| Jason Heyward | rf | 24.014 | Atlanta Braves | Atlanta Braves (MLB) | DL-15 Fractured right jaw [Hit by pitch in face by Jon Niese] |
| Paul Maholm | SP | 31.059 | Atlanta Braves | Atlanta Braves (MLB) | Activated from DL |
| Daisuke Matsuzaka | SP | 32.344 | New York Mets | New York Mets (MLB) | Signed to 1-year contract for 2013 ($0m) |
| Mike Kickham | RP | 24.254 | San Francisco Giants | Fresno (AAA) | Optioned to Fresno (AAA) |
| Nick Noonan | 2b | 24.111 | San Francisco Giants | San Francisco Giants (MLB) | Recalled from Fresno (AAA) |
| Francisco Peguero | LF | 25.083 | San Francisco Giants | San Francisco Giants (MLB) | Recalled from Fresno (AAA) |
| Andres Torres | cf | 35.209 | San Francisco Giants | San Francisco Giants (MLB) | DL-15 Strained left achilles + Surgery [Lingered for a couple of years] |
| Ozzie Chavez | SS | 30.041 | Milwaukee Brewers | Nashville (AAA) | DL-7 Injured |
| Chris Narveson | RP | 31.246 | Milwaukee Brewers | Nashville (AAA) | DL-7 Injured |
| Sean O'Sullivan | RP | 25.357 | San Diego Padres | Tucson (AAA) | Outrighted to Tucson (AAA) |
| Wade LeBlanc | RP | 29.016 | Houston Astros | Tucson (AAA) | Outrighted to Tucson (AAA) |
| Scott Shuman | P | 25.148 | San Francisco Giants | Richmond (AA) | DL-7 Foot |
| Keith Castillo | C | 26.044 | Tampa Bay Rays | Montgomery (AA) | Placed on temporarily inactive list |
| Brett Teschner | C | 22.000 | Texas Rangers | Frisco (AA) | Placed on temporarily inactive list |
| Pedro Vidal | P | 26.023 | Oakland Athletics | Midland (AA) | DL-7 Injured |
| Bryce Bandilla | P | 23.218 | San Francisco Giants | San Jose (A+) | DL-7 Injured |
| Cody Scarpetta | P | 24.363 | Milwaukee Brewers | Brevard County (A+) | DL-7 Injured |
| Bryan Rodriguez | P | 22.048 | San Diego Padres | Fort Wayne (A) | DL-7 Injured |
| Alex Glenn | OF | 22.073 | Arizona Diamondbacks | South Bend (A) | DL-7 Injured |
| Tyler Skulina | P | 21.340 | Chicago Cubs | Kane County (A) | DL-7 Injured |
| Wendell Soto | SS | 21.104 | Los Angeles Angels | Burlington (A) | DL-7 Injured |
| Rob Zastryzny | P | 21.150 | Chicago Cubs | Kane County (A) | DL-7 Injured |
| Mitchell Walding | SS | 20.347 | Philadelphia Phillies | Lakewood (A) | Placed on temporarily inactive list |
| Angelo Gumbs | 2B | 20.314 | New York Yankees | Charleston (sc) (A) | DL-7 Injured |
| Juancito Martinez | RF | 24.074 | Miami Marlins | Greensboro (A) | DL-7 Strained left groin |
| Luis Ortiz | 2B | 21.162 | Miami Marlins | Batavia (A-) | DL-7 Injured |
| David Sopilka | C | 19.358 | Boston Red Sox | Lowell (A-) | DL-7 Injured |
| Jaycob Brugman | OF | 21.218 | Oakland Athletics | Vermont (A-) | Placed on temporarily inactive list |
| Yoenny Gonzalez | CF-LF | 21.205 | St. Louis Cardinals | Johnson City (Rk) | suspended for 50 games for violating Minor League drug program |
| Eric Chavez | 3b-dh | 35.259 | Arizona Diamondbacks | Arizona Diamondbacks (Rk) | Assigned to AZL Diamondbacks (Rk) for rehab |
| Kevin Kouzmanoff | 3B | 32.029 | Miami Marlins | New Orleans (AAA) | Activated from DL |
| Matthew Shepherd | SS | 23.113 | San Diego Padres | Fort Wayne (A) | Activated from DL |
| Blake Davis | SS | 29.245 | Milwaukee Brewers | Nashville (AAA) | Activated from DL |
| Mauro Gomez | 1b | 28.350 | Toronto Blue Jays | Buffalo (AAA) | Activated from DL |
| Luis Rojas | P | 24.025 | San Francisco Giants | San Jose (A+) | Activated from DL |
| Brian Smith | P | 20.254 | Chicago Cubs | Kane County (A) | Activated from DL |
| Jose Berrios | P | 19.088 | Minnesota Twins | Cedar Rapids (A) | Activated from DL |
| Pedro Toribio | 2b | 23.033 | Los Angeles Angels | Burlington (A) | Activated from DL |
| Dakota Bacus | P | 22.143 | Washington Nationals | Washington Nationals (MLB) | Traded from Athletics to Nationals for Kurt Suzuki |
| Kurt Suzuki | c | 29.324 | Oakland Athletics | Oakland Athletics (MLB) | Traded from Nationals to Athletics for Dakota Bacus |
| Caleb Gindl | rf-LF | 24.357 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Recalled from Nashville (AAA) |
| Aaron Loup | RP | 25.248 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Placed on Paternity Leave list |
| Xavier Cedeno | RP | 26.362 | Washington Nationals | Washington Nationals (MLB) | Recalled from Syracuse (AAA) |
| Greg Burke | RP | 30.336 | New York Mets | Las Vegas (AAA) | Optioned to Las Vegas (AAA) |
| Carlos Martinez | SP-RP | 21.337 | St. Louis Cardinals | St. Louis Cardinals (MLB) | Recalled from Memphis (AAA) |
| Jake Westbrook | SP | 35.328 | St. Louis Cardinals | St. Louis Cardinals (MLB) | DL-15 Lower back strain |
| David DeJesus | lf | 33.247 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Traded from Nationals to Rays for future considerations |
| Rob Wooten | RP | 28.033 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Reinstated from Paternity Leave list |
| Derek Norris | c | 24.190 | Oakland Athletics | Oakland Athletics (MLB) | DL-15 Fractured left big toe [Play at the plate with Nick Franklin] |
| Freddy Garcia | SP | 36.321 | Atlanta Braves | Gwinnett (AAA) | Traded from Orioles to Braves for cash considerations |
| Cody Clark | c | 31.343 | Houston Astros | Houston Astros (MLB) | Contract purchased from Corpus Christi (AA) |
| Max Stassi | dh | 22.161 | Houston Astros | Houston Astros (MLB) | DL-7 Concussion [Hit in the face by a pitch from Tanner Scheppers] |
| Jason Bourgeois | lf | 31.231 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Designated for Assignment |
| Billy Buckner | RP | 29.362 | Los Angeles Angels | Los Angeles Angels (MLB) | Designated for Assignment |
| Cory Rasmus | RP | 25.291 | Los Angeles Angels | Los Angeles Angels (MLB) | Recalled from Salt Lake (AAA) |
| Brandon Beachy | SP | 26.354 | Atlanta Braves | Atlanta Braves (MLB) | DL-15 Right elbow inflammation |
| Todd Cunningham | lf | 24.156 | Atlanta Braves | Atlanta Braves (MLB) | Recalled from Gwinnett (AAA) |
| Jhonatan Solano | C | 28.011 | Washington Nationals | Washington Nationals (MLB) | Recalled from Syracuse (AAA) |
| Matt Cain | SP | 28.326 | San Francisco Giants | San Francisco Giants (MLB) | DL-15 Right forearm contusion [Hit by a Gaby Sanchez line drive] |
| Yusmeiro Petit | SP | 28.274 | San Francisco Giants | San Francisco Giants (MLB) | Contract purchased from Fresno (AAA) |
| Rafael Betancourt | RP | 38.116 | Colorado Rockies | Colorado Springs (AAA) | DL-15 Right elbow sprain |
| Jhoulys Chacin | SP | 25.229 | Colorado Rockies | Colorado Rockies (MLB) | Reinstated from Bereavement List |
| Edgmer Escalona | RP | 26.321 | Colorado Rockies | Colorado Rockies (MLB) | Designated for Assignment |
| Rob Scahill | RP | 26.189 | Colorado Rockies | Colorado Rockies (MLB) | Recalled from Colorado Springs (AAA) |
| Mike Kickham | RP | 24.254 | San Francisco Giants | San Francisco Giants (MLB) | Recalled from Fresno (AAA) |
| Nick Noonan | 2b | 24.111 | San Francisco Giants | Fresno (AAA) | Optioned to Fresno (AAA) |
| Guilder Rodriguez | SS | 30.030 | Texas Rangers | Frisco (AA) | Assigned to Frisco (AA) |
| David Cooper | 1B | 26.192 | Cleveland Indians | Columbus (AAA) | Assigned to Columbus (AAA) |
| Steven Souza | 1B | 24.121 | Washington Nationals | Harrisburg (AA) | Activated from DL |
| Zach Shank | IF | 22.229 | Seattle Mariners | Clinton (A) | Assigned to Clinton (A) |
| Ryan Walker | IF | 21.150 | Minnesota Twins | Cedar Rapids (A) | Assigned to Cedar Rapids (A) |
| Sharif Othman | C | 24.153 | Miami Marlins | Jupiter (A+) | Assigned to Jupiter (A+) |
| Avery Romero | SS | 20.104 | Miami Marlins | Greensboro (A) | Assigned to Greensboro (A) |
| Rehiner Cordova | | 19.224 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Oscar Hernandez | | 20.045 | Tampa Bay Rays | Bowling Green (A) | Assigned to Bowling Green (A) |
| Neftali Rosario | C | 20.032 | Chicago Cubs | Boise (A-) | Assigned to Boise (A-) |
| Leonardo Heras | OF | 23.086 | Houston Astros | Corpus Christi (AA) | Contract purchased from Mexico City (Mexico) |
| Wade LeBlanc | RP | 29.016 | Houston Astros | Oklahoma City (AAA) | Assigned to Oklahoma City (AAA) |
| Kyle Blair | P | 24.330 | Cleveland Indians | Akron (AA) | Assigned to Akron (AA) |
| Zach Russell | P | 24.027 | St. Louis Cardinals | Springfield (AA) | Assigned to Springfield (AA) |
| Matt Summers | P | 24.006 | Minnesota Twins | Fort Myers (A+) | Assigned to Fort Myers (A+) |
| Alan Williams | P | 23.171 | Milwaukee Brewers | Wisconsin (A) | Assigned to Wisconsin (A) |
| Joel Effertz | P | 22.330 | Miami Marlins | Batavia (A-) | Assigned to Batavia (A-) |
| Brad Schreiber | P | 22.191 | Tampa Bay Rays | Hudson Valley (A-) | Signed as undrafted free agent out of college |
| Jake Johansen | P | 22.212 | Washington Nationals | Hagerstown (A) | Assigned to Hagerstown (A) |
| Ian Krol | RP | 22.106 | Washington Nationals | Syracuse (AAA) | Assigned to Syracuse (AAA) |
| Euris Quezada | P | 24.139 | Houston Astros | Gulf Coast Astros (Rk) | Assigned to Gulf Coast Astros (Rk) |
| Greg Gonzalez | P | 24.338 | San Diego Padres | Tucson (AAA) | Assigned to Tucson (AAA) |
| Luis Ordosgoitti | P | 20.335 | Houston Astros | Greeneville (Rk) | Assigned to Greeneville (Rk) |
| Jonathan Keener | C | 23.256 | St. Louis Cardinals | Johnson City (Rk) | Assigned to Johnson City (Rk) |
| Jose Montero | | 20.213 | Houston Astros | Greeneville (Rk) | Assigned to Greeneville (Rk) |
| Ryan McChesney | | 23.201 | Tampa Bay Rays | Charlotte (A+) | Assigned to Charlotte (A+) |
| Geordy Parra | | 19.351 | Arizona Diamondbacks | South Bend (A) | Assigned to South Bend (A) |
| Tyler Brosius | P | 21.229 | Atlanta Braves | Rome (A) | Assigned to Rome (A) |
| Neil Ramirez | P | 24.090 | Chicago Cubs | Tennessee (AA) | Traded from Rangers to Cubs as PTBNL in Matt Garza deal |
| Bruedlin Suero | P | 23.176 | Tampa Bay Rays | Bowling Green (A) | Assigned to Bowling Green (A) |
