| Clayton Richard | RP | 31.296 | Chicago Cubs | Chicago Cubs (MLB) | Traded from Cubs to Pirates for cash |
| Zeke Spruill | SP | 25.296 | Boston Red Sox | Pawtucket (AAA) | Designated for Assignment |
| Donn Roach | SP | 25.202 | Chicago Cubs | Iowa (AAA) | Assigned to Iowa (AAA) |
| Noe Ramirez | RP | 25.194 | Boston Red Sox | Boston Red Sox (MLB) | Contract purchased from minors |
| Shane Victorino | RF | 34.216 | Boston Red Sox | Boston Red Sox (MLB) | Activated from DL |
| Blake Swihart | C | 23.092 | Boston Red Sox | Boston Red Sox (MLB) | DL-15 Sprained left foot |
| Jackie Bradley | RF | 25.076 | Boston Red Sox | Pawtucket (AAA) | Assigned to Pawtucket (AAA) |
| Josh Osich | RP | 26.304 | San Francisco Giants | San Francisco Giants (MLB) | Contract purchased from minors |
| Andy Oliver | P | 27.214 | | | Released by Rays |
| Mike Broadway | RP | 28.096 | San Francisco Giants | Sacramento (AAA) | Assigned to Sacramento (AAA) |
| Cory Rasmus | RP | 27.241 | Los Angeles Angels | Salt Lake (AAA) | Activated from DL and assigned to Salt Lake (AAA) |
| Jake Peavy | SP | 34.034 | San Francisco Giants | San Francisco Giants (MLB) | Activated from DL |
| Ryan Lollis | LF | 28.200 | San Francisco Giants | San Francisco Giants (MLB) | Contract purchased from minors |
| Travis Ishikawa | LF | 31.284 | San Francisco Giants | San Francisco Giants (MLB) | Designated for Assignment |
| Tim Hudson | SP | 39.356 | San Francisco Giants | San Francisco Giants (MLB) | DL-15 Strained right shoulder |
| Collin Cowgill | rf-LF | 29.043 | Los Angeles Angels | Los Angeles Angels (MLB) | Transferred to 60-day DL |
| Preston Guilmet | RP | 27.343 | Tampa Bay Rays | Durham (AAA) | Assigned to Durham (AAA) |
| Scott Atchison | RP | 39.097 | Minnesota Twins | Chattanooga (AA) | Signed to Minor League Contract |
| David Berg | p | 22.098 | Chicago Cubs | Myrtle Beach (A+) | Assigned to Myrtle Beach (A+) |
| Greg Bird | C | 22.237 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Assigned to Scranton/Wilkes-Barre (AAA) |
| Bryce Brentz | RF | 26.186 | Boston Red Sox | Pawtucket (AAA) | Activated from disabled list |
| Juan Centeno | C | 25.230 | Milwaukee Brewers | Colorado Springs (AAA) | Activated from disabled list |
| Ethan Chapman | OF | 25.180 | Philadelphia Phillies | Lehigh Valley (AAA) | Assigned to Lehigh Valley (AAA) |
| Nic Coffman | 3b | 22.201 | Arizona Diamondbacks | Missoula (Rk) | Assigned to Missoula (Rk) |
| David Dahl | OF | 21.094 | Colorado Rockies | Boise (A-) | Activated from disabled list |
| Taylor Davis | C | 25.218 | Chicago Cubs | Iowa (AAA) | Assigned to Iowa (AAA) |
| Roenis Elias | SP | 26.337 | Seattle Mariners | Tacoma (AAA) | Assigned to Tacoma (AAA) |
| Michael Feliz | P | 22.006 | Houston Astros | Corpus Christi (AA) | Assigned to Corpus Christi (AA) |
| Chris Flexen | P | 21.003 | New York Mets | Gulf Coast Mets (Rk) | Activated from disabled list |
| Balbino Fuenmayor | 3B | 25.220 | Kansas City Royals | Omaha (AAA) | Assigned to Omaha (AAA) |
| Reymond Fuentes | CF | 24.142 | Kansas City Royals | Omaha (AAA) | Activated from disabled list |
| Greg Garcia | PH | 25.330 | St. Louis Cardinals | Memphis (AAA) | Assigned to Memphis (AAA) |
| Chris Garia | OF | 22.200 | Texas Rangers | High Desert (A+) | Assigned to High Desert (A+) |
| Wade Gaynor | 3B | 27.076 | Detroit Tigers | Toledo (AAA) | Assigned to Toledo (AAA) |
| Derek Gibson | OF | 24.129 | St. Louis Cardinals | Springfield (AA) | Assigned to Springfield (AA) |
| Chi Chi Gonzalez | SP | 23.171 | Texas Rangers | Round Rock (AAA) | Assigned to Round Rock (AAA) |
| Miguel Gonzalez | C | 24.213 | Detroit Tigers | Erie (AA) | Assigned to Erie (AA) |
| Evan Grills | P | 23.021 | Houston Astros | Lancaster (A+) | Activated from disabled list |
| Johnny Hellweg | SP | 26.248 | Milwaukee Brewers | Biloxi (AA) | Assigned to Biloxi (AA) |
| Clay Holmes | P | 22.099 | Pittsburgh Pirates | Gulf Coast Pirates (Rk) | Assigned to Gulf Coast Pirates (Rk) |
| Kyle Hunter | P | 26.016 | Seattle Mariners | Jackson (AA) | Assigned to Jackson (AA) |
| Sam Koenig | of | 23.110 | Los Angeles Angels | Orem (Rk) | Assigned to Orem (Rk) |
| Kyle Kraus | P-IF | 25.166 | Boston Red Sox | Portland (AA) | Assigned to Portland (AA) |
| Nick Lee | P | 24.172 | Washington Nationals | Harrisburg (AA) | Assigned to Harrisburg (AA) |
| Raffy Lopez | C | 27.276 | Los Angeles Angels | Salt Lake (AAA) | Assigned to Salt Lake (AAA) |
| Jake Lowery | C | 24.348 | Cleveland Indians | Akron (AA) | Activated from disabled list |
| Chris Madera | of | 22.315 | Boston Red Sox | Gulf Coast Red Sox (Rk) | Assigned to Gulf Coast Red Sox (Rk) |
| John Magliozzi | P | 23.349 | New York Mets | Gulf Coast Mets (Rk) | Assigned to Gulf Coast Mets (Rk) |
| Danny Mars | OF | 21.163 | Boston Red Sox | Gulf Coast Red Sox (Rk) | Assigned to Gulf Coast Red Sox (Rk) |
| Jose Martinez | RF | 26.344 | Kansas City Royals | Omaha (AAA) | Activated from disabled list |
| Nick Martini | CF | 25.007 | St. Louis Cardinals | Memphis (AAA) | Assigned to Memphis (AAA) |
| Steven Mateo | 1B | 22.319 | Los Angeles Angels | Burlington (A) | Assigned to Burlington (A) |
| Andrew McKirahan | P | 25.146 | Atlanta Braves | Gwinnett (AAA) | Reinstated to active roster |
| Blake McKnight | P | 24.141 | St. Louis Cardinals | Palm Beach (A+) | Assigned to Palm Beach (A+) |
| Kyle McPherson | SP-RP | 27.236 | Tampa Bay Rays | Montgomery (AA) | Assigned to Montgomery (AA) |
| Ryan Meisinger | p | 21.061 | Baltimore Orioles | Aberdeen (A-) | Assigned to Aberdeen (A-) |
| Aderlin Mejia | SS-2B | 23.053 | Minnesota Twins | Chattanooga (AA) | Assigned to Chattanooga (AA) |
| Alex Meyer | RP | 25.182 | Minnesota Twins | Rochester (AAA) | Assigned to Rochester (AAA) |
| Albert Minnis | P | 23.242 | Houston Astros | Lancaster (A+) | Activated from disabled list |
| Jose Monegro | P | 25.288 | Texas Rangers | Frisco (AA) | Activated from disabled list |
| Jose Montero | P | 22.163 | Houston Astros | Greeneville (Rk) | Activated from disabled list |
| Charles Moorman | C | 21.176 | Texas Rangers | Hickory (A) | Activated from disabled list |
| Vidal Nuno | RP | 27.344 | Seattle Mariners | Tacoma (AAA) | Assigned to Tacoma (AAA) |
| Chris O'Grady | P | 25.078 | Los Angeles Angels | Salt Lake (AAA) | Assigned to Salt Lake (AAA) |
| Matt Oberste | IF | 23.330 | New York Mets | St. Lucie (A+) | Activated from disabled list |
| Willy Paredes | P | 26.152 | Arizona Diamondbacks | Mobile (AA) | Assigned to Mobile (AA) |
| Troy Patton | RP | 29.304 | Kansas City Royals | Omaha (AAA) | Reinstated to active roster |
| Jorge Perez | P | 21.339 | Houston Astros | Quad Cities (A) | Reinstated to active roster |
| Cameron Perkins | OF | 24.280 | Philadelphia Phillies | Reading (AA) | Activated from disabled list |
| Jorge Polanco | SS-3B | 21.364 | Minnesota Twins | Rochester (AAA) | Assigned to Rochester (AAA) |
| Stephen Pryor | RP | 25.346 | Minnesota Twins | Gulf Coast Twins (Rk) | Activated from disabled list |
| Humberto Quintero | c | 35.337 | Boston Red Sox | Pawtucket (AAA) | Activated from disabled list |
| Guillermo Quiroz | c | 33.217 | San Francisco Giants | Sacramento (AAA) | Activated from disabled list |
| Raudy Read | C | 21.248 | Washington Nationals | Hagerstown (A) | Reinstated to active roster |
| C.J. Riefenhauser | RP | 25.155 | Tampa Bay Rays | Durham (AAA) | Assigned to Durham (AAA) |
| Wilfredo Rodriguez | C | 21.160 | Colorado Rockies | Grand Junction (Rk) | Activated from disabled list |
| Manuel Rondon | p | 20.119 | Chicago Cubs | Arizona Cubs (Rk) | Assigned to Arizona Cubs (Rk) |
| Guilermo Salas | SS | 21.074 | Baltimore Orioles | Delmarva (A) | Assigned to Delmarva (A) |
| James Simmons | P | 28.278 | Washington Nationals | Syracuse (AAA) | Assigned to Syracuse (AAA) |
| Alexander Simon | 1B | 22.279 | Chicago White Sox | Kannapolis (A) | Assigned to Kannapolis (A) |
| Lucas Sims | P | 21.055 | Atlanta Braves | Carolina (A+) | Assigned to Carolina (A+) |
| Scott Sitz | P | 24.297 | Detroit Tigers | West Michigan (A) | Activated from disabled list |
| Jake Skole | CF | 23.169 | New York Yankees | Tampa (A+) | Assigned to Tampa (A+) |
| Jeff Smith | 2b | 22.275 | Arizona Diamondbacks | Hillsboro (A-) | Assigned to Hillsboro (A-) |
| Josh Smoker | P | 26.220 | New York Mets | Binghamton (AA) | Assigned to Binghamton (AA) |
| Matt Stites | RP | 25.037 | Arizona Diamondbacks | Reno (AAA) | Assigned to Reno (AAA) |
| Blake Taylor | P | 19.322 | New York Mets | Brooklyn (A-) | Assigned to Brooklyn (A-) |
| Matthew Taylor | P | 24.094 | Baltimore Orioles | Frederick (A+) | Assigned to Frederick (A+) |
| Andrew Velazquez | SS | 20.355 | Tampa Bay Rays | Gulf Coast Rays (Rk) | Assigned to Gulf Coast Rays (Rk) |
| David Washington | 1B | 24.226 | St. Louis Cardinals | Springfield (AA) | Assigned to Springfield (AA) |
| Shane Watson | P | 21.325 | Philadelphia Phillies | Lakewood (A) | Assigned to Lakewood (A) |
| Casey Weathers | P | 30.024 | Cleveland Indians | Akron (AA) | Assigned to Akron (AA) |
| Tom Wilhelmsen | RP | 31.201 | Seattle Mariners | Tacoma (AAA) | Assigned to Tacoma (AAA) |
| Tony Zych | P | 24.331 | Seattle Mariners | Jackson (AA) | Assigned to Jackson (AA) |
| Hector Sanchez | c | 25.229 | San Francisco Giants | Sacramento (AAA) | DL-7 Injured |
| Juan Perez | LF | 28.233 | San Francisco Giants | San Jose (A+) | DL-7 Injured |
| Luis Perez | P | 30.165 | Toronto Blue Jays | New Hampshire (AA) | DL-7 Injured |
| Nick Tropeano | P | 24.311 | Los Angeles Angels | Salt Lake (AAA) | DL-7 Injured |
| Pete Orr | LF-3B | 36.026 | Milwaukee Brewers | Colorado Springs (AAA) | Placed on temporary inactive list |
| Bobby Borchering | 1B-3B | 24.252 | | | Released by Tigers |
| Carlos Gonzalez | P | 25.022 | Cincinnati Reds | Pensacola (AA) | DL-7 Injured |
| Zach Eflin | P | 21.087 | Philadelphia Phillies | Reading (AA) | Placed on temporary inactive list |
| Alex Blandino | SS | 22.240 | Cincinnati Reds | Daytona (A+) | DL-7 Injured |
| Anyelo Gomez | P | 22.125 | New York Yankees | Gulf Coast Yankees (Rk) | DL-7 Injured |
| Dillon Moyer | SS | 23.352 | Los Angeles Dodgers | Rancho Cucamonga (A+) | DL-7 Injured |
| Gregory Lorenzo | CF | 24.034 | | | Released by Orioles |
| Nick Williams | P | 23.232 | Miami Marlins | Jupiter (A+) | DL-7 Injured |
| Tyler Palmer | IF-OF | 23.288 | Los Angeles Angels | Inland Empire (A+) | Placed on temporary inactive list |
| Brant Whiting | C | 23.149 | Los Angeles Dodgers | Great Lakes (A) | DL-7 Injured |
| Brock Dykxhoorn | P | 21.002 | Houston Astros | Quad Cities (A) | Placed on temporary inactive list |
| Forrest Wall | 2B | 19.227 | Colorado Rockies | Asheville (A) | DL-7 Injured |
| Gaither Bumgardner | P | 24.156 | New York Mets | Brooklyn (A-) | Placed on temporary inactive list |
| Joe Tuschak | CF | 22.260 | New York Mets | Savannah (A) | DL-7 Injured |
| Nigel Nootbaar | P | 22.102 | Baltimore Orioles | Delmarva (A) | DL-7 Injured |
| Scott Firth | P | 24.183 | Colorado Rockies | Asheville (A) | DL-7 Injured |
| Wes Rogers | OF | 21.119 | Colorado Rockies | Asheville (A) | DL-7 Injured |
| Nick Sabo | P | 22.020 | San Francisco Giants | Arizona Giants (Rk) | DL-60 Injured |
| Anthony Marzi | P | 22.219 | New York Yankees | Gulf Coast Yankees (Rk) | DL-7 Injured |
| Brandon Koch | P | 19.210 | | | Released by Orioles |
| Deshorn Lake | P | 21.248 | New York Yankees | Gulf Coast Yankees (Rk) | DL-60 Injured |
| Edgar Lorenzo | of | 18.170 | Houston Astros | Houston Astros (MLB) | Assigned to DSL Astros (Rk) |
| John Mcleod | P | 23.031 | | | Released by Orioles |
| Andy Parrino | 3B | 29.246 | Oakland Athletics | Nashville (AAA) | Placed on temporary inactive list |
| Daric Barton | 1B | 29.322 | | | Released by Blue Jays |
| Hector Noesi | RP | 28.159 | Chicago White Sox | Charlotte (AAA) | Placed on temporary inactive list |
| Jack Leathersich | RP | 24.355 | New York Mets | Las Vegas (AAA) | DL-7 Injured |
| Joel Pineiro | P | 36.282 | Toronto Blue Jays | New Hampshire (AA) | Placed on temporary inactive list |
| John Holdzkom | P | 27.259 | Pittsburgh Pirates | Indianapolis (AAA) | DL-7 Injured |
| Jon Link | P | 31.103 | | | Released by Marlins |
| Lester Oliveros | P | 27.037 | Minnesota Twins | Rochester (AAA) | DL-7 Injured |
| Sean Nolin | SP | 25.190 | Oakland Athletics | Nashville (AAA) | DL-7 Injured |
| Shawn O'Malley | SS-2B | 27.189 | Seattle Mariners | Tacoma (AAA) | DL-7 Injured |
| Shawn O'Malley | SS-2B | 27.189 | Seattle Mariners | Tacoma (AAA) | DL-7 Injured |
| Tyler Collins | lf | 25.028 | Detroit Tigers | Toledo (AAA) | DL-7 Injured |
| Wilton Lopez | RP | 31.351 | | | Released by Blue Jays |
| Hunter Morris | 1B | 26.270 | Pittsburgh Pirates | Indianapolis (AAA) | DL-7 Injured |
| James Nygren | P | 26.118 | | | Released by Marlins |
| Micah Gibbs | C | 26.342 | Kansas City Royals | Northwest Arkansas (AA) | DL-7 Injured |
| Tyler Pill | P | 25.036 | New York Mets | Las Vegas (AAA) | DL-7 Injured |
| Tyson Gillies | CF | 26.246 | San Diego Padres | San Antonio (AA) | Placed on temporary inactive list |
| Ali Williams | P | 25.361 | | | Released by Royals |
| Ryan Butler | P | 23.132 | San Diego Padres | San Antonio (AA) | DL-7 Injured |
| Travis Jankowski | OF | 24.019 | San Diego Padres | San Antonio (AA) | Placed on temporary inactive list |
| Zach Wright | C | 25.175 | | | Released by Angels |
| Adrian Abreu | C | 24.020 | New York Mets | Savannah (A) | Suspended 80 games for violating minor league drug program. |
| Alejandro Chacin | P | 22.010 | Cincinnati Reds | Daytona (A+) | DL-7 Injured |
| Allen Scott | P | 24.248 | Miami Marlins | Gulf Coast Marlins (Rk) | DL-60 Injured |
| Jonathan Davis | IF | 23.053 | Toronto Blue Jays | Dunedin (A+) | DL-7 Injured |
| Patrick Kaminska | P | 24.149 | Texas Rangers | High Desert (A+) | DL-7 Injured |
| Rehiner Cordova | 2B | 21.174 | Miami Marlins | Jupiter (A+) | DL-7 Injured |
| Eduard Pinto | OF | 20.254 | Texas Rangers | Hickory (A) | DL-7 Injured |
| Carlos Pizzolato | p | 19.120 | Houston Astros | Houston Astros (MLB) | Assigned to DSL Astros (Rk) |
| Eliezer Cuello | p | 18.228 | Miami Marlins | Gulf Coast Marlins (Rk) | DL-60 Injured |
| Jeremy Ovalle | p | 18.168 | Miami Marlins | Gulf Coast Marlins (Rk) | DL-60 Injured |
| Jose Quijada | p | 19.238 | Miami Marlins | Gulf Coast Marlins (Rk) | DL-7 Injured |
| Kelvin Flores | of | 18.289 | Miami Marlins | Gulf Coast Marlins (Rk) | DL-60 Injured |
| Kyle Simmons | P | 23.283 | Washington Nationals | Gulf Coast Nationals (Rk) | DL-7 Injured |
| Luis Rengel | 2b | 19.350 | Washington Nationals | Gulf Coast Nationals (Rk) | DL-7 Injured |
| Anthony Guardado | p | 17.232 | Atlanta Braves | Gulf Coast Braves (Rk) | Signed out of draft (California HS) |
| Connor Bennett | p | 18.085 | Cincinnati Reds | Arizona Reds (Rk) | Signed out of draft (Georgia HS) |
| Daz Cameron | of | 18.170 | Houston Astros | Gulf Coast Astros (Rk) | Signed out of draft (Georgia HS) |
| Donnie Cimino | 2b | 21.317 | Chicago Cubs | Arizona Cubs (Rk) | Signed out of draft (Wesleyan) |
| Gilbert Suarez | p | 18.015 | Atlanta Braves | Gulf Coast Braves (Rk) | Signed out of draft (California HS) |
| Isiah Gilliam | of | 18.346 | New York Yankees | Gulf Coast Yankees (Rk) | Signed out of draft (Georgia HS) |
| Josh Naylor | 1b | 18.012 | Miami Marlins | Gulf Coast Marlins (Rk) | Signed out of draft (Ontario HS) |
| Juan Echevarria | p | 18.009 | Baltimore Orioles | Gulf Coast Orioles (Rk) | Signed out of draft (Florida HS) |
| Marcus Mastrobuoni | c | 21.218 | Chicago Cubs | Arizona Cubs (Rk) | Signed out of draft (Cal State Stanislaus) |
| Ryan Colegate | p | 21.234 | Cleveland Indians | Arizona Indians (Rk) | Signed out of draft (Ohio Dominican) |
| Mickey Jannis | p | 27.201 | New York Mets | St. Lucie (A+) | Signed out of draft (Cal State Bakersfield) |
| Anderson Miller | of | 21.059 | Kansas City Royals | Burlington (Rk) | Signed out of draft (Western Kentucky) |
| Angelo Amendolare | 2b | 22.214 | Chicago Cubs | Iowa (AAA) | SIgned out of draft (Jacksonville) |
| Cody Jones | of | 22.040 | Kansas City Royals | Idaho Falls (Rk) | Signed out of draft (Texas Christian) |
| Jackson Lowery | p | 22.346 | Toronto Blue Jays | Gulf Coast Blue Jays (Rk) | Signed out of draft (Arkansas) |
| Joe McCarthy | of | 21.131 | Tampa Bay Rays | Hudson Valley (A-) | Signed out of draft (Virginia) |
| Matt Dacey | if | 21.095 | Tampa Bay Rays | Hudson Valley (A-) | Signed out of draft (Richmond) |
| Michael Murray | p | 21.281 | Oakland Athletics | Arizona Athletics (Rk) | Signed out of draft (Florida Gulf Coast) |
| Ben Rowen | P | 26.231 | | | Opts out of contract |
| Chris Valaika | 2b | 29.324 | Chicago Cubs | Iowa (AAA) | DL-7 Injured |
| Ervin Santana | SP | 32.175 | Minnesota Twins | Minnesota Twins (MLB) | Reinstated to active roster |
| Ervin Santana | SP | 32.175 | Minnesota Twins | Minnesota Twins (MLB) | DL-15 Lower back strain |
