| Drew Smyly | RP | 23.073 | Detroit Tigers | Detroit Tigers (MLB) | Recalled from Toledo (AAA) |
| Yunel Escobar | ss | 29.296 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Activated from Paternity Leave List |
| Brandon Morrow | SP | 28.030 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Activated from DL |
| Luke Putkonen | P | 26.107 | Detroit Tigers | Toledo (AAA) | Optioned to Toledo (AAA) |
| Anthony Gose | rf | 22.015 | Toronto Blue Jays | Las Vegas (AAA) | Optioned to Las Vegas (AAA) |
| Adeiny Hechavarria | ss | 23.132 | Toronto Blue Jays | Las Vegas (AAA) | Optioned to Las Vegas (AAA) |
| Chris Rusin | SP | 25.307 | Chicago Cubs | Iowa (AAA) | Optioned to Iowa (AAA) |
| Mitch Atkins | P | 26.328 | Washington Nationals | Syracuse (AAA) | Activated from DL |
| John Gast | P | 23.190 | St. Louis Cardinals | Memphis (AAA) | Activated from DL |
| Alfredo Aceves | CL | 29.260 | Boston Red Sox | Boston Red Sox (MLB) | Suspended 3 games by team for behaviour detrimental to team |
| Ivan DeJesus | 2B | 25.116 | Boston Red Sox | Boston Red Sox (MLB) | Traded from Dodgers with James Loney, Jerry Sands, Rubby de la Rosa and Allen Webster to Red Sox for Josh Beckett, Adrian Gonzalez, Carl Crawford and Nick Punto |
| James Loney | 1b | 28.110 | Boston Red Sox | Boston Red Sox (MLB) | Traded from Dodgers with Ivan DeJesus, Jerry Sands, Rubby de la Rosa and Allen Webster to Red Sox for Josh Beckett, Adrian Gonzalez, Carl Crawford and Nick Punto |
| Jerry Sands | LF-1B | 24.332 | Boston Red Sox | Boston Red Sox (MLB) | Traded from Dodgers with James Loney, Ivan DeJesus, Rubby de la Rosa and Allen Webster to Red Sox for Josh Beckett, Adrian Gonzalez, Carl Crawford and Nick Punto |
| Rubby De La Rosa | RP | 23.174 | Boston Red Sox | Boston Red Sox (MLB) | Traded from Dodgers with James Loney, Jerry Sands, Ivan DeJesus and Allen Webster to Red Sox for Josh Beckett, Adrian Gonzalez, Carl Crawford and Nick Punto |
| Allen Webster | P | 22.196 | Boston Red Sox | Boston Red Sox (MLB) | Traded from Dodgers with James Loney, Jerry Sands, Rubby de la Rosa and Ivan DeJesus to Red Sox for Josh Beckett, Adrian Gonzalez, Carl Crawford and Nick Punto |
| Josh Beckett | SP | 32.102 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Traded from Red Sox with Adrian Gonzalez, Carl Crawford and Nick Punto to Dodgers for Jerry Sands, James Loney, Ivan DeJesus, Rubby de la Rosa and Allen Webster |
| Adrian Gonzalez | 1B | 30.109 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Traded from Red Sox with Josh Beckett, Carl Crawford and Nick Punto to Dodgers for Jerry Sands, James Loney, Ivan DeJesus, Rubby de la Rosa and Allen Webster |
| Nick Punto | 3b-2b | 34.290 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Traded from Red Sox with Adrian Gonzalez, Carl Crawford and Josh Beckett to Dodgers for Jerry Sands, James Loney, Ivan DeJesus, Rubby de la Rosa and Allen Webster |
| Felix Doubront | SP | 24.307 | Boston Red Sox | Boston Red Sox (MLB) | Activated from DL |
| Jose Iglesias | ss | 22.232 | Boston Red Sox | Boston Red Sox (MLB) | Recalled from Pawtucket (AAA) |
| Che-Hsuan Lin | rf | 23.338 | Boston Red Sox | Boston Red Sox (MLB) | Recalled from Pawtucket (AAA) |
| Daniel Nava | dh | 29.186 | Boston Red Sox | Boston Red Sox (MLB) | DL-15 Sprained left wrist |
| Junichi Tazawa | RP | 26.080 | Boston Red Sox | Boston Red Sox (MLB) | Recalled from Pawtucket (AAA) |
| Scott Diamond | SP | 26.026 | Minnesota Twins | Minnesota Twins (MLB) | Suspended 6 games for throwing at Josh Hamilton |
| Miguel Batista | RP | 41.187 | Atlanta Braves | Atlanta Braves (MLB) | Contract purchased from Gwinnett (AAA) |
| Ben Sheets | SP | 34.038 | Atlanta Braves | Atlanta Braves (MLB) | DL-15 Right shoulder inflammation |
| Brooks Raley | SP | 24.057 | Chicago Cubs | Chicago Cubs (MLB) | Recalled from Iowa (AAA) |
| Fernando Abad | SP | 26.251 | Houston Astros | Houston Astros (MLB) | Recalled from Oklahoma CIty (AAA) |
| Chuck Fick | RP | 26.287 | Houston Astros | Oklahoma City (AAA) | Optioned to Oklahoma City (AAA) |
| Eric Hacker | RP | 29.152 | San Francisco Giants | Fresno (AAA) | Optioned to Fresno (AAA) |
| Jerry Hairston | 3B-2B | 36.088 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Transferred to 60-day DL |
| Tim Corcoran | P | 34.132 | Los Angeles Dodgers | Albuquerque (AAA) | Contract purchased from Carmen (Mexico) |
| Chad Billingsley | SP | 28.027 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | DL-15 Right elbow pain |
| Alex Castellanos | RF | 26.021 | Los Angeles Dodgers | Albuquerque (AAA) | Optioned to Albuquerque (AAA) |
| Blake Lalli | 1B-C | 29.105 | Chicago Cubs | Iowa (AAA) | Outrighted to Iowa (AAA) |
| Jack Cust | DH | 33.221 | Toronto Blue Jays | Las Vegas (AAA) | Placed on temporarily inactive list |
| Nate Samson | 2B | 25.006 | Chicago Cubs | Iowa (AAA) | DL-7 Injured |
| Mike Antonini | P | 27.019 | Los Angeles Dodgers | Albuquerque (AAA) | DL-7 Strained left elbow |
| Logan Kensing | P | 30.053 | Pittsburgh Pirates | Indianapolis (AAA) | DL-7 Injured |
| Chris Swauger | RF-LF | 26.014 | St. Louis Cardinals | Springfield (AA) | Activated from DL |
| Ray Kruml | RF-CF | 27.020 | St. Louis Cardinals | Springfield (AA) | DL-7 Injured |
| Jarret Martin | P | 23.011 | Los Angeles Dodgers | Rancho Cucamonga (A+) | DL-7 Injured |
| Robert Whitenack | P | 23.278 | Chicago Cubs | Daytona (A+) | DL-7 Injured |
| Cody Evans | P | 28.357 | Toronto Blue Jays | Dunedin (A+) | Placed on temporarily inactive list |
| Evan Englebrook | P | 30.119 | Toronto Blue Jays | Dunedin (A+) | DL-7 Injured |
| Curt Casali | C | 23.289 | Detroit Tigers | Lakeland (A+) | DL-7 Injured |
| Austin Wood | P | 22.045 | Los Angeles Angels | Cedar Rapids (A) | DL-7 Injured |
| Michael Jensen | P | 21.258 | Chicago Cubs | Peoria (A) | DL-7 Blister |
| Anthony Garcia | LF | 20.234 | St. Louis Cardinals | Quad Cities (A) | DL-7 Injured |
| Tyrell Jenkins | P | 20.036 | St. Louis Cardinals | Quad Cities (A) | DL-7 Injured |
| Robert Stock | C | 22.277 | St. Louis Cardinals | Quad Cities (A) | Activated from DL |
| Colin Kaline | 2B | 23.121 | Detroit Tigers | West Michigan (A) | Activated from DL |
| Kyle Petter | P | 22.142 | Cleveland Indians | Lake County (A) | Activated from DL |
| Jordan Scott | LF | 20.338 | Houston Astros | Lexington (A) | Placed on temporarily inactive list |
| Moises Rivas | P | 21.314 | Philadelphia Phillies | Lakewood (A) | Activated from DL |
| Jack Duffey | P | 20.129 | Detroit Tigers | Connecticut (A-) | DL-7 Injured |
| Eric Phillips | IF | 22.040 | Toronto Blue Jays | Vancouver (A-) | Transferred to 60-day DL |
| Jordan Schafer | CF | 25.355 | Houston Astros | Gulf Coast Astros (Rk) | Assigned to GCL Astros (Rk) for rehab |
| Anthony Giansanti | RF | 23.331 | Chicago Cubs | Daytona (A+) | Assigned to Daytona (A+) |
| Jhonatan Solano | c | 27.013 | Washington Nationals | Harrisburg (AA) | Assigned to Harrisburg (AA) for rehab |
| Ryan Dent | SS | 23.163 | Boston Red Sox | Pawtucket (AAA) | Assigned to Pawtucket (AAA) |
| Dee Gordon | ss | 24.125 | Los Angeles Dodgers | Albuquerque (AAA) | Assigned to Albuquerque (AAA) for rehab |
| Toby DeMello | C | 22.234 | Seattle Mariners | Arizona Mariners (Rk) | Assigned to Arizona Mariners (Rk) |
| Nathan Melendres | CF-LF | 22.143 | Seattle Mariners | High Desert (A+) | Assigned to High Desert (A+) |
| Sammie Starr | 2B-SS | 24.086 | Baltimore Orioles | Frederick (A+) | Assigned to Frederick (A+) |
| Anthony Caronia | IF-OF | 21.095 | Baltimore Orioles | Delmarva (A) | Assigned to Delmarva (A) |
| David Chester | 1B | 23.147 | Boston Red Sox | Salem (A+) | Assigned to Salem (A+) |
| Sean Jamieson | SS | 23.176 | Oakland Athletics | Burlington (A) | Assigned to Burlington (A) |
| Sean Jamieson | SS | 23.176 | Arizona Diamondbacks | South Bend (A) | Assigned to South Bend (A) |
| Dario Pizzano | OF | 21.122 | Seattle Mariners | Everett (A-) | Assigned to Everett (A-) |
| Johnathan Knight | OF | 19.083 | Philadelphia Phillies | Clearwater (A+) | Assigned to Clearwater (A+) |
| Greg Bird | C | 19.289 | New York Yankees | Staten Island (A-) | Assigned to Staten Island (A-) |
| Willie Collazo | P | 32.292 | Toronto Blue Jays | Dunedin (A+) | Assigned to Dunedin (A+) |
| Eric Eadington | P | 24.198 | Los Angeles Dodgers | Rancho Cucamonga (A+) | Assigned to Rancho Cucamonga (A+) |
| Kris Johnson | P | 27.315 | Pittsburgh Pirates | Altoona (AA) | Assigned to Altoona (AA) |
| Kyle Gibson | P | 24.307 | Minnesota Twins | Rochester (AAA) | Assigned to Rochester (AAA) |
| Matt Wickswat | P | 26.021 | Chicago White Sox | Birmingham (AA) | Assigned to Birmingham (AA) |
| Will Latimer | P | 26.264 | Boston Red Sox | Portland (AA) | Assigned to Portland (AA) |
| Cole Cook | P | 23.311 | Cleveland Indians | Columbus (AAA) | Assigned to Columbus (AAA) |
| Sean Bierman | P | 23.309 | Tampa Bay Rays | Bowling Green (A) | Assigned to Bowling Green (A) |
| Simon Castro | P | 24.138 | Chicago White Sox | Birmingham (AA) | Assigned to Birmingham (AA) |
| Rett Varner | P | 24.204 | Miami Marlins | New Orleans (AAA) | Assigned to New Orleans (AAA) |
| Kyle Hansen | P | 21.127 | Chicago White Sox | Great Falls (Rk) | Assigned to Great Falls (Rk) |
| Shane Halley | P | 22.331 | Kansas City Royals | Arizona Royals (Rk) | |
| Richie Mascheri | P-OF | 23.018 | New York Yankees | Tampa (A+) | Assigned to Tampa (A+) |
| Donny Medlinger | P | 21.330 | Arizona Diamondbacks | Visalia (A+) | Assigned to Visalia (A+) |
| Daniel Norris | P | 19.122 | Toronto Blue Jays | Vancouver (A-) | Assigned to Vancouver (A-) |
| Nick Goody | P | 21.050 | New York Yankees | Tampa (A+) | Assigned to Tampa (A+) |
| Isaac Sanchez | P | 19.315 | Pittsburgh Pirates | State College (A-) | Assigned to State College (A-) |
| Reid Scoggins | P | 22.038 | Los Angeles Angels | Cedar Rapids (A) | Assigned to Cedar Rapids (A) |
| Arjenis Fernandez | | 19.027 | Los Angeles Angels | Cedar Rapids (A) | Assigned to Cedar Rapids (A) |
| Teoscar Hernandez | | 19.314 | Houston Astros | Lexington (A) | Assigned to Lexington (A) |
| Brandon Welch | P | 21.001 | New York Mets | Kingsport (Rk) | Assigned to Kingsport (Rk) |
| Michael McClendon | P | 27.144 | Milwaukee Brewers | Nashville (AAA) | Outrighted to Nashville (AAA) |
| Carl Crawford | LF | 31.020 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Traded from Red Sox with Adrian Gonzalez, Josh Beckett and Nick Punto to Dodgers for Jerry Sands, James Loney, Ivan DeJesus, Rubby de la Rosa and Allen Webster |
| Matt Campbell | P | 24.350 | | | Released by Phillies |
