| Jimmy Paredes | 2b | 25.233 | Kansas City Royals | Kansas City Royals (MLB) | Designated for Assignment |
| A.J. Pierzynski | c | 37.198 | - | | Released by Red Sox |
| Andy Dirks | lf | 28.173 | Detroit Tigers | Detroit Tigers (MLB) | Recalled from minor league rehab assignment |
| Ryan Verdugo | P | 27.097 | Boston Red Sox | Boston Red Sox (MLB) | Traded from Royals to Red Sox for cash considerations |
| Hector Gimenez | c | 31.291 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Signed to minor league contract |
| Jose Adames | | 21.180 | Miami Marlins | Greensboro (A) | Assigned to Greensboro (A) |
| Breland Almadova | OF | 23.271 | Arizona Diamondbacks | Visalia (A+) | Assigned to Visalia (A+) |
| Andrew Beresford | P | 24.140 | New York Yankees | Charleston (sc) (A) | Assigned to Charleston (Sc) (A) |
| Zachary Bird | P | 20.002 | Los Angeles Dodgers | Great Lakes (A) | Activated from disabled list |
| Mark Blackmar | P | 22.079 | Baltimore Orioles | Aberdeen (A-) | Assigned to Aberdeen (A-) |
| Aaron Blair | P | 22.051 | Arizona Diamondbacks | Mobile (AA) | Assigned to Mobile (AA) |
| Dan Bowman | OF | 24.317 | Arizona Diamondbacks | South Bend (A) | Assigned to South Bend (A) |
| Brandon Brennan | P | 22.356 | Chicago White Sox | Kannapolis (A) | Assigned to Kannapolis (A) |
| Freddie Cabrera | P | 24.172 | Los Angeles Dodgers | Chattanooga (AA) | Activated from disabled list |
| Daniel Coulombe | P | 24.263 | Los Angeles Dodgers | Chattanooga (AA) | Assigned to Chattanooga (AA) |
| J.D. Davis | 3B | 21.080 | Houston Astros | Quad Cities (A) | Assigned to Quad Cities (A) |
| Logan Davis | SS | 22.328 | Kansas City Royals | Northwest Arkansas (AA) | Assigned to Northwest Arkansas (AA) |
| Alex Dickerson | 1B | 24.051 | San Diego Padres | Arizona Padres (Rk) | Assigned to Arizona Padres (Rk) |
| Sean Donatello | P | 23.326 | Miami Marlins | Jupiter (A+) | Assigned to Jupiter (A+) |
| James Dykstra | P | 23.236 | Chicago White Sox | Winston-Salem (A+) | Assigned to Winston-Salem (A+) |
| Pedro Encarnacion | P | 23.020 | Washington Nationals | Potomac (A+) | Assigned to Potomac (A+) |
| Cody Fassold | P | 25.287 | Atlanta Braves | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Brady Feigl | P | 23.201 | Atlanta Braves | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Raul Fernandez | P | 24.024 | Chicago White Sox | Winston-Salem (A+) | Assigned to Winston-Salem (A+) |
| Max Fried | P | 20.179 | San Diego Padres | Fort Wayne (A) | Assigned to Fort Wayne (A) |
| Martire Garcia | P | 24.137 | Texas Rangers | Frisco (AA) | Assigned to Frisco (AA) |
| Taylor Garrison | P | 24.053 | New York Yankees | Tampa (A+) | Assigned to Tampa (A+) |
| Ryan Gebhardt | SS | 22.285 | Arizona Diamondbacks | Visalia (A+) | Assigned to Visalia (A+) |
| Isaac Gil | P | 22.282 | Tampa Bay Rays | Bowling Green (A) | Assigned to Bowling Green (A) |
| Hector Gimenez | c | 31.291 | Milwaukee Brewers | Huntsville (AA) | Assigned to Huntsville (AA) |
| Nathan Hass | C | 20.131 | Atlanta Braves | Rome (A) | Activated from disabled list |
| Stefen Henderson | OF-P | 22.187 | Los Angeles Dodgers | Arizona Dodgers (Rk) | Assigned to Arizona Dodgers (Rk) |
| Lucas Herbst | OF-P | 23.310 | Baltimore Orioles | Frederick (A+) | Assigned to Frederick (A+) |
| T.J. House | P | 24.290 | Cleveland Indians | Mahoning Valley (A-) | Assigned to Mahoning Valley (A-) |
| Eric Jagielo | SS | 22.060 | New York Yankees | Tampa (A+) | Assigned to Tampa (A+) |
| Seong-Min Kim | C | 21.065 | Oakland Athletics | Vermont (A-) | Assigned to Vermont (A-) |
| Brady Lail | P | 20.341 | New York Yankees | Tampa (A+) | Assigned to Tampa (A+) |
| Jose Leal | | 19.150 | Seattle Mariners | Pulaski (Rk) | Assigned to Pulaski (Rk) |
| Jon Leroux | C | 23.300 | New York Mets | Brooklyn (A-) | Assigned to Brooklyn (A-) |
| Stefan Lopez | P | 23.103 | New York Yankees | Charleston (sc) (A) | Assigned to Charleston (Sc) (A) |
| Charlie Lowell | P | 23.264 | Miami Marlins | Gulf Coast Marlins (Rk) | Assigned to Gulf Coast Marlins (Rk) |
| Brandon Miller | C | 24.281 | Washington Nationals | Gulf Coast Nationals (Rk) | Activated from disabled list |
| Nick Mutz | P | 24.031 | San Diego Padres | Lake Elsinore (A+) | Assigned to Lake Elsinore (A+) |
| Bryson Myles | RF | 24.301 | Cleveland Indians | Arizona Indians (Rk) | Activated from disabled list |
| Luis Niebla | P | 23.193 | New York Yankees | Staten Island (A-) | Assigned to Staten Island (A-) |
| Giuseppe Papaccio | IF | 23.038 | Chicago Cubs | Kane County (A) | Assigned to Kane County (A) |
| Fidel Pena | 2B-C | 22.363 | Arizona Diamondbacks | South Bend (A) | Assigned to South Bend (A) |
| Chad Pinder | IF | 22.109 | Oakland Athletics | Stockton (A+) | Activated from disabled list |
| Brooks Pounders | P | 23.293 | Kansas City Royals | Idaho Falls (Rk) | Assigned to Idaho Falls (Rk) |
| Julian Ridings | OF | 22.137 | Tampa Bay Rays | Bowling Green (A) | Assigned to Bowling Green (A) |
| Wilman Rodriguez | OF | 23.039 | Washington Nationals | Auburn (A-) | Activated from disabled list |
| Avery Romero | SS | 21.066 | Miami Marlins | Jupiter (A+) | Assigned to Jupiter (A+) |
| Joe Ross | P | 21.056 | San Diego Padres | San Antonio (AA) | Assigned to San Antonio (AA) |
| Angel Sanchez | P | 24.230 | Chicago White Sox | Birmingham (AA) | Assigned to Birmingham (AA) |
| Juan Santana | | 19.334 | Houston Astros | Tri City (A-) | Assigned to Tri City (A-) |
| D.J. Slaton | P | 21.279 | Tampa Bay Rays | Bowling Green (A) | Assigned to Bowling Green (A) |
| Caleb Smith | P | 22.354 | New York Yankees | Tampa (A+) | Assigned to Tampa (A+) |
| Jesus Solorzano | CF | 23.342 | Miami Marlins | Jupiter (A+) | Activated from disabled list |
| Nate Tenbrink | 3B | 27.207 | Seattle Mariners | Arizona Mariners (Rk) | Activated from disabled list |
| Engelb Vielma | SS | 20.024 | Minnesota Twins | Cedar Rapids (A) | Activated from disabled list |
| Brady Wager | P | 23.241 | Baltimore Orioles | Frederick (A+) | Assigned to Frederick (A+) |
| Blayne Weller | P | 24.167 | Arizona Diamondbacks | Visalia (A+) | Assigned to Visalia (A+) |
| Tyler White | IF | 23.260 | Houston Astros | Lancaster (A+) | Assigned to Lancaster (A+) |
| Eric Yardley | P | 23.332 | San Diego Padres | Fort Wayne (A) | Assigned to Fort Wayne (A) |
| Herlis Rodriguez | OF | 20.036 | Philadelphia Phillies | Lakewood (A) | DL-7 Injured |
| Jayson Langfels | 3B | 25.333 | Colorado Rockies | Tulsa (AA) | DL-7 Injured |
| Lane Adams | CF | 24.245 | Kansas City Royals | Northwest Arkansas (AA) | DL-7 Injured |
| Alfredo Escalera-Maldonado | OF | 19.149 | Kansas City Royals | Lexington (A) | DL-7 Injured |
| Mike Connolly | IF | 22.259 | San Francisco Giants | Augusta (A) | DL-7 Injured |
| Ryan Newell | P | 23.028 | Miami Marlins | Greensboro (A) | DL-7 Injured |
| Shane Martin | P | 23.080 | | | Released by Phillies |
| Louis Coleman | RP | 28.103 | Kansas City Royals | Omaha (AAA) | Optioned to Omaha (AAA) |
| Duke Welker | RP | 28.156 | - | | Cleared Waivers and Became a Free Agent |
| Alfonso Soriano | lf | 38.191 | | | Cleared Waivers and Became a Free Agent |
| Michael Flores | P | 21.342 | Atlanta Braves | Danville (Rk) | Assigned to Danville (Rk) |
| Caleb Dirks | P | 21.037 | Atlanta Braves | Rome (A) | Assigned to Rome (A) |
| Clayvon Sambola | P | 21.239 | Atlanta Braves | Dominican Braves (Rk) | Assigned to DSL Braves (Dsl) |
| Gregory Greve | P | 22.193 | Miami Marlins | Myrtle Beach (A+) | Assigned to Myrtle Beach (A+) |
| Travis Hissong | P | 22.363 | New York Yankees | Gulf Coast Yankees (Rk) | Assigned to GCL Yankees (Rk) |
| Brian Anderson | SS | 21.058 | Miami Marlins | Greensboro (A) | Assigned to Greensboro (A) |
| John Mcleod | P | 22.043 | Baltimore Orioles | Delmarva (A) | Assigned to Delmarva (A) |
| Max Pentecost | C | 21.128 | Toronto Blue Jays | Vancouver (A-) | Assigned to Vancouver (A-) |
| Nick Vilter | 2B-3B | 20.283 | San Diego Padres | Eugene (A-) | Assigned to Eugene (A-) |
| Misja Harcksen | P | 19.088 | Los Angeles Dodgers | Arizona Dodgers (Rk) | Assigned to AZL Dodgers (Rk) |
| Wilfredy Liranzo | P | 19.263 | Minnesota Twins | Gulf Coast Twins (Rk) | DL-7 Injured |
| Luis Ramirez | p | 18.232 | Houston Astros | Dominican Astros (Rk) | Assigned to DSL Astros (Rk) |
