| J.P. Arencibia | C | 29.235 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Contract purchased from minors |
| Curt Casali | C | 26.292 | Tampa Bay Rays | Tampa Bay Rays (MLB) | DL-15 Strained left hamstring |
| Grayson Garvin | P | 25.305 | Tampa Bay Rays | Montgomery (AA) | Transferred to 60-day DL |
| Nick Goody | RP | 24.053 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| J.R. Graham | RP | 25.226 | Minnesota Twins | Minnesota Twins (MLB) | DL-15 Right shoulder inflammation |
| Blaine Boyer | RP | 34.048 | Minnesota Twins | Minnesota Twins (MLB) | Activated from DL |
| David Ross | C | 38.162 | Chicago Cubs | Chicago Cubs (MLB) | Placed on bereavement list |
| Matt Szczur | LF | 26.039 | Chicago Cubs | Chicago Cubs (MLB) | Recalled from Iowa (AAA) |
| Chris Perez | CL | 30.058 | | | Announced retirement |
| Steve Clevenger | DH | 29.145 | Baltimore Orioles | Baltimore Orioles (MLB) | Reinstated from Paternity Leave |
| Denard Span | CF | 31.183 | Washington Nationals | Washington Nationals (MLB) | DL-15 Left hip inflammation |
| Mike Zunino | C | 24.156 | Seattle Mariners | Tacoma (AAA) | Assigned to Tacoma (AAA) |
| John Hicks | C | 25.362 | Seattle Mariners | Seattle Mariners (MLB) | Recalled from Tacoma (AAA) |
| Alberto Callaspo | 3B | 32.131 | | | Released by Dodgers |
| Joey Butler | DH | 29.169 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Recalled from Durham (AAA) |
| Desmond Jennings | LF | 28.302 | Tampa Bay Rays | Tampa Bay Rays (MLB) | DL-15 Bruised left knee |
| Jorge Rondon | P | 27.194 | Baltimore Orioles | Norfolk (AAA) | Assigned to Norfolk (AAA) |
| Andre Rienzo | SP | 27.084 | Miami Marlins | Miami Marlins (MLB) | Activated from DL |
| Fernando Rodney | RP | 34.164 | Chicago Cubs | Chicago Cubs (MLB) | Traded from Mariners to Cubs for future considerations |
| Zac Rosscup | RP | 27.080 | Chicago Cubs | Iowa (AAA) | Assigned to Iowa (AAA) |
| Rafael Betancourt | RP | 40.121 | | | Released by Rockies |
| Jason Frasor | RP | 38.019 | | | Released by Braves |
| Dustin Ackley | LF | 27.184 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) for rehab |
| Jose Antequera | ss | 20.027 | Philadelphia Phillies | Clearwater (A+) | Assigned to Clearwater (A+) |
| Kyle Blanks | LF | 28.351 | Texas Rangers | Round Rock (AAA) | Assigned to Round Rock (AAA) for rehab |
| Daniel Bravo | SS | 20.193 | San Diego Padres | Lake Elsinore (A+) | Assigned to Lake Elsinore (A+) |
| Chris Capuano | RP | 36.009 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Outrighted to minors |
| Oswald Caraballo | OF | 22.235 | New York Mets | Brooklyn (A-) | Assigned to Brooklyn (A-) |
| Christian Cavaness | of | 21.165 | Minnesota Twins | Elizabethton (Rk) | Assigned to Elizabethton (Rk) |
| Trent Grisham | of | 18.300 | Milwaukee Brewers | Helena (Rk) | Assigned to Helena (Rk) |
| Garrett Cooper | IF | 24.246 | Milwaukee Brewers | Biloxi (AA) | Assigned to Biloxi (AA) |
| Carlos Corporan | C | 31.234 | Texas Rangers | Frisco (AA) | Assigned to Frisco (AA) |
| Dylan Cozens | OF | 21.089 | Philadelphia Phillies | Reading (AA) | Assigned to Reading (AA) |
| Taylor Davis | C | 25.273 | Chicago Cubs | Iowa (AAA) | Assigned to Iowa (AAA) |
| Miguel Diaz | P | 20.273 | Milwaukee Brewers | Arizona Brewers (Rk) | Activated from disabled list |
| Dakota Dill | OF | 24.100 | Atlanta Braves | Rome (A) | Assigned to Rome (A) |
| Jesen Therrien | P | 22.163 | Philadelphia Phillies | Clearwater (A+) | Reinstated to active roster |
| Edwin Espinal | 1B | 21.217 | Pittsburgh Pirates | Bradenton (A+) | Activated from disabled list |
| Icezack Flemming | p | 23.065 | New York Yankees | Gulf Coast Yankees 2 (Rk) | Assigned to Gulf Coast Yankees 2 (Rk) |
| Alex Gordon | LF | 31.200 | Kansas City Royals | Omaha (AAA) | Assigned to Omaha (AAA) for rehab |
| Bryan Haar | OF | 25.262 | Minnesota Twins | Gulf Coast Twins (Rk) | Assigned to Gulf Coast Twins (Rk) |
| Shane Halley | P | 25.334 | Colorado Rockies | Asheville (A) | Reinstated to active roster |
| Bryan Harper | P | 25.242 | Washington Nationals | Syracuse (AAA) | Assigned to Syracuse (AAA) |
| Jonah Heim | C | 20.062 | Baltimore Orioles | Gulf Coast Orioles (Rk) | Activated from disabled list |
| Sam Hentges | P | 19.041 | Cleveland Indians | Mahoning Valley (A-) | Assigned to Mahoning Valley (A-) |
| Jon Jay | CF | 30.166 | St. Louis Cardinals | Memphis (AAA) | Activated from disabled list |
| Connor Kaden | P | 22.305 | San Francisco Giants | Augusta (A) | Activated from disabled list |
| Gilbert Lara | ss | 17.302 | Milwaukee Brewers | Helena (Rk) | Assigned to Helena (Rk) |
| Josh Lester | 3b | 21.042 | Detroit Tigers | West Michigan (A) | Assigned to West Michigan (A) |
| Nick Martinez | SP | 25.023 | Texas Rangers | Round Rock (AAA) | Assigned to Round Rock (AAA) |
| D'vone McClure | OF | 21.218 | Cleveland Indians | Arizona Indians (Rk) | Activated from disabled list |
| Tyler Moore | LF | 28.210 | Washington Nationals | Syracuse (AAA) | Assigned to Syracuse (AAA) for rehab |
| Ramon Morla | 3B | 25.281 | Seattle Mariners | Bakersfield (A+) | Assigned to Bakersfield (A+) |
| Elliot Morris | P | 23.124 | San Diego Padres | Arizona Padres (Rk) | Activated from disabled list |
| Tommy Peterson | p | 21.321 | Washington Nationals | Hagerstown (A) | Assigned to Hagerstown (A) |
| Jurickson Profar | ss-dh | 22.189 | Texas Rangers | Hickory (A) | Assigned to Hickory (A) for rehab |
| Matt Purke | P | 25.042 | Washington Nationals | Harrisburg (AA) | Activated from disabled list |
| Gabriel Quintana | 3B | 22.355 | San Diego Padres | San Antonio (AA) | Assigned to San Antonio (AA) |
| Nolan Reimold | LF | 31.321 | Baltimore Orioles | Norfolk (AAA) | Outrighted to minors |
| Blake Rogers | p | 21.186 | San Diego Padres | Lake Elsinore (A+) | Assigned to Lake Elsinore (A+) |
| Greg Ross | P | 25.356 | Atlanta Braves | Mississippi (AA) | Activated from disabled list |
| Andres Santiago | P | 25.306 | Chicago Cubs | Tennessee (AA) | Activated from disabled list |
| Craig Schlitter | P | 23.104 | Colorado Rockies | Boise (A-) | Assigned to Boise (A-) |
| Casey Shane | p | 20.005 | Cleveland Indians | Lake County (A) | Assigned to Lake County (A) |
| Andrew Sohn | IF | 22.112 | St. Louis Cardinals | Springfield (AA) | Assigned to Springfield (AA) |
| Allen Staton | c | 22.352 | St. Louis Cardinals | Palm Beach (A+) | Assigned to Palm Beach (A+) |
| Skyler Stromsmoe | SS-LF | 31.151 | San Francisco Giants | Richmond (AA) | Assigned to Richmond (AA) |
| Starlyn Suriel | P | 21.284 | Toronto Blue Jays | Lansing (A) | Activated from disabled list |
| Christopher Thomas | P | 27.165 | St. Louis Cardinals | Memphis (AAA) | Assigned to Memphis (AAA) |
| Mike Thomas | P | 26.234 | Los Angeles Dodgers | Tulsa (AA) | Activated from disabled list |
| Ronald Torreyes | 2B | 22.360 | Los Angeles Dodgers | Oklahoma City (AAA) | Assigned to Oklahoma City (AAA) |
| Henry Urrutia | dh | 28.196 | Baltimore Orioles | Norfolk (AAA) | Assigned to Norfolk (AAA) |
| Daris Vargas | p | 23.016 | New York Yankees | Charleston (sc) (A) | Assigned to Charleston (sc) (A) |
| Emilio Vargas | p | 19.016 | Arizona Diamondbacks | Visalia (A+) | Assigned to Visalia (A+) |
| Drew Ward | 3B | 20.276 | Washington Nationals | Potomac (A+) | Assigned to Potomac (A+) |
| Garrett Whitley | of | 18.168 | Tampa Bay Rays | Hudson Valley (A-) | Assigned to Hudson Valley (A-) |
| Sam Wilson | P | 24.029 | Chicago Cubs | South Bend (A) | Activated from disabled list |
| Eric Yardley | P | 25.010 | San Diego Padres | San Antonio (AA) | Assigned to San Antonio (AA) |
| Drake Britton | RP | 26.098 | Chicago Cubs | Iowa (AAA) | DL-7 Injured |
| Lay Batista | P | 26.024 | Miami Marlins | Jacksonville (AA) | DL-7 Injured |
| Tyler Naquin | OF | 24.126 | Cleveland Indians | Columbus (AAA) | DL-7 Hip |
| Brett Phillips | OF | 21.090 | Milwaukee Brewers | Biloxi (AA) | DL-7 Injured |
| Avery Romero | SS | 22.109 | Miami Marlins | Jupiter (A+) | DL-7 Injured |
| Jhoan Urena | 3B | 20.361 | New York Mets | St. Lucie (A+) | DL-7 Injured |
| Omar Bencomo | p | 26.199 | Minnesota Twins | Fort Myers (A+) | DL-7 Injured |
| Ryan Eades | P | 23.257 | Minnesota Twins | Fort Myers (A+) | DL-7 Injured |
| Steven Inch | P | 24.208 | Philadelphia Phillies | Gulf Coast Phillies (Rk) | DL-7 Injured |
| Willy Adames | SS | 19.361 | Tampa Bay Rays | Charlotte (A+) | DL-7 Injured |
| Corey Oswalt | P | 21.359 | New York Mets | Savannah (A) | DL-7 Injured |
| Jimmy Pickens | OF-C | 23.163 | Cincinnati Reds | Dayton (A) | Placed on temporary inactive list |
| Mason Davis | IF | 22.229 | Miami Marlins | Greensboro (A) | DL-7 Injured |
| Tyler Cyr | p | 22.115 | San Francisco Giants | Augusta (A) | DL-7 Injured |
| Lewis Alezones | P | 19.273 | | | Released by Phillies |
| Alberto Guerrero | p | 17.258 | Miami Marlins | Gulf Coast Marlins (Rk) | DL-60 Injured |
| Joe Watson | P | 22.338 | | | Released by Rangers |
| Keaton Aldridge | p | 23.039 | New York Mets | Gulf Coast Mets (Rk) | DL-60 Injured |
| Chin-Hui Tsao | RP | 34.087 | Los Angeles Dodgers | Oklahoma City (AAA) | Placed on temporary inactive list |
| John Bowker | P | 32.051 | Pittsburgh Pirates | Indianapolis (AAA) | DL-7 Injured |
| John Holdzkom | P | 27.314 | Pittsburgh Pirates | Indianapolis (AAA) | DL-7 Injured |
| Mike Hessman | 1B | 37.176 | Detroit Tigers | Toledo (AAA) | DL-7 Injured |
| Bryson Smith | CF | 26.254 | Cincinnati Reds | Louisville (AAA) | DL-7 Injured |
| Jayce Boyd | IF | 24.241 | New York Mets | Las Vegas (AAA) | DL-7 Injured |
| Moises Hernandez | P | 31.163 | Seattle Mariners | Jackson (AA) | DL-7 Injured |
| David Dahl | OF | 21.149 | Colorado Rockies | New Britain (AA) | DL-7 Injured |
| Dixon Llorens | P | 22.283 | St. Louis Cardinals | Peoria (A) | DL-7 Injured |
| Henry Ramos | CF-RF | 23.135 | Boston Red Sox | Portland (AA) | DL-7 Injured |
| Alberto Triunfel | SS | 21.208 | Texas Rangers | High Desert (A+) | DL-7 Injured |
| Jake Gronsky | IF | 23.281 | St. Louis Cardinals | Peoria (A) | DL-7 Injured |
| Jake Yacinich | IF | 22.179 | Los Angeles Angels | Burlington (A) | DL-7 Injured |
| Mason McCullough | P | 22.233 | Arizona Diamondbacks | Visalia (A+) | DL-7 Injured |
| Nelson Ward | IF | 23.022 | Seattle Mariners | Bakersfield (A+) | DL-7 Injured |
| Alan Sharkey | 1B | 21.293 | Milwaukee Brewers | Wisconsin (A) | DL-7 Injured |
| Francisco Castillo | 2b | 22.085 | Milwaukee Brewers | Wisconsin (A) | DL-7 Injured |
| Jordan Luplow | OF | 21.336 | Pittsburgh Pirates | West Virginia (A) | DL-7 Injured |
| Nathan Kirby | p | 21.278 | Milwaukee Brewers | Wisconsin (A) | DL-7 Injured |
| Zach Varela | P | 23.009 | Los Angeles Angels | Burlington (A) | DL-7 Injured |
| Joaquin Arias | 2B | 30.341 | San Francisco Giants | Sacramento (AAA) | Placed on temporary inactive list |
| Ramon Flores | RF | 23.155 | Seattle Mariners | Tacoma (AAA) | DL-7 Injured |
| Ramon Troncoso | RP | 32.193 | Los Angeles Dodgers | Oklahoma City (AAA) | DL-7 Injured |
| Cameron Perkins | OF | 24.335 | Philadelphia Phillies | Reading (AA) | DL-7 Injured |
| Christian Binford | P | 22.251 | Kansas City Royals | Northwest Arkansas (AA) | DL-7 Injured |
| Delvis Morales | SS | 24.364 | Los Angeles Dodgers | Rancho Cucamonga (A+) | DL-7 Injured |
| Edward Salcedo | 3B | 24.029 | Kansas City Royals | Northwest Arkansas (AA) | DL-7 Injured |
| Griff Erickson | C | 27.170 | San Diego Padres | San Antonio (AA) | DL-7 Injured |
| Jordan Pries | P | 25.213 | Seattle Mariners | Tacoma (AAA) | DL-7 Injured |
| Cody Hebner | P | 24.280 | San Diego Padres | San Antonio (AA) | DL-7 Injured |
| Frank Lopez | P | 21.191 | Texas Rangers | Frisco (AA) | DL-7 Injured |
| Bryan Radziewski | P | 23.189 | Houston Astros | Lancaster (A+) | DL-7 Injured |
| Delvi Francisco | P | 23.004 | | | Released by Indians |
| Brian Gonzalez | P | 19.308 | Baltimore Orioles | Delmarva (A) | DL-7 Injured |
| Drew Smith | p | 21.338 | Detroit Tigers | West Michigan (A) | DL-7 Injured |
| Franly Mallen | ss | 18.093 | Milwaukee Brewers | Helena (Rk) | Assigned to Helena (Rk) |
| Garrett Harrison | p | 22.014 | Los Angeles Dodgers | Arizona Dodgers (Rk) | Signed as undrafted free agent (St. Cloud State) |
| Gavin Pittore | p | 21.344 | Los Angeles Dodgers | Arizona Dodgers (Rk) | Signed as undrafted free agent (Wesleyan) |
| Irving Ortega | ss | 18.302 | Baltimore Orioles | Gulf Coast Orioles (Rk) | Assigned to GCL Orioles (Rk) |
| Julian Fernandez | p | 19.267 | Colorado Rockies | Grand Junction (Rk) | Assigned to Grand Junction (Rk) |
| Marcos Almonte | 3b | 19.153 | Houston Astros | Gulf Coast Astros (Rk) | Assigned to GCL Astros (Rk) |
| Marcus Brakeman | p | 21.074 | Boston Red Sox | Gulf Coast Red Sox (Rk) | Signed out of draft (Stanford) |
| Nicolas Debora | p | 21.265 | New York Mets | Gulf Coast Mets (Rk) | Assigned to GCL Mets (Rk) |
| Oliver Pascual | ss | 18.285 | New York Mets | Gulf Coast Mets (Rk) | Assigned to GCL Mets (Rk) |
| Rafael Lara | p | 20.079 | New York Yankees | Gulf Coast Yankees (Rk) | Assigned to GCL Yankees (Rk) |
| Roniel Raudes | p | 17.224 | Boston Red Sox | Gulf Coast Red Sox (Rk) | Assigned to GCL Red Sox (Rk) |
| Nathan Lukes | of | 21.047 | Cleveland Indians | Arizona Indians (Rk) | DL-7 Injured |
| Kyle Garlick | of | 23.215 | Los Angeles Dodgers | Rancho Cucamonga (A+) | DL-7 Injured |
| Stephen McCray | P | 27.327 | | | Released by White Sox |
| Jair Jurrjens | RP | 29.211 | | | Released by Rockies |
