| Steve Johnson | P | 24.306 | Baltimore Orioles | Baltimore Orioles (MLB) | Recalled from Norfolk (AAA) |
| P.J. Walters | SP | 27.112 | Minnesota Twins | Rochester (AAA) | Assigned to Rochester (AAA) for rehab |
| Javy Guerra | P | 26.244 | Los Angeles Dodgers | Rancho Cucamonga (A+) | Assigned to Rancho Cucamonga (A+) for rehab |
| Ricky Orta | P | 27.238 | New York Yankees | Trenton (AA) | DL-7 Right arm soreness |
| Eswarlin Jimenez | P | 20.218 | Los Angeles Angels | Cedar Rapids (A) | DL-7 Injured |
| Virgil Hill | LF-CF | 22.296 | St. Louis Cardinals | Quad Cities (A) | DL-7 Injured |
| Cory Wade | RP | 29.035 | New York Yankees | Scranton/Wilkes-Barre (AAA) | Optioned to Scranton/Wilkes-Barre (AAA) |
| Dontrelle Willis | P | 30.171 | - | | Announced retirement |
| Ted Lilly | P | 36.180 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Transferred to 60-day DL |
| Luis Cruz | 3b | 28.143 | Los Angeles Dodgers | Los Angeles Dodgers (MLB) | Contract purchased from Albuquerque (AAA) |
| Shawn Tolleson | RP | 24.165 | Los Angeles Dodgers | Albuquerque (AAA) | Optioned to Albuquerque (AAA) |
| Geoff Blum | 3b | 39.067 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | Activated from DL |
| John McDonald | ss | 37.281 | Arizona Diamondbacks | Arizona Diamondbacks (MLB) | DL-15 Back stiffness |
| Tyler Gaffney | OF | 21.073 | Pittsburgh Pirates | Pittsburgh Pirates (MLB) | Signed out of draft |
| Brad Davis | C | 29.185 | - | | Released by Padres |
| Blake Tekotte | CF | 25.039 | San Diego Padres | Tucson (AAA) | DL-7 Injured |
| Hernan Iribarren | 2B | 28.003 | Colorado Rockies | Colorado Springs (AAA) | Activated from temporary inactive list |
| Jhonny Nunez | P | 26.218 | - | | Released by Rays |
| Stephen Vogt | C-LF | 27.243 | Tampa Bay Rays | Durham (AAA) | DL-7 Injured |
| Andy Reichard | P | 27.210 | San Francisco Giants | Richmond (AA) | DL-7 Right shoulder stiffness |
| T.J. Steele | CF | 25.284 | - | | Released by Padres |
| Beau Jones | P | 25.311 | Oakland Athletics | Midland (AA) | Signed to minor league contract |
| Tim Murphy | P | 25.056 | Texas Rangers | Frisco (AA) | Activated from DL |
| Tyler Tufts | P | 25.209 | Texas Rangers | Frisco (AA) | DL-7 Injured |
| Willy Kesler | P | 24.326 | Seattle Mariners | High Desert (A+) | DL-7 Injured |
| Joe Bonfe | 1B | 24.187 | New York Mets | St. Lucie (A+) | Activated from DL |
| Matt Shelton | P | 23.214 | Los Angeles Dodgers | Great Lakes (A) | DL-7 Injured |
| Kyung-Min Na | LF-CF | 20.203 | San Diego Padres | Fort Wayne (A) | Activated from DL |
| Jay Austin | CF | 21.326 | Houston Astros | Lexington (A) | DL-7 Injured |
| Brandon Miller | C | 22.267 | Washington Nationals | Auburn (A-) | DL-7 Injured |
| Andrew Carpenter | IF | 22.088 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Contract purchased from Las Vegas (AAA) |
| David Pauley | RP | 29.015 | Toronto Blue Jays | Toronto Blue Jays (MLB) | Designated for Assignment |
| Alan Ahmady | RF-LF | 24.201 | St. Louis Cardinals | Gulf Coast Cardinals (Rk) | |
| Jason Hagerty | C | 24.293 | San Diego Padres | Eugene (A-) | Assigned to Eugene (A-) for rehab |
| Jordan Parraz | RF | 27.267 | Atlanta Braves | Gulf Coast Braves (Rk) | Assigned to GCL Braves (Rk) for rehab |
| Shawn McGill | C | 28.124 | Atlanta Braves | Lynchburg (A+) | Assigned to Lynchburg (A+) |
| Nevin Ashley | C | 27.322 | Tampa Bay Rays | Gulf Coast Rays (Rk) | |
| Jimmy Gallagher | 1B | 26.302 | Chicago White Sox | Charlotte (AAA) | Assigned to Charlotte (AAA) |
| Shane Peterson | LF-CF | 24.142 | Oakland Athletics | Sacramento (AAA) | Assigned to Sacramento (AAA) |
| Brandon Bantz | C | 25.176 | Seattle Mariners | Tacoma (AAA) | Assigned to Tacoma (AAA) |
| Ross Wilson | 2B | 23.235 | Chicago White Sox | Winston-Salem (A+) | Assigned to Winston-Salem (A+) |
| Sandy Leon | C | 23.111 | Washington Nationals | Harrisburg (AA) | Assigned to Harrisburg (AA) for rehab |
| Patrick Palmeiro | 3B | 22.118 | Chicago White Sox | Great Falls (Rk) | |
| Matthew Cerda | 3B-2B | 22.012 | Chicago Cubs | Daytona (A+) | Assigned to Daytona (A+) |
| Jharmidy De Jesus | 1B | 22.306 | Seattle Mariners | Clinton (A) | Assigned to Clinton (A) |
| Cesar Puello | RF-CF | 21.092 | New York Mets | St. Lucie (A+) | Assigned to St. Lucie (A+) |
| Brady Shoemaker | LF | 25.053 | Chicago White Sox | Birmingham (AA) | Assigned to Birmingham (AA) |
| James Ramsey | OF-IF | 22.195 | St. Louis Cardinals | Palm Beach (A+) | |
| David Lyon | C | 22.164 | Texas Rangers | Arizona Rangers (Rk) | |
| Sherman Johnson | IF | 21.352 | Los Angeles Angels | Orem (Rk) | |
| Danny Vicioso | C | 23.248 | Cincinnati Reds | Clinton (A) | Assigned to Clinton (A) |
| Jayce Boyd | IF | 21.184 | New York Mets | Brooklyn (A-) | |
| Joey Demichele | IF | 21.147 | Chicago White Sox | Kannapolis (A) | Assigned to Kannapolis (A) |
| Kyle Von Tungeln | OF | 21.287 | Colorado Rockies | Tri-City (A-) | |
| Roberto Reyes | RF | 23.053 | St. Louis Cardinals | Quad Cities (A) | Assigned to Quad Cities (A) |
| Carlos Willoughby | 2B | 23.232 | San Francisco Giants | Augusta (A) | |
| Trevor Brown | C | 20.230 | San Francisco Giants | Salem-Keizer (A-) | |
| Jorge Vega-Rosado | SS-2B | 20.210 | Toronto Blue Jays | Bluefield (Rk) | Assigned to Bluefield (Rk) |
| Dustin Hayes | CF | 20.224 | Chicago White Sox | Great Falls (Rk) | Assigned to Great Falls (Rk) |
| Gregori Gonzalez | 3B-RF | 22.356 | Chicago Cubs | Arizona Cubs (Rk) | Assigned to Arizona Cubs (Rk) |
| Fernando Perez | SS | 18.292 | San Diego Padres | Arizona Padres (Rk) | |
| Andy Loomis | P | 26.219 | Baltimore Orioles | Norfolk (AAA) | Assigned to Norfolk (AAA) |
| Nick Rogers | P | 24.274 | Kansas City Royals | Northwest Arkansas (AA) | Assigned to Northwest Arkansas (AA) |
| Scott Olsen | P | 28.172 | Chicago White Sox | Charlotte (AAA) | Assigned to Charlotte (AAA) |
| Merkin Valdez | P | 30.234 | Oakland Athletics | Sacramento (AAA) | Assigned to Sacramento (AAA) |
| Tim Bascom | P | 27.179 | Baltimore Orioles | Norfolk (AAA) | Assigned to Norfolk (AAA) |
| David Bromberg | P | 24.292 | Minnesota Twins | New Britain (AA) | Assigned to New Britain (AA) |
| Chris Carpenter | P | 26.188 | Boston Red Sox | Gulf Coast Red Sox (Rk) | Assigned to Gulf Coast Red Sox (Rk) for rehab |
| Salvador Sanchez | P | 26.292 | Chicago White Sox | Winston-Salem (A+) | Assigned to Winston-Salem (A+) |
| Shane Dyer | P | 24.115 | Tampa Bay Rays | Montgomery (AA) | Assigned to Montgomery (AA) |
| Jon Bachanov | P | 23.153 | Chicago White Sox | Birmingham (AA) | Assigned to Birmingham (AA) |
| Jack McGeary | P | 23.105 | Washington Nationals | Gulf Coast Nationals (Rk) | |
| Pete Ruiz | P | 24.316 | Boston Red Sox | Gulf Coast Red Sox (Rk) | |
| Stosh Wawrzasek | P | 21.306 | Milwaukee Brewers | Wisconsin (A) | |
| Luis Sanz | C | 24.226 | Detroit Tigers | Lakeland (A+) | Assigned to Lakeland (A+) |
| Shane Riedie | P | 22.178 | Los Angeles Angels | Cedar Rapids (A) | Assigned to Cedar Rapids (A) |
| Tyler Johnson | P | 21.349 | Oakland Athletics | Arizona Athletics (Rk) | Assigned to Arizona Athletics (Rk) |
| Louis Head | P | 22.070 | Cleveland Indians | Mahoning Valley (A-) | Assigned to Mahoning Valley (A-) |
| Collin Reynolds | P | 22.005 | San Diego Padres | Eugene (A-) | Assigned to Eugene (A-) |
| Justin Haley | P | 21.016 | Boston Red Sox | Lowell (A-) | |
| Corey Black | UT | 20.333 | New York Yankees | Gulf Coast Yankees (Rk) | |
| Bryan Blough | P | 22.307 | Chicago White Sox | Winston-Salem (A+) | Assigned to Winston-Salem (A+) |
| Tyler Deloach | P | 21.081 | Los Angeles Angels | Orem (Rk) | |
| Alex Muren | OF-P | 20.239 | Minnesota Twins | Gulf Coast Twins (Rk) | |
| Seth Streich | P | 21.133 | Oakland Athletics | Vermont (A-) | Assigned to Vermont (A-) |
| Joseph Lopez | P | 22.103 | Kansas City Royals | Idaho Falls (Rk) | Assigned to Idaho Falls (Rk) |
| Preston Gainey | P | 21.139 | Milwaukee Brewers | Helena (Rk) | |
| Clint Wright | P | 22.064 | Atlanta Braves | Danville (Rk) | Assigned to Danville (Rk) |
| Jose Azor | P | 23.263 | Oakland Athletics | Arizona Athletics (Rk) | |
| Lucas Sims | P | 18.053 | Atlanta Braves | Gulf Coast Braves (Rk) | |
| Max Fried | P | 18.165 | San Diego Padres | Arizona Padres (Rk) | Signed out of draft (California HS) |
| Geoff Broussard | P | 21.284 | Philadelphia Phillies | Lakewood (A) | Assigned to Lakewood (A) |
| Nic Dellatorre | P | 20.309 | Los Angeles Angels | Arizona Angels (Rk) | |
| Melvin Mercedes | | 22.308 | New York Yankees | Tampa (A+) | Assigned to Tampa (A+) |
| Bryan Rodriguez | | 20.362 | San Diego Padres | Arizona Padres (Rk) | Assigned to Arizona Padres (Rk) |
| Orlando Ramirez | | 20.059 | Los Angeles Angels | Arizona Angels (Rk) | Assigned to Arizona Angels (Rk) |
| Antonio Cruz | | 20.269 | Kansas City Royals | Wilmington (A+) | Assigned to Wilmington (A+) |
| Loiger Padron | | 21.180 | Chicago Cubs | Arizona Cubs (Rk) | |
| Paul Schwendel | | 22.327 | Texas Rangers | Arizona Rangers (Rk) | |
| Aris Angeles | | 22.296 | Los Angeles Dodgers | Arizona Dodgers (Rk) | |
| Jeremy Bleich | P | 25.014 | New York Yankees | Staten Island (A-) | Assigned to Staten Island (A-) for rea |
| Joshua Lopez | C | 16.120 | St. Louis Cardinals | St. Louis Cardinals (MLB) | Signed as undrafted free agent (Venezuela) |
