| Daniel Coulombe | RP | 26.031 | Oakland Athletics | Oakland Athletics (MLB) | Designated for Assignment |
| Bud Norris | RP | 30.269 | Atlanta Braves | Atlanta Braves (MLB) | Signed to 1-year contract for 2016-2016 ($2.5m) [Free Agent] |
| Rex Brothers | RP | 27.344 | Chicago Cubs | Chicago Cubs (MLB) | Traded from Rockies to Cubs for Wander Cabrera |
| Michael Choice | RF | 26.016 | Cleveland Indians | Columbus (AAA) | Designated for Assignment |
| Kirby Yates | RP | 28.246 | Cleveland Indians | Cleveland Indians (MLB) | Traded from Rays to Indians for cash considerations |
| Matt Hague | 1B | 30.098 | | | Released by Blue Jays |
| Edgar Garcia | P | 28.067 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | Signed to Minor League Contract |
| Anthony Seratelli | 1B | 32.272 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | Signed to Minor League Contract |
| Raul Navarro | SS | 23.295 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | Signed to Minor League Contract |
| Kyle Jensen | RF | 27.190 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | Signed to Minor League Contract |
| Ericson Leonora | OF | 23.093 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | Signed to Minor League Contract |
| Jake Barrett | RP | 24.127 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | Contract purchased from minors |
| Matt Koch | P | 25.024 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | Contract purchased from minors |
| Gabby Guerrero | P | 21.350 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | Contract purchased from minors |
| Joel De La Cruz | P | 26.170 | Atlanta Braves | Atlanta Braves (MLB) | Signed to Minor League Contract |
| Willians Astudillo | c | 24.043 | Atlanta Braves | Atlanta Braves (MLB) | Signed to Minor League Contract |
| Jordy Lara | 1B | 24.189 | Atlanta Braves | Atlanta Braves (MLB) | Signed to Minor League Contract |
| Steve Borkowski | p | 23.019 | | | Released by Braves |
| Daniel Cordero | P | 22.172 | | | Released by Braves |
| Mitchell Osnowitz | P | 24.147 | | | Released by Braves |
| Ronny Guillermo | 3b | 19.116 | | | Released by Braves |
| John Gant | P | 23.112 | Atlanta Braves | Atlanta Braves (MLB) | Contract purchased from minors |
| Mallex Smith | CF | 22.204 | Atlanta Braves | Atlanta Braves (MLB) | Contract purchased from minors |
| Zach Booker | C | 30.216 | Baltimore Orioles | Baltimore Orioles (MLB) | Signed to Minor League Contract |
| Shawn McGill | C | 31.271 | Baltimore Orioles | Baltimore Orioles (MLB) | Signed to Minor League Contract |
| Pedro Perez | C | 24.202 | Baltimore Orioles | Baltimore Orioles (MLB) | Signed to Minor League Contract |
| Joel Polanco | C | 30.060 | Baltimore Orioles | Baltimore Orioles (MLB) | Signed to Minor League Contract |
| Nick Cunningham | P | 24.189 | | | Released by Orioles |
| Jared Breen | IF | 24.199 | | | Released by Orioles |
| Parker Bridwell | P | 24.116 | Baltimore Orioles | Baltimore Orioles (MLB) | Contract purchased from minors |
| Andrew Triggs | P | 26.255 | Baltimore Orioles | Baltimore Orioles (MLB) | Contract purchased from minors |
| Chris Lee | P | 23.101 | Baltimore Orioles | Baltimore Orioles (MLB) | Contract purchased from minors |
| Pat Light | P | 24.242 | Boston Red Sox | Boston Red Sox (MLB) | Contract purchased from minors |
| Williams Jerez | CF | 23.194 | Boston Red Sox | Boston Red Sox (MLB) | Contract purchased from minors |
| Marco Hernandez | SS | 23.081 | Boston Red Sox | Boston Red Sox (MLB) | Contract purchased from minors |
| Jeff Antigua | P | 25.156 | Chicago Cubs | Chicago Cubs (MLB) | Signed to Minor League Contract |
| Pierce Johnson | P | 24.200 | Chicago Cubs | Chicago Cubs (MLB) | Contract purchased from minors |
| Willson Contreras | 3B | 23.197 | Chicago Cubs | Chicago Cubs (MLB) | Contract purchased from minors |
| Jeimer Candelario | 3b | 22.002 | Chicago Cubs | Chicago Cubs (MLB) | Contract purchased from minors |
| Colin Kleven | P | 24.225 | Chicago White Sox | Chicago White Sox (MLB) | Signed to Minor League Contract |
| Matt Lollis | P | 25.076 | Chicago White Sox | Chicago White Sox (MLB) | Signed to Minor League Contract |
| Chadd Krist | C | 25.302 | Chicago White Sox | Chicago White Sox (MLB) | Signed to Minor League Contract |
| Scott Hairston | lf | 35.185 | Chicago White Sox | Chicago White Sox (MLB) | Signed to Minor League Contract |
| Jose Brito | P | 25.047 | | | Released by White Sox |
| Brandon Brennan | P | 24.123 | Chicago White Sox | Chicago White Sox (MLB) | Contract purchased from minors |
| Stephen Johnson | P | 24.278 | Cincinnati Reds | Cincinnati Reds (MLB) | Contract purchased from minors |
| Sal Romano | P | 22.045 | Cincinnati Reds | Cincinnati Reds (MLB) | Contract purchased from minors |
| Martin Cervenka | C | 23.115 | Cleveland Indians | Cleveland Indians (MLB) | Signed to Minor League Contract |
| Adam Moore | C | 31.202 | Cleveland Indians | Cleveland Indians (MLB) | Signed to Minor League Contract |
| Michael Martinez | LF | 33.071 | Cleveland Indians | Cleveland Indians (MLB) | Signed to Minor League Contract |
| Dylan Baker | P | 23.234 | Cleveland Indians | Cleveland Indians (MLB) | Contract purchased from minors |
| Mike Clevinger | P | 24.340 | Cleveland Indians | Cleveland Indians (MLB) | Contract purchased from minors |
| Shawn Morimando | P | 23.006 | Cleveland Indians | Cleveland Indians (MLB) | Contract purchased from minors |
| Tyler Naquin | OF | 24.216 | Cleveland Indians | Cleveland Indians (MLB) | Contract purchased from minors |
| James Ramsey | OF-IF | 25.342 | Cleveland Indians | Cleveland Indians (MLB) | Contract purchased from minors |
| Carlos Hernandez | P | 28.267 | Colorado Rockies | Colorado Rockies (MLB) | Signed to Minor League Contract |
| Carlos Estevez | P | 22.333 | Colorado Rockies | Colorado Rockies (MLB) | Contract purchased from minors |
| Antonio Senzatela | P | 20.309 | Colorado Rockies | Colorado Rockies (MLB) | Contract purchased from minors |
| Michael Fulmer | P | 22.256 | Detroit Tigers | Detroit Tigers (MLB) | Contract purchased from minors |
| Montreal Robertson | P | 25.160 | Detroit Tigers | Detroit Tigers (MLB) | Contract purchased from minors |
| Jairo Labourt | P | 21.264 | Detroit Tigers | Detroit Tigers (MLB) | Contract purchased from minors |
| Jandel Gustave | P | 23.045 | Houston Astros | Houston Astros (MLB) | Contract purchased from minors |
| Juan Minaya | P | 25.069 | Houston Astros | Houston Astros (MLB) | Contract purchased from minors |
| Joe Musgrove | P | 22.357 | Houston Astros | Houston Astros (MLB) | Contract purchased from minors |
| David Paulino | P | 21.293 | Houston Astros | Houston Astros (MLB) | Contract purchased from minors |
| Alfredo Gonzalez | C | 23.136 | Houston Astros | Houston Astros (MLB) | Contract purchased from minors |
| Nolan Fontana | IF | 24.173 | Houston Astros | Houston Astros (MLB) | Contract purchased from minors |
| Andrew Aplin | OF | 24.250 | Houston Astros | Houston Astros (MLB) | Contract purchased from minors |
| Roman Colon | P | 36.105 | Kansas City Royals | Kansas City Royals (MLB) | Signed to Minor League Contract |
| J.C. Boscan | C | 35.336 | Kansas City Royals | Kansas City Royals (MLB) | Signed to Minor League Contract |
| Ryan Eigsti | C | 30.094 | Kansas City Royals | Kansas City Royals (MLB) | Signed to Minor League Contract |
| Angel Franco | 2B | 25.187 | Kansas City Royals | Kansas City Royals (MLB) | Signed to Minor League Contract |
| Cruz Guevara | p | 21.181 | | | Released by Royals |
| Wandy Rodriguez | SP | 36.312 | | | Released by Royals |
| Brawlun Gomez | OF | 23.113 | | | Released by Royals |
| Alec Mills | P | 23.362 | Kansas City Royals | Kansas City Royals (MLB) | Contract purchased from minors |
| Kyle Zimmer | P | 24.074 | Kansas City Royals | Kansas City Royals (MLB) | Contract purchased from minors |
| Matt Strahm | P | 24.014 | Kansas City Royals | Kansas City Royals (MLB) | Contract purchased from minors |
| Ramon Torres | SS-2B | 22.308 | Kansas City Royals | Kansas City Royals (MLB) | Contract purchased from minors |
| Brett Eibner | CF | 26.359 | Kansas City Royals | Kansas City Royals (MLB) | Contract purchased from minors |
| Edward Paredes | P | 29.057 | Los Angeles Angels | Los Angeles Angels (MLB) | Signed to Minor League Contract |
| Victor Alcantara | P | 22.237 | Los Angeles Angels | Los Angeles Angels (MLB) | Contract purchased from minors |
| Adrian Salcedo | P | 24.294 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Signed to Minor League Contract |
| Matt West | RP | 27.005 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Signed to Minor League Contract |
| Shawn Zarraga | C | 26.309 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Signed to Minor League Contract |
| Jeff Malm | 1B | 25.026 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Signed to Minor League Contract |
| Jharel Cotton | P | 23.312 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Contract purchased from minors |
| Ross Stripling | P | 26.003 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Contract purchased from minors |
| Francisco Arcia | C | 26.073 | Miami Marlins | Miami Marlins (MLB) | Signed to Minor League Contract |
| Destin Hood | RF | 25.237 | Miami Marlins | Miami Marlins (MLB) | Signed to Minor League Contract |
| Junior Sosa | RF-LF | 25.054 | Miami Marlins | Miami Marlins (MLB) | Signed to Minor League Contract |
| Kenny Wilson | CF | 25.300 | Miami Marlins | Miami Marlins (MLB) | Signed to Minor League Contract |
| Matt Ramsey | P | 26.063 | Miami Marlins | New Orleans (AAA) | Outrighted to minors |
| Austin Brice | P | 23.160 | Miami Marlins | Miami Marlins (MLB) | Contract purchased from minors |
| Jake Esch | P | 25.244 | Miami Marlins | Miami Marlins (MLB) | Contract purchased from minors |
| Nick Wittgren | P | 24.181 | Miami Marlins | Miami Marlins (MLB) | Contract purchased from minors |
| Jarlin Garcia | p | 22.312 | Miami Marlins | Miami Marlins (MLB) | Contract purchased from minors |
| Rene Garcia | C | 25.250 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Signed to Minor League Contract |
| Jacob Barnes | P | 25.226 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Contract purchased from minors |
| Damien Magnifico | P | 24.186 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Contract purchased from minors |
| Shannon Wilkerson | LF-CF | 27.129 | Minnesota Twins | Minnesota Twins (MLB) | Signed to Minor League Contract |
| Yorman Landa | P | 21.168 | Minnesota Twins | Minnesota Twins (MLB) | Contract purchased from minors |
| Pat Dean | P | 26.185 | Minnesota Twins | Minnesota Twins (MLB) | Contract purchased from minors |
| Mason Melotakis | P | 24.151 | Minnesota Twins | Minnesota Twins (MLB) | Contract purchased from minors |
| Taylor Rogers | P | 24.344 | Minnesota Twins | Minnesota Twins (MLB) | Contract purchased from minors |
| Randy Rosario | P | 21.192 | Minnesota Twins | Minnesota Twins (MLB) | Contract purchased from minors |
| Adam Walker | OF-C | 24.039 | Minnesota Twins | Minnesota Twins (MLB) | Contract purchased from minors |
| Ty Kelly | 3B-LF | 27.129 | New York Mets | New York Mets (MLB) | Signed to Minor League Contract |
| Robert Gsellman | P | 22.131 | New York Mets | New York Mets (MLB) | Contract purchased from minors |
| Seth Lugo | P | 26.009 | New York Mets | New York Mets (MLB) | Contract purchased from minors |
| Jeffrey Walters | P | 28.020 | New York Mets | New York Mets (MLB) | Contract purchased from minors |
| Spencer Mahoney | p | 22.169 | New York Yankees | New York Yankees (MLB) | Signed to Minor League Contract |
| Kyle Higashioka | C | 25.220 | New York Yankees | New York Yankees (MLB) | Signed to Minor League Contract |
| Rainiero Coa | C | 22.327 | | | Released by Yankees |
| John Barbato | RP | 23.138 | New York Yankees | New York Yankees (MLB) | Contract purchased from minors |
| Rookie Davis | P | 22.211 | New York Yankees | New York Yankees (MLB) | Contract purchased from minors |
| Ben Gamel | RF | 23.193 | New York Yankees | New York Yankees (MLB) | Contract purchased from minors |
| Eduard Santos | P | 26.035 | Oakland Athletics | Oakland Athletics (MLB) | Signed to Minor League Contract |
| Chris Smith | P | 34.231 | Oakland Athletics | Oakland Athletics (MLB) | Signed to Minor League Contract |
| Carson Blair | C | 26.039 | Oakland Athletics | Oakland Athletics (MLB) | Signed to Minor League Contract |
| Jose Torres | p | 22.063 | Oakland Athletics | Oakland Athletics (MLB) | Contract purchased from minors |
| Joey Wendle | 2B | 25.214 | Oakland Athletics | Oakland Athletics (MLB) | Contract purchased from minors |
| James Russell | RP | 29.322 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Signed to Minor League Contract |
| Angelys Nina | 2B | 27.010 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Signed to Minor League Contract |
| Jimmy Cordero | P | 24.038 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Contract purchased from minors |
| Edubray Ramos | P | 22.342 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Contract purchased from minors |
| Roman Quinn | SS | 22.196 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Contract purchased from minors |
| Curtis Partch | RP | 28.286 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Signed to Minor League Contract |
| Danny Ortiz | RF-LF | 25.325 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Signed to Minor League Contract |
| Omar Basulto | P | 22.094 | | | Sold to Mexico City (Mexico) |
| Max Moroff | SS | 22.197 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Contract purchased from minors |
| Harold Ramirez | OF | 21.081 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Contract purchased from minors |
| Deck McGuire | P | 26.156 | St. Louis Cardinals | St. Louis Cardinals (MLB) | Signed to Minor League Contract |
| Dean Kiekhefer | P | 26.172 | St. Louis Cardinals | St. Louis Cardinals (MLB) | Contract purchased from minors |
| Aledmys Diaz | SS | 25.117 | St. Louis Cardinals | St. Louis Cardinals (MLB) | Contract purchased from minors |
| Charlie Tilson | CF-LF | 22.359 | St. Louis Cardinals | St. Louis Cardinals (MLB) | Contract purchased from minors |
| Martires Arias | P | 25.016 | San Diego Padres | San Diego Padres (MLB) | Signed to Minor League Contract |
| Luis Diaz | P | 23.231 | San Diego Padres | San Diego Padres (MLB) | Signed to Minor League Contract |
| Daniel McCutchen | P | 33.061 | San Diego Padres | San Diego Padres (MLB) | Signed to Minor League Contract |
| Albert Suarez | P | 26.049 | San Francisco Giants | San Francisco Giants (MLB) | Signed to Minor League Contract |
| Ricky Romero | SP | 31.020 | San Francisco Giants | San Francisco Giants (MLB) | Signed to Minor League Contract |
| Hak-Ju Lee | SS | 25.022 | San Francisco Giants | San Francisco Giants (MLB) | Signed to Minor League Contract |
| Junior Arias | 3B | 23.322 | San Francisco Giants | San Francisco Giants (MLB) | Signed to Minor League Contract |
| Carlos Moncrief | RF | 27.023 | San Francisco Giants | San Francisco Giants (MLB) | Signed to Minor League Contract |
| E.J. Encinosa | P | 24.113 | | | Released by Giants |
| Nicholas Gonzalez | P | 23.153 | | | Released by Giants |
| Drew Leenhouts | P | 25.243 | | | Released by Giants |
| Eric Sim | C | 26.327 | | | Released by Giants |
| Ian Gardeck | P | 25.005 | San Francisco Giants | San Francisco Giants (MLB) | Contract purchased from minors |
| Jake Smith | P | 25.177 | San Francisco Giants | San Francisco Giants (MLB) | Contract purchased from minors |
| Chris Stratton | P | 25.096 | San Francisco Giants | San Francisco Giants (MLB) | Contract purchased from minors |
| Ty Blach | P | 25.037 | San Francisco Giants | San Francisco Giants (MLB) | Contract purchased from minors |
| Steven Okert | P | 24.140 | San Francisco Giants | San Francisco Giants (MLB) | Contract purchased from minors |
| Kyle Schepel | P | 25.111 | Seattle Mariners | Seattle Mariners (MLB) | Signed to Minor League Contract |
| Arby Fields | OF | 24.154 | Seattle Mariners | Seattle Mariners (MLB) | Signed to Minor League Contract |
| Jefferson Arias | P | 22.232 | | | Released by Mariners |
| Yohailys Millord | P | 21.357 | | | Released by Mariners |
| Grady Wood | P | 25.192 | | | Released by Mariners |
| Gianni Zayas | p | 21.222 | | | Released by Mariners |
| Scott Dececco | P | 24.202 | | | Released by Mariners |
| Cameron Hobson | P | 26.230 | | | Released by Mariners |
| Yordi Calderon | 3B | 21.284 | | | Released by Mariners |
| Julius Gaines | ss | 23.077 | | | Released by Mariners |
| Hersin Martinez | OF | 20.272 | | | Released by Mariners |
| Guillermo Pimentel | RF | 23.052 | | | Released by Mariners |
| Taylor Zeutenhorst | OF | 23.032 | | | Released by Mariners |
| Patrick Kivlehan | 3B | 25.339 | Seattle Mariners | Seattle Mariners (MLB) | Contract purchased from minors |
| Boog Powell | OF | 22.316 | Seattle Mariners | Seattle Mariners (MLB) | Contract purchased from minors |
| Tyler Sturdevant | P | 29.341 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Signed to Minor League Contract |
| Wilmer Dominguez | c | 25.160 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Signed to Minor League Contract |
| Jake Faria | P | 22.119 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Contract purchased from minors |
| Blake Snell | P | 22.357 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Contract purchased from minors |
| Taylor Motter | 3B-SS | 26.069 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Contract purchased from minors |
| Jefri Hernandez | P | 24.213 | Texas Rangers | Texas Rangers (MLB) | Signed to Minor League Contract |
| Jose Leclerc | P | 21.342 | Texas Rangers | Texas Rangers (MLB) | Contract purchased from minors |
| Connor Sadzeck | P | 24.056 | Texas Rangers | Texas Rangers (MLB) | Contract purchased from minors |
| Yohander Mendez | P | 20.313 | Texas Rangers | Texas Rangers (MLB) | Contract purchased from minors |
| Murphy Smith | P | 28.093 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Signed to Minor League Contract |
| Jio Mier | SS | 25.092 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Signed to Minor League Contract |
| Brandon Hinkle | P | 25.011 | | | Released by Blue Jays |
| Brady Dragmire | P | 22.294 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Contract purchased from minors |
| Blake McFarland | P | 27.298 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Contract purchased from minors |
| Sean Burnett | RP | 33.070 | Washington Nationals | Washington Nationals (MLB) | Signed to Minor League Contract |
| Scott Sizemore | 2b | 30.326 | Washington Nationals | Washington Nationals (MLB) | Signed to Minor League Contract |
| Nick Lee | P | 24.317 | Washington Nationals | Washington Nationals (MLB) | Contract purchased from minors |
| Spencer Kieboom | C | 24.255 | Washington Nationals | Washington Nationals (MLB) | Contract purchased from minors |
| Chris Bostick | SS-2B | 22.247 | Washington Nationals | Washington Nationals (MLB) | Contract purchased from minors |
