| Matt Boyd | SP | 24.145 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Contract purchased from minors |
| Rob Rasmussen | RP | 26.086 | Toronto Blue Jays | Buffalo (AAA) | Assigned to Buffalo (AAA) |
| Jose De Paula | RP | 27.115 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Outrighted to minors |
| Rob Scahill | RP | 28.132 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | DL-15 Right forearm tightness |
| Deolis Guerra | RP | 26.071 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Contract purchased from minors |
| Andrew Lambo | rf | 26.320 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Transferred to 60-day DL |
| Luke Montz | dh | 31.356 | | | Released by Red Sox |
| Wei-Yin Chen | SP | 29.341 | Baltimore Orioles | Baltimore Orioles (MLB) | Recalled from Frederick (A+) |
| T.J. McFarland | RP | 26.019 | Baltimore Orioles | Norfolk (AAA) | Assigned to Norfolk (AAA) |
| Allan Dykstra | 1B | 28.037 | | | Released by Rays |
| Marc Krauss | 1B | 27.266 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Contract purchased from minors |
| Brandon Cunniff | RP | 26.263 | Atlanta Braves | Atlanta Braves (MLB) | DL-15 Strained groin |
| Sugar Ray Marimon | P | 26.270 | Atlanta Braves | Atlanta Braves (MLB) | Recalled from Gwinnett (AAA) |
| Reed Johnson | lf | 38.201 | Washington Nationals | Washington Nationals (MLB) | Transferred to 60-day DL |
| Mike Broadway | RP | 28.089 | San Francisco Giants | San Francisco Giants (MLB) | Recalled from Sacramento (AAA) |
| Jeremy Affeldt | RP | 36.022 | San Francisco Giants | San Francisco Giants (MLB) | DL-15 Left shoulder strain |
| Justin Miller | RP | 28.014 | Colorado Rockies | Albuquerque (AAA) | Assigned to Albuquerque (AAA) |
| Rafael Betancourt | RP | 40.059 | Colorado Rockies | Colorado Rockies (MLB) | Activated from DL |
| Hector Noesi | RP | 28.152 | Chicago White Sox | Chicago White Sox (MLB) | Outrighted to minors |
| Phillippe Aumont | SP | 26.171 | | | Refused minor league assignment, declared free agent |
| Caleb Adams | OF | 22.152 | Los Angeles Angels | Inland Empire (A+) | Assigned to Inland Empire (A+) |
| Trever Allen | of | 23.255 | Los Angeles Angels | Burlington (A) | Assigned to Burlington (A) |
| Claudio Bautista | | 21.210 | Cleveland Indians | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Tim Beckham | SS-2B | 25.151 | Tampa Bay Rays | Durham (AAA) | Activated from DL and assigned to Durham (AAA) |
| Carter Burgess | IF | 22.082 | Tampa Bay Rays | Bowling Green (A) | Assigned to Bowling Green (A) |
| Alan Busenitz | P | 24.309 | Los Angeles Angels | Inland Empire (A+) | Assigned to Inland Empire (A+) |
| Francisco Carrillo | P | 25.104 | Chicago Cubs | Eugene (A-) | Assigned to Eugene (A-) |
| Yu-Cheng Chang | SS | 19.314 | Cleveland Indians | Lake County (A) | Activated from disabled list |
| Phil Coke | RP | 32.343 | Oakland Athletics | Stockton (A+) | Signed to Minor League Contract |
| Sean Donatello | P | 24.307 | Miami Marlins | Gulf Coast Marlins (Rk) | Activated from disabled list |
| Chris Dula | P | 22.325 | Texas Rangers | Hickory (A) | Activated from disabled list |
| Mike Fish | OF | 24.175 | Los Angeles Angels | Arkansas (AA) | Assigned to Arkansas (AA) |
| Dallas Gallant | P | 26.153 | Minnesota Twins | Gulf Coast Twins (Rk) | Assigned to Gulf Coast Twins (Rk) |
| Leonardo Garcia | p | 21.178 | New York Yankees | Gulf Coast Yankees 2 (Rk) | Assigned to Gulf Coast Yankees 2 (Rk) |
| Casey Gillaspie | 1B | 22.153 | Tampa Bay Rays | Charlotte (A+) | Assigned to Charlotte (A+) |
| Anyelo Gomez | P | 22.118 | New York Yankees | Gulf Coast Yankees (Rk) | Assigned to Gulf Coast Yankees (Rk) |
| Bengie Gonzalez | SS | 25.162 | San Diego Padres | Lake Elsinore (A+) | Assigned to Lake Elsinore (A+) |
| Drew Heid | LF-RF | 27.196 | Philadelphia Phillies | Reading (AA) | Signed to Minor League Contract (From Indy) |
| Mitch Horacek | P | 23.207 | Baltimore Orioles | Frederick (A+) | Assigned to Frederick (A+) |
| Steve Janas | P | 23.067 | Atlanta Braves | Carolina (A+) | Activated from disabled list |
| Yorman Landa | P | 21.016 | Minnesota Twins | Gulf Coast Twins (Rk) | Activated from disabled list |
| Brandon Leibrandt | P | 22.196 | Philadelphia Phillies | Gulf Coast Phillies (Rk) | Activated from disabled list |
| Sicnarf Loopstok | C | 22.062 | Cleveland Indians | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Dillon Maples | P | 23.049 | Chicago Cubs | South Bend (A) | Assigned to South Bend (A) |
| Emmanuel Marrero | IF | 22.042 | Philadelphia Phillies | Lakewood (A) | Assigned to Lakewood (A) |
| Anthony Marzi | P | 22.212 | New York Yankees | Gulf Coast Yankees (Rk) | Assigned to Gulf Coast Yankees (Rk) |
| Yoervis Medina | RP | 26.335 | Chicago Cubs | Iowa (AAA) | Assigned to Iowa (AAA) |
| Casey Meisner | P | 20.036 | New York Mets | St. Lucie (A+) | Assigned to St. Lucie (A+) |
| John Mincone | P | 25.339 | New York Mets | Savannah (A) | Assigned to Savannah (A) |
| Ty Morrison | CF | 24.340 | Tampa Bay Rays | Gulf Coast Rays (Rk) | Assigned to Gulf Coast Rays (Rk) |
| Bryce Morrow | P | 27.177 | San Diego Padres | Tri-City (A-) | Activated from disabled list |
| Chris Narveson | RP | 33.189 | Miami Marlins | New Orleans (AAA) | Assigned to New Orleans (AAA) |
| Dovydas Neverauskas | P | 22.164 | Pittsburgh Pirates | West Virginia (A) | Assigned to West Virginia (A) |
| Tyler Palmer | IF-OF | 23.281 | Los Angeles Angels | Inland Empire (A+) | Activated from disabled list |
| David Paulino | P | 21.141 | Houston Astros | Quad Cities (A) | Assigned to Quad Cities (A) |
| David Peterson | P | 25.174 | Atlanta Braves | Mississippi (AA) | Assigned to Mississippi (AA) |
| J.T. Riddle | SS | 23.259 | Miami Marlins | Jacksonville (AA) | Assigned to Jacksonville (AA) |
| Richard Rodriguez | P | 25.115 | Baltimore Orioles | Bowie (AA) | Traded from Giants to Orioles for cash |
| Yonauris Rodriguez | ss | 18.109 | New York Yankees | Gulf Coast Yankees 2 (Rk) | Assigned to Gulf Coast Yankees 2 (Rk) |
| Wilson Santos | P | 23.251 | San Diego Padres | Arizona Padres (Rk) | Assigned to Arizona Padres (Rk) |
| Joe Sever | IF | 24.319 | Cleveland Indians | Akron (AA) | Assigned to Akron (AA) |
| Travis Shaw | 1B | 25.072 | Boston Red Sox | Pawtucket (AAA) | Assigned to Pawtucket (AAA) |
| Jake Shull | p | 21.062 | Detroit Tigers | Connecticut (A-) | Assigned to Connecticut (A-) |
| Donovan Solano | PH | 27.193 | Miami Marlins | New Orleans (AAA) | Assigned to New Orleans (AAA) |
| Drew Steckenrider | OF-P | 24.168 | Miami Marlins | Jupiter (A+) | Assigned to Jupiter (A+) |
| Ronaldo Suarez | c | 17.301 | New York Yankees | Gulf Coast Yankees (Rk) | Assigned to Gulf Coast Yankees (Rk) |
| Andrew Woeck | p | 23.054 | Tampa Bay Rays | Charlotte (A+) | Assigned to Charlotte (A+) |
| Joey Wong | 3B-SS | 27.076 | Colorado Rockies | Boise (A-) | Activated from disabled list |
| Corey Zangari | if | 18.051 | Chicago White Sox | Arizona White Sox (Rk) | Assigned to Arizona White Sox (Rk) |
| Donnie Murphy | 3b | 32.109 | Milwaukee Brewers | Colorado Springs (AAA) | DL-7 Injured |
| Duane Below | RP | 29.224 | | | Released by Mets |
| Eugenio Velez | RF-3B | 33.042 | | | Released by Rays |
| Juan Centeno | C | 25.223 | Milwaukee Brewers | Colorado Springs (AAA) | DL-7 Injured |
| Paul Clemens | SP | 27.134 | | | Released by Phillies |
| Austin Chubb | C | 26.071 | Los Angeles Dodgers | Rancho Cucamonga (A+) | DL-7 Injured |
| Danny Black | SS | 26.312 | Miami Marlins | Jacksonville (AA) | DL-7 Injured |
| Nick Benedetto | OF | 22.120 | Cincinnati Reds | Louisville (AAA) | DL-7 Injured |
| Parker Morin | C | 23.361 | Kansas City Royals | Northwest Arkansas (AA) | Placed on temporary inactive list |
| Andy Fermin | 3B | 25.335 | Toronto Blue Jays | New Hampshire (AA) | DL-7 Injured |
| Chris O'Brien | C | 25.338 | Baltimore Orioles | Bowie (AA) | DL-7 Injured |
| Curt Powell | IF | 24.058 | Detroit Tigers | Erie (AA) | DL-7 Injured |
| Dan Barnes | P | 25.249 | Toronto Blue Jays | New Hampshire (AA) | DL-7 Injured |
| Daniel Tillman | P | 26.105 | Los Angeles Dodgers | Rancho Cucamonga (A+) | DL-7 Injured |
| David Chester | 1B | 26.088 | Boston Red Sox | Portland (AA) | DL-7 Injured |
| Dennis Torres | P | 25.041 | Baltimore Orioles | Bowie (AA) | Suspended 50 games for testing positive for a drug of abuse |
| Devyn Bolasky | OF | 22.154 | New York Yankees | Charleston (sc) (A) | DL-7 Injured |
| Jason Esposito | 3B | 24.343 | | | Announced retirement |
| Matt Newman | LF-CF | 26.280 | Toronto Blue Jays | New Hampshire (AA) | DL-7 Injured |
| Chris Sadberry | P | 23.232 | Miami Marlins | Jupiter (A+) | DL-7 Injured |
| Fernando Perez | SS | 21.287 | San Diego Padres | Lake Elsinore (A+) | DL-7 Injured |
| Matt Smoral | P | 21.101 | Toronto Blue Jays | Dunedin (A+) | DL-7 Injured |
| Phillip Kish | p | 25.301 | Toronto Blue Jays | Dunedin (A+) | DL-7 Injured |
| Yuniel Ramirez | of | 26.187 | | | Signed with Quintana Roo (Mex) |
| Mike Ahmed | IF-P | 23.159 | Los Angeles Dodgers | Great Lakes (A) | DL-7 Injured |
| Thomas Lindauer | IF | 23.208 | | | Released by Astros |
| Anthony Dimino | c | 21.326 | New York Mets | Gulf Coast Mets (Rk) | Signed out of draft (Belmont Abbey) |
| Dalton Blumenfeld | c | 18.225 | Los Angeles Angels | Arizona Angels (Rk) | Signed out of draft (California HS) |
| Andrew Elliott | p | 23.144 | Baltimore Orioles | Gulf Coast Orioles (Rk) | Signed out of draft (Wright State) |
| Andrew Lee | p | 21.207 | Washington Nationals | Gulf Coast Nationals (Rk) | Signed out of draft (Tennessee) |
| Bobby Wernes | 3b | 20.358 | Houston Astros | Tri City (A-) | Signed out of draft (Arkansas) |
| Calvin Copping | p | 21.167 | Washington Nationals | Gulf Coast Nationals (Rk) | Signed out of draft (Cal State Northridge) |
| Dalton DiNatale | 3b | 22.093 | Washington Nationals | Gulf Coast Nationals (Rk) | Signed out of draft (Arizona State) |
| Keaton Jones | ss | 22.262 | Detroit Tigers | Gulf Coast Tigers (East) (Rk) | Signed as undrafted free agent (Texas Christian) |
| Trey Killian | p | 21.123 | Colorado Rockies | Grand Junction (Rk) | Signed out of draft (Arkansas) |
| Zac Person | p | 22.257 | Houston Astros | Tri City (A-) | Signed out of draft (LSU) |
| Mark Clark | C | 19.001 | | | Announced retirement |
