| Jorge Polanco | SS-3B | 22.024 | Minnesota Twins | Minnesota Twins (MLB) | Recalled from Rochester (AAA) |
| Trevor Plouffe | 3B | 29.044 | Minnesota Twins | Minnesota Twins (MLB) | Placed on paternity leave |
| David Carpenter | RP | 27.332 | Atlanta Braves | Atlanta Braves (MLB) | Designated for Assignment |
| Donovan Solano | 2b | 27.225 | Miami Marlins | Miami Marlins (MLB) | Placed on paternity leave |
| Manny Banuelos | SP | 24.138 | Atlanta Braves | Atlanta Braves (MLB) | DL-15 Left elbow inflammation |
| Dee Gordon | 2B | 27.098 | Miami Marlins | Miami Marlins (MLB) | Activated from DL |
| Jaime Garcia | SP | 29.021 | St. Louis Cardinals | St. Louis Cardinals (MLB) | Activated from DL |
| Jenrry Mejia | RP | 25.291 | New York Mets | New York Mets (MLB) | Suspended 162 games for violating MLB drug program |
| Emmanuel Burriss | 2B | 30.193 | Washington Nationals | Syracuse (AAA) | Outrighted to minors |
| Ryan Zimmerman | 1B | 30.304 | Washington Nationals | Washington Nationals (MLB) | Activated from DL |
| Jayson Werth | LF | 36.070 | Washington Nationals | Washington Nationals (MLB) | Activated from DL |
| Daniel Butler | C | 28.285 | Washington Nationals | Syracuse (AAA) | Designated for Assignment |
| Jonathan Papelbon | RP | 34.248 | Washington Nationals | Washington Nationals (MLB) | Traded from Phillies to Nationals for Nick Pivetta |
| Nick Pivetta | P | 22.165 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Traded from Nationals to Phillies for Jonathan Papelbon |
| Troy Tulowitzki | SS | 30.292 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Traded from Rockies with Latroy Hawkins to Blue Jays for Jose Reyes, Miguel Castro, Jeff Hoffman and Jesus Tinoco |
| LaTroy Hawkins | RP | 42.220 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Traded from Rockies with Troy Tulowitzki to Blue Jays for Jose Reyes, Miguel Castro, Jeff Hoffman and Jesus Tinoco |
| Jose Reyes | SS | 32.048 | Colorado Rockies | Colorado Rockies (MLB) | Traded from Blue Jays with Miguel Castro, Jesus Tinoco and Jeff Hoffman to Rockies for Troy Tulowitzki and Latroy Hawkins |
| Brent Morel | 3B | 28.099 | | | Refused minor league assignment, declared free agent |
| Clay Buchholz | SP | 30.349 | Boston Red Sox | Boston Red Sox (MLB) | Transferred to 60-day DL |
| Jean Machi | RP | 32.178 | Boston Red Sox | Boston Red Sox (MLB) | Claimed off waivers from Giants by Red Sox |
| Asdrubal Cabrera | SS | 29.258 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Activated from DL |
| Diego Moreno | RP | 28.008 | New York Yankees | New York Yankees (MLB) | Recalled from Scranton/Wilkes-Barre (AAA) |
| Efren Navarro | 1B | 29.076 | Los Angeles Angels | Los Angeles Angels (MLB) | Recalled from Salt Lake (AAA) |
| Matt Joyce | LF | 30.360 | Los Angeles Angels | Los Angeles Angels (MLB) | DL-7 Concussion |
| David DeJesus | LF | 35.222 | Los Angeles Angels | Los Angeles Angels (MLB) | Traded from Rays to Angels for Eduar Lopez |
| Eduar Lopez | P | 20.158 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Traded from Angels to Rays for David Dejesus |
| David Murphy | LF | 33.284 | Los Angeles Angels | Los Angeles Angels (MLB) | Traded from Indians to Angels for Eric Stamets |
| Eric Stamets | IF | 23.308 | Cleveland Indians | Cleveland Indians (MLB) | Traded from Angels to Indians for David Murphy |
| Vinnie Pestano | RP | 30.159 | Los Angeles Angels | Salt Lake (AAA) | Designated for Assignment |
| Ben Zobrist | 2B-LF | 34.064 | Kansas City Royals | Kansas City Royals (MLB) | Traded from Athletics to Royals for Aaron Brooks and Sean Manaea |
| Sean Manaea | P | 23.179 | Oakland Athletics | Oakland Athletics (MLB) | Traded from Royals with Aaron brooks to Athletics for Ben Zobrist |
| Joe Blanton | CL | 34.230 | Kansas City Royals | Kansas City Royals (MLB) | Designated for Assignment |
| R.J. Alvarez | RP | 24.051 | Oakland Athletics | Oakland Athletics (MLB) | Recalled from Nashville (AAA) |
| Max Muncy | 3B | 24.338 | Oakland Athletics | Oakland Athletics (MLB) | Recalled from Nashville (AAA) |
| Michael Roth | RP | 25.164 | Cleveland Indians | Cleveland Indians (MLB) | Contract purchased from minors |
| Nick Hagadone | RP | 29.209 | Cleveland Indians | Cleveland Indians (MLB) | Transferred to 60-day DL |
| Dallas Beeler | SP | 26.047 | Chicago Cubs | Chicago Cubs (MLB) | Recalled from Iowa (AAA) |
| Wily Peralta | SP | 26.082 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Activated from DL |
| Justin Miller | RP | 28.046 | Colorado Rockies | Colorado Rockies (MLB) | Recalled from Albuquerque (AAA) |
| Aaron Laffey | RP | 30.105 | Colorado Rockies | Colorado Rockies (MLB) | Contract purchased from minors |
| Chris Dominguez | 1b | 28.249 | Cincinnati Reds | Louisville (AAA) | Outrighted to minors |
| Cristhian Adames | SS | 24.003 | Colorado Rockies | Albuquerque (AAA) | Assigned to Albuquerque (AAA) |
| Jayson Aquino | P | 22.249 | Cleveland Indians | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Dallas Beeler | SP | 26.047 | Chicago Cubs | Iowa (AAA) | Assigned to Iowa (AAA) |
| Craig Brooks | p | 22.309 | Chicago Cubs | Eugene (A-) | Assigned to Eugene (A-) |
| Trevor Clifton | P | 20.079 | Chicago Cubs | South Bend (A) | Activated from disabled list |
| Keith Couch | P | 25.266 | Boston Red Sox | Lowell (A-) | Assigned to Lowell (A-) |
| Dylan Covey | P | 23.350 | Oakland Athletics | Stockton (A+) | Activated from disabled list |
| Derek De Young | P | 23.225 | Oakland Athletics | Vermont (A-) | Assigned to Vermont (A-) |
| Dean Deetz | P | 21.242 | Houston Astros | Quad Cities (A) | Assigned to Quad Cities (A) |
| Justin Ferrell | P | 21.099 | Houston Astros | Quad Cities (A) | Reinstated to active roster |
| Carson Fulmer | p | 21.228 | Chicago White Sox | Winston-Salem (A+) | Assigned to Winston-Salem (A+) |
| Carlos Gonzalez | P | 25.047 | Cincinnati Reds | Daytona (A+) | Activated from disabled list |
| Franklin Guzman | OF | 23.176 | Boston Red Sox | Salem (A+) | Activated from disabled list |
| Mike Hauschild | P | 25.188 | Houston Astros | Fresno (AAA) | Reinstated to active roster |
| Brock Hebert | IF | 24.079 | Seattle Mariners | Clinton (A) | Assigned to Clinton (A) |
| D.J. Hicks | IF-P | 25.118 | Minnesota Twins | Chattanooga (AA) | Assigned to Chattanooga (AA) |
| Sam Johns | P | 24.017 | Washington Nationals | Auburn (A-) | Assigned to Auburn (A-) |
| Eric Jokisch | P | 26.000 | Chicago Cubs | Arizona Cubs (Rk) | Activated from disabled list |
| Phil Klein | RP | 26.090 | Texas Rangers | Round Rock (AAA) | Assigned to Round Rock (AAA) |
| Marcus Knecht | LF | 25.038 | Minnesota Twins | Fort Myers (A+) | Assigned to Fort Myers (A+) |
| Logan Landon | of | 22.162 | Los Angeles Dodgers | Arizona Dodgers (Rk) | Assigned to Arizona Dodgers (Rk) |
| Dustin Lawley | 3B-CF | 26.109 | Boston Red Sox | Portland (AA) | Assigned to Portland (AA) |
| Damien Magnifico | P | 24.066 | Milwaukee Brewers | Biloxi (AA) | Activated from disabled list |
| Camden Maron | C | 24.190 | Cincinnati Reds | Pensacola (AA) | Activated from disabled list |
| Nick Maronde | RP | 25.327 | Cleveland Indians | Columbus (AAA) | Reinstated to active roster |
| Matt McBride | RF-1B | 30.067 | Colorado Rockies | Albuquerque (AAA) | Activated from disabled list |
| Edwin Medina | OF | 22.168 | Houston Astros | Lancaster (A+) | Assigned to Lancaster (A+) |
| Mike Miller | IF | 25.305 | Boston Red Sox | Pawtucket (AAA) | Assigned to Pawtucket (AAA) |
| Estarlyn Morales | | 22.274 | Seattle Mariners | Clinton (A) | Assigned to Clinton (A) |
| Kevin Munson | P | 26.207 | Arizona Diamondbacks | Reno (AAA) | Assigned to Reno (AAA) |
| Chris Murphy | p | 22.304 | Houston Astros | Tri City (A-) | Assigned to Tri City (A-) |
| Shawn O'Malley | SS-2B | 27.214 | Seattle Mariners | Everett (A-) | Activated from disabled list |
| D.J. Peterson | 1B-3B | 23.211 | Seattle Mariners | Tacoma (AAA) | Assigned to Tacoma (AAA) |
| Rohn Pierce | P | 22.189 | Seattle Mariners | Everett (A-) | Assigned to Everett (A-) |
| Tyler Pill | P | 25.061 | New York Mets | Las Vegas (AAA) | Reinstated to active roster |
| Moreno Polanco | p | 21.000 | Houston Astros | Greeneville (Rk) | Assigned to Greeneville (Rk) |
| Christian Powell | P | 24.026 | Houston Astros | Lancaster (A+) | Assigned to Lancaster (A+) |
| Milton Ramos | SS | 19.277 | New York Mets | Kingsport (Rk) | Assigned to Kingsport (Rk) |
| Dan Robertson | LF | 29.302 | Los Angeles Angels | Salt Lake (AAA) | Assigned to Salt Lake (AAA) |
| Antonio Romero | P | 24.219 | Cleveland Indians | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Adderling Ruiz | C | 24.087 | Washington Nationals | Syracuse (AAA) | Activated from disabled list |
| Erick Salcedo | | 22.031 | Los Angeles Angels | Arkansas (AA) | Assigned to Arkansas (AA) |
| Adrian Sanchez | 2B | 24.347 | Washington Nationals | Gulf Coast Nationals (Rk) | Activated from disabled list |
| Tayler Saucedo | p | 22.041 | Toronto Blue Jays | Vancouver (A-) | Assigned to Vancouver (A-) |
| Zach Shank | IF | 24.204 | Seattle Mariners | Jackson (AA) | Assigned to Jackson (AA) |
| Sammy Solis | RP | 26.353 | Washington Nationals | Syracuse (AAA) | Assigned to Syracuse (AAA) |
| Mike Soroka | p | 17.359 | Atlanta Braves | Danville (Rk) | Assigned to Danville (Rk) |
| Christian Turnipseed | p | 23.060 | Baltimore Orioles | Aberdeen (A-) | Assigned to Aberdeen (A-) |
| M.J. Villegas | P | 20.326 | Los Angeles Dodgers | Ogden (Rk) | Assigned to Ogden (Rk) |
| Jake Yacinich | IF | 22.149 | Los Angeles Angels | Inland Empire (A+) | Assigned to Inland Empire (A+) |
| Mookie Betts | CF | 22.295 | Boston Red Sox | Boston Red Sox (MLB) | DL-7 concussion |
| Neil Ramirez | RP | 26.065 | Chicago Cubs | Chicago Cubs (MLB) | DL-15 Left abdominal soreness |
| Andrew Albers | SP | 29.296 | Toronto Blue Jays | Buffalo (AAA) | DL-7 Injured |
| Charles Brewer | RP | 27.113 | Cleveland Indians | Akron (AA) | DL-7 Injured |
| Yorman Rodriguez | RF | 22.348 | Cincinnati Reds | Louisville (AAA) | DL-7 Injured |
| Grant Dayton | P | 27.247 | Los Angeles Dodgers | Oklahoma City (AAA) | Placed on temporary inactive list |
| Jeremy McBryde | P | 28.089 | Los Angeles Angels | Salt Lake (AAA) | Designated for Assignment |
| Mark Lamm | P | 27.143 | | | Released by Braves |
| Rafael Fernandez | SS | 21.099 | Seattle Mariners | Arizona Mariners (Rk) | DL-7 Injured |
| Shawn Zarraga | C | 26.189 | Los Angeles Dodgers | Oklahoma City (AAA) | DL-7 Injured |
| Stephen Smith | P | 29.075 | Los Angeles Dodgers | Oklahoma City (AAA) | Placed on temporary inactive list |
| Barrett Astin | P | 23.281 | Cincinnati Reds | Pensacola (AA) | Placed on temporary inactive list |
| Colin Kleven | P | 24.105 | Philadelphia Phillies | Reading (AA) | DL-7 Injured |
| Elliot Morris | P | 23.094 | San Diego Padres | San Antonio (AA) | DL-7 Injured |
| Stephen Johnson | P | 24.158 | San Francisco Giants | Richmond (AA) | DL-7 Injured |
| Adrian Marin | SS | 21.143 | Baltimore Orioles | Frederick (A+) | DL-7 Injured |
| Luis De Paula | P | 23.094 | Los Angeles Dodgers | Great Lakes (A) | DL-7 Injured |
| Pedro Ruiz | 2B-SS | 23.334 | | | Released by Angels |
| Alexander Hernandez | SS | 23.116 | | | Released by Astros |
| Victor Gonzalez | P | 19.256 | Los Angeles Dodgers | Great Lakes (A) | DL-7 Injured |
| Logan James | p | 21.256 | Seattle Mariners | Everett (A-) | DL-7 Injured |
| Lachlan Fontaine | 3B | 19.337 | Seattle Mariners | Arizona Mariners (Rk) | DL-7 Injured |
| Miguel Diaz | P | 20.243 | Milwaukee Brewers | Arizona Brewers (Rk) | DL-7 Injured |
| Miguel Ferreras | P | 23.314 | | | Announced retirement |
| Trevor Lubking | P | 22.328 | Milwaukee Brewers | Arizona Brewers (Rk) | DL-7 Injured |
| Alvin Herrera | p | 22.136 | Baltimore Orioles | Gulf Coast Orioles (Rk) | Assigned to GCL Orioles (Rk) |
| Angel Jimenez | 3b | 20.324 | Seattle Mariners | Arizona Mariners (Rk) | Assigned to AZL Mariners (Rk) |
| Jesus Heredia | p | 20.189 | Atlanta Braves | Gulf Coast Braves (Rk) | Assigned to GCL Braves (Rk) |
