| Hisanori Takahashi | RP | 37.122 | Los Angeles Angels | Salt Lake (AAA) | Optioned to Salt Lake (AAA) |
| Jordan Walden | RP | 24.280 | Los Angeles Angels | Los Angeles Angels (MLB) | Activated from DL |
| Yan Gomes | 1b | 25.034 | Toronto Blue Jays | Las Vegas (AAA) | Optioned to Las Vegas (AAA) |
| Alex Hinshaw | RP | 29.295 | Chicago Cubs | Chicago Cubs (MLB) | Claimed off waivers from Padres |
| Arodys Vizcaino | P | 21.282 | Chicago Cubs | Chicago Cubs (MLB) | Transferred to 60-day DL |
| Scott Elbert | RP | 27.009 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Activated from DL |
| Elian Herrera | lf | 27.202 | Los Angeles Dodgers | Albuquerque (AAA) | Optioned to Albuquerque (AAA) |
| Hector Luna | lf | 30.202 | Philadelphia Phillies | Lehigh Valley (AAA) | Optioned to Lehigh Valley (AAA) |
| Starling Marte | lf | 23.317 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | DL-15 Strained right oblique |
| Jose Tabata | rf-lf | 24.010 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Recalled from Indianapolis (AAA) |
| Andrew Brown | RF-LF | 27.346 | Colorado Rockies | Colorado Rockies (MLB) | Recalled from Colorado Springs (AAA) |
| Michael Cuddyer | 1b | 33.148 | Colorado Rockies | Colorado Rockies (MLB) | DL-15 Strained right oblique |
| Nick Blackburn | SP | 30.179 | Minnesota Twins | Rochester (AAA) | Outrighted to Rochester (AAA) |
| Tsuyoshi Nishioka | SS | 28.026 | Minnesota Twins | Rochester (AAA) | Outrighted to Rochester (AAA) |
| Brett Anderson | SP-RP | 24.203 | Oakland Athletics | Oakland Athletics (MLB) | Activated from DL |
| Stephen Drew | ss | 29.159 | Oakland Athletics | Oakland Athletics (MLB) | Traded from Diamondbacks to Athletics for Sean Jamieson |
| Sean Jamieson | SS | 23.173 | Arizona Diamondbacks | South Bend (A) | Traded from Athletics to Diamondbacks for Stephen Drew |
| Anthony Recker | C | 28.359 | Oakland Athletics | Sacramento (AAA) | Designated for assignment |
| Dan Straily | SP | 23.264 | Oakland Athletics | Sacramento (AAA) | Optioned to Sacramento (AAA) |
| Ryan Dempster | SP | 35.111 | Texas Rangers | Texas Rangers (MLB) | Activated from restricted list |
| Cesar Izturis | SS | 32.194 | - | | Refused minor league assignment. Elected free agency |
| Rob Johnson | c | 30.031 | New York Mets | Buffalo (AAA) | DL-15 Torn ligament, left thumb |
| Placido Polanco | 3b | 36.317 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Activated from DL |
| Juan Cruz | RP | 33.311 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Designated for assignment |
| Kyle McPherson | P | 24.285 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Recalled from Indianapolis (AAA) |
| Jordy Mercer | 2b-ss | 25.360 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Placed on Paternity Leave |
| Justin Wilson | P | 25.004 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Recalled from Indianapolis (AAA) |
| Carl Crawford | lf | 31.017 | Boston Red Sox | Boston Red Sox (MLB) | DL-15 Left elbow surgery |
| Daniel Nava | dh | 29.183 | Boston Red Sox | Boston Red Sox (MLB) | Activated from DL |
| Vicente Padilla | RP | 34.349 | Boston Red Sox | Boston Red Sox (MLB) | Activated from DL |
| Danny Valencia | 3b | 27.337 | Boston Red Sox | Pawtucket (AAA) | Optioned to Pawtucket (AAA) |
| Jordan Danks | cf | 26.015 | Chicago White Sox | Chicago White Sox (MLB) | Recalled from Charlotte (AAA) |
| Alejandro De Aza | cf | 28.133 | Chicago White Sox | Chicago White Sox (MLB) | DL-15 Bruised left ribcage |
| Liam Hendriks | SP | 23.193 | Minnesota Twins | Minnesota Twins (MLB) | Recalled from Rochester (AAA) |
| Graham Godfrey | P | 28.013 | Oakland Athletics | Sacramento (AAA) | Designated for assignment |
| Jordan Norberto | RP | 25.257 | Oakland Athletics | Oakland Athletics (MLB) | DL-15 Left shoulder tendinitis |
| Seth Smith | lf | 29.326 | Oakland Athletics | Oakland Athletics (MLB) | Activated from DL |
| Jemile Weeks | 2b | 25.208 | Oakland Athletics | Sacramento (AAA) | Optioned to Sacramento (AAA) |
| Yorvit Torrealba | c | 34.034 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Contract purchased from New Hampshire (AA) |
| Jeff Beliveau | RP | 25.217 | Chicago Cubs | Iowa (AAA) | Optioned to Iowa (AAA) |
| Adrian Cardenas | 2b | 24.317 | Chicago Cubs | Iowa (AAA) | Optioned to Iowa (AAA) |
| Matt Garza | P | 28.285 | Chicago Cubs | Chicago Cubs (MLB) | Transferred to 60-day DL |
| Chris Rusin | SP | 25.304 | Chicago Cubs | Chicago Cubs (MLB) | Contract purchased from Iowa (AAA) |
| Devin Mesoraco | c | 24.064 | Cincinnati Reds | Cincinnati Reds (MLB) | Suspended 3 games. Serving. |
| Dioner Navarro | c | 28.195 | Cincinnati Reds | Cincinnati Reds (MLB) | Recalled from Louisville (AAA) |
| Logan Ondrusek | RP | 27.190 | Cincinnati Reds | Louisville (AAA) | Optioned to Louisville (AAA) |
| Rubby De La Rosa | RP | 23.171 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Activated from DL |
| Javy Guerra | RP | 26.295 | Los Angeles Dodgers | Albuquerque (AAA) | Optioned to Albuquerque (AAA) |
| Robert Carson | RP | 23.211 | New York Mets | New York Mets (MLB) | Recalled from Buffalo (AAA) |
| Jeremy Hefner | RP-SP | 26.164 | New York Mets | New York Mets (MLB) | Placed on Paternity Leave |
| Phillippe Aumont | RP | 23.227 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Recalled from Lehigh Valley (AAA) |
| Jeremy Horst | RP | 26.325 | Philadelphia Phillies | Philadelphia Phillies (MLB) | Placed on Paternity Leave |
| Daniel McCutchen | P | 29.330 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Recalled from Indianapolis (AAA) |
| Kyle McPherson | P | 24.285 | Pittsburgh Pirates | Indianapolis (AAA) | Optioned to Indianapolis (AAA) |
| Chad Qualls | RP | 34.005 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Activated from bereavement list |
| Justin Wilson | P | 25.004 | Pittsburgh Pirates | Indianapolis (AAA) | Optioned to Indianapolis (AAA) |
| Jhoulys Chacin | SP | 24.228 | Colorado Rockies | Colorado Rockies (MLB) | Activated from DL |
| Eric Young | lf | 27.089 | Colorado Rockies | Colorado Rockies (MLB) | DL-15 Left intercostal strain |
| Sam Demel | P | 26.303 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | Recalled from Reno (AAA) |
| Sean Rodriguez | 3b | 27.118 | Tampa Bay Rays | Durham (AAA) | Optioned to Durham (AAA) |
| Luke Scott | dh | 34.058 | Tampa Bay Rays | Tampa Bay Rays (MLB) | Activated from DL |
| Andrew Werner | SP | 25.178 | San Diego Padres | San Diego Padres (MLB) | Contract purchased from Tucson (AAA) |
| Gil Velazquez | 3b | 32.310 | Miami Marlins | New Orleans (AAA) | Outrighted to New Orleans (AAA) |
| Dylan Owen | P | 26.041 | New York Mets | Buffalo (AAA) | Activated from DL |
| Jose Flores | P | 23.079 | Cleveland Indians | Akron (AA) | DL-7 Right shoulder strain |
| Gabe Jacobo | 1B | 25.130 | Toronto Blue Jays | New Hampshire (AA) | Activated from DL |
| Brett Bochy | P | 24.361 | San Francisco Giants | Richmond (AA) | DL-7 Right shoulder fatigue |
| Kris Harvey | P | 28.230 | Pittsburgh Pirates | Altoona (AA) | DL-7 Right shoulder inflammation |
| Jandy Sena | P | 23.012 | Seattle Mariners | Jackson (AA) | DL-7 Injured |
| Moises Hernandez | P | 28.157 | Seattle Mariners | Jackson (AA) | Activated from DL |
| Brandon Maurer | P | 22.050 | Seattle Mariners | Jackson (AA) | Placed on temporarily inactive list |
| Kalian Sams | RF | 25.362 | Seattle Mariners | Jackson (AA) | Activated from DL |
| Casio Grider | 2B | 25.005 | Los Angeles Dodgers | Rancho Cucamonga (A+) | DL-7 Strained lower back |
| Angel Raga | P | 23.028 | Seattle Mariners | High Desert (A+) | DL-7 Injured |
| Alexis Aguilar | 2B-3B | 21.066 | Los Angeles Dodgers | Rancho Cucamonga (A+) | Activated from DL |
| Scott Wingo | 2B | 23.150 | Los Angeles Dodgers | Rancho Cucamonga (A+) | Activated from DL |
| Nate Karns | P | 24.271 | Washington Nationals | Potomac (A+) | DL-7 Injured |
| Rafael Fernandez | RF | 24.019 | New York Mets | St. Lucie (A+) | DL-7 Injured |
| Darrell Ceciliani | CF | 22.061 | New York Mets | St. Lucie (A+) | Activated from DL |
| Pedro Guerra | P | 22.225 | New York Yankees | Charleston (sc) (A) | Activated from DL |
| Fred Lewis | P | 25.249 | New York Yankees | Charleston (sc) (A) | Activated from DL |
| Junior Sosa | CF-LF | 21.323 | Pittsburgh Pirates | West Virginia (A) | DL-7 Injured |
| Derek Law | P | 21.342 | San Francisco Giants | Augusta (A) | DL-7 Injured |
| Phil Wetherell | P | 22.317 | New York Yankees | Charleston (sc) (A) | Placed on temporarily inactive list |
| Brad Mincey | P | 23.256 | Miami Marlins | Greensboro (A) | Activated from temporary inactive list |
| Christian Powell | P | 21.050 | Minnesota Twins | Elizabethton (Rk) | Placed on temporarily inactive list |
| Luke Bard | P | 21.282 | Minnesota Twins | Elizabethton (Rk) | DL-7 Injured |
| Randy Wolf | SP | 36.000 | - | | Released by Brewers |
| Jeff Bianchi | 3b | 25.321 | Milwaukee Brewers | Milwaukee Brewers (MLB) | Recalled from Nashville (AAA) |
| Bartolo Colon | SP | 37.090 | Oakland Athletics | Oakland Athletics (MLB) | Suspended 50 games for violating MLB drug policy |
| Peter Bourjos | cf | 25.144 | Los Angeles Angels | Los Angeles Angels (MLB) | DL-15 Sore right wrist |
| Garrett Richards | RP | 24.087 | Los Angeles Angels | Los Angeles Angels (MLB) | Recalled from Salt Lake (AAA) |
| Yunel Escobar | ss | 29.293 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Placed on Paternity Leave |
| Chad Beck | P | 27.217 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Recalled from Las Vegas (AAA) |
| Johan Santana | SP | 33.162 | New York Mets | New York Mets (MLB) | DL-15 Lower back inflammation |
| Brad Boxberger | RP | 24.087 | San Diego Padres | Tucson (AAA) | Optioned to Tucson (AAA) |
| Jeremy Hermida | RF | 28.205 | San Diego Padres | Tucson (AAA) | Designated for assignment |
| Carlos Gonzalez | lf | 26.309 | Colorado Rockies | Colorado Rockies (MLB) | Activated from bereavement list |
| Guillermo Moscoso | SP-RP | 28.282 | Colorado Rockies | Colorado Springs (AAA) | Optioned to Colorado Springs (AAA) |
| Jacob Turner | SP | 21.093 | Miami Marlins | Miami Marlins (MLB) | Recalled from New Orleans (AAA) |
| Sam Demel | RP | 26.303 | Arizona Diamondbacks | Reno (AAA) | Optioned to Reno (AAA) |
| A.J. Pollock | lf | 24.261 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | Recalled from Reno (AAA) |
| Tyler Skaggs | SP | 21.040 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | Contract purchased from Reno (AAA) |
| Hector Ambriz | RP | 28.085 | Houston Astros | Houston Astros (MLB) | Contract purchased from Oklahoma City (AAA) |
| Dan Merklinger | P | 26.276 | Colorado Rockies | Colorado Springs (AAA) | Signed to minor league contract |
| Armando Galarraga | SP | 30.219 | Houston Astros | Houston Astros (MLB) | Designated for assignment |
| Collin McHugh | SP | 25.064 | New York Mets | New York Mets (MLB) | Contract purchased from Buffalo (AAA) |
| Ryan Raburn | 2B-LF | 31.127 | Detroit Tigers | Toledo (AAA) | Assigned to Toledo (AAA) for rehab |
| Luis Vasquez | P | 26.141 | Los Angeles Dodgers | Albuquerque (AAA) | DL-7 Left calf strain |
| Aneury Rodriguez | P | 24.253 | Houston Astros | Oklahoma City (AAA) | Activated from temporary inactive list |
| Jose Garcia | 2B | 24.193 | St. Louis Cardinals | Memphis (AAA) | DL-7 Injured |
| Eric Junge | P | 35.229 | Colorado Rockies | Colorado Springs (AAA) | DL-7 Right shoulder inflammation |
| Tyler Henson | RF | 24.251 | Los Angeles Dodgers | Albuquerque (AAA) | DL-7 Right quad strain |
| A.J. Griffin | SP | 24.207 | Oakland Athletics | Sacramento (AAA) | Assigned to Sacramento (AAA) for rehab |
| Drew Bowlin | P | 25.237 | San Francisco Giants | San Jose (A+) | Activated from DL |
| Edward Concepcion | P | 23.323 | San Francisco Giants | San Jose (A+) | DL-7 Injured |
| Patrick Urckfitz | P | 24.032 | Houston Astros | Lancaster (A+) | Activated from DL |
| Zach Grimmett | P | 22.198 | Houston Astros | Lancaster (A+) | DL-7 Injured |
| Santiago Garrido | P | 22.322 | Kansas City Royals | Wilmington (A+) | Activated from DL |
| Chase Boruff | P | 24.026 | Kansas City Royals | Wilmington (A+) | DL-7 Sore right elbow |
| Kevin David | C | 24.134 | Kansas City Royals | Kane County (A) | DL-7 Injured |
| Maverick Lasker | P | 22.186 | Milwaukee Brewers | Wisconsin (A) | DL-7 Injured |
| Trevor Shull | P | 22.015 | Tampa Bay Rays | Bowling Green (A) | DL-7 Injured |
| Charlie Lowell | P | 21.301 | Miami Marlins | Greensboro (A) | Activated from temporary inactive list |
| Zach Good | P | 20.075 | Boston Red Sox | Lowell (A-) | Activated from DL |
| Robert Benincasa | P | 21.351 | Washington Nationals | Auburn (A-) | DL-7 Injured |
| Dallas Poulk | 2B | 24.098 | Miami Marlins | Jupiter (A+) | Assigned to Jupiter (A+) |
| Matt Marquis | LF | 22.181 | Boston Red Sox | Lowell (A-) | Assigned to Lowell (A-) |
| Josmil Pinto | C | 23.144 | Minnesota Twins | New Britain (AA) | Assigned to New Britain (AA) |
| David Renfroe | 3B | 21.279 | Boston Red Sox | Salem (A+) | Assigned to Salem (A+) |
| Alex Fuselier | RF-LF | 22.343 | Pittsburgh Pirates | West Virginia (A) | Assigned to West Virginia (A) |
| Lucas Herbst | OF-P | 21.347 | Baltimore Orioles | Delmarva (A) | Assigned to Delmarva (A) |
| Brett Frantini | C | 22.196 | Baltimore Orioles | Gulf Coast Orioles (Rk) | |
| Jake Skole | CF | 20.218 | Texas Rangers | Spokane (A-) | Assigned to Spokane (A-) |
| Jose Dore | LF | 20.195 | San Diego Padres | Arizona Padres (Rk) | |
| Eric Sim | C | 23.231 | San Francisco Giants | Arizona Giants (Rk) | |
| Sean Jamieson | SS | 23.173 | Oakland Athletics | Burlington (A) | Assigned to Burlington (A) |
| Sean Jamieson | SS | 23.173 | Arizona Diamondbacks | South Bend (A) | Assigned to South Bend (A) |
| Jason Leblebijian | IF | 21.101 | Toronto Blue Jays | Lansing (A) | Assigned to Lansing (A) |
| Vance Albitz | SS | 24.204 | St. Louis Cardinals | Memphis (AAA) | Assigned to Memphis (AAA) |
| Christian Lopes | SS | 19.325 | Toronto Blue Jays | Vancouver (A-) | Assigned to Vancouver (A-) |
| Carlos Alvarez | 2B-3B | 26.270 | Washington Nationals | Auburn (A-) | Assigned to Auburn (A-) |
| Roderick Bernadina | RF | 20.012 | Baltimore Orioles | Delmarva (A) | Assigned to Delmarva (A) |
| Manuel Hernandez | LF | 20.003 | Baltimore Orioles | Aberdeen (A-) | Assigned to Aberdeen (A-) |
| Glynn Davis | CF | 20.259 | Baltimore Orioles | Frederick (A+) | Assigned to Frederick (A+) |
| Santiago Nessy | C | 19.257 | Toronto Blue Jays | Vancouver (A-) | Assigned to Vancouver (A-) |
| Michael Vaughn | C | 21.246 | Miami Marlins | Gulf Coast Marlins (Rk) | Assigned to Gulf Coast Marlins (Rk) |
| Andre Lamontagne | P | 26.151 | Milwaukee Brewers | Arizona Brewers (Rk) | |
| Sean Gleason | P | 27.001 | Baltimore Orioles | Norfolk (AAA) | Assigned to Norfolk (AAA) |
| Luis Rojas | P | 23.024 | San Francisco Giants | Arizona Giants (Rk) | |
| David Walters | P | 25.009 | Baltimore Orioles | Frederick (A+) | Assigned to Frederick (A+) |
| Ross Seaton | P | 22.338 | Houston Astros | Corpus Christi (AA) | Assigned to Corpus Christi (AA) |
| Taylor Hill | P | 23.163 | Washington Nationals | Potomac (A+) | Assigned to Potomac (A+) |
| Ryan Searle | P | 23.061 | Chicago Cubs | Daytona (A+) | Assigned to Daytona (A+) |
| Michael Aldrete | IF | 22.326 | St. Louis Cardinals | Batavia (A-) | Assigned to Batavia (A-) |
| Benjamin Wells | P | 19.346 | Chicago Cubs | Arizona Cubs (Rk) | |
| Jason Townsend | P | 23.339 | Pittsburgh Pirates | Altoona (AA) | Assigned to Altoona (AA) |
| Mark Hardy | P | 24.111 | San Diego Padres | San Antonio (AA) | Assigned to San Antonio (AA) |
| Daniel Sarria | P | 24.204 | San Diego Padres | Eugene (A-) | Assigned to Eugene (A-) |
| Jose Dominguez | P | 22.015 | Los Angeles Dodgers | Chattanooga (AA) | Assigned to Chattanooga (AA) |
| Sean Lucas | P | 23.138 | Cincinnati Reds | Clinton (A) | Assigned to Clinton (A) |
| Joshua Nervis | P | 23.301 | Cleveland Indians | Lake County (A) | Assigned to Lake County (A) |
| Gilberto Mendez | | 19.278 | Washington Nationals | Auburn (A-) | Assigned to Auburn (A-) |
| Lyle Overbay | 1B | 35.206 | Atlanta Braves | Gwinnett (AAA) | Signed to minor league contract |
| Jason Bartlett | SS | 32.297 | | | Released by Padres |
| Ryan Eigsti | C | 26.363 | Toronto Blue Jays | Las Vegas (AAA) | DL-7 Injured |
| Zack Hardoin | P | 24.042 | | | Released by Astros |
| Dan Jennings | RP | 25.127 | Miami Marlins | Miami Marlins (MLB) | Recalled from New Orleans (AAA) |
