| Juan Lagares | cf | 25.101 | New York Mets | New York Mets (MLB) | Activated from DL |
| Daniel Schlereth | P | 28.048 | Detroit Tigers | Toledo (AAA) | Traded from Pirates to Tigers for cash considerations |
| Christian Bergman | P | 26.053 | Colorado Rockies | Colorado Rockies (MLB) | DL-60 Fractured left thumb |
| Scott Downs | RP | 38.101 | Chicago White Sox | Chicago White Sox (MLB) | Designated for Assignment |
| Eric Surkamp | SP | 26.346 | Chicago White Sox | Chicago White Sox (MLB) | Recalled from Charlotte (AAA) |
| Jose Veras | RP | 33.249 | Houston Astros | Houston Astros (MLB) | Contract purchased from minors |
| Evan Reed | RP | 28.177 | Detroit Tigers | Detroit Tigers (MLB) | Outrighted to minors |
| Wilson Ramos | c | 26.321 | Washington Nationals | Washington Nationals (MLB) | Activated from DL |
| Robbie Erlin | SP | 23.261 | San Diego Padres | San Diego Padres (MLB) | Transferred to 60-day DL |
| Juan Uribe | 3b | 35.096 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Activated from DL |
| Xavier Nady | LF | 35.224 | - | | Released by Mariners |
| Michael McKenry | c | 29.114 | Colorado Rockies | Colorado Rockies (MLB) | Reinstated from Bereavement |
| Nicholas Additon | P | 26.193 | Baltimore Orioles | Bowie (AA) | Assigned to Bowie (AA) |
| Christian Arroyo | SS | 19.027 | San Francisco Giants | Salem-Keizer (A-) | Assigned to Salem-Keizer (A-) |
| Christopher Beck | P | 23.295 | Chicago White Sox | Charlotte (AAA) | Assigned to Charlotte (AAA) |
| Colton Cain | P | 23.141 | Houston Astros | Gulf Coast Astros (Rk) | Activated from disabled list |
| John Cannon | C | 24.046 | Los Angeles Dodgers | Albuquerque (AAA) | Activated from disabled list |
| Russ Canzler | 1B-LF | 28.076 | Philadelphia Phillies | Lehigh Valley (AAA) | Assigned to Lehigh Valley (AAA) |
| Brian Cavazos-Galvez | 1B-LF | 27.040 | Los Angeles Dodgers | Albuquerque (AAA) | Assigned to Albuquerque (AAA) |
| Gerardo Concepcion | P | 22.117 | Chicago Cubs | Arizona Cubs (Rk) | Activated from disabled list |
| Dylan De Meyer | | 21.283 | Seattle Mariners | Clinton (A) | Assigned to Clinton (A) |
| Ryan Demmin | P | 26.082 | Philadelphia Phillies | Reading (AA) | Assigned to Reading (AA) |
| Michael Dimock | P | 24.243 | San Diego Padres | San Antonio (AA) | Assigned to San Antonio (AA) |
| Austin Elkins | IF | 23.187 | Houston Astros | Lancaster (A+) | Assigned to Lancaster (A+) |
| Gabe Encinas | P | 22.188 | New York Yankees | Charleston (sc) (A) | Assigned to Charleston (Sc) (A) |
| Luis Exposito | c | 27.157 | Oakland Athletics | Sacramento (AAA) | Assigned to Sacramento (AAA) |
| Cody Fassold | P | 25.267 | Atlanta Braves | Mississippi (AA) | Assigned to Mississippi (AA) |
| Mike Fiers | SP | 29.011 | Milwaukee Brewers | Nashville (AAA) | Assigned to Nashville (AAA) |
| Luis Flores | C | 27.236 | Chicago Cubs | Tennessee (AA) | Assigned to Tennessee (AA) |
| Wilmer Flores | 3b | 22.325 | New York Mets | Las Vegas (AAA) | Assigned to Las Vegas (AAA) |
| Dan Gamache | 3B-2B | 23.218 | Pittsburgh Pirates | Gulf Coast Pirates (Rk) | Assigned to Gulf Coast Pirates (Rk) |
| Robbie Grossman | lf | 24.283 | Houston Astros | Oklahoma City (AAA) | Assigned to Oklahoma City (AAA) |
| Angelo Gumbs | 2B | 21.256 | New York Yankees | Tampa (A+) | Assigned to Tampa (A+) |
| Jason Gurka | P | 26.168 | Baltimore Orioles | Norfolk (AAA) | Assigned to Norfolk (AAA) |
| Nate Hanson | 1B | 27.138 | Minnesota Twins | Rochester (AAA) | Assigned to Rochester (AAA) |
| Josh Hart | CF | 19.267 | Baltimore Orioles | Gulf Coast Orioles (Rk) | Activated from disabled list |
| Dylan Hawkins | P | 21.000 | St. Louis Cardinals | Palm Beach (A+) | Assigned to Palm Beach (A+) |
| Destin Hood | RF | 24.084 | Washington Nationals | Syracuse (AAA) | Activated from disabled list |
| Luke Jackson | P | 22.307 | Texas Rangers | Round Rock (AAA) | Assigned to Round Rock (AAA) |
| Phil Klein | P | 25.057 | Texas Rangers | Round Rock (AAA) | Assigned to Round Rock (AAA) |
| Jeff Kobernus | cf | 25.361 | Washington Nationals | Syracuse (AAA) | Assigned to Syracuse (AAA) |
| Pete Kozma | ss | 26.076 | St. Louis Cardinals | Memphis (AAA) | Optioned to Memphis (AAA), DFA reversed |
| Taylor Krick | C | 26.087 | Miami Marlins | New Orleans (AAA) | Activated from disabled list |
| John Lannan | SP | 29.272 | New York Mets | Brooklyn (A-) | Assigned to Brooklyn (A-) |
| Mark Leiter | P | 23.105 | Philadelphia Phillies | Clearwater (A+) | Assigned to Clearwater (A+) |
| Sandy Leon | c | 25.105 | Washington Nationals | Syracuse (AAA) | Assigned to Syracuse (AAA) |
| Jeff Mckenzie | P | 23.042 | Chicago White Sox | Kannapolis (A) | Assigned to Kannapolis (A) |
| Melvin Mercedes | SS | 22.165 | Oakland Athletics | Beloit (A) | Activated from disabled list |
| Adam Miller | P | 24.180 | Arizona Diamondbacks | Arizona Diamondbacks (Rk) | Activated from disabled list |
| Bryan Mitchell | P | 23.068 | New York Yankees | Trenton (AA) | Assigned to Trenton (AA) |
| Raymundo Montero | P | 24.279 | San Francisco Giants | Salem-Keizer (A-) | Assigned to Salem-Keizer (A-) |
| Conor Mullee | P | 26.122 | New York Yankees | Charleston (sc) (A) | Assigned to Charleston (Sc) (A) |
| Luis Niebla | P | 23.173 | New York Yankees | Charleston (sc) (A) | Assigned to Charleston (Sc) (A) |
| Lester Oliveros | P | 26.029 | Minnesota Twins | Rochester (AAA) | Assigned to Rochester (AAA) |
| Brian Pearl | P | 26.040 | Cincinnati Reds | Arizona Reds (Rk) | Assigned to Arizona Reds (Rk) |
| Elvin Perez | P | 23.327 | New York Yankees | Gulf Coast Yankees (Rk) | Assigned to Gulf Coast Yankees (Rk) |
| Jeremias Pineda | CF | 23.222 | Minnesota Twins | Cedar Rapids (A) | Assigned to Cedar Rapids (A) |
| Yohan Pino | P | 30.183 | Minnesota Twins | Rochester (AAA) | Assigned to Rochester (AAA) |
| Kevin Plawecki | C | 23.120 | New York Mets | Las Vegas (AAA) | Assigned to Las Vegas (AAA) |
| Bryan Price | P | 27.225 | Cleveland Indians | Columbus (AAA) | Assigned to Columbus (AAA) |
| J.C. Ramirez | RP | 25.314 | Cleveland Indians | Akron (AA) | Assigned to Akron (AA) |
| Manny Ramirez | DH | 42.027 | Chicago Cubs | Iowa (AAA) | Assigned to Iowa (AAA) |
| Evan Reed | RP | 28.177 | Detroit Tigers | Toledo (AAA) | Assigned to Toledo (AAA) |
| Nate Roberts | LF | 25.121 | Minnesota Twins | Fort Myers (A+) | Activated from disabled list |
| Ryan Rua | 3B | 24.107 | Texas Rangers | Round Rock (AAA) | Assigned to Round Rock (AAA) |
| Rusty Ryal | 2B-3B | 31.102 | Philadelphia Phillies | Reading (AA) | Assigned to Reading (AA) |
| Grady Sizemore | CF | 31.328 | Philadelphia Phillies | Lehigh Valley (AAA) | Assigned to Lehigh Valley (AAA) |
| Jake Smolinski | LF | 25.137 | Texas Rangers | Round Rock (AAA) | Assigned to Round Rock (AAA) |
| Brad Snyder | RF | 32.032 | Texas Rangers | Round Rock (AAA) | Outrighted to Round Rock (AAA) |
| Kurt Spomer | P | 24.351 | Los Angeles Angels | Inland Empire (A+) | Assigned to Inland Empire (A+) |
| Trevor Story | SS | 21.223 | Colorado Rockies | Tulsa (AA) | Assigned to Tulsa (AA) |
| Ashur Tolliver | P | 26.154 | Baltimore Orioles | Bowie (AA) | Assigned to Bowie (AA) |
| Justin Topa | P | 23.111 | Pittsburgh Pirates | West Virginia (A) | Activated from disabled list |
| Luis Torrens | C | 18.055 | New York Yankees | Charleston (sc) (A) | Assigned to Charleston (Sc) (A) |
| Andres Torres | cf | 36.151 | Boston Red Sox | Pawtucket (AAA) | Assigned to Pawtucket (AAA) |
| Kylin Turnbull | P | 24.287 | Washington Nationals | Gulf Coast Nationals (Rk) | Activated from disabled list |
| Logan Wade | 2B | 22.226 | Minnesota Twins | Cedar Rapids (A) | Assigned to Cedar Rapids (A) |
| Keenyn Walker | CF-RF | 23.318 | Chicago White Sox | Winston-Salem (A+) | Activated from disabled list |
| Daniel Watts | P | 24.243 | Atlanta Braves | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Kyle Weiland | P | 27.287 | Houston Astros | Gulf Coast Astros (Rk) | Assigned to Gulf Coast Astros (Rk) |
| Eli Whiteside | C | 34.248 | Chicago Cubs | Iowa (AAA) | Assigned to Iowa (AAA) |
| Shannon Wilkerson | LF-CF | 25.341 | Boston Red Sox | Portland (AA) | Assigned to Portland (AA) |
| Everett Williams | LF | 23.268 | Philadelphia Phillies | Gulf Coast Phillies (Rk) | Activated from disabled list |
| Jackson Williams | C | 28.043 | Colorado Rockies | Colorado Springs (AAA) | Assigned to Colorado Springs (AAA) |
| JaDamion Williams | RF | 23.218 | Minnesota Twins | Cedar Rapids (A) | Activated from disabled list |
| Nick Maronde | RP | 24.294 | Los Angeles Angels | Arkansas (AA) | DL-7 Injured |
| Preston Claiborne | RP | 26.157 | New York Yankees | Scranton/Wilkes-Barre (AAA) | DL-7 Injured |
| Adam Heisler | CF | 26.019 | Chicago White Sox | Winston-Salem (A+) | Suspended 50 games for violating Minor League drug policy |
| Matt Clark | LF-1B | 27.198 | | | Released by Mets |
| Suk-Min Yoon | P | 27.337 | Baltimore Orioles | Norfolk (AAA) | DL-7 Injured |
| Layne Somsen | P | 25.021 | Cincinnati Reds | Bakersfield (A+) | DL-7 Injured |
| Sam Stafford | P | 24.060 | Texas Rangers | Myrtle Beach (A+) | DL-7 Injured |
| Tyler Danish | P | 19.287 | Chicago White Sox | Winston-Salem (A+) | DL-7 Injured |
| German Marquez | P | 19.124 | Tampa Bay Rays | Bowling Green (A) | DL-7 Injured |
| Jaime Schultz | P | 23.006 | Tampa Bay Rays | Bowling Green (A) | DL-7 Injured |
| Chris Smith | | 33.078 | San Diego Padres | San Diego Padres (MLB) | Signed to minor league contract |
| Irving Falu | 2b-ss | 31.020 | San Diego Padres | San Diego Padres (MLB) | Claimed off waivers from Brewers by Padres |
| Jorge Polanco | SS-3B | 20.356 | Minnesota Twins | Minnesota Twins (MLB) | Contract purchaed from Fort Myers (A+) |
| J.J. Putz | RP | 37.124 | - | | Released by Diamondbacks |
| Kevin Slowey | RP | 30.053 | - | | Cleared Waivers and Became a Free Agent |
| Julio DePaula | | 31.177 | Baltimore Orioles | Baltimore Orioles (MLB) | Signed to minor league contract |
| Tim Collins | RP | 24.309 | Kansas City Royals | Omaha (AAA) | Optioned to Omaha (AAA) |
| Jimmy Reed | P | 23.190 | St. Louis Cardinals | Palm Beach (A+) | Assigned to Palm Beach (A+) |
| Jesus Rivas | P | 20.096 | Oakland Athletics | Arizona Athletics (Rk) | Assigned to AZL Athletics (Rk) |
| Alexander Gutierrez | P | 21.093 | | | Released by Pirates |
| Brandon Brosher | OF | 19.129 | New York Mets | Kingsport (Rk) | DL-7 Injured |
| Tyler Clark | C | 22.088 | Arizona Diamondbacks | Missoula (Rk) | Assigned to Missoula (Rk) |
| Alex Blandino | SS | 21.232 | Cincinnati Reds | Billings (Rk) | Signed out of draft (Stanford) |
| Matt Borens | P | 21.136 | New York Yankees | Staten Island (A-) | Assigned to Staten Island (A-) |
| Alex Durham | P | 17.283 | New York Mets | Gulf Coast Mets (Rk) | Signed out of draft (North Carolina HS) |
| Alex Jackson | C-OF | 18.184 | Seattle Mariners | Arizona Mariners (Rk) | Signed out of draft (California HS) |
| David Trexler | P | 23.295 | Chicago White Sox | Arizona White Sox (Rk) | Signed out of draft (North Florida) |
| Erik Manoah | P | 18.187 | New York Mets | Gulf Coast Mets (Rk) | Signed out of draft (Florida HS) |
| Jacob Petersen | P | 23.075 | Los Angeles Angels | Orem (Rk) | Assigned to Orem (Rk) |
| Jake Jewell | P | 21.041 | Los Angeles Angels | Arizona Angels (Rk) | Signed out of draft (Northeastern Oklahoma A&M) |
| Jordan Yamamoto | P | 18.046 | Milwaukee Brewers | Arizona Brewers (Rk) | Signed out of draft (Hawaii HS) |
| Kyle Bogese | P | 23.245 | Philadelphia Phillies | Gulf Coast Phillies (Rk) | Signed out of draft (Trinity) |
| Luis Lacen | OF | 17.256 | San Francisco Giants | Arizona Giants (Rk) | Signed out of draft (Puerto Rico) |
| Tanner Banks | P | 22.246 | Chicago White Sox | Arizona White Sox (Rk) | Signed out of draft (Salt Lake CC) |
| Tanner English | OF | 21.107 | Minnesota Twins | Elizabethton (Rk) | Signed out of draft (South Carolina) |
| Tyler Hill | OF | 18.114 | Boston Red Sox | Boston Red Sox (MLB) | Signed out of draft (Delaware HS) |
| Aaron Dott | P | 26.040 | New York Yankees | Trenton (AA) | Placed on temporary inactive list |
