| Brandon Workman | RP | 26.295 | Boston Red Sox | Pawtucket (AAA) | Transferred to 60-day DL |
| Alejandro De Aza | LF | 31.054 | Boston Red Sox | Boston Red Sox (MLB) | Traded from Orioles to Red Sox for Joe Gunkel |
| Joey Gunkel | P | 23.157 | Baltimore Orioles | Baltimore Orioles (MLB) | Traded from Red Sox to Orioles for Alejandro De Aza |
| Shane Peterson | LF | 27.114 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Recalled from Colorado Springs (AAA) |
| Dillon Gee | SP | 29.037 | New York Mets | New York Mets (MLB) | Activated from DL |
| Tommy Milone | SP | 28.108 | Minnesota Twins | Minnesota Twins (MLB) | Recalled from Rochester (AAA) |
| Ricky Nolasco | SP | 32.173 | Minnesota Twins | Minnesota Twins (MLB) | DL-15 Right ankle impingement |
| Archie Bradley | P | 22.298 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | DL-15 Shoulder tendinitis |
| Robbie Ray | SP | 23.247 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | Recalled from Reno (AAA) |
| Anthony Rendon | 2b | 24.363 | Washington Nationals | Washington Nationals (MLB) | Activated from DL |
| A.J. Cole | P | 23.151 | Washington Nationals | Washington Nationals (MLB) | Recalled from Syracuse (AAA) |
| Wilmer Difo | PH | 23.063 | Washington Nationals | Harrisburg (AA) | Assigned to Harrisburg (AA) |
| Taylor Jordan | SP | 26.138 | Washington Nationals | Syracuse (AAA) | Assigned to Syracuse (AAA) |
| Carlos Peguero | rf | 28.102 | Boston Red Sox | Boston Red Sox (MLB) | Designated for Assignment |
| Travis Demeritte | SS | 20.247 | Texas Rangers | Hickory (A) | Suspended 80 games for violating minor league drug program. |
| Joan Baez | P | 20.160 | Washington Nationals | Hagerstown (A) | Assigned to Hagerstown (A) |
| Steven Baron | C | 24.179 | Seattle Mariners | Tacoma (AAA) | Assigned to Tacoma (AAA) |
| Ramon Benjamin | P | 27.356 | Los Angeles Dodgers | Rancho Cucamonga (A+) | Assigned to Rancho Cucamonga (A+) |
| Jairo Beras | OF | 19.162 | Texas Rangers | Hickory (A) | Assigned to Hickory (A) |
| Dante Bichette | 3B | 22.251 | New York Yankees | Tampa (A+) | Assigned to Tampa (A+) |
| Greg Bird | C | 22.207 | New York Yankees | Trenton (AA) | Activated from disabled list |
| Jared Breen | IF | 24.024 | Baltimore Orioles | Delmarva (A) | Assigned to Delmarva (A) |
| Jaye Chapman | P | 28.013 | Milwaukee Brewers | Colorado Springs (AAA) | Assigned to Colorado Springs (AAA) |
| Kevin Comer | P | 22.307 | Houston Astros | Lancaster (A+) | Assigned to Lancaster (A+) |
| Jonathan Davis | IF | 23.023 | Toronto Blue Jays | Dunedin (A+) | Activated from disabled list |
| Brandon Downes | OF | 22.248 | Kansas City Royals | Lexington (A) | Activated from disabled list |
| Derek Eitel | P | 27.196 | Arizona Diamondbacks | Mobile (AA) | Activated from disabled list |
| Edgar Garcia | P | 27.258 | Arizona Diamondbacks | Reno (AAA) | Assigned to Reno (AAA) |
| Alex Glenn | OF | 23.359 | Arizona Diamondbacks | Visalia (A+) | Assigned to Visalia (A+) |
| Stephen Gonsalves | P | 20.331 | Minnesota Twins | Fort Myers (A+) | Assigned to Fort Myers (A+) |
| Gabby Guerrero | P | 21.175 | Arizona Diamondbacks | Mobile (AA) | Assigned to Mobile (AA) |
| Elian Herrera | lf | 30.123 | Milwaukee Brewers | Colorado Springs (AAA) | Outrighted to minors |
| Williams Jerez | CF | 23.019 | Boston Red Sox | Salem (A+) | Assigned to Salem (A+) |
| Chad Johnson | C | 21.004 | Kansas City Royals | Lexington (A) | Activated from disabled list |
| Jason Leblebijian | IF | 24.022 | Toronto Blue Jays | Lansing (A) | Assigned to Lansing (A) |
| Luis Liberato | OF | 19.169 | Seattle Mariners | Jackson (AA) | Assigned to Jackson (AA) |
| Tyler Marlette | C | 22.132 | Seattle Mariners | Jackson (AA) | Assigned to Jackson (AA) |
| Jose Marmolejos | 1B | 22.153 | Washington Nationals | Hagerstown (A) | Assigned to Hagerstown (A) |
| Brett Marshall | RP | 25.074 | Colorado Rockies | New Britain (AA) | Assigned to New Britain (AA) |
| Jose Mayorga | C | 22.288 | Philadelphia Phillies | Clearwater (A+) | Assigned to Clearwater (A+) |
| Kuehl Mceachern | P | 22.028 | Boston Red Sox | Greenville (A) | Assigned to Greenville (A) |
| Adalberto Mejia | P | 21.349 | San Francisco Giants | Richmond (AA) | Reinstated to active roster |
| Tyler Mizenko | P | 25.056 | San Francisco Giants | Richmond (AA) | Activated from disabled list |
| Raul Navarro | SS | 23.120 | Arizona Diamondbacks | Visalia (A+) | Assigned to Visalia (A+) |
| T.J. Olesczuk | OF | 23.120 | Baltimore Orioles | Delmarva (A) | Assigned to Delmarva (A) |
| Zach Osborne | IF | 25.045 | Colorado Rockies | Modesto (A+) | Assigned to Modesto (A+) |
| Tyler Pearson | C | 23.050 | Chicago Cubs | Tennessee (AA) | Assigned to Tennessee (AA) |
| Eric Peterson | P | 22.088 | Houston Astros | Quad Cities (A) | Reinstated to active roster |
| Juniel Querecuto | SS | 22.258 | Tampa Bay Rays | Montgomery (AA) | Assigned to Montgomery (AA) |
| Heri Quevedo | P | 24.362 | Boston Red Sox | Portland (AA) | Activated from disabled list |
| Travis Radke | P | 22.090 | San Diego Padres | Lake Elsinore (A+) | Assigned to Lake Elsinore (A+) |
| Frankie Reed | P | 27.113 | Miami Marlins | Jacksonville (AA) | Assigned to Jacksonville (AA) |
| Jack Reinheimer | SS | 22.320 | Arizona Diamondbacks | Mobile (AA) | Assigned to Mobile (AA) |
| Jose Reyes | | 24.152 | San Francisco Giants | San Jose (A+) | Assigned to San Jose (A+) |
| C.J. Robinson | P | 22.024 | Miami Marlins | Greensboro (A) | Assigned to Greensboro (A) |
| Robbie Ross | RP | 25.345 | Boston Red Sox | Pawtucket (AAA) | Assigned to Pawtucket (AAA) |
| Nate Samson | 3B-2B | 27.290 | Los Angeles Dodgers | Oklahoma City (AAA) | Activated from disabled list |
| Alex Sanabia | SP | 26.269 | Los Angeles Angels | Salt Lake (AAA) | Activated from disabled list |
| Trevor Seidenberger | P | 22.360 | Milwaukee Brewers | Biloxi (AA) | Assigned to Biloxi (AA) |
| Chuck Taylor | OF | 21.256 | Arizona Diamondbacks | Kane County (A) | Assigned to Kane County (A) |
| Mike Tonkin | RP | 25.197 | Minnesota Twins | Rochester (AAA) | Assigned to Rochester (AAA) |
| Daniel Torres | C | 23.006 | Seattle Mariners | Bakersfield (A+) | Assigned to Bakersfield (A+) |
| Jiandido Tromp | OF | 21.250 | Philadelphia Phillies | Lakewood (A) | Activated from disabled list |
| Ramon Troncoso | RP | 32.108 | Los Angeles Dodgers | Oklahoma City (AAA) | Activated from disabled list |
| Logan Uxa | OF | 24.130 | Baltimore Orioles | Frederick (A+) | Assigned to Frederick (A+) |
| Jose Vinicio | SS | 21.329 | Boston Red Sox | Portland (AA) | Assigned to Portland (AA) |
| Beamer Weems | SS | 27.312 | Texas Rangers | Frisco (AA) | Signed to Minor League Contract |
| Grahamm Wiest | P | 23.300 | Colorado Rockies | Asheville (A) | Assigned to Asheville (A) |
| Austen Williams | P | 22.167 | Washington Nationals | Syracuse (AAA) | Assigned to Syracuse (AAA) |
| Corey Williams | P | 24.335 | Minnesota Twins | Fort Myers (A+) | Activated from disabled list |
| Jared Wilson | P | 25.039 | Minnesota Twins | Cedar Rapids (A) | Assigned to Cedar Rapids (A) |
| Josh Hamilton | dh | 34.014 | Texas Rangers | Texas Rangers (MLB) | DL-15 Strained left hamstring |
| Dana Eveland | P | 31.219 | Boston Red Sox | Pawtucket (AAA) | Placed on temporary inactive list |
| Darwin Barney | 2b | 29.208 | Los Angeles Dodgers | Oklahoma City (AAA) | DL-7 Injured |
| John Hester | c | 31.264 | | | Released by Phillies |
| Juan Gutierrez | RP | 31.326 | | | Released by Giants |
| Ketel Marte | SS | 21.235 | Seattle Mariners | Tacoma (AAA) | DL-7 Broken thumb |
| Parker Frazier | P | 26.205 | Arizona Diamondbacks | Reno (AAA) | DL-7 Injured |
| Chris Smith | 2b | 26.290 | New York Yankees | Staten Island (A-) | Assigned to Staten Island (A-) |
| Dallas Gallant | P | 26.130 | Minnesota Twins | Fort Myers (A+) | DL-7 Injured |
| Ethan Chapman | OF | 25.150 | | | Released by Royals |
| Aaron Brown | RF | 22.349 | Philadelphia Phillies | Williamsport (A-) | Assigned to Williamsport (A-) |
| Brett Mooneyham | P | 25.131 | | | Released by Nationals |
| Matt Milroy | P | 24.242 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Travis Brewster | OF | 23.135 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Brant Whiting | C | 23.119 | Los Angeles Dodgers | Great Lakes (A) | DL-7 Injured |
| Corey Miller | P | 23.204 | Oakland Athletics | Vermont (A-) | Assigned to Vermont (A-) |
| Coty Blanchard | SS | 23.171 | Tampa Bay Rays | Bowling Green (A) | Suspended 50 games for violating Minor League drug program |
| Jordan Schwartz | P | 23.097 | Oakland Athletics | Vermont (A-) | Assigned to Vermont (A-) |
| Kevin Guzman | P | 20.210 | Los Angeles Dodgers | Great Lakes (A) | DL-7 Injured |
| Mark Armstrong | P | 20.190 | Cincinnati Reds | Dayton (A) | DL-7 Injured |
| Matt Tellor | 1B | 23.254 | Atlanta Braves | Danville (Rk) | Assigned to Danville (Rk) |
| Hector Olivera | 2b | 30.060 | Los Angeles Dodgers | Tulsa (AA) | Assigned to Tulsa (AA) |
