (AA) | Assigned to Montgomery (AA) |
| Randy Choate | RP | 40.292 | Los Angeles Dodgers | Arizona Dodgers (Rk) | Signed to Minor League Contract |
| Taylor Cockrell | p | 22.002 | Atlanta Braves | Danville (Rk) | Assigned to Danville (Rk) |
| P.J. Conlon | p | 22.224 | New York Mets | St. Lucie (A+) | Assigned to St. Lucie (A+) |
| Allen Cordoba | ss | 20.200 | St. Louis Cardinals | Johnson City (Rk) | Assigned to Johnson City (Rk) |
| Max Cordy | p | 23.014 | Minnesota Twins | Elizabethton (Rk) | Assigned to Elizabethton (Rk) |
| Kevin Cornelius | SS | 23.299 | New York Yankees | Pulaski (Rk) | Assigned to Pulaski (Rk) |
| Augustus Craig | of | 23.074 | Seattle Mariners | Bakersfield (A+) | Assigned to Bakersfield (A+) |
| Landon Cray | of | 22.149 | Tampa Bay Rays | Bowling Green (A) | Assigned to Bowling Green (A) |
| Aaron Crow | RP | 29.224 | Chicago Cubs | Arizona Cubs (Rk) | Activated from disabled list |
| Brandon Cunniff | RP | 27.259 | Atlanta Braves | Gwinnett (AAA) | Assigned to Gwinnett (AAA) |
| Devin Davis | 1b | 19.129 | Tampa Bay Rays | Princeton (Rk) | Assigned to Princeton (Rk) |
| Jaylin Davis | of | 21.357 | Minnesota Twins | Elizabethton (Rk) | Assigned to Elizabethton (Rk) |
| Yeffry De Aza | 3b | 19.160 | New York Mets | Kingsport (Rk) | Assigned to Kingsport (Rk) |
| Bryan De la Cruz | of | 19.189 | Houston Astros | Greeneville (Rk) | Assigned to Greeneville (Rk) |
| Michael De La Cruz | OF | 19.348 | Pittsburgh Pirates | Bristol (Rk) | Assigned to Bristol (Rk) |
| Jeff Degano | p | 23.236 | New York Yankees | Pulaski (Rk) | Assigned to Pulaski (Rk) |
| Miguel Del Castillo | C | 24.253 | San Diego Padres | El Paso (AAA) | Assigned to El Paso (AAA) |
| Bryce Denton | 3b | 18.326 | St. Louis Cardinals | Johnson City (Rk) | Assigned to Johnson City (Rk) |
| Andy Diaz | of | 20.215 | New York Yankees | Pulaski (Rk) | Assigned to Pulaski (Rk) |
| Denis Diaz | p | 21.215 | Toronto Blue Jays | Bluefield (Rk) | Assigned to Bluefield (Rk) |
| Yennsy Diaz | p | 19.220 | Toronto Blue Jays | Bluefield (Rk) | Assigned to Bluefield (Rk) |
| Austin Diemer | OF | 23.056 | Minnesota Twins | Cedar Rapids (A) | Assigned to Cedar Rapids (A) |
| Anthony Dimino | c | 22.322 | New York Mets | Kingsport (Rk) | Assigned to Kingsport (Rk) |
| Jose Disla | p | 20.104 | Tampa Bay Rays | Princeton (Rk) | Assigned to Princeton (Rk) |
| Dustin Driver | P | 21.255 | Oakland Athletics | Beloit (A) | Assigned to Beloit (A) |
| Abel Duarte | p | 22.034 | New York Yankees | Pulaski (Rk) | Assigned to Pulaski (Rk) |
| Mauricio Dubon | SS | 21.339 | Boston Red Sox | Portland (AA) | Assigned to Portland (AA) |
| Samir Duenez | 1B | 20.012 | Kansas City Royals | Wilmington (A+) | Assigned to Wilmington (A+) |
| Brandon Dulin | 1B | 23.176 | Kansas City Royals | Lexington (A) | Assigned to Lexington (A) |
| Juan Duran | LF | 24.295 | Cincinnati Reds | Dayton (A) | Reinstated to active roster |
| Nicholas Economos | p | 20.362 | Pittsburgh Pirates | Bristol (Rk) | Assigned to Bristol (Rk) |
| Billy Endris | of | 22.248 | Arizona Diamondbacks | Missoula (Rk) | Assigned to Missoula (Rk) |
| Jose Espada | p | 19.121 | Toronto Blue Jays | Bluefield (Rk) | Assigned to Bluefield (Rk) |
| Gregorix Estevez | p | 22.072 | New York Mets | Kingsport (Rk) | Assigned to Kingsport (Rk) |
| Mike Estevez | p | 23.269 | Toronto Blue Jays | Bluefield (Rk) | Assigned to Bluefield (Rk) |
| Zane Evans | C-P | 24.207 | Kansas City Royals | Burlington (Rk) | Activated from disabled list |
| Luke Farrell | p | 25.016 | Kansas City Royals | Arizona Royals (Rk) | Activated from disabled list |
| Frankeny Fernandez | 2B | 19.198 | Houston Astros | Greeneville (Rk) | Assigned to Greeneville (Rk) |
| Jeffry Fernandez | P | 23.090 | Boston Red Sox | Greenville (A) | Assigned to Greenville (A) |
| Jose Fernandez | SS | 23.034 | Atlanta Braves | Carolina (A+) | Activated from disabled list |
| Victor Fernandez | of | 21.249 | Pittsburgh Pirates | Bristol (Rk) | Assigned to Bristol (Rk) |
| Icezack Flemming | p | 23.364 | New York Yankees | Pulaski (Rk) | Assigned to Pulaski (Rk) |
| Rudy Flores | IF-OF | 25.193 | Arizona Diamondbacks | Mobile (AA) | Assigned to Mobile (AA) |
| Estevan Florial | of | 18.210 | New York Yankees | Pulaski (Rk) | Assigned to Pulaski (Rk) |
| Andrew Florides | SS | 21.152 | Toronto Blue Jays | Bluefield (Rk) | Assigned to Bluefield (Rk) |
| Wander Franco | 3b | 19.255 | Houston Astros | Greeneville (Rk) | Assigned to Greeneville (Rk) |
| Rocky Gale | C | 28.122 | San Diego Padres | San Antonio (AA) | Assigned to San Antonio (AA) |
| Alan Garcia | of | 19.143 | San Diego Padres | Fort Wayne (A) | Assigned to Fort Wayne (A) |
| Dermis Garcia | ss | 18.167 | New York Yankees | Pulaski (Rk) | Assigned to Pulaski (Rk) |
| Deybi Garcia | C | 24.133 | Pittsburgh Pirates | Bristol (Rk) | Assigned to Bristol (Rk) |
| Hector Garcia | P | 20.263 | Pittsburgh Pirates | West Virginia (A) | Assigned to West Virginia (A) |
| Wilkerman Garcia | ss | 18.083 | New York Yankees | Pulaski (Rk) | Assigned to Pulaski (Rk) |
| Wilson Garcia | C | 22.163 | Philadelphia Phillies | Lakewood (A) | Activated from disabled list |
| Edwin German | p | 23.286 | New York Mets | Kingsport (Rk) | Assigned to Kingsport (Rk) |
| Michael Gettys | OF | 20.245 | San Diego Padres | Lake Elsinore (A+) | Assigned to Lake Elsinore (A+) |
| Isiah Gilliam | of | 19.335 | New York Yankees | Pulaski (Rk) | Assigned to Pulaski (Rk) |
| Darin Gillies | p | 23.229 | Seattle Mariners | Bakersfield (A+) | Assigned to Bakersfield (A+) |
| Stephen Gonsalves | P | 21.350 | Minnesota Twins | Chattanooga (AA) | Assigned to Chattanooga (AA) |
| Ivan Gonzalez | 2b | 20.239 | Seattle Mariners | Arizona Mariners (Rk) | Assigned to Arizona Mariners (Rk) |
| Roberto Gonzalez | OF | 21.101 | Minnesota Twins | Elizabethton (Rk) | Assigned to Elizabethton (Rk) |
| Yoel Gonzalez | C | 19.326 | Pittsburgh Pirates | Bristol (Rk) | Assigned to Bristol (Rk) |
| Marvin Gorgas | P | 20.156 | Seattle Mariners | Clinton (A) | Assigned to Clinton (A) |
| Blake Grant-Parks | C | 22.343 | Tampa Bay Rays | Princeton (Rk) | Assigned to Princeton (Rk) |
| Marcus Greene | C | 21.308 | San Diego Padres | Fort Wayne (A) | Assigned to Fort Wayne (A) |
| Anfernee Grier | of | 20.254 | Arizona Diamondbacks | Missoula (Rk) | Assigned to Missoula (Rk) |
| Scott Griggs | P | 25.041 | Los Angeles Dodgers | Tulsa (AA) | Activated from disabled list |
| Ronald Guedez | p | 20.149 | New York Mets | Kingsport (Rk) | Assigned to Kingsport (Rk) |
| Ismael Guillon | P | 24.131 | Cincinnati Reds | Daytona (A+) | Activated from disabled list |
| Osman Gutierrez | p | 21.190 | Toronto Blue Jays | Bluefield (Rk) | Assigned to Bluefield (Rk) |
| Matt Hall | p | 22.335 | Detroit Tigers | Lakeland (A+) | Assigned to Lakeland (A+) |
| Jacob Hannemann | CF | 25.055 | Chicago Cubs | Tennessee (AA) | Reinstated to active roster |
| Ian Happ | of | 21.315 | Chicago Cubs | Tennessee (AA) | Assigned to Tennessee (AA) |
| Garrett Harrison | p | 22.313 | Los Angeles Dodgers | Ogden (Rk) | Assigned to Ogden (Rk) |
| Bryant Hayman | c | 23.253 | Minnesota Twins | Elizabethton (Rk) | Assigned to Elizabethton (Rk) |
| Jaret Hellinger | p | 19.217 | Atlanta Braves | Danville (Rk) | Assigned to Danville (Rk) |
| Anthony Hermelyn | c | 22.217 | Houston Astros | Quad Cities (A) | Reinstated to active roster |
| Oscar Hernandez | C | 22.349 | Arizona Diamondbacks | Mobile (AA) | Assigned to Mobile (AA) |
| Jhoan Herrera | 3B | 21.009 | Pittsburgh Pirates | Bristol (Rk) | Assigned to Bristol (Rk) |
| Jordan Hicks | p | 19.290 | St. Louis Cardinals | Johnson City (Rk) | Assigned to Johnson City (Rk) |
| Kyle Higashioka | C | 26.064 | New York Yankees | Trenton (AA) | Activated from disabled list |
| Kurtis Horne | P | 19.322 | New York Mets | Kingsport (Rk) | Assigned to Kingsport (Rk) |
| Jordan Humphreys | p | 20.012 | New York Mets | Kingsport (Rk) | Assigned to Kingsport (Rk) |
| Nick Hutchings | P | 20.134 | Pittsburgh Pirates | Bristol (Rk) | Assigned to Bristol (Rk) |
| Zach Jones | C-LF | 25.201 | Minnesota Twins | Chattanooga (AA) | Assigned to Chattanooga (AA) |
| Kelyn Jose | p | 21.035 | Toronto Blue Jays | Bluefield (Rk) | Assigned to Bluefield (Rk) |
| Kevin Josephina | 2b | 19.264 | Atlanta Braves | Danville (Rk) | Assigned to Danville (Rk) |
| Shane kemp | p | 21.346 | Pittsburgh Pirates | Bristol (Rk) | Assigned to Bristol (Rk) |
| A.J. Kennedy | c | 22.151 | San Diego Padres | Lake Elsinore (A+) | Assigned to Lake Elsinore (A+) |
| Sam Kennelly | SS | 20.166 | Pittsburgh Pirates | Bristol (Rk) | Assigned to Bristol (Rk) |
| Ben Klimesh | P | 26.040 | Cincinnati Reds | Arizona Reds (Rk) | Activated from disabled list |
| Nash Knight | 3b | 23.276 | Toronto Blue Jays | Bluefield (Rk) | Assigned to Bluefield (Rk) |
| Michael Kopech | P | 20.054 | Boston Red Sox | Salem (A+) | Assigned to Salem (A+) |
| Confesor Lara | P | 25.320 | Detroit Tigers | Lakeland (A+) | Assigned to Lakeland (A+) |
| Rafael Lara | p | 21.013 | New York Yankees | Pulaski (Rk) | Assigned to Pulaski (Rk) |
| Louie Lechich | P | 24.217 | Chicago White Sox | Arizona White Sox (Rk) | Assigned to Arizona White Sox (Rk) |
| Angelo Leclerc | P | 24.258 | Boston Red Sox | Salem (A+) | Assigned to Salem (A+) |
| Jose Leclerc | P | 22.186 | Texas Rangers | Round Rock (AAA) | Reinstated to active roster |
| Ryan Ledbetter | P | 24.131 | Texas Rangers | Frisco (AA) | Assigned to Frisco (AA) |
| Zech Lemond | P | 23.257 | San Diego Padres | Lake Elsinore (A+) | Assigned to Lake Elsinore (A+) |
| Reign Letkeman | p | 21.042 | Tampa Bay Rays | Princeton (Rk) | Assigned to Princeton (Rk) |
| Connor Lien | OF | 22.100 | Atlanta Braves | Mississippi (AA) | Activated from disabled list |
| Taylor Lindsey | 2B | 24.204 | San Diego Padres | El Paso (AAA) | Assigned to El Paso (AAA) |
| Gabriel Lino | C | 23.037 | Philadelphia Phillies | Reading (AA) | Assigned to Reading (AA) |
| Jorge Lopez | SP | 23.133 | Milwaukee Brewers | Colorado Springs (AAA) | Reinstated to active roster |
| Rafelin Lorenzo | c | 19.159 | Tampa Bay Rays | Princeton (Rk) | Assigned to Princeton (Rk) |
| Vicente Lupo | OF | 22.209 | New York Mets | Columbia (A) | Assigned to Columbia (A) |
| Connor MacDonald | 1b | 20.117 | Houston Astros | Greeneville (Rk) | Assigned to Greeneville (Rk) |
| Tyler Mahle | P | 21.267 | Cincinnati Reds | Pensacola (AA) | Assigned to Pensacola (AA) |
| Spencer Mahoney | p | 23.013 | New York Yankees | Pulaski (Rk) | Assigned to Pulaski (Rk) |
| Luis Marte | SS | 22.190 | Texas Rangers | Arizona Rangers (Rk) | Activated from disabled list |
| Santo Marte | 2B | 22.266 | New York Mets | Kingsport (Rk) | Assigned to Kingsport (Rk) |
| Chad Martin | p | 22.172 | New York Yankees | Pulaski (Rk) | Assigned to Pulaski (Rk) |
| Emerson Martinez | P | 21.163 | Texas Rangers | Hickory (A) | Assigned to Hickory (A) |
| Jhon Martinez | P | 21.134 | Atlanta Braves | Danville (Rk) | Assigned to Danville (Rk) |
| Jose Martinez | p | 19.237 | Minnesota Twins | Elizabethton (Rk) | Assigned to Elizabethton (Rk) |
| Welfrin Mateo | 2b | 20.289 | New York Yankees | Pulaski (Rk) | Assigned to Pulaski (Rk) |
| Kenny Mathews | P | 22.321 | Cleveland Indians | Arizona Indians (Rk) | Assigned to Arizona Indians (Rk) |
| Kevin McCanna | p | 22.142 | Houston Astros | Lancaster (A+) | Assigned to Lancaster (A+) |
| Joe McCarthy | of | 22.120 | Tampa Bay Rays | Charlotte (A+) | Assigned to Charlotte (A+) |
| Jose Medina | P | 19.302 | New York Mets | Kingsport (Rk) | Assigned to Kingsport (Rk) |
| Juandy Mendoza | ss | 21.256 | Toronto Blue Jays | Bluefield (Rk) | Assigned to Bluefield (Rk) |
| Joey Meneses | IF | 24.048 | Atlanta Braves | Mississippi (AA) | Assigned to Mississippi (AA) |
| Kewby Meyer | 1b | 23.239 | Tampa Bay Rays | Bowling Green (A) | Assigned to Bowling Green (A) |
| Matt Milroy | P | 25.261 | Texas Rangers | High Desert (A+) | Assigned to High Desert (A+) |
| Juan Minaya | P | 25.278 | Chicago White Sox | Charlotte (AAA) | Activated from disabled list |
| Ronnie Mitchell | OF | 25.002 | Miami Marlins | Jacksonville (AA) | Assigned to Jacksonville (AA) |
| Leonardo Molina | OF | 18.345 | New York Yankees | Pulaski (Rk) | Assigned to Pulaski (Rk) |
| Robert Molina | c | 19.280 | Minnesota Twins | Elizabethton (Rk) | Assigned to Elizabethton (Rk) |
| Dustin Molleken | P | 31.306 | Detroit Tigers | Toledo (AAA) | Assigned to Toledo (AAA) |
| Yoan Moncada | 2b | 21.027 | Boston Red Sox | Portland (AA) | Assigned to Portland (AA) |
| Nate Mondou | 2b | 21.091 | Oakland Athletics | Vermont (A-) | Assigned to Vermont (A-) |
| Jose Monegro | P | 26.277 | Texas Rangers | Frisco (AA) | Assigned to Frisco (AA) |
| Ariel Montesino | SS | 20.276 | Minnesota Twins | Elizabethton (Rk) | Assigned to Elizabethton (Rk) |
| Gerson Moreno | P | 20.287 | Detroit Tigers | Lakeland (A+) | Assigned to Lakeland (A+) |
| Ronald Morillo | p | 26.159 | Arizona Diamondbacks | Hillsboro (A-) | Assigned to Hillsboro (A-) |
| Jason Morozowski | of | 22.013 | Arizona Diamondbacks | Missoula (Rk) | Assigned to Missoula (Rk) |
| El'Hajj Muhammad | P | 24.352 | Cincinnati Reds | Daytona (A+) | Assigned to Daytona (A+) |
| A.J. Murray | c | 23.080 | Minnesota Twins | Fort Myers (A+) | Assigned to Fort Myers (A+) |
| Yuhei Nakaushiro | p | 26.279 | Arizona Diamondbacks | Kane County (A) | Assigned to Kane County (A) |
| Logan Nottebrok | 3b | 24.091 | Kansas City Royals | Burlington (Rk) | Assigned to Burlington (Rk) |
| Jose Nova | p | 21.078 | Toronto Blue Jays | Bluefield (Rk) | Assigned to Bluefield (Rk) |
| Cameron O'Brien | c | 23.318 | Toronto Blue Jays | Bluefield (Rk) | Assigned to Bluefield (Rk) |
| David Oca | p | 20.355 | St. Louis Cardinals | Johnson City (Rk) | Assigned to Johnson City (Rk) |
| Joseph Odom | C | 24.166 | Atlanta Braves | Mississippi (AA) | Assigned to Mississippi (AA) |
| Edward Olivares | of | 20.109 | Toronto Blue Jays | Bluefield (Rk) | Assigned to Bluefield (Rk) |
| Nate Orf | C | 26.142 | Milwaukee Brewers | Colorado Springs (AAA) | Assigned to Colorado Springs (AAA) |
| Nestor Oronel | p | 19.192 | Pittsburgh Pirates | Bristol (Rk) | Assigned to Bristol (Rk) |
| Evertz Orozco | p | 21.280 | Atlanta Braves | Danville (Rk) | Assigned to Danville (Rk) |
| Angel Ortega | SS | 22.285 | Milwaukee Brewers | Biloxi (AA) | Assigned to Biloxi (AA) |
| Randy Ortiz | OF | 23.008 | San Francisco Giants | San Jose (A+) | Assigned to San Jose (A+) |
| Willy Ortiz | p | 20.339 | Tampa Bay Rays | Princeton (Rk) | Assigned to Princeton (Rk) |
| Ian Oxnevad | p | 19.263 | St. Louis Cardinals | Johnson City (Rk) | Assigned to Johnson City (Rk) |
| Adonis Paula | 3B | 22.002 | Chicago Cubs | Arizona Cubs (Rk) | Assigned to Arizona Cubs (Rk) |
| Luis Paula | P | 23.001 | Pittsburgh Pirates | West Virginia (A) | Assigned to West Virginia (A) |
| Starlin Peralta | P | 25.224 | Chicago Cubs | Iowa (AAA) | Assigned to Iowa (AAA) |
| Eury Perez | LF | 26.024 | Tampa Bay Rays | Durham (AAA) | Traded from Astros to Rays for cash considerations |
| Julio Perez | p | 24.159 | Arizona Diamondbacks | Kane County (A) | Assigned to Kane County (A) |
| Michael Perez | C | 23.320 | Arizona Diamondbacks | Visalia (A+) | Assigned to Visalia (A+) |
| Kyle Petty | 1B | 25.114 | Seattle Mariners | Jackson (AA) | Assigned to Jackson (AA) |
| Jose Pina | OF | 20.062 | Atlanta Braves | Danville (Rk) | Assigned to Danville (Rk) |
| Tito Polo | OF | 21.304 | Pittsburgh Pirates | Bradenton (A+) | Assigned to Bradenton (A+) |
| Reggie Pruitt | of | 19.047 | Toronto Blue Jays | Bluefield (Rk) | Assigned to Bluefield (Rk) |
| Andrew Pullin | OF | 22.271 | Philadelphia Phillies | Reading (AA) | Assigned to Reading (AA) |
| Juniel Querecuto | SS | 23.277 | Tampa Bay Rays | Durham (AAA) | Assigned to Durham (AAA) |
| Johan Quezada | p | 21.302 | Minnesota Twins | Elizabethton (Rk) | Assigned to Elizabethton (Rk) |
| Raphael Ramirez | OF | 20.191 | New York Mets | Kingsport (Rk) | Assigned to Kingsport (Rk) |
| Walter Rasquin | 3b | 20.094 | New York Mets | Kingsport (Rk) | Assigned to Kingsport (Rk) |
| Sean Ratcliffe | P | 21.073 | Atlanta Braves | Danville (Rk) | Assigned to Danville (Rk) |
| Tony Renda | SS | 25.150 | Cincinnati Reds | Louisville (AAA) | Assigned to Louisville (AAA) |
| Victor Rey | 3b | 20.360 | New York Yankees | Pulaski (Rk) | Assigned to Pulaski (Rk) |
| Brian Reyes | C | 20.361 | New York Yankees | Pulaski (Rk) | Assigned to Pulaski (Rk) |
| Robelys Reyes | 2B | 25.333 | Arizona Diamondbacks | Visalia (A+) | Assigned to Visalia (A+) |
| C.J. Riefenhauser | RP | 26.144 | Chicago Cubs | Arizona Cubs (Rk) | Assigned to Arizona Cubs (Rk) |
| Ryan Riga | p | 23.244 | Chicago White Sox | Winston-Salem (A+) | Assigned to Winston-Salem (A+) |
| Jonathan Rivera | of | 19.057 | St. Louis Cardinals | Johnson City (Rk) | Assigned to Johnson City (Rk) |
| Michael Rivera | p | 19.004 | Seattle Mariners | Arizona Mariners (Rk) | Assigned to Arizona Mariners (Rk) |
| Hansel Rodriguez | P | 19.116 | Toronto Blue Jays | Bluefield (Rk) | Assigned to Bluefield (Rk) |
| Juan Rodriguez | 3b | 19.130 | Tampa Bay Rays | Princeton (Rk) | Assigned to Princeton (Rk) |
| Mel Rojas | CF | 26.030 | Atlanta Braves | Gwinnett (AAA) | Assigned to Gwinnett (AAA) |
| Orlando Romero | P | 19.270 | Tampa Bay Rays | Princeton (Rk) | Assigned to Princeton (Rk) |
| Adrian Rondon | ss | 17.351 | Tampa Bay Rays | Princeton (Rk) | Assigned to Princeton (Rk) |
| Amed Rosario | SS | 20.216 | New York Mets | Binghamton (AA) | Assigned to Binghamton (AA) |
| Storm Rynard | P | 20.272 | Texas Rangers | Hickory (A) | Assigned to Hickory (A) |
| Connor Sabanosh | C | 22.321 | San Francisco Giants | Arizona Giants (Rk) | Assigned to Arizona Giants (Rk) |
| Abdiel Saldana | p | 20.102 | Houston Astros | Greeneville (Rk) | Assigned to Greeneville (Rk) |
| Carlos Sanabria | p | 19.150 | Houston Astros | Greeneville (Rk) | Assigned to Greeneville (Rk) |
| Vicente Sanchez | of | 19.262 | Houston Astros | Greeneville (Rk) | Assigned to Greeneville (Rk) |
| Patrick Sandoval | p | 19.248 | Houston Astros | Greeneville (Rk) | Assigned to Greeneville (Rk) |
| Ike Schlabach | p | 19.178 | Pittsburgh Pirates | Bristol (Rk) | Assigned to Bristol (Rk) |
| Levi Scott | 1b | 23.323 | Toronto Blue Jays | Bluefield (Rk) | Assigned to Bluefield (Rk) |
| Sam Selman | P | 25.221 | Kansas City Royals | Northwest Arkansas (AA) | Activated from disabled list |
| Jose Sermo | RF | 25.093 | Boston Red Sox | Salem (A+) | Assigned to Salem (A+) |
| Jesus Severino | ss | 19.012 | Toronto Blue Jays | Bluefield (Rk) | Assigned to Bluefield (Rk) |
| Zach Shank | IF | 25.168 | Seattle Mariners | Tacoma (AAA) | Assigned to Tacoma (AAA) |
| JaVon Shelby | 3b | 21.048 | Oakland Athletics | Vermont (A-) | Assigned to Vermont (A-) |
| Jacob Shortslef | p | 21.176 | Texas Rangers | Spokane (A-) | Assigned to Spokane (A-) |
| Vinny Siena | 2b | 22.181 | New York Mets | St. Lucie (A+) | Assigned to St. Lucie (A+) |
| Miguel Angel Sierra | ss | 18.203 | Houston Astros | Greeneville (Rk) | Assigned to Greeneville (Rk) |
| Rainis Silva | C | 20.095 | Minnesota Twins | Cedar Rapids (A) | Assigned to Cedar Rapids (A) |
| Jake Simon | p | 19.153 | New York Mets | Kingsport (Rk) | Assigned to Kingsport (Rk) |
| Nick Sinay | of | 22.231 | Toronto Blue Jays | Bluefield (Rk) | Assigned to Bluefield (Rk) |
| Rinku Singh | P | 27.319 | Pittsburgh Pirates | Bradenton (A+) | Assigned to Bradenton (A+) |
| Kraig Sitton | P | 27.345 | Seattle Mariners | Jackson (AA) | Assigned to Jackson (AA) |
| Mason Smith | CF | 21.099 | San Diego Padres | Tri-City (A-) | Assigned to Tri-City (A-) |
| Taylor Sparks | 3B | 23.081 | Cincinnati Reds | Pensacola (AA) | Assigned to Pensacola (AA) |
| Jeffrey Springs | p | 23.276 | Texas Rangers | High Desert (A+) | Assigned to High Desert (A+) |
| Brandon Stephens | p | 24.027 | Seattle Mariners | Arizona Mariners (Rk) | Assigned to Arizona Mariners (Rk) |
| Thomas Szapucki | p | 20.011 | New York Mets | Kingsport (Rk) | Assigned to Kingsport (Rk) |
| Donavan Tate | CF | 25.269 | Los Angeles Dodgers | Great Lakes (A) | Activated from disabled list |
| Jacob Taylor | p | 20.354 | Pittsburgh Pirates | West Virginia (A-) | Assigned to West Virginia (A-) |
| Luis Tejada | 1B | 23.254 | San Diego Padres | San Antonio (AA) | Assigned to San Antonio (AA) |
| Isaias Tejeda | C | 24.239 | Atlanta Braves | Carolina (A+) | Assigned to Carolina (A+) |
| Michael Theofanopoulos | OF-P | 23.322 | Minnesota Twins | Fort Myers (A+) | Assigned to Fort Myers (A+) |
| Carlos Torres | OF | 23.265 | St. Louis Cardinals | Johnson City (Rk) | Assigned to Johnson City (Rk) |
| Jiandido Tromp | OF | 22.269 | Philadelphia Phillies | Clearwater (A+) | Assigned to Clearwater (A+) |
| Kyle Tucker | of | 19.157 | Houston Astros | Quad Cities (A) | Activated from disabled list |
| Adonis Uceta | P | 22.044 | New York Mets | Kingsport (Rk) | Assigned to Kingsport (Rk) |
| Miguel Urena | p | 21.116 | Los Angeles Dodgers | Ogden (Rk) | Assigned to Ogden (Rk) |
| Framber Valdez | p | 22.216 | Houston Astros | Greeneville (Rk) | Assigned to Greeneville (Rk) |
| Adrian Valerio | ss | 19.102 | Pittsburgh Pirates | Bristol (Rk) | Assigned to Bristol (Rk) |
| Andrew Vasquez | p | 22.282 | Minnesota Twins | Elizabethton (Rk) | Assigned to Elizabethton (Rk) |
| Gerwuins Velazco | C | 24.260 | St. Louis Cardinals | Peoria (A) | Assigned to Peoria (A) |
| Josciel Veras | SS | 23.198 | Cincinnati Reds | Dayton (A) | Assigned to Dayton (A) |
| Luis Veras | OF | 22.231 | Arizona Diamondbacks | Hillsboro (A-) | Assigned to Hillsboro (A-) |
| Jared Walker | 3B | 20.140 | Los Angeles Dodgers | Great Lakes (A) | Assigned to Great Lakes (A) |
| Davis Ward | P | 24.121 | St. Louis Cardinals | Johnson City (Rk) | Assigned to Johnson City (Rk) |
| Zak Wasserman | 1B | 25.297 | New York Yankees | Pulaski (Rk) | Assigned to Pulaski (Rk) |
| Jordan Watson | p | 22.282 | Arizona Diamondbacks | Missoula (Rk) | Assigned to Missoula (Rk) |
| Jacob Webb | P | 22.312 | Atlanta Braves | Danville (Rk) | Assigned to Danville (Rk) |
| Lachlan Wells | p | 19.116 | Minnesota Twins | Elizabethton (Rk) | Assigned to Elizabethton (Rk) |
| Tyler Willman | P | 23.258 | Oakland Athletics | Beloit (A) | Assigned to Beloit (A) |
| Izzy Wilson | of | 18.109 | Atlanta Braves | Danville (Rk) | Assigned to Danville (Rk) |
| K.J. Woods | RF | 20.350 | Chicago White Sox | Kannapolis (A) | Assigned to Kannapolis (A) |
| Max Wotell | p | 19.283 | New York Mets | Kingsport (Rk) | Assigned to Kingsport (Rk) |
| Jack Wynkoop | p | 22.233 | Colorado Rockies | Modesto (A+) | Assigned to Modesto (A+) |
| Sterling Wynn | P | 22.212 | Texas Rangers | Hickory (A) | Assigned to Hickory (A) |
| Collin Yelich | c | 22.265 | Atlanta Braves | Danville (Rk) | Assigned to Danville (Rk) |
| Stephen Zavala | c | 23.042 | St. Louis Cardinals | Johnson City (Rk) | Assigned to Johnson City (Rk) |
| Grant Zawadzki | p | 24.057 | San Diego Padres | Arizona Padres (Rk) | Assigned to Arizona Padres (Rk) |
| Adam Loewen | RP | 32.075 | Arizona Diamondbacks | Reno (AAA) | DL-7 Injured |
| Chad Jenkins | RP | 28.184 | Toronto Blue Jays | Buffalo (AAA) | DL-7 Injured |
| Dalton Pompey | CF | 23.194 | Toronto Blue Jays | Buffalo (AAA) | DL-7 Injured |
| Jason Berken | P | 32.209 | Toronto Blue Jays | New Hampshire (AA) | DL-7 Injured |
| Matt Magill | SP | 26.225 | Cincinnati Reds | Louisville (AAA) | DL-7 Injured |
| Steven Delabar | RP | 32.342 | Cincinnati Reds | Louisville (AAA) | Placed on temporary inactive list |
| Anthony Fernandez | P | 26.015 | Detroit Tigers | Erie (AA) | DL-7 Injured |
| Brian Jeroloman | C | 31.044 | Washington Nationals | Harrisburg (AA) | Placed on temporary inactive list |
| Juan Silva | LF | 25.166 | | | Released by Yankees |
| Luis Hurtado | C | 27.231 | Toronto Blue Jays | Buffalo (AAA) | DL-7 Injured |
| T.J. Rivera | 2B | 27.239 | New York Mets | Las Vegas (AAA) | DL-7 Injured |
| Trever Adams | 1B | 27.266 | | | Released by Rangers |
| Andy Fermin | 3B | 26.331 | Toronto Blue Jays | Dunedin (A+) | DL-7 Injured |
| David Paulino | P | 22.137 | Houston Astros | Corpus Christi (AA) | Placed on temporary inactive list |
| Raul Alcantara | P | 23.201 | Oakland Athletics | Midland (AA) | DL-7 Injured |
| Seth Conner | 3B | 24.146 | Toronto Blue Jays | New Hampshire (AA) | DL-7 Injured |
| Angel Ventura | P | 23.077 | Milwaukee Brewers | Brevard County (A+) | DL-7 Injured |
| Logan Wade | 2B | 24.223 | | | Released by Twins |
| Patrick Biondi | OF | 25.165 | New York Mets | St. Lucie (A+) | DL-7 Injured |
| Samuel Hiciano | OF | 22.149 | | | Released by Phillies |
| Tom Hackimer | p | 21.360 | Minnesota Twins | Cedar Rapids (A) | Signed out of draft (St. John's) |
| Austin Hays | of | 20.354 | Baltimore Orioles | Aberdeen (A-) | Signed out of draft (Jacksonville) |
| Grant Dyer | p | 20.328 | Philadelphia Phillies | Williamsport (A-) | Signed out of draft (UCLA) |
| Henri Lartigue | c | 21.119 | Philadelphia Phillies | Williamsport (A-) | Signed out of draft (Mississippi) |
| Jake Kelzer | p | 22.358 | Philadelphia Phillies | Williamsport (A-) | Signed out of draft (Indiana) |
| Julian Garcia | p | 21.041 | Philadelphia Phillies | Williamsport (A-) | Signed out of draft (Metro State) |
| Max Knutson | p | 21.083 | Baltimore Orioles | Aberdeen (A-) | Signed out of draft (Nebraska) |
| Nick Banks | of | 21.217 | Washington Nationals | Auburn (A-) | Signed out of draft (Texas A&M) |
| Nick Hartman | p | 21.242 | Toronto Blue Jays | Vancouver (A-) | Signed out of draft (Old Dominion) |
| Robert Tyler | p | 21.005 | Colorado Rockies | Boise (A-) | Signed out of draft (Georgia) |
| Tyler Leffler | ss | 21.347 | Pittsburgh Pirates | West Virginia (A-) | Signed out of draft (Bradley) |
| Adam Oller | p | 21.249 | Pittsburgh Pirates | Bristol (Rk) | Signed out of draft (Northwestern State) |
| Alex Bostic | p | 21.221 | San Francisco Giants | Arizona Giants (Rk) | Signed out of draft (Clemson) |
| Alex Lee | 1b | 22.243 | Atlanta Braves | Danville (Rk) | Signed out of draft (Samford) |
| Alex Massey | p | 23.142 | Kansas City Royals | Burlington (Rk) | Signed out of draft (Tulane) |
| Alex Schick | p | 21.204 | Minnesota Twins | Elizabethton (Rk) | Signed out of draft (California) |
| Andre Jernigan | ss | 22.219 | Minnesota Twins | Elizabethton (Rk) | Signed out of draft (Xavier) |
| Andrew Deramo | p | 21.028 | Toronto Blue Jays | Bluefield (Rk) | Signed out of draft (Central Florida) |
| Andrew Knizner | c | 21.140 | St. Louis Cardinals | Johnson City (Rk) | Signed out of draft (North Carolina State) |
| Andy Yerzy | c | 17.353 | Arizona Diamondbacks | Missoula (Rk) | Signed out of draft (Ontario HS) |
| Angel Alicea | p | 21.298 | Toronto Blue Jays | Bluefield (Rk) | Signed out of draft (Alabama State) |
| Angel Manzanarez | ss | 19.035 | New York Mets | Kingsport (Rk) | Assigned to Kingsport (Rk) |
| Angelo Serrano | p | 24.036 | Houston Astros | Greeneville (Rk) | Assigned to Greeneville (Rk) |
| Anthony Kidston | p | 23.036 | Kansas City Royals | Burlington (Rk) | Signed as undrafted free agent (Louisville) |
| Anthony Shew | p | 22.232 | St. Louis Cardinals | Johnson City (Rk) | Signed as undrafted free agent (San Francisco) |
| Austin Sexton | p | 21.341 | St. Louis Cardinals | Johnson City (Rk) | Signed out of draft (Mississippi State) |
| Ben Ruta | of | 22.015 | New York Yankees | Pulaski (Rk) | Signed out of draft (Wagner) |
| Blake Cederlind | p | 20.161 | Pittsburgh Pirates | Bristol (Rk) | Signed out of draft (Merced) |
| Bobby Melley | p | 22.074 | Tampa Bay Rays | Princeton (Rk) | Signed out of draft (Connecticut) |
| Braden Bristo | p | 21.234 | New York Yankees | Pulaski (Rk) | Signed out of draft (Louisiana Tech) |
| Bradley Jones | 3b | 21.011 | Toronto Blue Jays | Bluefield (Rk) | Signed out of draft (Charleston) |
| Brandon White | p | 21.184 | Atlanta Braves | Danville (Rk) | Signed out of draft (Lander) |
| Brent Gibbs | c | 21.269 | Pittsburgh Pirates | Bristol (Rk) | Signed out of draft (Central Arizona) |
| Brian Mcafee | p | 23.266 | Tampa Bay Rays | Princeton (Rk) | Signed out of draft (Duke) |
| Caleb Hamilton | ss | 21.138 | Minnesota Twins | Elizabethton (Rk) | Signed out of draft (Oregon State) |
| Caleb Lopes | 2b | 20.338 | St. Louis Cardinals | Johnson City (Rk) | Signed out of draft (West Georgia) |
| Cameron Stanton | p | 22.003 | Atlanta Braves | Danville (Rk) | Signed out of draft (St. Edward's) |
| Casey Scoggins | of | 22.101 | Minnesota Twins | Elizabethton (Rk) | Signed out of draft (Tampa) |
| Chaz Pal | of | 23.048 | Houston Astros | Greeneville (Rk) | Signed out of draft (South Carolina-Aiken) |
| Chris DeVito | 1b | 21.204 | Kansas City Royals | Burlington (Rk) | Signed out of draft (New Mexico) |
| Chris Hall | p | 22.147 | Toronto Blue Jays | Bluefield (Rk) | Signed out of draft (Elon) |
| Chris Viall | p | 20.269 | New York Mets | Kingsport (Rk) | Signed out of draft (Stanford) |
| Colin Holderman | p | 20.259 | New York Mets | Kingsport (Rk) | Signed out of draft (Heartland) |
| Colin McKee | p | 22.002 | Houston Astros | Greeneville (Rk) | Signed out of draft (Mercyhurst) |
| Colton Davis | p | 22.169 | Minnesota Twins | Elizabethton (Rk) | Signed out of draft (Western Carolina) |
| Connor Eller | p | 22.151 | Toronto Blue Jays | Bluefield (Rk) | Signed out of draft (Ouachita Baptist) |
| Corbin Clouse | p | 20.363 | Atlanta Braves | Danville (Rk) | Signed out of draft (Davenport) |
| Cory Geisler | p | 22.348 | Los Angeles Angels | Arizona Angels (Rk) | Signed as undrafted free agent (Texas State) |
| Cristhian Vasquez | of | 19.285 | Kansas City Royals | Burlington (Rk) | Assigned to Burlington (Rk) |
| Cristian Castillo | p | 21.271 | Kansas City Royals | Burlington (Rk) | Assigned to Burlington (Rk) |
| Dalton Moats | p | 21.030 | Tampa Bay Rays | Princeton (Rk) | Signed out of draft (Delta State) |
| Daniel Castano | p | 21.279 | St. Louis Cardinals | Johnson City (Rk) | Signed out of draft (Baylor) |
| Darien McLemore | 2b | 22.194 | Atlanta Braves | Danville (Rk) | Signed out of draft (UT Arlington) |
| David McKay | p | 21.084 | Kansas City Royals | Burlington (Rk) | Signed out of draft (Florida Atlantic) |
| Devan Watts | p | 21.063 | Atlanta Braves | Danville (Rk) | Signed out of draft (Tusculum) |
| Domenick Carlini | p | 22.216 | Minnesota Twins | Elizabethton (Rk) | Signed out of draft (Southeastern Louisiana) |
| Emilio Gustave | of | 21.148 | Tampa Bay Rays | Princeton (Rk) | Assigned to Princeton (Rk) |
| Emmanuel Rivera | ss | 19.359 | Kansas City Royals | Burlington (Rk) | Assigned to Burlington (Rk) |
| Felix Familia | p | 20.208 | Kansas City Royals | Burlington (Rk) | Assigned to Burlington (Rk) |
| Gabriel Cancel | ss | 19.197 | Kansas City Royals | Burlington (Rk) | Assigned to Burlington (Rk) |
| Garrett Brown | of | 22.099 | Pittsburgh Pirates | Bristol (Rk) | Signed out of draft (Western Carolina) |
| Garrett Davila | p | 19.157 | Kansas City Royals | Burlington (Rk) | Assigned to Burlington (Rk) |
| Geoff Hartlieb | p | 22.196 | Pittsburgh Pirates | Bristol (Rk) | Signed out of draft (Lindenwood) |
| Geoffrey Bramblett | p | 21.058 | Kansas City Royals | Burlington (Rk) | Signed out of draft (Alabama) |
| Greg Weissert | p | 21.139 | New York Yankees | Pulaski (Rk) | Signed out of draft (Fordham) |
| Hank Morrison | of | 22.090 | Minnesota Twins | Elizabethton (Rk) | Signed out of draft (Mercyhurst) |
| Hever Bueno | p | 21.212 | Texas Rangers | Arizona Rangers (Rk) | Signed out of draft (Arizona State) |
| Howie Brey | p | 22.032 | Houston Astros | Greeneville (Rk) | Signed out of draft (Rutgers) |
| Huascar Fuentes | 1b | 24.021 | Pittsburgh Pirates | Bristol (Rk) | Assigned to Bristol (Rk) |
| Ian Strom | of | 21.193 | New York Mets | Kingsport (Rk) | Signed out of draft (Mass-Lowell) |
| Isaac Benard | of | 20.173 | Tampa Bay Rays | Princeton (Rk) | Signed out of draft (Mount Hood) |
| J.B. Moss | of | 23.002 | Atlanta Braves | Danville (Rk) | Signed out of draft (Texas A&M) |
| Jared James | of | 22.121 | Atlanta Braves | Danville (Rk) | Signed out of draft (Long Beach State) |
| Jean Ramirez | c | 23.057 | Tampa Bay Rays | Princeton (Rk) | Signed out of draft (Illinois State) |
| Jeremy Walker | p | 21.011 | Atlanta Braves | Danville (Rk) | Signed out of draft (Gardner-Webb) |
| Jeremy Wolf | of | 22.233 | New York Mets | Kingsport (Rk) | Signed out of draft (Trinity) |
| John Pomeroy | p | 21.257 | Pittsburgh Pirates | Bristol (Rk) | Signed out of draft (Oregon State) |
| Jonathan McCray | 2b | 21.166 | Kansas City Royals | Burlington (Rk) | Assigned to Burlington (Rk) |
| Jordan Jess | p | 23.145 | Pittsburgh Pirates | Bristol (Rk) | Signed out of draft (Minnesota) |
| Jose Veras | p | 21.343 | Kansas City Royals | Burlington (Rk) | Assigned to Burlington (Rk) |
| Julian Aybar | p | 24.131 | New York Yankees | Pulaski (Rk) | Assigned to Pulaski (Rk) |
| Justin Camp | p | 23.037 | Kansas City Royals | Burlington (Rk) | Signed out of draft (Auburn) |
| Keaton Siomkin | p | 24.006 | St. Louis Cardinals | Johnson City (Rk) | Signed as undrafted free agent (California) |
| Kenny Mendoza | p | 18.103 | Texas Rangers | Arizona Rangers (Rk) | Signed out of draft (New Jersey HS) |
| Kenny Rosenberg | p | 20.350 | Tampa Bay Rays | Princeton (Rk) | Signed out of draft (Cal State Northridge) |
| Kobie Taylor | of | 17.314 | Texas Rangers | Arizona Rangers (Rk) | Signed out of draft (New Hampshire HS) |
| Kort Peterson | of | 22.055 | Kansas City Royals | Burlington (Rk) | Signed out of draft (UCLA) |
| Kyle Roberts | p | 19.244 | Texas Rangers | Arizona Rangers (Rk) | Signed out of draft (Henry Ford) |
| Kyle Weatherly | p | 21.263 | Toronto Blue Jays | Bluefield (Rk) | Signed out of draft (Grayson) |
| Leland Tilley | p | 24.166 | St. Louis Cardinals | Johnson City (Rk) | Signed out of draft (Bellevue NE) |
| Levi MaVorhis | p | 21.327 | St. Louis Cardinals | Johnson City (Rk) | Signed as undrafted free agent (Kansas State) |
| Logan Gray | of | 21.162 | Kansas City Royals | Burlington (Rk) | Signed out of draft (Austin Peay) |
| Lucas Williams | p | 21.338 | Houston Astros | Greeneville (Rk) | Signed out of draft (Central Missouri) |
| Luis Mora | p | 21.006 | Atlanta Braves | Danville (Rk) | Assigned to Danville (Rk) |
| Luis Santos | p | 21.278 | Cleveland Indians | Arizona Indians (Rk) | Assigned to AZL Indians (Rk) |
| Luke Gillingham | p | 22.111 | Toronto Blue Jays | Bluefield (Rk) | Signed out of draft (Navy) |
| Marcus Mooney | ss | 22.154 | Atlanta Braves | Danville (Rk) | Signed out of draft (South Carolina) |
| Matt Eckelman | p | 22.260 | Pittsburgh Pirates | Bristol (Rk) | Signed out of draft (Saint Louis) |
| Matt Fiedler | of | 21.093 | St. Louis Cardinals | Johnson City (Rk) | Signed out of draft (Minnesota) |
| Matt Gonzalez | 2b | 22.205 | Atlanta Braves | Danville (Rk) | Signed out of draft (Georgia Tech) |
| Matt Krook | p | 21.245 | San Francisco Giants | Arizona Giants (Rk) | Signed out of draft (Oregon) |
| Max Kuhns | p | 21.316 | New York Mets | Kingsport (Rk) | Signed out of draft (Santa Clara) |
| Michael Arroyo | c | 20.175 | Kansas City Royals | Burlington (Rk) | Assigned to Burlington (Rk) |
| Michael Silva | p | 21.213 | Kansas City Royals | Burlington (Rk) | Signed out of draft (Loyola Marymount) |
| Mikey York | p | 20.120 | Tampa Bay Rays | Princeton (Rk) | Signed out of draft (Southern Nevada) |
| Miles Chambers | p | 22.244 | New York Yankees | Pulaski (Rk) | Signed out of draft (Cal State Fullerton) |
| Mitchell Kranson | c | 22.163 | Minnesota Twins | Elizabethton (Rk) | Signed out of draft (California) |
| Nate Esposito | c | 22.363 | Kansas City Royals | Burlington (Rk) | Assigned to Burlington (Rk) |
| Nathan Thompson | p | 22.221 | Houston Astros | Greeneville (Rk) | Signed out of draft (Oklahoma Baptist) |
| Nick Nelson | p | 20.201 | New York Yankees | Pulaski (Rk) | Signed out of draft (Gulf Coast State) |
| Nick Yarnall | of | 21.249 | Los Angeles Dodgers | Arizona Dodgers (Rk) | Signed out of draft (Pittsburgh) |
| Nicky Lopez | ss | 21.102 | Kansas City Royals | Burlington (Rk) | Signed out of draft (Creighton) |
| Noel Gonzalez | p | 22.116 | St. Louis Cardinals | Johnson City (Rk) | Signed out of draft (Lewis-Clark State) |
| Ofreidy Gomez | p | 20.353 | Kansas City Royals | Burlington (Rk) | Assigned to Burlington (Rk) |
| Peter Bayer | p | 22.109 | Tampa Bay Rays | Princeton (Rk) | Signed out of draft (Cal Poly Pomona) |
| Phillip Diehl | p | 21.342 | New York Yankees | Pulaski (Rk) | Signed out of draft (Louisiana Tech) |
| Placido Torres | p | 23.037 | New York Mets | Kingsport (Rk) | Signed out of draft (Tusculum) |
| Rafael Cedeno | p | 21.261 | Texas Rangers | Arizona Rangers (Rk) | Assigned to AZL Rangers (Rk) |
| Ray Henderson | c | 20.179 | Houston Astros | Greeneville (Rk) | Signed out of draft (Grayson) |
| Reimin Ramos | p | 20.057 | Tampa Bay Rays | Princeton (Rk) | Assigned to Princeton (Rk) |
| Resly Linares | p | 18.194 | Tampa Bay Rays | Princeton (Rk) | Assigned to Princeton (Rk) |
| Ridge Smith | c | 21.058 | Toronto Blue Jays | Bluefield (Rk) | Signed out of draft (Austin Peay) |
| Robbie Coursel | p | 22.193 | Pittsburgh Pirates | Bristol (Rk) | Signed out of draft (Florida Atlantic) |
| Robbie Tenerowicz | 3b | 21.168 | Tampa Bay Rays | Princeton (Rk) | Signed out of draft (California) |
| Ross Vance | p | 24.199 | St. Louis Cardinals | Johnson City (Rk) | Signed as undrafted free agent |
| Ryan Calloway | of | 21.359 | Tampa Bay Rays | Princeton (Rk) | Signed as undrafted free agent (New Orleans) |
| Ryan Mason | p | 21.262 | Minnesota Twins | Elizabethton (Rk) | Signed out of draft (California) |
| Ryan Schlosser | p | 20.144 | Atlanta Braves | Danville (Rk) | Signed out of draft (Century) |
| Sean Poppen | p | 22.100 | Minnesota Twins | Elizabethton (Rk) | Signed out of draft (Harvard) |
| Sean Stutzman | p | 22.350 | Houston Astros | Greeneville (Rk) | Signed as undrafted free agent (Dallas Baptist) |
| Shane Billings | of | 21.191 | St. Louis Cardinals | Johnson City (Rk) | Signed out of draft (Wingate) |
| Shane Carrier | of | 20.020 | Minnesota Twins | Elizabethton (Rk) | Signed out of draft (Fullerton) |
| Spencer Johnson | of | 22.234 | Houston Astros | Greeneville (Rk) | Signed out of draft (Missouri State) |
| Tim Lynch | 1b | 23.020 | New York Yankees | Pulaski (Rk) | Signed out of draft (Southern Miss) |
| Travis Eckert | p | 22.177 | Kansas City Royals | Burlington (Rk) | Signed out of draft (Oregon State) |
| Trent Johnson | p | 19.315 | New York Mets | Kingsport (Rk) | Signed out of draft (Santa Fe CC) |
| Tyler Beardsley | p | 22.037 | Minnesota Twins | Elizabethton (Rk) | Signed out of draft (Sacramento State) |
| Tyler Britton | p | 22.109 | Houston Astros | Greeneville (Rk) | Signed out of draft (High Point) |
| Tyler Honahan | p | 22.169 | New York Yankees | Pulaski (Rk) | Signed out of draft (Stony Brook) |
| Tyler Straub | ss | 22.350 | Kansas City Royals | Burlington (Rk) | Signed as undrafted free agent (UT San Antonio) |
| Tyler Wolfe | 2b | 22.275 | Houston Astros | Greeneville (Rk) | Signed out of draft (Kansas State) |
| Vance Tatum | p | 21.052 | Kansas City Royals | Burlington (Rk) | Signed out of draft (Mississippi State) |
| Vance Vizcaino | of | 21.326 | Kansas City Royals | Burlington (Rk) | Signed out of draft (Stetson) |
| Walker Sheller | p | 21.033 | Kansas City Royals | Burlington (Rk) | Signed out of draft (Stetson) |
| Will Jones | p | 23.100 | New York Yankees | Pulaski (Rk) | Signed out of draft (Lander) |
| Yordany Salva | c | 19.237 | Kansas City Royals | Burlington (Rk) | Signed out of draft (Puerto Rico HS) |
| Zach Rice | p | 20.252 | Atlanta Braves | Danville (Rk) | Signed out of draft (North Carolina) |
| David Carpenter | RP | 30.343 | | | Released by Angels |
| Warwick Saupold | RP | 26.158 | Detroit Tigers | Toledo (AAA) | Assigned to Toledo (AAA) for rehab |
| Rony Bautista | p | 24.280 | | | Released by Yankees |
